Detailed information for compound 1152432

Basic information

Technical information
  • TDR Targets ID: 1152432
  • Name: 1-(2,5-dimethoxyphenyl)butan-2-amine
  • MW: 209.285 | Formula: C12H19NO2
  • H donors: 1 H acceptors: 0 LogP: 2.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(Cc1cc(OC)ccc1OC)N
  • InChi: 1S/C12H19NO2/c1-4-10(13)7-9-8-11(14-2)5-6-12(9)15-3/h5-6,8,10H,4,7,13H2,1-3H3
  • InChiKey: BGWUWDWDTLZQAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,5-dimethoxybenzyl)propylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0016 0.0511 0.0848
Toxoplasma gondii exonuclease III APE 0.0019 0.0641 0.0072
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1906 0.1906
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0089 0.3691 0.6124
Chlamydia trachomatis hypothetical protein 0.0018 0.0629 0.5
Trichomonas vaginalis helicase, putative 0.0007 0.0118 0.0318
Brugia malayi CAAX amino terminal protease family protein 0.0089 0.3691 0.3691
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0217 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0118 0.0318
Schistosoma mansoni bromodomain containing protein 0.0005 0.0056 0.0093
Schistosoma mansoni ap endonuclease 0.0019 0.0641 0.1064
Schistosoma mansoni ap endonuclease 0.0019 0.0641 0.1064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0118 0.0318
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.109 0.109
Schistosoma mansoni cpg binding protein 0.0031 0.1162 0.1928
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1298 0.1298
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Brugia malayi CXXC zinc finger family protein 0.0029 0.109 0.109
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0004 0.0006 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Brugia malayi Bromodomain containing protein 0.0005 0.0056 0.0056
Echinococcus multilocularis muscleblind protein 0.0147 0.6216 0.6216
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0049 0.1976 0.1976
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1976 0.1976
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.3728 0.6187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.3728 0.3728
Loa Loa (eye worm) hypothetical protein 0.0034 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.0235 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.3728 0.3728
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.1654 0.4482
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0641 0.0641
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.3728 0.3728
Onchocerca volvulus 0.0048 0.1906 1
Schistosoma mansoni cpg binding protein 0.0029 0.109 0.1809
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.3728 0.6187
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0005 0.0056 0.0056
Giardia lamblia Hypothetical protein 0.0089 0.3691 1
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.6027 0.6027
Schistosoma mansoni bromodomain containing protein 0.0005 0.0056 0.0093
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.1654 0.5901
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0641 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.3728 0.3728
Schistosoma mansoni hypothetical protein 0.0016 0.0511 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0145 0.0145
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0511 0.0511
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.1654 0.1654
Echinococcus granulosus CAAX prenyl protease 2 0.0089 0.3691 0.3691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.3728 0.6187
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0145 0.0145
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0005 0.0056 0.0056
Echinococcus granulosus muscleblind protein 0.0147 0.6216 0.6216
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0222 0.0222
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0118 0.0318
Echinococcus multilocularis survival motor neuron protein 1 0.0235 1 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.6216 0.6216
Echinococcus granulosus cpg binding protein 0.0031 0.1162 0.1162
Echinococcus multilocularis muscleblind protein 1 0.0147 0.6216 0.6216
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0089 0.3691 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0089 0.3691 0.6124
Schistosoma mansoni hypothetical protein 0.0016 0.0511 0.0848
Echinococcus granulosus survival motor neuron protein 1 0.0235 1 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.1906 0.3163
Echinococcus multilocularis cpg binding protein 0.0031 0.1162 0.1162
Entamoeba histolytica CAAX amino terminal protease family 0.0018 0.0629 0.1704
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0089 0.3691 1
Onchocerca volvulus 0.0029 0.109 0.5717
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0222 0.0222
Brugia malayi Muscleblind-like protein 0.0147 0.6216 0.6216
Echinococcus multilocularis CAAX prenyl protease 2 0.0089 0.3691 0.3691
Schistosoma mansoni hypothetical protein 0.0048 0.1906 0.3163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0511 0.0511
Schistosoma mansoni hypothetical protein 0.0034 0.1298 0.2154
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0641 0.1738
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Schistosoma mansoni cpg binding protein 0.0031 0.1162 0.1928
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0641 0.1738
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0511 0.0511
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.6027 0.6027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0089 0.3691 0.3691
Loa Loa (eye worm) hypothetical protein 0.0016 0.0511 0.0511
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.5853 0.5853
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0118 0.0318
Echinococcus multilocularis GPCR, family 2 0.0016 0.0511 0.0511
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0089 0.3691 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0118 0.0318
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0511 0.0511
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1976 0.1976
Loa Loa (eye worm) hypothetical protein 0.0005 0.0056 0.0056
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.6027 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Plasmodium vivax protease, putative 0.0018 0.0629 0.3756
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.1502 0.2824
Entamoeba histolytica CAAX amino terminal protease family 0.0018 0.0629 0.1704
Entamoeba histolytica CAAX prenyl protease family 0.0089 0.3691 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0641 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0118 0.0318
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.2366 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0145 0.0145
Echinococcus granulosus zinc finger protein 0.0005 0.0056 0.0056
Loa Loa (eye worm) acetyltransferase 0.0143 0.6027 0.6027
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0118 0.0318
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0641 0.1738
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0222 0.0222
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0511 0.0511
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0013 0.0022
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0641 0.0641
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1976 0.1976
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.1654 0.4482
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1502 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0641 0.0641
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0641 0.0143
Trypanosoma brucei CAAX amino terminal protease, putative 0.0089 0.3691 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0118 0.0318
Loa Loa (eye worm) hypothetical protein 0.0005 0.0056 0.0056
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.1654 1
Echinococcus granulosus GPCR family 2 0.0016 0.0511 0.0511
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.3728 0.3728
Loa Loa (eye worm) hypothetical protein 0.0147 0.6216 0.6216
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0511 0.0511
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0145 0.0241
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0089 0.3691 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.3728 0.3728
Brugia malayi PHD-finger family protein 0.0005 0.0056 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.1654 0.5901
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0118 0.0318
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0641 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1502 0.4071
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0004 0.0006 0.0017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0145 0.0145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0641 0.3833
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0641 0.5
Echinococcus multilocularis zinc finger protein 0.0005 0.0056 0.0056
Schistosoma mansoni zinc finger protein 0.0005 0.0056 0.0093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.2499 0.4147
Schistosoma mansoni hypothetical protein 0.0016 0.0511 0.0848

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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