Detailed information for compound 1165252

Basic information

Technical information
  • TDR Targets ID: 1165252
  • Name: 1-[3-[(6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy ]propyl]-4-phenylpiperazine
  • MW: 354.461 | Formula: C22H27FN2O
  • H donors: 0 H acceptors: 0 LogP: 4.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc2CCCc2cc1OCCCN1CCN(CC1)c1ccccc1
  • InChi: 1S/C22H27FN2O/c23-21-16-18-6-4-7-19(18)17-22(21)26-15-5-10-24-11-13-25(14-12-24)20-8-2-1-3-9-20/h1-3,8-9,16-17H,4-7,10-15H2
  • InChiKey: HDCDCNQOCFAIKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[3-(6-fluoroindan-5-yl)oxypropyl]-4-phenyl-piperazine
  • 1-[3-[(6-fluoro-5-indanyl)oxy]propyl]-4-phenylpiperazine
  • 1-[3-[(6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy]propyl]-4-phenyl-piperazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.052 0.0731
Loa Loa (eye worm) XPG I-region family protein 0.0006 0.0095 0.0153
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.2676 0.4285
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1783 0.2505
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.2676 0.3761
Loa Loa (eye worm) hypothetical protein 0.0039 0.1433 0.2294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1783 0.2505
Loa Loa (eye worm) hypothetical protein 0.0039 0.1433 0.2294
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0004 0.0023 0.0131
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.2676 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.2676 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.2453 0.3447
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.052 0.0731
Brugia malayi Bromodomain containing protein 0.0006 0.007 0.0112
Onchocerca volvulus 0.0039 0.1433 1
Giardia lamblia hypothetical protein 0.0006 0.0095 0.0607
Echinococcus granulosus tar DNA binding protein 0.0068 0.264 0.371
Echinococcus multilocularis geminin 0.0178 0.7116 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0224 0.0358
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.1726 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Brugia malayi Isocitrate dehydrogenase 0.0017 0.052 0.0832
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0224 0.0314
Loa Loa (eye worm) acetyltransferase 0.0157 0.6247 1
Echinococcus multilocularis flap endonuclease 1 0.003 0.1084 0.1523
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.052 0.3314
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.1726 0.7405
Brugia malayi XPG I-region family protein 0.0006 0.0095 0.0153
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.1433 0.2014
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.1569 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.1433 0.2294
Brugia malayi CXXC zinc finger family protein 0.003 0.1074 0.1719
Echinococcus granulosus flap endonuclease 1 0.003 0.1084 0.1523
Echinococcus multilocularis zinc finger protein 0.0006 0.007 0.0099
Loa Loa (eye worm) hypothetical protein 0.0006 0.0095 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0122 0.0706
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.1084 0.628
Trichomonas vaginalis esterase, putative 0.0039 0.1433 0.8301
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.1433 0.8301
Giardia lamblia Exonuclease 1 0.0006 0.0095 0.0607
Schistosoma mansoni tar DNA-binding protein 0.0068 0.264 0.371
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.1084 0.405
Leishmania major hypothetical protein, conserved 0.0039 0.1433 0.5354
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.1433 0.5
Schistosoma mansoni cpg binding protein 0.0032 0.1144 0.1607
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Brugia malayi RNA binding protein 0.0068 0.264 0.4227
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0112
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0095 0.0409
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.1084 0.465
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0006 0.0095 0.0134
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0095 0.0409
Loa Loa (eye worm) beta-lactamase 0.0039 0.1433 0.2294
Mycobacterium tuberculosis Conserved protein 0.0039 0.1433 0.0963
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.2331 1
Echinococcus granulosus transcription factor Dp 1 0.004 0.1483 0.2084
Mycobacterium leprae Probable lipase LipE 0.0039 0.1433 0.5
Plasmodium vivax SET domain containing protein 0.0004 0.0027 0.0156
Entamoeba histolytica DNA-repair protein, putative 0.0006 0.0095 0.0212
Onchocerca volvulus 0.0039 0.1433 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1783 0.2505
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.6247 0.8778
Echinococcus multilocularis tar DNA binding protein 0.0068 0.264 0.371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1783 0.2505
Schistosoma mansoni tar DNA-binding protein 0.0068 0.264 0.371
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.1433 0.8301
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.2676 0.5949
Echinococcus granulosus geminin 0.0178 0.7116 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.1433 0.5
Trichomonas vaginalis helicase, putative 0.0007 0.0122 0.0706
Brugia malayi TAR-binding protein 0.0068 0.264 0.4227
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.1569 0.3488
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0122 0.0706
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0224 0.0314
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.1084 0.405
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0095 0.0356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0122 0.0706
Schistosoma mansoni hypothetical protein 0.0178 0.7116 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.1483 0.2084
Loa Loa (eye worm) hypothetical protein 0.0006 0.0095 0.0153
Schistosoma mansoni hypothetical protein 0.0178 0.7116 1
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.6247 1
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0006 0.0095 0.0134
Entamoeba histolytica hypothetical protein 0.0114 0.4499 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.6067 0.8525
Mycobacterium leprae conserved hypothetical protein 0.0039 0.1433 0.5
Schistosoma mansoni flap endonuclease-1 0.0027 0.0965 0.1356
Giardia lamblia Flap structure-specific endonuclease 0.003 0.1084 0.6908
Schistosoma mansoni bromodomain containing protein 0.0006 0.007 0.0099
Echinococcus granulosus exonuclease 1 0.0006 0.0095 0.0134
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.1433 0.0963
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.2676 1
Plasmodium vivax DNA repair protein RAD2, putative 0.0006 0.0095 0.0552
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0122 0.0706
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0149 0.0209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1783 0.2505
Loa Loa (eye worm) hypothetical protein 0.0006 0.007 0.0112
Plasmodium vivax exonuclease I, putative 0.0006 0.0095 0.0552
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0095 0.0552
Brugia malayi Flap endonuclease-1 0.003 0.1084 0.1735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0122 0.0706
Entamoeba histolytica Flap nuclease, putative 0.003 0.1084 0.241
Echinococcus granulosus zinc finger protein 0.0006 0.007 0.0099
Trichomonas vaginalis exonuclease%2C+putative 0.0006 0.0095 0.0552
Plasmodium vivax flap endonuclease 1, putative 0.003 0.1084 0.628
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1783 0.2854
Loa Loa (eye worm) hypothetical protein 0.0039 0.1433 0.2294
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.2676 0.4285
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.1433 0.8301
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.4499 0.6322
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.2676 1
Entamoeba histolytica hypothetical protein 0.0114 0.4499 1
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0006 0.0095 0.0134
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.052 0.2231
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0219 0.035
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1074 0.1719
Brugia malayi beta-lactamase family protein 0.0039 0.1433 0.2294
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.1084 0.405
Entamoeba histolytica hypothetical protein 0.0114 0.4499 1
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0095 0.0409
Echinococcus multilocularis exonuclease 1 0.0006 0.0095 0.0134
Schistosoma mansoni cpg binding protein 0.0032 0.1144 0.1607
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.2676 0.3761
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0149 0.0209
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.052 0.3012
Loa Loa (eye worm) hypothetical protein 0.0039 0.1433 0.2294
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.1433 0.8301
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0095 0.0552
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.1726 0.2426
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.052 0.0832
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1433 0.5354
Schistosoma mansoni tar DNA-binding protein 0.0068 0.264 0.371
Loa Loa (eye worm) flap endonuclease-1 0.003 0.1084 0.1735
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.052 0.0731
Mycobacterium ulcerans lipase LipD 0.0039 0.1433 0.5
Echinococcus granulosus cpg binding protein 0.0032 0.1144 0.1607
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.1433 0.0963
Loa Loa (eye worm) RNA binding protein 0.0068 0.264 0.4227
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0122 0.0706
Schistosoma mansoni cpg binding protein 0.003 0.1074 0.1509
Schistosoma mansoni hypothetical protein 0.0114 0.4499 0.6322
Entamoeba histolytica exonuclease, putative 0.0006 0.0095 0.0212
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0004 0.0023 0.0131
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.1433 0.0963
Plasmodium falciparum flap endonuclease 1 0.003 0.1084 0.6908
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.2676 0.3761
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.1433 0.0963
Brugia malayi hypothetical protein 0.0114 0.4499 0.7202
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0095 0.0552
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.1433 0.2014
Loa Loa (eye worm) TAR-binding protein 0.0068 0.264 0.4227
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.1569 1
Entamoeba histolytica hypothetical protein 0.0114 0.4499 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.1433 0.2014
Mycobacterium ulcerans beta-lactamase 0.0039 0.1433 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.1433 0.8301
Plasmodium falciparum DNA repair protein RAD2, putative 0.0006 0.0095 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0006 0.007 0.0099
Echinococcus granulosus flap endonuclease GEN 1 0.0006 0.0095 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0095 0.0356
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.052 0.2231
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.1433 0.2294
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.1726 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.052 0.1943
Trypanosoma brucei exonuclease, putative 0.0006 0.0095 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0122 0.0706
Entamoeba histolytica exonuclease, putative 0.0006 0.0095 0.0212
Onchocerca volvulus 0.0039 0.1433 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.264 0.371
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0149 0.0209
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0149 0.0209
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.1433 0.0963
Brugia malayi beta-lactamase family protein 0.0039 0.1433 0.2294
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0006 0.007 0.0099
Brugia malayi isocitrate dehydrogenase 0.0017 0.052 0.0832
Mycobacterium ulcerans hypothetical protein 0.0039 0.1433 0.5
Trichomonas vaginalis flap endonuclease-1, putative 0.0006 0.0095 0.0552
Onchocerca volvulus 0.003 0.1074 0.7492
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.052 0.1943
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.1433 0.2014
Mycobacterium tuberculosis Conserved protein 0.0039 0.1433 0.0963
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0122 0.0706
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.1726 0.7405
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.052 0.1943
Echinococcus multilocularis flap endonuclease GEN 1 0.0006 0.0095 0.0134
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0149 0.0209
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.264 0.4227
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.1433 0.5354
Schistosoma mansoni exonuclease 0.0006 0.0095 0.0134
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.052 0.0731
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.4499 0.6322
Echinococcus multilocularis cpg binding protein 0.0032 0.1144 0.1607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1783 0.2505
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.052 0.0731
Leishmania major hypothetical protein, conserved 0.0006 0.0095 0.0356
Trypanosoma brucei DNA repair protein RAD2, putative 0.0006 0.0095 0.0356
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1783 0.2854
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0095 0.0356
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.6247 0.8778
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0006 0.0095 0.0356
Plasmodium vivax hypothetical protein, conserved 0.0039 0.1433 0.8301
Schistosoma mansoni zinc finger protein 0.0006 0.007 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.002 0.0028
Mycobacterium tuberculosis Conserved protein 0.0039 0.1433 0.0963
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.4499 0.6322
Plasmodium falciparum exonuclease I, putative 0.0006 0.0095 0.0607
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0006 0.0095 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1783 0.2505
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.1433 0.0963
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.1726 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1433 0.5354
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.052 0.1943
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.1433 0.2294
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0006 0.0095 0.0409
Brugia malayi PHD-finger family protein 0.0006 0.007 0.0112
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.052 0.1943
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.264 0.4227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.052 0.0731
Schistosoma mansoni tar DNA-binding protein 0.0068 0.264 0.371
Schistosoma mansoni bromodomain containing protein 0.0006 0.007 0.0099
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.1433 0.0963
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.052 0.0731
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0122 0.0706
Toxoplasma gondii ABC1 family protein 0.0039 0.1433 0.6147
Brugia malayi beta-lactamase 0.0039 0.1433 0.2294
Loa Loa (eye worm) hypothetical protein 0.0039 0.1433 0.2294

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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