Detailed information for compound 1166580

Basic information

Technical information
  • TDR Targets ID: 1166580
  • Name: tris(dipropylamino)-methylphosphanium
  • MW: 346.554 | Formula: C19H45N3P+
  • H donors: 0 H acceptors: 0 LogP: 6.01 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN([P+](N(CCC)CCC)(N(CCC)CCC)C)CCC
  • InChi: 1S/C19H45N3P/c1-8-14-20(15-9-2)23(7,21(16-10-3)17-11-4)22(18-12-5)19-13-6/h8-19H2,1-7H3/q+1
  • InChiKey: MXDAMLZEMXQJHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tris(dipropylamino)-methyl-phosphonium
  • tris(dipropylamino)-methylphosphonium
  • tris(dipropylamino)-methyl-phosphanium
  • BAS 00102532
  • ZINC05002950

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0042 0.0963 1
Loa Loa (eye worm) carboxylesterase 0.0011 0.0125 0.0076
Schistosoma mansoni nAChR subunit 0.0018 0.0314 0.0693
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0064 0.0111
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0314 0.0265
Schistosoma mansoni nAChR subunit 0.0018 0.0314 0.0693
Mycobacterium leprae Probable lipase LipE 0.0042 0.0963 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.1065 0.102
Onchocerca volvulus 0.0011 0.0125 0.0826
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0076
Echinococcus granulosus geminin 0.0166 0.4301 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0314 0.0265
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0125 0.0253
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0314 0.0693
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.2505 0.2468
Echinococcus granulosus carboxylesterase 5A 0.0066 0.1608 0.3714
Onchocerca volvulus 0.0011 0.0125 0.0826
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0008 0.005 0.0077
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1608 0.3714
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0008 0.005 0.0077
Loa Loa (eye worm) acetyltransferase 0.0141 0.3619 0.3588
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0131 0.3365 1
Echinococcus granulosus GPCR family 2 0.0046 0.1065 0.2446
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0314 0.0693
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.08 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0963 0.1646
Mycobacterium tuberculosis Conserved protein 0.0042 0.0963 0.1201
Schistosoma mansoni cpg binding protein 0.0031 0.0646 0.1469
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0963 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0008 0.005 0.0077
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.1065 0.102
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0963 1
Schistosoma mansoni nAChR subunit 0.0018 0.0314 0.0693
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.7103 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1474 0.3402
Onchocerca volvulus 0.0018 0.0314 0.2892
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) hypothetical protein 0.0042 0.0963 0.0918
Brugia malayi Carboxylesterase family protein 0.0011 0.0125 0.0076
Brugia malayi beta-lactamase family protein 0.0042 0.0963 0.0918
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0314 0.0265
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0125 0.13
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0314 0.0693
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.3619 0.3588
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0314 0.0693
Onchocerca volvulus 0.0018 0.0314 0.2892
Echinococcus granulosus neuroligin 0.0011 0.0125 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Onchocerca volvulus 0.001 0.0088 0.0416
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0314 0.0693
Onchocerca volvulus 0.0042 0.0963 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0008 0.005 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.3747 0.3715
Brugia malayi hypothetical protein 0.0016 0.0254 0.0205
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.1608 0.1566
Mycobacterium tuberculosis Conserved protein 0.0042 0.0963 0.1201
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.08 0.9377
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0088 0.0038
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.3513 0.8161
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.1065 0.2446
Echinococcus multilocularis GPCR, family 2 0.0046 0.1065 0.2446
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0125 0.0253
Trypanosoma brucei calpain, putative 0.0131 0.3365 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0963 0.1201
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.094 0.2154
Brugia malayi Latrophilin receptor protein 2 0.0046 0.1065 0.102
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0125 0.0253
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0314 0.0265
Schistosoma mansoni nAChR subunit 0.0008 0.005 0.0077
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0963 0.1201
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0847 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.08 0.1827
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0963 0.1646
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0314 0.0265
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0314 0.0693
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0314 0.0693
Schistosoma mansoni cpg binding protein 0.0031 0.0646 0.1469
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0963 0.1201
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0314 0.0265
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0314 0.0693
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0314 0.0693
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0314 0.0265
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0314 0.0693
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.1065 0.2446
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0314 0.0693
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Brugia malayi Temporarily assigned gene name protein 44 0.0032 0.0685 0.0638
Echinococcus granulosus acetylcholinesterase 0.0066 0.1608 0.3714
Loa Loa (eye worm) hypothetical protein 0.0042 0.0963 0.0918
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0963 0.2208
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0314 0.0265
Trichomonas vaginalis esterase, putative 0.0042 0.0963 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0314 0.0693
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0963 0.0918
Onchocerca volvulus 0.0018 0.0314 0.2892
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0963 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.3747 0.3715
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0963 0.1201
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.08 0.1827
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1608 0.3714
Mycobacterium tuberculosis Conserved protein 0.0042 0.0963 0.1201
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Onchocerca volvulus 0.0018 0.0314 0.2892
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0847 0.5
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0314 0.0265
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0008 0.005 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0076
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1608 0.3714
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0314 0.0265
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0314 0.0693
Loa Loa (eye worm) carboxylesterase 0.0011 0.0125 0.0076
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.1608 0.3714
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0314 0.0693
Loa Loa (eye worm) tumor suppressor 0.0378 1 1
Schistosoma mansoni nAChR subunit 0.0018 0.0314 0.0693
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0314 0.0693
Echinococcus granulosus acetylcholinesterase 0.0066 0.1608 0.3714
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.08 0.8303
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.08 0.1078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0314 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0963 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0314 0.0265
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.08 0.1078
Schistosoma mansoni hypothetical protein 0.0032 0.0685 0.1558
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0314 0.0265
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0088 0.0038
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0314 0.0265
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0314 0.0265
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0963 0.1646
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0125 0.0253
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Schistosoma mansoni hypothetical protein 0.0011 0.0122 0.0246
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.08 0.8303
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0963 0.1201
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0064 0.0111
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0314 0.0265
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0125 0.0253
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0963 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0125 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.08 0.805
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0314 0.0265
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0088 0.0038
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.3365 1
Brugia malayi Inositol-1 0.0036 0.08 0.0754
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Mycobacterium ulcerans beta-lactamase 0.0042 0.0963 1
Schistosoma mansoni nAChR subunit 0.0018 0.0314 0.0693
Brugia malayi Carboxylesterase family protein 0.0066 0.1608 0.1566
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.3747 0.3715
Brugia malayi Carboxylesterase family protein 0.0011 0.0125 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.094 0.976
Brugia malayi hypothetical protein 0.0011 0.0125 0.0076
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0125 0.0253
Schistosoma mansoni hypothetical protein 0.0166 0.4301 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0963 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.3365 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0314 0.0693
Onchocerca volvulus 0.0018 0.0314 0.2892
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0314 0.0265
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.3619 0.8409
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Echinococcus granulosus hypothetical protein 0.0032 0.0685 0.1558
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0314 0.0265
Schistosoma mansoni neurotransmitter gated ion channel 0.0008 0.005 0.0077
Brugia malayi Cation transporter family protein 0.0018 0.0314 0.0265
Echinococcus multilocularis protein quaking 0.0032 0.0685 0.1558
Schistosoma mansoni hypothetical protein 0.0046 0.1065 0.2446
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.1065 0.2446
Onchocerca volvulus 0.0042 0.0963 1
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0314 0.0693
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0088 0.0165
Echinococcus multilocularis nAChR subunit 0.0018 0.0314 0.0693
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0314 0.0693
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0125 0.13
Schistosoma mansoni cpg binding protein 0.0029 0.0602 0.1365
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0131 0.3365 1
Onchocerca volvulus 0.0018 0.0314 0.2892
Leishmania major hypothetical protein, conserved 0.0042 0.0963 0.1646
Echinococcus multilocularis nAChR subunit 0.001 0.0088 0.0165
Loa Loa (eye worm) hypothetical protein 0.0025 0.049 0.0442
Schistosoma mansoni inositol monophosphatase 0.0036 0.08 0.1827
Trypanosoma brucei hypothetical protein 0.0131 0.3365 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.08 0.3438
Loa Loa (eye worm) hypothetical protein 0.0042 0.0963 0.0918
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0314 0.0693
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.094 0.4994
Onchocerca volvulus 0.001 0.0088 0.0416
Loa Loa (eye worm) beta-lactamase 0.0042 0.0963 0.0918
Brugia malayi beta-lactamase family protein 0.0042 0.0963 0.0918
Loa Loa (eye worm) carboxylesterase 0.0066 0.1608 0.1566
Toxoplasma gondii ABC1 family protein 0.0042 0.0963 0.525
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0963 0.0918
Loa Loa (eye worm) inositol-1 0.0036 0.08 0.0754
Onchocerca volvulus 0.0011 0.0125 0.0826
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.3619 0.8409
Schistosoma mansoni hypothetical protein 0.0046 0.1065 0.2446
Loa Loa (eye worm) hypothetical protein 0.01 0.2505 0.2468
Onchocerca volvulus 0.0011 0.0125 0.0826
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0314 0.0693
Schistosoma mansoni hypothetical protein 0.0032 0.0685 0.1558
Loa Loa (eye worm) hypothetical protein 0.0042 0.0963 0.0918
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0314 0.0693
Loa Loa (eye worm) hypothetical protein 0.0046 0.1065 0.102
Echinococcus granulosus nAChR subunit 0.001 0.0088 0.0165
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0314 0.0693
Schistosoma mansoni neurotransmitter gated ion channel 0.0008 0.005 0.0077
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.094 0.4994
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0064 0.0015
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0314 0.0265
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0847 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0076
Schistosoma mansoni acetylcholinesterase 0.0011 0.0125 0.0253
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0314 0.0693
Mycobacterium ulcerans lipase LipD 0.0042 0.0963 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1608 0.1566
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0963 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0314 0.0265
Brugia malayi Cation transporter family protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0088 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Brugia malayi hypothetical protein 0.0025 0.049 0.0442
Onchocerca volvulus Putative nachr subunit 0.0018 0.0314 0.2892
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0125 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Echinococcus granulosus nAChR subunit 0.0018 0.0314 0.0693
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0314 0.0265
Schistosoma mansoni nAChR subunit 0.0008 0.005 0.0077
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0963 0.1201
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0314 0.0693
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0963 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0314 0.0265
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0088 0.0165
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.08 0.1827
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.094 0.9513
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0061 0.0012
Onchocerca volvulus 0.0011 0.0125 0.0826
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0314 0.0693
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0314 0.0265
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0131 0.3365 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0602 0.0555
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0963 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0963 0.2208
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.08 0.1078
Echinococcus granulosus cpg binding protein 0.0031 0.0646 0.1469
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0125 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0963 0.2208
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0122 0.0246
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0125 0.0253
Trypanosoma brucei calpain-like protein, putative 0.0131 0.3365 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0697 0.082
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Brugia malayi Carboxylesterase family protein 0.0011 0.0125 0.0076
Loa Loa (eye worm) hypothetical protein 0.0066 0.1608 0.1566
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.1065 0.2446
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1391 1
Brugia malayi Carboxylesterase family protein 0.0011 0.0125 0.0076
Echinococcus multilocularis cpg binding protein 0.0031 0.0646 0.1469
Loa Loa (eye worm) hypothetical protein 0.0042 0.0963 0.0918
Brugia malayi hypothetical protein 0.0032 0.0685 0.0638
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0314 0.0693
Echinococcus multilocularis neuroligin 0.0011 0.0125 0.0253
Loa Loa (eye worm) hypothetical protein 0.0042 0.0963 0.0918
Schistosoma mansoni acetylcholine receptor-related 0.0008 0.005 0.0077
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0314 0.0265
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0314 0.0693
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0122 0.0246
Loa Loa (eye worm) hypothetical protein 0.0032 0.0685 0.0638
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0314 0.0693
Schistosoma mansoni nAChR subunit 0.0018 0.0314 0.0693
Schistosoma mansoni hypothetical protein 0.0166 0.4301 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0088 0.0038
Schistosoma mansoni nAChR subunit 0.0018 0.0314 0.0693
Echinococcus multilocularis geminin 0.0166 0.4301 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.08 0.8303
Loa Loa (eye worm) hypothetical protein 0.0146 0.3747 0.3715
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.08 0.1078
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0008 0.005 0.0077
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.094 0.976
Schistosoma mansoni hypothetical protein 0.0046 0.1065 0.2446
Onchocerca volvulus 0.0029 0.0602 0.6046
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0125 0.0253
Schistosoma mansoni hypothetical protein 0.01 0.2505 0.5809
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0131 0.3365 1
Brugia malayi beta-lactamase 0.0042 0.0963 0.0918
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0963 0.1201
Mycobacterium ulcerans hypothetical protein 0.0042 0.0963 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0131 0.3365 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0314 0.0693
Echinococcus granulosus protein quaking 0.0032 0.0685 0.1558
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0314 0.0693
Schistosoma mansoni hypothetical protein 0.0046 0.1065 0.2446
Brugia malayi Cation transporter family protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) hypothetical protein 0.0011 0.0125 0.0076
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0963 0.2208
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0131 0.3365 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038
Brugia malayi Carboxylesterase family protein 0.0066 0.1608 0.1566
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0088 0.0165
Schistosoma mansoni gliotactin 0.0011 0.0125 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0314 0.0265
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0602 0.0555
Loa Loa (eye worm) hypothetical protein 0.001 0.0088 0.0038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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