Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1276 | 0.8395 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1505 | 1 | 1 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Plasmodium falciparum | MO15-related protein kinase | 0.0246 | 0.1183 | 0.1223 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0362 | 0.1996 | 0.2212 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Loa Loa (eye worm) | DNA-binding protein | 0.0102 | 0.0179 | 0.0213 |
Brugia malayi | initiation factor 2-associated protein. | 0.0102 | 0.0179 | 0.0213 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.0467 | 0.2735 | 0.3111 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0083 | 0.0042 | 0.0042 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0102 | 0.0179 | 0.5 |
Echinococcus multilocularis | Proliferation associated protein 2G4 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0102 | 0.0179 | 0.0179 |
Giardia lamblia | Methionine aminopeptidase | 0.0102 | 0.0179 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0809 | 0.5124 | 0.6018 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | thymidylate synthase | 0.0314 | 0.166 | 0.1977 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0149 | 0.0509 | 0.0401 |
Toxoplasma gondii | hypothetical protein | 0.0467 | 0.2735 | 0.3111 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.1276 | 0.8395 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Schistosoma mansoni | peptidase | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0102 | 0.0179 | 0.0213 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0809 | 0.5124 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1276 | 0.8395 | 0.8395 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0314 | 0.166 | 0.2995 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0809 | 0.5124 | 0.6018 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.023 | 0.107 | 0.1085 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0362 | 0.1996 | 0.2377 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1276 | 0.8395 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0809 | 0.5124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0717 | 0.0717 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0149 | 0.0509 | 1 |
Echinococcus granulosus | cyclin dependent kinase 7 | 0.0083 | 0.0042 | 0.0042 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1276 | 0.8395 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0809 | 0.5124 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0809 | 0.5124 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Echinococcus granulosus | geminin | 0.0179 | 0.0717 | 0.0717 |
Echinococcus multilocularis | thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Echinococcus multilocularis | FACT complex subunit SPT16 | 0.0102 | 0.0179 | 0.0179 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0362 | 0.1996 | 0.2212 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1276 | 0.8395 | 1 |
Onchocerca volvulus | 0.0314 | 0.166 | 1 | |
Toxoplasma gondii | methionine aminopeptidase | 0.0809 | 0.5124 | 0.6018 |
Mycobacterium ulcerans | thymidylate synthase | 0.0314 | 0.166 | 0.2995 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0083 | 0.0042 | 0.0042 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0099 | 0.0155 | 0.0185 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Echinococcus granulosus | Proliferation associated protein 2G4 | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0102 | 0.0179 | 0.0213 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0809 | 0.5124 | 1 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0246 | 0.1183 | 0.1223 |
Echinococcus granulosus | methionine aminopeptidase type I | 0.0102 | 0.0179 | 0.0179 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0809 | 0.5124 | 1 |
Echinococcus granulosus | Xaa Pro aminopeptidase 3 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | Xaa Pro aminopeptidase 3 | 0.0102 | 0.0179 | 0.0179 |
Plasmodium vivax | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0102 | 0.0179 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0809 | 0.5124 | 0.6018 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | hypothetical protein | 0.0149 | 0.0509 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.1996 | 0.2377 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0144 | 0.0472 | 0.0563 |
Toxoplasma gondii | methionine aminopeptidase | 0.1276 | 0.8395 | 1 |
Brugia malayi | thymidylate synthase | 0.0314 | 0.166 | 0.1977 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0758 | 0.0903 |
Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0083 | 0.0042 | 0.005 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1505 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0083 | 0.0042 | 0.0042 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0314 | 0.166 | 0.1802 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1276 | 0.8395 | 0.8395 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0149 | 0.0509 | 0.0667 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0314 | 0.166 | 0.2995 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0102 | 0.0179 | 0.0179 |
Entamoeba histolytica | aminopeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Echinococcus multilocularis | methionine aminopeptidase, type I | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0717 | 0.0717 |
Entamoeba histolytica | peptidase, putative | 0.0102 | 0.0179 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1276 | 0.8395 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0362 | 0.1996 | 0.2212 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0144 | 0.0472 | 0.0563 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Echinococcus multilocularis | geminin | 0.0179 | 0.0717 | 0.0717 |
Echinococcus granulosus | FACT complex subunit SPT16 | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0102 | 0.0179 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.