TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 573.041 | Formula: C27H33ClN6O6
H donors: 2 H acceptors: 7 LogP: -0.66 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCN(CC1)C(=O)N1C(=O)[C@@H]([C@H]1C(=O)O)CC1CCNCC1)CCCc1onc(n1)c1ccc(cc1)Cl
InChi: 1S/C27H33ClN6O6/c28-19-6-4-18(5-7-19)24-30-21(40-31-24)2-1-3-22(35)32-12-14-33(15-13-32)27(39)34-23(26(37)38)20(25(34)36)16-17-8-10-29-11-9-17/h4-7,17,20,23,29H,1-3,8-16H2,(H,37,38)/t20-,23+/m1/s1
InChiKey: RTVGVVNPBUBPDD-OFNKIYASSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tryptase gamma 1		References
Bos taurus	Trypsin I	Starlite/ChEMBL	References
Homo sapiens	tryptase alpha/beta 1		References
Homo sapiens	tryptase delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma japonicum	ko:K09639 transmembrane protease, serine 8, putative	Get druggable targets OG5_126639	All targets in OG5_126639
Brugia malayi	Trypsin family protein	Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Get druggable targets OG5_126639	All targets in OG5_126639
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126639	All targets in OG5_126639
Onchocerca volvulus		Get druggable targets OG5_126639	All targets in OG5_126639
Onchocerca volvulus		Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma japonicum	ko:K09639 transmembrane protease, serine 8, putative	Get druggable targets OG5_126639	All targets in OG5_126639
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126639	All targets in OG5_126639

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Drosophila melanogaster	CG18180 gene product from transcript CG18180-RA	Trypsin I	246 aa	233 aa	30.0 %
Schistosoma mansoni	aminopeptidase PILS (M01 family)	Trypsin I	246 aa	301 aa	23.9 %
Echinococcus multilocularis	transmembrane protease serine 3	Trypsin I	246 aa	233 aa	33.9 %
Echinococcus granulosus	Mastin	Trypsin I	246 aa	306 aa	23.2 %
Drosophila melanogaster	Spatzle-Processing Enzyme	Trypsin I	246 aa	272 aa	31.6 %
Echinococcus granulosus	glycoprotein Antigen 5	Trypsin I	246 aa	299 aa	23.4 %
Drosophila melanogaster	CG33458 gene product from transcript CG33458-RA	Trypsin I	246 aa	248 aa	28.2 %
Drosophila melanogaster	Jonah 99Ci	Trypsin I	246 aa	237 aa	32.9 %
Echinococcus multilocularis	Mastin	Trypsin I	246 aa	306 aa	23.2 %
Drosophila melanogaster	Jonah 66Ci	Trypsin I	246 aa	272 aa	30.5 %
Drosophila melanogaster	CG30323 gene product from transcript CG30323-RB	Trypsin I	246 aa	208 aa	23.1 %
Brugia malayi	Trypsin family protein	tryptase alpha/beta 1	275 aa	288 aa	25.4 %
Drosophila melanogaster	CG31326 gene product from transcript CG31326-RA	Trypsin I	246 aa	249 aa	24.5 %
Onchocerca volvulus		Trypsin I	246 aa	210 aa	21.0 %
Loa Loa (eye worm)	hypothetical protein	Trypsin I	246 aa	217 aa	24.0 %
Drosophila melanogaster	CG3916 gene product from transcript CG3916-RA	Trypsin I	246 aa	269 aa	31.6 %
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	Trypsin I	246 aa	287 aa	27.9 %
Drosophila melanogaster	CG17239 gene product from transcript CG17239-RB	Trypsin I	246 aa	223 aa	34.5 %
Schistosoma japonicum	ko:K01346 pancreatic elastase II [EC3.4.21.71], putative	Trypsin I	246 aa	305 aa	23.9 %
Drosophila melanogaster	Jonah 65Aiii	Trypsin I	246 aa	235 aa	34.9 %
Drosophila melanogaster	CG33465 gene product from transcript CG33465-RC	Trypsin I	246 aa	235 aa	25.1 %
Schistosoma mansoni	cercarial elastase (S01 family)	Trypsin I	246 aa	241 aa	27.0 %
Echinococcus granulosus	Mastin	tryptase gamma 1	321 aa	334 aa	26.9 %
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Trypsin I	246 aa	304 aa	24.0 %
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Trypsin I	246 aa	262 aa	34.0 %
Drosophila melanogaster	CG31267 gene product from transcript CG31267-RA	Trypsin I	246 aa	234 aa	32.5 %
Drosophila melanogaster	CG4914 gene product from transcript CG4914-RA	Trypsin I	246 aa	246 aa	38.2 %
Drosophila melanogaster	CG3505 gene product from transcript CG3505-RA	Trypsin I	246 aa	235 aa	29.8 %
Echinococcus multilocularis	glycoprotein Antigen 5	Trypsin I	246 aa	299 aa	21.7 %
Schistosoma japonicum	Transmembrane protease, serine 9, putative	Trypsin I	246 aa	250 aa	23.6 %
Drosophila melanogaster	CG32277 gene product from transcript CG32277-RA	Trypsin I	246 aa	267 aa	29.2 %
Drosophila melanogaster	CG10405 gene product from transcript CG10405-RB	Trypsin I	246 aa	251 aa	33.9 %
Brugia malayi	Trypsin family protein	tryptase delta 1	242 aa	204 aa	30.9 %
Echinococcus multilocularis	enteropeptidase	Trypsin I	246 aa	230 aa	27.0 %
Drosophila melanogaster	CG30288 gene product from transcript CG30288-RC	Trypsin I	246 aa	250 aa	29.6 %
Echinococcus granulosus	transmembrane protease serine 3	Trypsin I	246 aa	233 aa	33.5 %
Mycobacterium tuberculosis	Membrane-associated serine protease	Trypsin I	246 aa	203 aa	20.7 %
Drosophila melanogaster	CG30287 gene product from transcript CG30287-RA	Trypsin I	246 aa	259 aa	26.6 %
Echinococcus granulosus	enteropeptidase	Trypsin I	246 aa	230 aa	27.0 %
Drosophila melanogaster	CG4815 gene product from transcript CG4815-RA	Trypsin I	246 aa	205 aa	27.8 %
Drosophila melanogaster	Jonah 65Aii	Trypsin I	246 aa	265 aa	34.3 %
Drosophila melanogaster	CG18420 gene product from transcript CG18420-RA	Trypsin I	246 aa	243 aa	28.8 %
Drosophila melanogaster	CG9733 gene product from transcript CG9733-RB	Trypsin I	246 aa	262 aa	30.1 %
Drosophila melanogaster	CG34436 gene product from transcript CG34436-RA	Trypsin I	246 aa	208 aa	24.0 %
Drosophila melanogaster	CG11313 gene product from transcript CG11313-RC	Trypsin I	246 aa	223 aa	31.8 %
Onchocerca volvulus		Trypsin I	246 aa	266 aa	22.2 %
Drosophila melanogaster	CG30083 gene product from transcript CG30083-RB	Trypsin I	246 aa	209 aa	31.1 %
Drosophila melanogaster	CG13744 gene product from transcript CG13744-RA	Trypsin I	246 aa	249 aa	31.3 %
Schistosoma mansoni	cercarial elastase (S01 family)	Trypsin I	246 aa	241 aa	27.0 %
Drosophila melanogaster	CG9673 gene product from transcript CG9673-RB	Trypsin I	246 aa	260 aa	27.7 %
Onchocerca volvulus		Trypsin I	246 aa	247 aa	21.1 %
Brugia malayi	Trypsin family protein	Trypsin I	246 aa	270 aa	23.3 %
Neospora caninum	glycine cleavage T-protein domain containing protein, putative	Trypsin I	246 aa	203 aa	21.7 %
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	Trypsin I	246 aa	287 aa	27.5 %
Drosophila melanogaster	CG14990 gene product from transcript CG14990-RA	Trypsin I	246 aa	238 aa	28.6 %
Schistosoma japonicum	ko:K09637 transmembrane protease, serine 6, putative	Trypsin I	246 aa	242 aa	30.6 %
Drosophila melanogaster	CG31220 gene product from transcript CG31220-RB	Trypsin I	246 aa	227 aa	29.5 %
Schistosoma mansoni	cercarial elastase (S01 family)	Trypsin I	246 aa	234 aa	26.9 %
Schistosoma japonicum	Enteropeptidase, putative	Trypsin I	246 aa	264 aa	24.6 %
Drosophila melanogaster	CG5909 gene product from transcript CG5909-RA	Trypsin I	246 aa	261 aa	28.0 %
Schistosoma japonicum	Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative	Trypsin I	246 aa	207 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Mastin	0.0037	0.0708	0.1112
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0032	0.0226	0.5
Echinococcus granulosus	lactate dehydrogenase a	0.0081	0.4562	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0037	0.0708	0.1112
Plasmodium falciparum	L-lactate dehydrogenase	0.0081	0.4562	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Plasmodium vivax	malate dehydrogenase, putative	0.0081	0.4562	1
Brugia malayi	hypothetical protein	0.0037	0.0708	0.0708
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.0867	0.1477
Schistosoma mansoni	malate dehydrogenase	0.0032	0.0226	0.0226
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0042	0.1172	0.1172
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Trypanosoma brucei	glycosomal malate dehydrogenase	0.0032	0.0226	0.5
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0143	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.0867	0.1477
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0708	0.0708
Mycobacterium tuberculosis	Probable malate dehydrogenase Mdh	0.0032	0.0226	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0708	0.0708
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0143	1	1
Onchocerca volvulus		0.0106	0.676	0.6513
Toxoplasma gondii	lactate dehydrogenase LDH1	0.0081	0.4562	0.5
Trypanosoma cruzi	malate dehydrogenase, putative	0.0032	0.0226	0.5
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0708	0.1112
Echinococcus multilocularis	glycoprotein Antigen 5	0.0037	0.0708	0.1112
Echinococcus multilocularis	transmembrane protease serine 3	0.0037	0.0708	0.1112
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Toxoplasma gondii	malate dehydrogenase MDH	0.0081	0.4562	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1172	0.1172
Echinococcus multilocularis	L lactate dehydrogenase B chain	0.0081	0.4562	1
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0032	0.0226	0.5
Brugia malayi	Trypsin family protein	0.0037	0.0708	0.0708
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0708	0.0708
Onchocerca volvulus		0.0143	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Echinococcus multilocularis	enteropeptidase	0.0037	0.0708	0.1112
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0037	0.0708	0.1112
Schistosoma mansoni	hypothetical protein	0.0037	0.0708	0.0708
Leishmania major	malate dehydrogenase, putative	0.0081	0.4562	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0039	0.0867	0.0867
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0032	0.0226	0.5
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0708	0.0708
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Toxoplasma gondii	lactate dehydrogenase LDH2	0.0081	0.4562	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.0867	0.1477
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Wolbachia endosymbiont of Brugia malayi	malate dehydrogenase	0.0081	0.4562	0.5
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Echinococcus multilocularis	lactate dehydrogenase a	0.0081	0.4562	1
Echinococcus granulosus	lactate dehydrogenase a	0.0081	0.4562	1
Schistosoma mansoni	L-lactate dehydrogenase	0.0032	0.0226	0.0226
Giardia lamblia	Malate dehydrogenase	0.0032	0.0226	0.5
Trypanosoma cruzi	mitochondrial malate dehydrogenase, putative	0.0032	0.0226	0.5
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0037	0.0708	0.1112
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0032	0.0226	0.5
Loa Loa (eye worm)	hypothetical protein	0.0081	0.4562	0.4562
Mycobacterium leprae	PROBABLE MALATE DEHYDROGENASE MDH	0.0032	0.0226	0.5
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Entamoeba histolytica	malate dehydrogenase, putative	0.0081	0.4562	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0708	0.0708
Loa Loa (eye worm)	trypsin family protein	0.0037	0.0708	0.0708
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0042	0.1172	0.1172
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0143	1	1
Echinococcus granulosus	L lactate dehydrogenase B chain	0.0081	0.4562	1
Echinococcus granulosus	transmembrane protease serine 3	0.0037	0.0708	0.1112
Schistosoma mansoni	malate dehydrogenase	0.0032	0.0226	0.0226
Echinococcus granulosus	lactate dehydrogenase protein	0.0081	0.4562	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0708	0.0708
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Echinococcus granulosus	glycoprotein Antigen 5	0.0037	0.0708	0.1112
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.0867	0.1477
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0037	0.0708	0.0708
Plasmodium vivax	lactate dehydrogenase	0.0081	0.4562	1
Brugia malayi	lactate dehydrogenase.	0.0081	0.4562	0.4562
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0037	0.0708	0.0708
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0867	0.0867
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Chlamydia trachomatis	malate dehydrogenase	0.0032	0.0226	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0143	1	1
Echinococcus multilocularis	lactate dehydrogenase a	0.0081	0.4562	1
Trypanosoma brucei	malate dehydrogenase-related	0.0032	0.0226	0.5
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0032	0.0226	0.5
Brugia malayi	Trypsin family protein	0.0037	0.0708	0.0708
Loa Loa (eye worm)	malate dehydrogenase	0.0032	0.0226	0.0226
Echinococcus granulosus	L lactate dehydrogenase	0.005	0.1805	0.3641
Plasmodium falciparum	malate dehydrogenase	0.0081	0.4562	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0032	0.0226	0.5
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0037	0.0708	0.0708
Echinococcus multilocularis	lactate dehydrogenase protein	0.0081	0.4562	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0867	0.0867
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0032	0.0226	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0867	0.0867
Brugia malayi	Trypsin family protein	0.0037	0.0708	0.0708
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Brugia malayi	Malate dehydrogenase, cytoplasmic	0.0032	0.0226	0.0226
Schistosoma mansoni	malate dehydrogenase	0.0032	0.0226	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0708	0.0708
Trypanosoma cruzi	malate dehydrogenase, putative	0.0032	0.0226	0.5
Schistosoma mansoni	hypothetical protein	0.0037	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0708	0.0708
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0039	0.0867	0.0867
Brugia malayi	Trypsin-like protease protein 5	0.0037	0.0708	0.0708
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0042	0.1172	0.1172
Schistosoma mansoni	malate dehydrogenase	0.0081	0.4562	0.4562
Schistosoma mansoni	L-lactate dehydrogenase	0.0081	0.4562	0.4562
Echinococcus multilocularis	lactate dehydrogenase a	0.0081	0.4562	1
Brugia malayi	Probable malate dehydrogenase, mitochondrial precursor	0.0032	0.0226	0.0226
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0032	0.0226	0.5
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0708	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0037	0.0708	0.0708
Loa Loa (eye worm)	malate dehydrogenase	0.0032	0.0226	0.0226
Trypanosoma brucei	cytosolic malate dehydrogenase	0.0032	0.0226	0.5
Echinococcus granulosus	enteropeptidase	0.0037	0.0708	0.1112
Trichomonas vaginalis	malate dehydrogenase, putative	0.0032	0.0226	0.5
Echinococcus multilocularis	L lactate dehydrogenase	0.005	0.1805	0.3641
Echinococcus granulosus	Mastin	0.0037	0.0708	0.1112
Trypanosoma brucei	mitochondrial malate dehydrogenase	0.0032	0.0226	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.005 uM	Inhibitory activity against human tryptase	ChEMBL.	15081015
IC50 (binding)	= 0.005 uM	Inhibitory activity against human tryptase	ChEMBL.	15081015
IC50 (binding)	= 0.15 uM	Inhibitory activity against bovine trypsin	ChEMBL.	15081015
IC50 (binding)	= 0.15 uM	Inhibitory activity against bovine trypsin	ChEMBL.	15081015
Selectivity (binding)	= 30	Selectivity of trypsin compared to tryptase	ChEMBL.	15081015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL70766

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 116951