TDR Targets

Basic information

Technical information

TDR Targets ID: 1171836
Name: 4-[2-(4-fluorophenoxy)ethyl]-1-(phenylmethyl) piperidine
MW: 313.409 | Formula: C20H24FNO
H donors: 0 H acceptors: 0 LogP: 4.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)OCCC1CCN(CC1)Cc1ccccc1
InChi: 1S/C20H24FNO/c21-19-6-8-20(9-7-19)23-15-12-17-10-13-22(14-11-17)16-18-4-2-1-3-5-18/h1-9,17H,10-16H2
InChiKey: IRGCLOHNAHIYPC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(benzyl)-4-[2-(4-fluorophenoxy)ethyl]piperidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.1149	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0471	0.0471
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0133	0.0546
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.1347	0.1347
Plasmodium falciparum	cysteine repeat modular protein 1	0.002	0.078	0.0655
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.1149	0.103
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0133	0.0546
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0324	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0035	0.0035
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.1149	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.078	0.078
Schistosoma mansoni	lamin	0.0031	0.1347	0.3954
Loa Loa (eye worm)	hypothetical protein	0.0015	0.05	0.05
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0133	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Onchocerca volvulus		0.0008	0.0133	0.0916
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0324	0.0324
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0083	0.41	0.41
Brugia malayi	steroid hormone receptor	0.0012	0.0324	0.0324
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.1149	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0035	0.0035
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0133	0.0857
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0035	0.0223
Schistosoma mansoni	cpg binding protein	0.0033	0.1453	0.4266
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.078	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0035	0.0102
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0324	0.2086
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.1149	0.1149
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0324	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0324	0.0324
Mycobacterium ulcerans	hypothetical protein	0.0027	0.1149	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0324	0.2086
Schistosoma mansoni	lamin	0.0031	0.1347	0.3954
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0133	0.5
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0195	1	1
Echinococcus multilocularis	musashi	0.0031	0.1347	0.8676
Onchocerca volvulus		0.0008	0.0133	0.0916
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0324	0.0951
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.1149	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0727	0.6071
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0324	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0324	0.0324
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0324	0.0324
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0324	0.0951
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0727	0.6071
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0786	0.0661
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0324	0.0324
Echinococcus granulosus	intermediate filament protein	0.0031	0.1347	0.8676
Loa Loa (eye worm)	histone methyltransferase	0.001	0.025	0.025
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.1149	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0324	0.2086
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0324	0.0951
Brugia malayi	nuclear receptor RXR	0.0006	0.0035	0.0035
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0133	0.0857
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0133	0.0133
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0035	0.0102
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0727	0.6071
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0324	0.2086
Brugia malayi	Protein kinase domain containing protein	0.002	0.078	0.078
Echinococcus multilocularis	tissue type plasminogen activator	0.002	0.078	0.5022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0324	0.0324
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0133	0.0546
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0133	0.0133
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0324	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0195	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0324	0.0324
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0195	1	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0144	0.0925
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0324	0.0951
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0324	0.0324
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0144	0.0925
Loa Loa (eye worm)	hypothetical protein	0.002	0.0786	0.0786
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0133	0.0028
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.1149	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0324	0.2086
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.1149	0.103
Loa Loa (eye worm)	hypothetical protein	0.002	0.0786	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1149	0.1149
Loa Loa (eye worm)	hypothetical protein	0.002	0.0786	0.0786
Echinococcus multilocularis	lamin	0.0031	0.1347	0.8676
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.1347	0.1347
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0195	1	1
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0008	0.0133	0.5
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0133	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0471	0.0471
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0144	0.0422
Onchocerca volvulus		0.0012	0.0324	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0324	0.0324
Schistosoma mansoni	cpg binding protein	0.0035	0.1553	0.4557
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0133	0.0391
Schistosoma mansoni	intermediate filament proteins	0.0031	0.1347	0.3954
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0324	0.2086
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0133	0.0546
Onchocerca volvulus		0.0031	0.1347	0.9269
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0133	0.0133
Brugia malayi	nuclear hormone receptor	0.0012	0.0324	0.0324
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0133	0.0133
Onchocerca volvulus		0.002	0.078	0.5366
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0324	0.0324
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0324	0.2086
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.025	0.1609
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.1149	0.1149
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0324	0.2229
Onchocerca volvulus		0.0027	0.1149	0.7908
Echinococcus multilocularis	lamin dm0	0.0031	0.1347	0.8676
Echinococcus granulosus	lamin	0.0031	0.1347	0.8676
Leishmania major	hypothetical protein, conserved	0.002	0.078	0.0655
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0324	0.2086
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0324	0.2086
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0324	0.2086
Brugia malayi	ecdysteroid receptor	0.0012	0.0324	0.0324
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.1149	0.1149
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0133	0.0546
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0324	0.0951
Giardia lamblia	Macrophage migration inhibitory factor	0.0195	1	0.5
Schistosoma mansoni	coup transcription factor	0.0012	0.0324	0.0951
Schistosoma mansoni	cpg binding protein	0.0035	0.1553	0.4557
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.003	0.1317	0.1317
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0133	0.0133
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.1149	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1149	0.1149
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0035	0.0035
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0144	0.0925
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0324	0.0951
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0324	0.0324
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0324	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0144	0.0925
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0133	0.0028
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0324	0.2229
Echinococcus granulosus	lamin dm0	0.0031	0.1347	0.8676
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0133	0.0133
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0195	1	1
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0133	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0324	0.0324
Leishmania major	macrophage migration inhibitory factor-like protein	0.0195	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1149	0.1149
Echinococcus granulosus	tissue type plasminogen activator	0.002	0.078	0.5022
Brugia malayi	CXXC zinc finger family protein	0.0033	0.1453	0.1453
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.3012	0.2918
Onchocerca volvulus		0.0008	0.0133	0.0916
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.002	0.078	0.0655
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0133	0.0133
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0324	0.2086
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.1149	1
Onchocerca volvulus		0.0008	0.0133	0.0916
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.05	0.3223
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0324	0.0951
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0035	0.0035
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.1149	0.103
Loa Loa (eye worm)	hypothetical protein	0.002	0.0786	0.0786
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.1149	1
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0195	1	1
Brugia malayi	hypothetical protein	0.0006	0.0035	0.0035
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0324	0.0951
Plasmodium falciparum	macrophage migration inhibitory factor	0.0195	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.1149	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.1347	0.1347
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0035	0.0223
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0786	0.0661
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0786	0.5
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0133	0.0546
Toxoplasma gondii	kringle domain-containing protein	0.002	0.078	0.0655
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0324	0.2229
Schistosoma mansoni	hypothetical protein	0.002	0.078	0.2289
Onchocerca volvulus		0.0031	0.1347	0.9269
Onchocerca volvulus		0.0033	0.1453	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0324	0.0324
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0035	0.0035
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0324	0.0951
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0324	0.2086
Brugia malayi	hypothetical protein	0.0006	0.0035	0.0035
Brugia malayi	Kringle domain containing protein	0.002	0.078	0.078
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0727	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0133	0.0133
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0324	0.2086
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0324	0.0951
Brugia malayi	intermediate filament protein	0.0031	0.1347	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0324	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0324	0.0324
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0324	0.0951
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.1149	0.103
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.1453	0.1453
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0587	0.0587
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.025	0.1609
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0133	0.0546
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0786	0.6421
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0324	0.2086
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0008	0.0133	0.0133
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0324	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0035	0.0035
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0786	0.6617
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.1149	0.103
Loa Loa (eye worm)	hypothetical protein	0.002	0.0786	0.0786
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0587	0.0587
Echinococcus granulosus	cpg binding protein	0.0035	0.1553	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1347	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0133	0.0546
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0324	0.0324
Leishmania major	macrophage migration inhibitory factor-like protein	0.0195	1	1
Echinococcus multilocularis	cpg binding protein	0.0035	0.1553	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0324	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0324	0.0324
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0133	0.0133
Loa Loa (eye worm)	TK/ROR protein kinase	0.002	0.078	0.078
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0083	0.41	0.41
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.1149	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0243	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0035	0.0035
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.3407	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.05	0.3223
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0324	0.0324
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.1149	0.103
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0324	0.0324
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0035	0.0035
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0324	0.2086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1198748

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1171836