Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0495 | 0.0343 |
Echinococcus multilocularis | geminin | 0.0184 | 0.2188 | 0.2064 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0191 | 0.0109 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0056 | 0.0418 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0225 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1467 | 0.4182 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.3289 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.0495 | 0.0343 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0324 | 0.2208 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0056 | 0.0418 | 0.0265 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0157 | 0.1072 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0056 | 0.0418 | 0.0265 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0194 | 0.2318 | 0.2196 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0056 | 0.0418 | 0.0265 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0324 | 0.0169 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1467 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0049 | 0.0324 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1467 | 0.4182 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0049 | 0.0324 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.3289 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0056 | 0.0418 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0651 | 0.1577 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0194 | 0.2318 | 0.2196 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0324 | 0.0532 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0394 | 0.0756 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 0.1467 | 1 |
Brugia malayi | mbt repeat family protein | 0.0049 | 0.0324 | 0.2208 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.3768 | 0.3668 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0394 | 0.2685 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0049 | 0.0324 | 0.0532 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0394 | 0.2685 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.0545 | 0.0394 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.019 | 0.1297 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0503 | 0.6584 | 0.653 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0049 | 0.0324 | 0.017 |
Brugia malayi | hypothetical protein | 0.0132 | 0.1467 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0049 | 0.0324 | 0.017 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0049 | 0.0324 | 0.017 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.0712 | 0.4854 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0056 | 0.0418 | 0.2848 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0503 | 0.6584 | 0.653 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0394 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0418 | 0.0832 |
Echinococcus granulosus | neuropeptide s receptor | 0.0503 | 0.6584 | 0.653 |
Toxoplasma gondii | hypothetical protein | 0.0264 | 0.3289 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0264 | 0.3289 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0503 | 0.6584 | 0.653 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.2188 | 0.2064 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0056 | 0.0418 | 0.0265 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0049 | 0.0324 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.3289 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.2188 | 0.2064 |
Echinococcus granulosus | geminin | 0.0184 | 0.2188 | 0.2064 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0252 | 0.0303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 17.4 uM | Growth inhibition of human CCRF-CEM cells | ChEMBL. | 18590961 |
GI50 (functional) | = 18.6 uM | Growth inhibition of human K562 cells | ChEMBL. | 18590961 |
GI50 (functional) | = 19.5 uM | Growth inhibition of human MOLT4 cells | ChEMBL. | 18590961 |
LC50 (functional) | > 100 uM | Cytotoxicity against human MOLT4 cells assessed as cell death | ChEMBL. | 18590961 |
LC50 (functional) | > 100 uM | Cytotoxicity against human K562 cells assessed as cell death | ChEMBL. | 18590961 |
LC50 (functional) | > 100 uM | Cytotoxicity against human CCRF-CEM cells assessed as cell death | ChEMBL. | 18590961 |
TGI (functional) | = 46.4 uM | Growth inhibition of human K562 cells | ChEMBL. | 18590961 |
TGI (functional) | = 46.6 uM | Growth inhibition of human MOLT4 cells | ChEMBL. | 18590961 |
TGI (functional) | = 51.7 uM | Growth inhibition of human CCRF-CEM cells | ChEMBL. | 18590961 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.