Detailed information for compound 1184936

Basic information

Technical information
  • TDR Targets ID: 1184936
  • Name: 3-chloro-N-[2-(cyclopropylamino)-2-oxoethyl]- 5-nitrobenzamide
  • MW: 297.694 | Formula: C12H12ClN3O4
  • H donors: 2 H acceptors: 4 LogP: 1.56 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CC1)CNC(=O)c1cc(Cl)cc(c1)[N+](=O)[O-]
  • InChi: 1S/C12H12ClN3O4/c13-8-3-7(4-10(5-8)16(19)20)12(18)14-6-11(17)15-9-1-2-9/h3-5,9H,1-2,6H2,(H,14,18)(H,15,17)
  • InChiKey: QUQFOHJDZPBDTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-N-[2-(cyclopropylamino)-2-oxo-ethyl]-5-nitro-benzamide
  • 3-chloro-N-[2-(cyclopropylamino)-2-keto-ethyl]-5-nitro-benzamide
  • T5221383
  • ZINC03311080

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0788 0.3218 0.3074
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0118 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0087 0.0309 0.0309
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0087 0.0309 0.1056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0175 0.0175
Onchocerca volvulus Huntingtin homolog 0.0133 0.0499 0.0499
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0747 0.3046 0.3046
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0138 0.0138
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0019 0.0019
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0218 0.0311
Schistosoma mansoni pyruvate kinase 0.0109 0.0401 0.1371
Trypanosoma brucei pyruvate kinase 1 0.0109 0.0401 0.1317
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0087 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Brugia malayi conserved hypotetical protein 0.0041 0.0118 0.0118
Schistosoma mansoni pyruvate kinase 0.0109 0.0401 0.1371
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0083 0.0083
Brugia malayi pyruvate kinase 0.0023 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0087 0.0309 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0087 0.0309 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0087 0.0309 0.0309
Plasmodium falciparum pyruvate kinase 0.0109 0.0401 1
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0208 0.0208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0235 0.0803
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0019 0.0019
Loa Loa (eye worm) pyruvate kinase 0.0109 0.0401 0.0401
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1676 0.6901 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0175 0.0175
Brugia malayi nuclear receptor NHR-67 0.0041 0.0118 0.0118
Leishmania major pyruvate kinase 0.0109 0.0401 0.1317
Loa Loa (eye worm) hypothetical protein 0.0046 0.0138 0.0138
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0118 0.0168
Plasmodium falciparum basic transcription factor 3b, putative 0.0071 0.0243 0.6058
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0118 0.0403
Echinococcus multilocularis lamin 0.0031 0.0075 0.0107
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0243 0.0798
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0204 0.509
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0189 0.027
Echinococcus granulosus lamin dm0 0.0031 0.0075 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0118 0.0403
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0189 0.0647
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.037 0.037
Treponema pallidum exodeoxyribonuclease (exoA) 0.0063 0.0208 0.0314
Trypanosoma cruzi pyruvate kinase 2, putative 0.0109 0.0401 0.1317
Echinococcus multilocularis geminin 0.0379 0.1519 0.217
Giardia lamblia Fructose-bisphosphate aldolase 0.1614 0.6643 0.6643
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0133 0.0499 0.0499
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.037 0.037
Brugia malayi steroid hormone receptor 0.0087 0.0309 0.0309
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.037 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0087 0.0309 0.0309
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0087 0.0309 0.1056
Trypanosoma brucei pyruvate kinase 1, putative 0.0109 0.0401 0.1317
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0009 0.0013
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0208 0.5192
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.037 0.037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0028
Echinococcus multilocularis musashi 0.0031 0.0075 0.0107
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0063 0.0208 0.0208
Schistosoma mansoni ap endonuclease 0.0063 0.0208 0.0712
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0189 0.0647
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.037 0.1264
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0075 0.0075
Onchocerca volvulus 0.0041 0.0118 0.0118
Schistosoma mansoni cpg binding protein 0.0035 0.0091 0.031
Schistosoma mansoni hypothetical protein 0.0379 0.1519 0.5192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0063 0.0208 0.0208
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0118 0.0403
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0138 0.0138
Loa Loa (eye worm) pyruvate kinase 0.0109 0.0401 0.0401
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0016 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0109 0.0401 0.0401
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0118 0.0168
Entamoeba histolytica hypothetical protein 0.0151 0.0572 0.0572
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0189 0.0647
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Brugia malayi tailless protein 0.0041 0.0118 0.0118
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0218 0.0743
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0087 0.0309 0.1056
Loa Loa (eye worm) DR-78 0.0041 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0046 0.0138 0.0138
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0218 0.0714
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0189 0.0621
Schistosoma mansoni zinc finger protein 0.0041 0.0118 0.0403
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0075 0.0075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0063 0.0208 0.0298
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Echinococcus granulosus dnaJ subfamily B 0.0465 0.1878 0.642
Onchocerca volvulus 0.0087 0.0309 0.0309
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0118 0.0118
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0118 0.0403
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0138 0.0198
Loa Loa (eye worm) hypothetical protein 0.0046 0.0138 0.0138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Entamoeba histolytica hypothetical protein 0.0151 0.0572 0.0572
Echinococcus multilocularis cpg binding protein 0.0035 0.0091 0.0129
Toxoplasma gondii exonuclease III APE 0.0063 0.0208 0.5192
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.037 0.037
Brugia malayi exodeoxyribonuclease III family protein 0.0063 0.0208 0.0208
Schistosoma mansoni lamin 0.0031 0.0075 0.0255
Brugia malayi hypothetical protein 0.0133 0.0499 0.0499
Onchocerca volvulus Pyruvate kinase homolog 0.0109 0.0401 0.0401
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0218 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0087 0.0309 0.0309
Echinococcus multilocularis transcription factor btf3 0.0071 0.0243 0.0347
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0309 0.0309
Echinococcus multilocularis pyruvate kinase 0.0109 0.0401 0.0573
Schistosoma mansoni ap endonuclease 0.0063 0.0208 0.0712
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0087 0.0309 0.0441
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.17 0.6999 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0063 0.0208 0.0684
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0019 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0189 0.0189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0087 0.0309 0.0441
Brugia malayi photoreceptor-specific nuclear receptor 0.0087 0.0309 0.0309
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0066
Schistosoma mansoni pyruvate kinase 0.0056 0.018 0.0616
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0189 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0158 0.0158
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.2926 0.418
Brugia malayi nuclear receptor NHR-88 0.0087 0.0309 0.0309
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0118 0.0168
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Echinococcus granulosus pyruvate kinase 0.0056 0.018 0.0616
Entamoeba histolytica pyruvate kinase, putative 0.0076 0.0264 0.0264
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.037 0.0528
Giardia lamblia Kinase, PLK 0.0102 0.037 0.037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0788 0.3218 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.037 0.1214
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0218 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0087 0.0309 0.0309
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0243 0.0798
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0118 0.0403
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0747 0.3046 1
Loa Loa (eye worm) steroid hormone receptor 0.0087 0.0309 0.0309
Entamoeba histolytica hypothetical protein 0.0151 0.0572 0.0572
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0087 0.0309 0.0441
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0066
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0016 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0063 0.0208 0.0684
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0118 0.0118
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0189 0.0189
Brugia malayi hypothetical protein 0.0151 0.0572 0.0572
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0118 0.0168
Echinococcus granulosus transcription factor btf3 0.0071 0.0243 0.0831
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0118 0.0118
Entamoeba histolytica transcription factor BTF3, putative 0.0071 0.0243 0.0243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0309 0.1056
Toxoplasma gondii NAC domain-containing protein 0.0071 0.0243 0.6058
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0189 0.0621
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0087 0.0309 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0243 0.0243
Onchocerca volvulus 0.0031 0.0075 0.0075
Brugia malayi beta-NAC-like protein 0.0071 0.0243 0.0243
Brugia malayi ecdysteroid receptor 0.0087 0.0309 0.0309
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.003 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0076 0.0264 0.0264
Echinococcus granulosus pyruvate kinase 0.0109 0.0401 0.1371
Trypanosoma cruzi hypothetical protein, conserved 0.0747 0.3046 1
Echinococcus granulosus pyruvate kinase 0.0056 0.018 0.0616
Schistosoma mansoni transcription factor btf3 0.0071 0.0243 0.0831
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0063 0.0208 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0103 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0189 0.0189
Echinococcus multilocularis pyruvate kinase 0.0056 0.018 0.0258
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0063 0.0208 0.0712
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0118 0.0118
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.037 0.037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0309 0.0309
Echinococcus multilocularis pyruvate kinase 0.0056 0.018 0.0258
Chlamydia trachomatis pyruvate kinase 0.0109 0.0401 0.5
Leishmania major pyruvate kinase 0.0109 0.0401 0.1317
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0087 0.0309 0.0309
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0151 0.0572 0.1956
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0118 0.0118
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0066
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0189 0.4717
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0189 0.0621
Plasmodium vivax basic transcription factor 3b, putative 0.0071 0.0243 0.6058
Schistosoma mansoni retinoic acid receptor RXR 0.0087 0.0309 0.1056
Onchocerca volvulus 0.0041 0.0118 0.0118
Entamoeba histolytica hypothetical protein 0.0071 0.0243 0.0243
Plasmodium falciparum pyruvate kinase 2 0.0056 0.018 0.4493
Schistosoma mansoni cpg binding protein 0.0033 0.0083 0.0283
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.037 0.037
Loa Loa (eye worm) pyruvate kinase-PB 0.0076 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0189 0.0621
Brugia malayi Steroid receptor seven-up type 2 0.0087 0.0309 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0218 0.0009
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0138 0.0473
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0118 0.0403
Loa Loa (eye worm) ICD-1 protein 0.0071 0.0243 0.0243
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0087 0.0309 0.1056
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0158 0.0158
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0118 0.0403
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0087 0.0309 0.1056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0151 0.0572 0.1956
Onchocerca volvulus Pyruvate kinase homolog 0.0109 0.0401 0.0401
Schistosoma mansoni RAR-like nuclear receptor 0.0087 0.0309 0.1056
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0041 0.0118 0.0168
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0087 0.0309 0.1056
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0189 0.0621
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.037 0.037
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0747 0.3046 0.3046
Echinococcus granulosus FTZ F1 alpha 0.0087 0.0309 0.1056
Brugia malayi nuclear receptor RXR 0.0046 0.0138 0.0138
Schistosoma mansoni transcription factor LCR-F1 0.0151 0.0572 0.1956
Loa Loa (eye worm) pyruvate kinase 0.0109 0.0401 0.0401
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Brugia malayi CXXC zinc finger family protein 0.0033 0.0083 0.0083
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0138 0.0473
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Schistosoma mansoni lamin 0.0031 0.0075 0.0255
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0109 0.0401 0.0581
Trichomonas vaginalis pyruvate kinase, putative 0.0109 0.0401 0.0401
Schistosoma mansoni thyroid hormone receptor 0.0087 0.0309 0.1056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Giardia lamblia Pyruvate kinase 0.0056 0.018 0.018
Brugia malayi hypothetical protein 0.0041 0.0118 0.0118
Mycobacterium ulcerans pyruvate kinase 0.0109 0.0401 0.0197
Plasmodium vivax pyruvate kinase 2, putative 0.0056 0.018 0.4493
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.037 0.037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0087 0.0309 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0243 0.0243
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0118 0.0118
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.037 0.1214
Onchocerca volvulus Huntingtin homolog 0.0133 0.0499 0.0499
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.037 0.037
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0189 0.0621
Brugia malayi nuclear receptor RXR 0.0041 0.0118 0.0118
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0118 0.0118
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0087 0.0309 0.1056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0218 0.0009
Brugia malayi pyruvate kinase, muscle isozyme 0.0023 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Echinococcus granulosus pyruvate kinase 0.0109 0.0401 0.1371
Schistosoma mansoni thyroid hormone receptor 0.0087 0.0309 0.1056
Plasmodium vivax pyruvate kinase, putative 0.0109 0.0401 1
Echinococcus multilocularis FTZ F1 alpha 0.0087 0.0309 0.0441
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Onchocerca volvulus 0.0031 0.0075 0.0075
Echinococcus multilocularis ecdysone induced protein 78C 0.0087 0.0309 0.0441
Loa Loa (eye worm) pyruvate kinase 0.0023 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0465 0.1878 0.642
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0087 0.0309 0.0309
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0009 0.003
Echinococcus multilocularis pyruvate kinase 0.0086 0.0306 0.0437
Onchocerca volvulus Bile acid receptor homolog 0.0087 0.0309 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0309 0.1056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0103 0.0103
Schistosoma mansoni steroid hormone receptor ad4bp 0.0087 0.0309 0.1056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Echinococcus granulosus ecdysone induced protein 78C 0.0087 0.0309 0.1056
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0218 0.0743
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.037 0.1264
Schistosoma mansoni hypothetical protein 0.0037 0.0103 0.0351
Treponema pallidum fructose-bisphosphate aldolase 0.1614 0.6643 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0138 0.0138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0175 0.0175
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0087 0.0309 0.1056
Echinococcus granulosus cpg binding protein 0.0035 0.0091 0.031
Leishmania major basic transcription factor 3a, putative 0.0071 0.0243 0.0798
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0218 0.0315
Brugia malayi MAP kinase sur-1 0.0058 0.0189 0.0189
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0087 0.0309 0.1056
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0087 0.0309 0.0309
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0028
Schistosoma mansoni hypothetical protein 0.0379 0.1519 0.5192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0309 0.0441
Brugia malayi hypothetical protein 0.0041 0.0118 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0189 0.0189
Schistosoma mansoni nuclear receptor 0.0041 0.0118 0.0403
Trichomonas vaginalis ap endonuclease, putative 0.0063 0.0208 0.0208
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0063 0.0208 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0243 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0087 0.0309 0.0309
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.2926 1
Giardia lamblia Pyruvate kinase 0.0109 0.0401 0.0401
Leishmania major hypothetical protein, conserved 0.0747 0.3046 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0118 0.0403
Loa Loa (eye worm) hypothetical protein 0.0087 0.0309 0.0309
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0063 0.0208 0.0302
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0087 0.0309 0.1056
Trypanosoma cruzi hypothetical protein, conserved 0.0747 0.3046 1
Brugia malayi nuclear hormone receptor 0.0041 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0066
Toxoplasma gondii pyruvate kinase PyKII 0.0056 0.018 0.4493
Echinococcus multilocularis pyruvate kinase 0.0109 0.0401 0.0573
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0075 0.0075
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0118 0.0118
Entamoeba histolytica hypothetical protein 0.0151 0.0572 0.0572
Echinococcus granulosus intermediate filament protein 0.0031 0.0075 0.0255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0118 0.0403
Onchocerca volvulus 0.0033 0.0083 0.0083
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0118 0.0403
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0006
Onchocerca volvulus Protein ultraspiracle homolog 0.0087 0.0309 0.0309
Trypanosoma brucei transcription factor BTF3, putative 0.0071 0.0243 0.0798
Loa Loa (eye worm) hypothetical protein 0.0055 0.0175 0.0175
Echinococcus multilocularis lamin dm0 0.0031 0.0075 0.0107
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0033 0.0085 0.0085
Trypanosoma brucei protein kinase, putative 0.0058 0.0189 0.0621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0118 0.0118
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0189 0.0621
Echinococcus granulosus lamin 0.0031 0.0075 0.0255
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0066
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0087 0.0309 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1614 0.6643 0.6643
Brugia malayi intermediate filament protein 0.0031 0.0075 0.0075
Schistosoma mansoni cpg binding protein 0.0035 0.0091 0.031
Brugia malayi nuclear hormone receptor 0.0087 0.0309 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0087 0.0309 0.0309
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0118 0.0168
Brugia malayi Pyruvate kinase, M2 isozyme 0.0109 0.0401 0.0401
Schistosoma mansoni coup transcription factor 0.0087 0.0309 0.1056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0075 0.0075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0151 0.0572 0.0818
Brugia malayi Nuclear hormone receptor-like 1 0.0087 0.0309 0.0309
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0138 0.0473
Toxoplasma gondii pyruvate kinase PyK1 0.0109 0.0401 1
Echinococcus granulosus GPCR family 2 0.0017 0.0019 0.0066
Brugia malayi Pyruvate kinase, muscle isozyme 0.0109 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0133 0.0499 0.0499
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0118 0.0118
Schistosoma mansoni kinase 0.0052 0.0163 0.0558
Echinococcus granulosus geminin 0.0379 0.1519 0.5192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0087 0.0309 0.0309
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0063 0.0208 0.5192
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0309 0.1056
Echinococcus multilocularis GPCR, family 2 0.0017 0.0019 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0087 0.0309 0.0441
Trypanosoma brucei polo-like protein kinase 0.0102 0.037 0.1214
Loa Loa (eye worm) hypothetical protein 0.0046 0.0138 0.0138
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0189 0.0189
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0087 0.0309 0.0441
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0218 0.5422
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0063 0.0208 0.0208
Schistosoma mansoni nuclear receptor 0.0041 0.0118 0.0403
Schistosoma mansoni intermediate filament proteins 0.0031 0.0075 0.0255
Trypanosoma cruzi pyruvate kinase 2, putative 0.0109 0.0401 0.1317
Brugia malayi hypothetical protein 0.0046 0.0138 0.0138
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0788 0.3218 0.4663
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0087 0.0309 0.1056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0063 0.0208 0.0684
Echinococcus granulosus pyruvate kinase 0.0056 0.018 0.0616
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.037 0.1214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0309 0.0441
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0087 0.0309 0.0309
Trichomonas vaginalis pyruvate kinase, putative 0.0109 0.0401 0.0401
Echinococcus granulosus microtubule associated protein 2 0.0718 0.2926 1
Brugia malayi ecdysone receptor 0.0041 0.0118 0.0118
Brugia malayi nuclear receptor NHR-88 0.0041 0.0118 0.0118
Onchocerca volvulus Pyruvate kinase homolog 0.0109 0.0401 0.0401
Echinococcus multilocularis pyruvate kinase 0.0056 0.018 0.0258
Brugia malayi hypothetical protein 0.0046 0.0138 0.0138
Echinococcus multilocularis dnaJ subfamily B 0.0465 0.1878 0.2684

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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