TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.342 | Formula: C16H18F3N5O2
H donors: 2 H acceptors: 3 LogP: 3.98 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)/C=C(/Nc1ccc(cc1)C(F)(F)F)\NCCCn1cncc1C
InChi: 1S/C16H18F3N5O2/c1-12-9-20-11-23(12)8-2-7-21-15(10-24(25)26)22-14-5-3-13(4-6-14)16(17,18)19/h3-6,9-11,21-22H,2,7-8H2,1H3/b15-10+
InChiKey: XJRNFGBWDPSCST-XNTDXEJSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutaminyl-peptide cyclotransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	Get druggable targets OG5_129821	All targets in OG5_129821
Onchocerca volvulus	Glutaminyl cyclase homolog	Get druggable targets OG5_129821	All targets in OG5_129821
Echinococcus granulosus	glutaminyl peptide cyclotransferase	Get druggable targets OG5_129821	All targets in OG5_129821
Schistosoma japonicum	ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative	Get druggable targets OG5_129821	All targets in OG5_129821
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129821	All targets in OG5_129821
Brugia malayi	Peptidase family M28 containing protein	Get druggable targets OG5_129821	All targets in OG5_129821
Schistosoma mansoni	glutaminyl cyclase (M28 family)	Get druggable targets OG5_129821	All targets in OG5_129821

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	glutaminyl-peptide cyclotransferase	361 aa	292 aa	21.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0024	0.0549	0.5804
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0022	0.0488	0.0488
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0065	0.0096
Entamoeba histolytica	hypothetical protein	0.0222	0.6477	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.0024	0.0557	0.0557
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0022	0.0488	0.0488
Schistosoma mansoni	retinoic acid receptor RXR	0.0008	0.0065	0.0065
Onchocerca volvulus		0.0079	0.2205	0.3204
Leishmania major	protein kinase, putative	0.0024	0.0549	0.5804
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0024	0.0549	0.0814
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0483	1
Onchocerca volvulus		0.0022	0.0488	0.0633
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0024	0.0557	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0483	0.5
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0022	0.0488	0.0488
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0024	0.0549	0.1676
Schistosoma mansoni	hypothetical protein	0.0222	0.6477	0.6477
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0022	0.0488	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0079	0.2205	0.2452
Leishmania major	protein kinase, putative	0.0024	0.0549	0.5804
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.2581	0.2581
Onchocerca volvulus	Glutaminyl cyclase homolog	0.0136	0.3923	0.5778
Brugia malayi	Importin beta-1 subunit	0.0029	0.0695	0.1025
Entamoeba histolytica	hypothetical protein	0.0222	0.6477	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0708	0.7489
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0469	0.0691
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0022	0.0488	0.0488
Schistosoma mansoni	transcription factor LCR-F1	0.0222	0.6477	0.6477
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0945	0.146
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0024	0.0549	0.0814
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0483	0.0746
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0008	0.0065	0.0065
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0469	0.6622
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0483	0.0483
Brugia malayi	FXNA	0.0022	0.0488	0.0719
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1402	0.2067
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0483	0.5109
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0008	0.0065	0.0072
Schistosoma mansoni	ap endonuclease	0.0022	0.0483	0.0483
Entamoeba histolytica	hypothetical protein	0.0023	0.0533	0.0823
Schistosoma mansoni	hypothetical protein	0.0017	0.0333	0.0333
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0024	0.0549	0.1676
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0008	0.0065	0.0065
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0945	1
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0055	0.1494	0.2202
Echinococcus granulosus	ecdysone induced protein 78C	0.0008	0.0065	0.0065
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0022	0.0488	0.0488
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0945	0.1402
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1494	0.1662
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0024	0.0557	0.0557
Brugia malayi	PAS domain containing protein	0.0024	0.0549	0.0809
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0022	0.0488	0.0488
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0469	0.4959
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.2581	0.2871
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0695	0.7353
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0065	0.0096
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0008	0.0065	0.0072
Brugia malayi	Pre-SET motif family protein	0.0029	0.0708	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0488	0.0543
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0708	0.0708
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0333	0.0491
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0008	0.0065	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0488	0.0724
Entamoeba histolytica	Ran family GTPase	0.0021	0.0469	0.0724
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0056	0.1502	0.1671
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0333	0.037
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0022	0.0488	0.0488
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0945	0.1402
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0483	0.5109
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0483	0.6823
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0008	0.0065	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0065	0.0096
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0056	0.1502	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3923	0.4364
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0945	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Echinococcus granulosus	snurportin 1	0.0306	0.899	0.899
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0022	0.0488	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0065	0.0065
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.0136	0.3923	0.3923
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0549	0.0814
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0533	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0488	0.0543
Brugia malayi	nuclear receptor NHR-88	0.0008	0.0065	0.0096
Brugia malayi	nuclear hormone receptor	0.0008	0.0065	0.0096
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0483	0.0483
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0945	0.0945
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0333	0.0491
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0008	0.0065	0.0065
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0945	1
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.0065	0.0065
Schistosoma mansoni	hypothetical protein	0.0036	0.0907	0.0907
Mycobacterium tuberculosis	Conserved protein	0.0022	0.0488	0.0142
Trichomonas vaginalis	adenylate cyclase, putative	0.0024	0.0549	0.0814
Schistosoma mansoni	single-minded	0.0024	0.0549	0.0549
Schistosoma mansoni	ran	0.0021	0.0469	0.0469
Echinococcus multilocularis	ecdysone induced protein 78C	0.0008	0.0065	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0008	0.0065	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0549	0.0814
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0549	0.0814
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0065	0.0096
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0024	0.0549	0.1676
Onchocerca volvulus		0.0029	0.0708	0.0963
Echinococcus granulosus	aryl hydrocarbon receptor	0.0079	0.2213	0.2213
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0469	0.0521
Brugia malayi	Inositol-1	0.0037	0.0945	0.1394
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0022	0.0488	0.0107
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0945	0.1402
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0695	0.9819
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1402	0.156
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0708	0.0708
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0483	0.0712
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0708	0.0708
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0008	0.0065	0.0096
Schistosoma mansoni	nicalin (M28 family)	0.0022	0.0488	0.0488
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0333	0.0333
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0483	0.0299
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0024	0.0549	0.0814
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0024	0.0549	0.1676
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0065	0.0096
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0065	0.0065
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0065	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0488	0.0724
Onchocerca volvulus	Fxna peptidase homolog	0.0022	0.0488	0.0633
Schistosoma mansoni	hypothetical protein	0.0017	0.0333	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1494	0.1662
Brugia malayi	Peptidase family M28 containing protein	0.0136	0.3923	0.5784
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0483	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0695	0.0695
Echinococcus granulosus	GPCR family 2	0.0017	0.0333	0.0333
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0469	0.4959
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0022	0.0488	0.0402
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0158	0.457	0.6738
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0008	0.0065	0.0065
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0533	0.5638
Onchocerca volvulus	Protein cycle homolog	0.0056	0.1502	0.2152
Schistosoma mansoni	ran	0.0021	0.0469	0.0469
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0533	0.1347
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0222	0.6477	0.6477
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.0065	0.0065
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.5904	0.6568
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0469	0.6744
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0024	0.0549	0.1676
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0024	0.0549	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0488	0.0543
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0483	0.0716
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0695	0.7353
Brugia malayi	hypothetical protein	0.0055	0.1494	0.2202
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0333	0.0333
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0907	0.1338
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.0136	0.3923	0.3923
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0708	0.0708
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0008	0.0065	0.0065
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0695	0.0695
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0333	0.0333
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0024	0.0549	0.0814
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0829	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0695	0.0773
Schistosoma mansoni	importin beta-1	0.0029	0.0695	0.0695
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0008	0.0065	0.0065
Toxoplasma gondii	peptidase, M28 family protein	0.0022	0.0488	0.5162
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0333	0.037
Leishmania major	glutaminyl cyclase, putative	0.0022	0.0488	0.5162
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0065	0.0096
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0008	0.0065	0.0065
Loa Loa (eye worm)	inositol-1	0.0037	0.0945	0.1052
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0488	0.0724
Plasmodium falciparum	importin beta, putative	0.0029	0.0695	1
Brugia malayi	RNA, U transporter 1	0.0081	0.2276	0.3355
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0945	0.0945
Trichomonas vaginalis	guanylate cyclase, putative	0.0024	0.0549	0.0814
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0008	0.0065	0.0072
Toxoplasma gondii	exonuclease III APE	0.0022	0.0483	0.5109
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0488	0.0107
Brugia malayi	nicalin	0.0022	0.0488	0.0719
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0008	0.0065	0.0096
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0222	0.6477	0.6477
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0533	0.0791
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0469	0.0469
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0469	0.0469
Entamoeba histolytica	hypothetical protein	0.0222	0.6477	1
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.6742	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0333	0.0333
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0065	0.0065
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0008	0.0065	0.0065
Schistosoma mansoni	ap endonuclease	0.0022	0.0483	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1494	0.1662
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.2581	0.2581
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0008	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0549	0.061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0008	0.0065	0.0072
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0022	0.0488	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1494	0.1662
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0945	0.0945
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0065	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0008	0.0065	0.0096
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0079	0.2213	0.2213
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0829	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0676	0.0676
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0483	0.0299
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0708	0.0708
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0945	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0008	0.0065	0.0065
Brugia malayi	Pre-SET motif family protein	0.0203	0.5904	0.8705
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0483	0.6949
Brugia malayi	steroid hormone receptor	0.0008	0.0065	0.0096
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0056	0.1502	0.2214
Onchocerca volvulus	Fxna peptidase homolog	0.0022	0.0488	0.0633
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1402	0.156
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0065	0.0096
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0945	1
Brugia malayi	hypothetical protein	0.0079	0.2205	0.325
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0333	0.0333
Loa Loa (eye worm)	STAT protein	0.0158	0.457	0.5084
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0079	0.2213	0.2461
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0022	0.0488	0.0488
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0232	0.6783	0.7545
Schistosoma mansoni	RAR-like nuclear receptor	0.0008	0.0065	0.0065
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0008	0.0065	0.0065
Toxoplasma gondii	hypothetical protein	0.0022	0.0488	0.5162
Trichomonas vaginalis	guanylate cyclase, putative	0.0024	0.0549	0.0814
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0945	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0945	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1402	0.2067
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0008	0.0065	0.0065
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0008	0.0065	0.0065
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.2581	0.2581
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0008	0.0065	0.0072
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0008	0.0065	0.0065
Leishmania major	hypothetical protein, conserved	0.0022	0.0488	0.5162
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.2581	0.2581
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0695	0.7353
Loa Loa (eye worm)	leucyl aminopeptidase	0.0022	0.0488	0.0543
Brugia malayi	hypothetical protein	0.0056	0.1502	0.2214
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.2581	0.2581
Brugia malayi	follicle stimulating hormone receptor	0.0232	0.6783	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0708	0.0788
Echinococcus granulosus	FTZ F1 alpha	0.0008	0.0065	0.0065
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0483	0.0716
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.2581	0.2581
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.0136	0.3923	0.3923
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.2581	0.2581
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.899	1
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0056	0.1502	0.1502
Schistosoma mansoni	hypothetical protein	0.0306	0.899	0.899
Brugia malayi	ecdysteroid receptor	0.0008	0.0065	0.0096
Onchocerca volvulus		0.0231	0.6742	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0945	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0008	0.0065	0.0096
Echinococcus multilocularis	snurportin 1	0.0306	0.899	0.899
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0333	0.0333
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0008	0.0065	0.0065
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0533	0.0791
Brugia malayi	Steroid receptor seven-up type 2	0.0008	0.0065	0.0096
Entamoeba histolytica	hypothetical protein	0.0222	0.6477	1
Plasmodium vivax	SET domain protein, putative	0.0029	0.0708	1
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0488	0.0543
Brugia malayi	hypothetical protein	0.0222	0.6477	0.9549
Echinococcus multilocularis	FTZ F1 alpha	0.0008	0.0065	0.0065
Schistosoma mansoni	coup transcription factor	0.0008	0.0065	0.0065
Leishmania major	GTP-binding protein, putative	0.0021	0.0469	0.4959
Trichomonas vaginalis	ran, putative	0.0021	0.0469	0.0695
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0008	0.0065	0.0096
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0008	0.0065	0.0072
Loa Loa (eye worm)	steroid hormone receptor	0.0008	0.0065	0.0072
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0008	0.0065	0.0096
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0024	0.0549	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0024	0.0549	0.1676
Trypanosoma brucei	glutaminyl cyclase, putative	0.0022	0.0488	0.5162
Schistosoma mansoni	hypothetical protein	0.0017	0.0333	0.0333
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0708	0.0708
Onchocerca volvulus	Fxna peptidase homolog	0.0022	0.0488	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0907	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0072
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.2581	0.3805
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0008	0.0065	0.0065
Brugia malayi	leucyl aminopeptidase	0.0022	0.0488	0.0719

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 34 nM	Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assay	ChEMBL.	19863057

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL578153

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1188601