Detailed information for compound 1193938

Basic information

Technical information
  • TDR Targets ID: 1193938
  • Name: 2-ethylsulfanyl-5,6-dimethyl-1H-pyrimidin-4-o ne
  • MW: 184.259 | Formula: C8H12N2OS
  • H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1nc(C)c(c(n1)O)C
  • InChi: 1S/C8H12N2OS/c1-4-12-8-9-6(3)5(2)7(11)10-8/h4H2,1-3H3,(H,9,10,11)
  • InChiKey: FWSSUAUZSSDSFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(ethylthio)-5,6-dimethyl-1H-pyrimidin-4-one
  • NRB 04181
  • NSC111107
  • IDI1_015779
  • SMR000528513
  • MLS000737713
  • ZINC00174169
  • Maybridge3_004392

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0708 0.087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.4889 0.4885
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0204 0.0316
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.3697 0.5726
Echinococcus granulosus smad 0.0017 0.0204 0.0197
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0552 0.5677
Schistosoma mansoni hypothetical protein 0.0149 0.3697 0.3692
Brugia malayi hypothetical protein 0.003 0.0552 0.0855
Echinococcus multilocularis GPCR, family 2 0.0069 0.1575 0.1569
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0708 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0012
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0012
Onchocerca volvulus 0.001 0.0008 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.4889 0.4885
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0708 1
Brugia malayi MH1 domain containing protein 0.0017 0.0204 0.0316
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0708 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0552 0.5677
Brugia malayi MH1 domain containing protein 0.0017 0.0204 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0012
Schistosoma mansoni smad1 5 8 and 0.0017 0.0204 0.0197
Brugia malayi Smad1 0.0017 0.0204 0.0316
Brugia malayi Latrophilin receptor protein 2 0.0069 0.1575 0.244
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0552 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.1575 0.1569
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.1575 0.1569
Schistosoma mansoni inositol monophosphatase 0.0036 0.0708 0.0701
Brugia malayi MH2 domain containing protein 0.0017 0.0204 0.0316
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0177 0.4425 1
Echinococcus granulosus long chain fatty acid transport protein 4 0.0179 0.4486 0.4482
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0552 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0012
Echinococcus granulosus Smad4 0.0017 0.0204 0.0197
Loa Loa (eye worm) hypothetical protein 0.0149 0.3697 0.5726
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0348 0.5
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0348 0.0539
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0708 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0204 0.0197
Leishmania major fatty acid transporter protein-like protein 0.0177 0.4425 1
Schistosoma mansoni hypothetical protein 0.0069 0.1575 0.1569
Brugia malayi MH2 domain containing protein 0.0017 0.0204 0.0316
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.1575 0.1569
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0708 0.0839
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Echinococcus multilocularis Smad4 0.0017 0.0204 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0012
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.4889 0.4885
Schistosoma mansoni hypothetical protein 0.0388 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.6457 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0012
Schistosoma mansoni hypothetical protein 0.0069 0.1575 0.1569
Echinococcus granulosus GPCR family 2 0.0069 0.1575 0.1569
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0179 0.4486 0.4482
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0012
Schistosoma mansoni smad1 5 8 and 0.0017 0.0204 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0012
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0204 0.0197
Brugia malayi AMP-binding enzyme family protein 0.0185 0.464 0.7186
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.4889 0.4885
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0012
Echinococcus multilocularis geminin 0.0388 1 1
Brugia malayi hypothetical protein 0.002 0.0267 0.0413
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0012
Schistosoma mansoni ap endonuclease 0.0023 0.0348 0.0341
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0179 0.4486 1
Schistosoma mansoni hypothetical protein 0.0388 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.1575 0.244
Schistosoma mansoni hypothetical protein 0.0069 0.1575 0.1569
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.5526 0.8558
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0348 0.0539
Echinococcus multilocularis smad 0.0017 0.0204 0.0197
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0708 0.0701
Schistosoma mansoni Smad4 0.0017 0.0204 0.0197
Loa Loa (eye worm) inositol-1 0.0036 0.0708 0.1096
Loa Loa (eye worm) Smad1 0.0017 0.0204 0.0316
Loa Loa (eye worm) hypothetical protein 0.003 0.0552 0.0855
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.4889 0.7572
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0204 0.0197
Schistosoma mansoni FFA transport protein 0.0179 0.4486 0.4482
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.1575 0.1569
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0012
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0708 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.4889 0.4885
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0179 0.4486 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0708 1
Leishmania major hypothetical protein, conserved 0.003 0.0552 0.0501
Schistosoma mansoni hypothetical protein 0.0014 0.0108 0.0101
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0108 0.0101
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.4889 0.7572
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0348 0.0341
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0552 0.0494
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0708 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.4889 0.4885
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0204 0.0316
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0185 0.464 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0348 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0177 0.4425 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0204 0.0197
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0708 0.0883
Brugia malayi MH2 domain containing protein 0.0254 0.6457 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0204 0.0197
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0348 0.5
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0552 0.0494
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0607 0.0636
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0108 0.0101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.4889 0.4885
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0069 0.1575 0.244
Schistosoma mansoni ap endonuclease 0.0023 0.0348 0.0341
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.1575 0.244
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0552 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0708 0.0701
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.6457 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.5526 0.8558
Schistosoma mansoni smad 0.0017 0.0204 0.0197
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0708 0.087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.5526 0.8558
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0204 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Brugia malayi Inositol-1 0.0036 0.0708 0.1096
Schistosoma mansoni hypothetical protein 0.0069 0.1575 0.1569
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0185 0.464 0.7186
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0708 0.0701
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0218 0.5526 0.8558

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0024 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.