Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.4951 | 0.4747 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0388 | 0.0527 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0947 | 0.1287 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0388 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4417 | 0.4769 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3258 | 0.4427 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0388 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1407 | 0.1519 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1407 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0388 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0435 | 0.0592 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0388 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4951 | 0.6206 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9262 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0435 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0618 | 0.0774 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0388 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1407 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4951 | 0.6206 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0388 | 0.0527 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0388 | 0.0527 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1407 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4951 | 0.6727 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0388 | 0.0418 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0618 | 0.0667 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0388 | 0.0486 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0388 | 0.0527 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0388 | 0.0527 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4951 | 0.6727 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0388 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3679 | 0.3972 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0947 | 0.1287 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.4951 | 0.6206 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0388 | 0.0486 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0388 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.4951 | 0.5346 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3258 | 0.4427 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.4951 | 0.6727 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7978 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.736 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1407 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1407 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4087 | 0.4413 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.736 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0106 | 0.0114 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0435 | 0.0592 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.4951 | 0.6727 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0388 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1407 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0947 | 0.1188 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0388 | 0.0486 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0388 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.1407 | 0.1061 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.1356 | 0.1008 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1407 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3667 | 0.3411 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0388 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.