Detailed information for compound 1208716

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 769.263 | Formula: C39H50ClN4O8P
  • H donors: 5 H acceptors: 5 LogP: 8.12 Rotable bonds: 28
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OCc1ccccc1)NCC(=O)N[C@@H](C(=O)NCCCCCCCCCCCCOP(=O)(Oc1ccccc1Cl)O)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C39H50ClN4O8P/c40-33-21-13-15-23-36(33)52-53(48,49)51-25-17-8-6-4-2-1-3-5-7-16-24-41-38(46)35(26-31-27-42-34-22-14-12-20-32(31)34)44-37(45)28-43-39(47)50-29-30-18-10-9-11-19-30/h9-15,18-23,27,35,42H,1-8,16-17,24-26,28-29H2,(H,41,46)(H,43,47)(H,44,45)(H,48,49)/t35-/m1/s1
  • InChiKey: GEEJZLGSINTQLI-PGUFJCEWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase eta 0.0045 0.0194 0.0194
Onchocerca volvulus 0.0051 0.0236 0.0888
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0236 0.0486
Onchocerca volvulus 0.0058 0.029 0.1092
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0306 0.063
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0172 0.0355
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0271 0.1872 0.3861
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0652 0.4704 0.9704
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.0236 0.1636
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0288
Giardia lamblia Telomerase catalytic subunit 0.0103 0.0621 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0002 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0236 0.0486
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0388 0.0388
Leishmania major inosine-5-monophosphate dehydrogenase 0.0671 0.4847 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0172 0.0355
Loa Loa (eye worm) IMP dehydrogenase 1 0.0671 0.4847 1
Trypanosoma cruzi GMP reductase 0.0671 0.4847 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0288
Leishmania major DNA polymerase kappa, putative 0.002 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0088 0.0508 0.0508
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0021 0.0044
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0279 0.1931 0.1931
Echinococcus granulosus Niemann Pick C1 protein 0.0212 0.1431 0.1431
Entamoeba histolytica hypothetical protein 0.0112 0.0691 0.4826
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0247 0.051
Leishmania major telomerase reverse transcriptase, putative 0.0103 0.0621 0.128
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0172 0.0355
Echinococcus granulosus dna polymerase kappa 0.002 0.0002 0.0002
Echinococcus multilocularis dna polymerase kappa 0.002 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0236 0.0486
Brugia malayi Pre-SET motif family protein 0.0211 0.1424 0.2937
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0588 0.0588
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0542 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0124 0.0256
Mycobacterium ulcerans hypothetical protein 0.0042 0.0172 0.0355
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0081
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0021 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0247 0.0247
Leishmania major DNA polymerase eta, putative 0.0045 0.0194 0.04
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0081 0.0168
Loa Loa (eye worm) hypothetical protein 0.0092 0.0542 0.1117
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0314 0.0314
Toxoplasma gondii hypothetical protein 0.0032 0.0093 0.0191
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0542 0.1117
Brugia malayi beta-lactamase family protein 0.0042 0.0172 0.0355
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0172 0.0355
Loa Loa (eye worm) hypothetical protein 0.0113 0.07 0.1444
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.1091 0.225
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0306 0.063
Schistosoma mansoni patched 1 0.0091 0.0532 0.0532
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0091 0.0532 0.1098
Loa Loa (eye worm) hypothetical protein 0.0051 0.0236 0.0486
Loa Loa (eye worm) hypothetical protein 0.0042 0.0172 0.0355
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0021 0.0044
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0288 0.1998 0.4122
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0051 0.0236 0.0486
Plasmodium vivax SET domain protein, putative 0.003 0.0081 0.0128
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.07 0.1444
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0172 0.0355
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0542 0.1151
Entamoeba histolytica hypothetical protein 0.0112 0.0691 0.4826
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0172 0.1038
Echinococcus multilocularis microtubule associated protein 2 0.1364 1 1
Brugia malayi TAR-binding protein 0.0062 0.0314 0.0648
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.014 0.0288
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0172 0.0355
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0021 0.0393
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0671 0.4847 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0172 0.0355
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0124 0.0256
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.1091 0.225
Loa Loa (eye worm) GMP reductase 0.0288 0.1998 0.4122
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0002 0.0004
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0652 0.4704 1
Schistosoma mansoni ap endonuclease 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0166 0.1091 0.225
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0194 0.04
Echinococcus granulosus Protein patched homolog 1 0.0091 0.0532 0.0532
Schistosoma mansoni hypothetical protein 0.0088 0.0508 0.0508
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0314 0.0648
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0093 0.0193
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0236 0.0486
Leishmania major DNA polymerase eta, putative 0.0032 0.0093 0.0193
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0691 0.0691
Leishmania major hypothetical protein, conserved 0.0042 0.0172 0.0355
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0172 0.0355
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0314 0.0648
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0279 0.1931 0.1931
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0236 0.0486
Toxoplasma gondii hypothetical protein 0.0047 0.0208 0.0429
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0588 0.1213
Mycobacterium ulcerans lipase LipD 0.0042 0.0172 0.0355
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.014 0.258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0588 0.1213
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0314 0.0314
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.029 0.029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.0236 0.0486
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0888 0.1831
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0388 0.0801
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0388 0.0801
Loa Loa (eye worm) hypothetical protein 0.0042 0.0172 0.0355
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0542 0.1117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0172 0.0355
Schistosoma mansoni hypothetical protein 0.0113 0.07 0.07
Schistosoma mansoni hypothetical protein 0.0052 0.0247 0.0247
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0002 0.0004
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.014 0.0297
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0306 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0092 0.0542 0.1117
Brugia malayi Telomerase reverse transcriptase 0.0273 0.189 0.3898
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0092 0.0542 0.1117
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0236 0.0486
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0247 0.051
Schistosoma mansoni ap endonuclease 0.0022 0.0021 0.0021
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.3318 0.3318
Onchocerca volvulus 0.024 0.164 0.6181
Onchocerca volvulus 0.0042 0.0172 0.0648
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0247 0.051
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0888 0.1831
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0002 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0236 0.0486
Schistosoma mansoni hypothetical protein 0.0052 0.0247 0.0247
Leishmania major guanosine monophosphate reductase 0.0671 0.4847 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0212 0.1431 0.2951
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0021 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0002 0.0004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0172 0.0355
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0092 0.0542 0.1111
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0376 0.2654 1
Echinococcus granulosus neuropeptide s receptor 0.0465 0.3318 0.3318
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0671 0.4847 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0081
Trypanosoma brucei telomerase reverse transcriptase 0.0103 0.0621 0.128
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0021 0.0343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0588 0.0588
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0052 0.0247 0.051
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.023 0.0474
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0236 0.0486
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0081 0.0081
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0215 0.1455 0.1455
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0093 0.0193
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0092 0.0542 0.0542
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0236 0.0486
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0168
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0542 0.1117
Echinococcus multilocularis Niemann Pick C1 protein 0.0302 0.2106 0.2106
Echinococcus granulosus sterol regulatory element binding protein 0.0091 0.0532 0.0532
Brugia malayi RNA binding protein 0.0062 0.0314 0.0648
Loa Loa (eye worm) hypothetical protein 0.0058 0.029 0.0598
Onchocerca volvulus 0.003 0.0081 0.0306
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.0542 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.0236 0.0486
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0163 0.0336
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0671 0.4847 1
Schistosoma mansoni hypothetical protein 0.0088 0.0508 0.0508
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0314 0.0314
Toxoplasma gondii ABC1 family protein 0.0042 0.0172 0.0355
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0236 0.1636
Schistosoma mansoni hypothetical protein 0.0052 0.0247 0.0247
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0021 0.0044
Brugia malayi CHE-14 protein 0.0091 0.0532 0.1098
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0671 0.4847 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0247 0.0247
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2035 0.4198
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0542 0.1117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0124 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0002 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0163 0.0336
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0288
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0032 0.0093 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0532 0.3236
Echinococcus multilocularis GPCR, family 2 0.0052 0.0247 0.0247
Schistosoma mansoni peptidase Clp (S14 family) 0.0092 0.0542 0.0542
Brugia malayi Pre-SET motif family protein 0.003 0.0081 0.0168
Loa Loa (eye worm) hypothetical protein 0.0042 0.0172 0.0355
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0021 0.0044
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0081 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Onchocerca volvulus 0.0042 0.0172 0.0648
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0172 0.0172
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0172 0.1038
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0002 0.0004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.0236 0.0486
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0236 0.0486
Mycobacterium tuberculosis Conserved protein 0.0042 0.0172 0.0355
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.3318 0.3318
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0247 0.0247
Mycobacterium tuberculosis Conserved protein 0.0042 0.0172 0.0355
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0021 0.0136
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0306 0.0306
Toxoplasma gondii RNA-directed DNA polymerase 0.0103 0.0621 0.128
Mycobacterium tuberculosis Conserved protein 0.0042 0.0172 0.0355
Entamoeba histolytica hypothetical protein 0.0112 0.0691 0.4826
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0306 0.0306
Echinococcus multilocularis tumor protein p63 0.0398 0.2817 0.2817
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0307 0.2142 0.4418
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0652 0.4704 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.5717 0.5717
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0002 0.0004
Brugia malayi GMP reductase 0.0288 0.1998 0.4122
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0307 0.2142 0.4418
Trypanosoma brucei GMP reductase 0.0671 0.4847 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0288 0.1998 0.4122
Loa Loa (eye worm) hypothetical protein 0.0111 0.0684 0.1411
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0002 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0088 0.0508 0.0508
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0073 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0081
Onchocerca volvulus 0.0042 0.0172 0.0648
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0002 0.0004
Toxoplasma gondii IMP dehydrogenas 0.0671 0.4847 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0588 0.0588
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0172 0.0322
Echinococcus granulosus GPCR family 2 0.0052 0.0247 0.0247
Trypanosoma cruzi GMP reductase 0.0671 0.4847 1
Schistosoma mansoni microtubule-associated protein tau 0.1364 1 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0671 0.4847 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0172 0.1038
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.014 0.0253
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0671 0.4847 0.4847
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.1424 0.2937
Loa Loa (eye worm) hypothetical protein 0.0045 0.0194 0.04
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.014 0.0288
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0021 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0588 0.0588
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0093 0.1709
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0364 0.2562 0.5286
Brugia malayi beta-lactamase 0.0042 0.0172 0.0355
Mycobacterium ulcerans beta-lactamase 0.0042 0.0172 0.0355
Brugia malayi beta-lactamase family protein 0.0042 0.0172 0.0355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0588 0.0588
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0236 0.1636
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0172 0.0355
Echinococcus granulosus tumor protein p63 0.0398 0.2817 0.2817
Schistosoma mansoni hypothetical protein 0.0052 0.0247 0.0247
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0021 0.0119
Loa Loa (eye worm) hypothetical protein 0.0212 0.1431 0.2951
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0124 0.0256
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0021 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.1091 0.225
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.2035 0.4198
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0388 0.0801
Loa Loa (eye worm) hypothetical protein 0.0042 0.0172 0.0355
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0671 0.4847 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2035 0.4198
Echinococcus multilocularis expressed conserved protein 0.0199 0.1335 0.1335
Loa Loa (eye worm) beta-lactamase 0.0042 0.0172 0.0355
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0671 0.4847 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0314 0.0648
Onchocerca volvulus Putative GMP reductase 0.0288 0.1998 0.753
Loa Loa (eye worm) hypothetical protein 0.0038 0.014 0.0288
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0247 0.0247
Echinococcus multilocularis protein patched 0.0091 0.0532 0.0532
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0212 0.1431 1
Echinococcus granulosus expressed conserved protein 0.0199 0.1335 0.1335
Echinococcus multilocularis Niemann Pick C1 protein 0.0212 0.1431 0.1431
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0032 0.0093 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0671 0.4847 0.4847
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0172 0.0355
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0172 0.1038
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0388 0.0388
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0172 0.0355
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0364 0.2562 0.5286
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0092 0.0542 0.0542
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0388 0.0388
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0163 0.0336
Trichomonas vaginalis set domain proteins, putative 0.024 0.164 1
Mycobacterium ulcerans hypothetical protein 0.0154 0.1004 0.2071
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0172 0.0355
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0236 0.0486
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0671 0.4847 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0671 0.4847 0.4847
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0194 0.04
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0172 0.0355
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0172 0.0355
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0236 0.0486
Brugia malayi photoreceptor-specific nuclear receptor 0.0257 0.1767 0.3646
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0021 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0588 0.0588
Entamoeba histolytica hypothetical protein 0.0112 0.0691 0.4826
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0314 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0103 0.0621 0.128
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0163 0.0336
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.2035 0.4198
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0081 0.0081
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1004 0.2071
Echinococcus multilocularis sterol regulatory element binding protein 0.0091 0.0532 0.0532
Trichomonas vaginalis esterase, putative 0.0042 0.0172 0.1038
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0236 0.0486
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0388 0.0801
Plasmodium vivax telomerase reverse transcriptase, putative 0.0103 0.0621 0.128
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Echinococcus granulosus Niemann Pick C1 protein 0.0302 0.2106 0.2106
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0093 0.0197
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0388 0.0801
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0671 0.4847 1
Mycobacterium ulcerans hypothetical protein 0.0051 0.0236 0.0486
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0314 0.0314
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0021 0.0044
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0021 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0691 0.0691
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0103 0.0621 0.128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0172 0.0172
Echinococcus multilocularis protein dispatched 1 0.0104 0.0627 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0194 0.04
Trypanosoma brucei unspecified product 0.002 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0091 0.0532 0.1098
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0888 0.1831
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0021 0.0119
Echinococcus granulosus tar DNA binding protein 0.0062 0.0314 0.0314
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0314 0.0314
Echinococcus multilocularis dna polymerase eta 0.0045 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0051 0.0236 0.0486
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0172 0.1038
Mycobacterium leprae Probable lipase LipE 0.0042 0.0172 0.0355
Toxoplasma gondii exonuclease III APE 0.0022 0.0021 0.0044
Loa Loa (eye worm) RNA binding protein 0.0062 0.0314 0.0648
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0325 0.0671
Echinococcus granulosus dna polymerase eta 0.0045 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0257 0.1767 0.3646
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0691 0.0691
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0112 0.0691 0.0691
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.3318 0.3318
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.0236 0.0486
Giardia lamblia DINP protein human, muc B family 0.002 0.0002 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0588 0.0588
Onchocerca volvulus 0.0023 0.0031 0.0116
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0002 0.0002
Brugia malayi Probable ClpP-like protease 0.0092 0.0542 0.1117
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0172 0.0355
Plasmodium falciparum telomerase reverse transcriptase 0.0103 0.0621 0.1319
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0002 0.0004
Brugia malayi hypothetical protein 0.0112 0.0691 0.1426

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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