TDR Targets

Basic information

Technical information

TDR Targets ID: 1235090
Name: 5-methyl-4-propan-2-yl-2-[(4-thiophen-2-ylsul fonylpiperazin-1-yl)methyl]phenol
MW: 394.551 | Formula: C19H26N2O3S2
H donors: 1 H acceptors: 3 LogP: 3.53 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cc(C)c(cc1CN1CCN(CC1)S(=O)(=O)c1cccs1)C(C)C
InChi: 1S/C19H26N2O3S2/c1-14(2)17-12-16(18(22)11-15(17)3)13-20-6-8-21(9-7-20)26(23,24)19-5-4-10-25-19/h4-5,10-12,14,22H,6-9,13H2,1-3H3
InChiKey: WLAVXTXZILOMOB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-isopropyl-5-methyl-2-[[4-(2-thienylsulfonyl)piperazin-1-yl]methyl]phenol
4-isopropyl-5-methyl-2-[[4-(2-thienylsulfonyl)-1-piperazinyl]methyl]phenol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.002	0.0141	0.0226
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0504	0.1512
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0707	0.1201
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0504	0.0479
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0707	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0141	0.1988
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0316	0.3187	0.5116
Giardia lamblia	DINP protein human, muc B family	0.002	0.0141	0.4482
Leishmania major	DNA polymerase eta, putative	0.002	0.0141	0.1988
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0026	0.0083
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.0707	0.0682
Echinococcus granulosus	dna polymerase eta	0.002	0.0141	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0612	0.6229	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0707	0.1135
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0504	0.1512
Mycobacterium ulcerans	beta-lactamase	0.0075	0.0707	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0707	0.2218
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0141	0.1988
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.0707	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0504	0.1583
Mycobacterium ulcerans	lipase LipD	0.0075	0.0707	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0504	0.1583
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0707	1
Onchocerca volvulus		0.0075	0.0707	0.5
Brugia malayi	MH1 domain containing protein	0.0009	0.0026	0.0043
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0707	1
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0141	0.1988
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.0707	0.1135
Plasmodium falciparum	importin beta, putative	0.003	0.0241	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0313	0.4436
Schistosoma mansoni	ran	0.0022	0.0161	0.0505
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0026	0.0083
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0161	0.0258
Onchocerca volvulus		0.0075	0.0707	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0313	1
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0184	0.0761
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0161	0.2276
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0707	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0504	0.081
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0313	0.0908
Echinococcus multilocularis	dna polymerase eta	0.002	0.0141	0.0114
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0141	0.0441
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0161	0.513
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0184	0.2598
Echinococcus multilocularis	snurportin 1	0.0316	0.3187	0.3169
Toxoplasma gondii	ABC1 family protein	0.0075	0.0707	1
Trypanosoma brucei	unspecified product	0.0014	0.0077	0.1094
Schistosoma mansoni	hypothetical protein	0.0316	0.3187	1
Brugia malayi	NNMT/PNMT/TEMT family protein	0.0612	0.6229	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0026	0.0043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0504	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0612	0.6229	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0161	0.0135
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.0707	0.1201
Schistosoma mansoni	DNA polymerase eta	0.002	0.0141	0.0441
Brugia malayi	MH2 domain containing protein	0.0009	0.0026	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0707	0.1135
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0313	0.0908
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.0612	0.6229	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0313	0.4436
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0707	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.0707	0.1135
Loa Loa (eye worm)	beta-lactamase	0.0075	0.0707	0.1135
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0479	0.4855	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0707	1
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.0707	0.1201
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0313	0.4436
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0184	0.0761
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0504	0.081
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0141	0.0226
Brugia malayi	MH2 domain containing protein	0.0128	0.1254	0.2013
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.0707	1
Brugia malayi	beta-lactamase family protein	0.0075	0.0707	0.1135
Brugia malayi	MH1 domain containing protein	0.0009	0.0026	0.0043
Echinococcus granulosus	importin subunit beta 1	0.003	0.0241	0.0679
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Brugia malayi	beta-lactamase family protein	0.0075	0.0707	0.1135
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0707	0.1201
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0313	0.3055
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0141	0.1988
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0026	0.0043
Entamoeba histolytica	Ran family GTPase	0.0022	0.0161	0.1174
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0141	0.0114
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0707	0.1201
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0077	0.1094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0077	0.1094
Brugia malayi	beta-lactamase	0.0075	0.0707	0.1135
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0241	0.0215
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0141	0.0114
Brugia malayi	RNA, U transporter 1	0.0084	0.0802	0.1288
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0026	0.0083
Schistosoma mansoni	Smad4	0.0009	0.0026	0.0083
Loa Loa (eye worm)	hypothetical protein	0.003	0.0241	0.0387
Trichomonas vaginalis	esterase, putative	0.0075	0.0707	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0161	0.2276
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0313	0.3055
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0141	0.0361
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0141	0.0226
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.0707	0.2152
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0161	0.6668
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0141	0.1988
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0313	0.0288
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.0707	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0077	0.1094
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0313	0.0503
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0141	0.1988
Schistosoma mansoni	ran	0.0022	0.0161	0.0505
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.1254	0.2013
Leishmania major	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0184	0.2598
Echinococcus granulosus	dna polymerase kappa	0.002	0.0141	0.0361
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0161	0.2276
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0313	0.0288
Brugia malayi	Smad1	0.0009	0.0026	0.0043
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.0707	0.1201
Trichomonas vaginalis	ran, putative	0.0022	0.0161	0.0359
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Schistosoma mansoni	smad	0.0009	0.0026	0.0083
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0313	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0313	0.0984
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0241	0.3413
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.1254	0.2013
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.0707	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0707	0.1135
Leishmania major	GTP-binding protein, putative	0.0022	0.0161	0.2276
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0707	0.2218
Brugia malayi	Importin beta-1 subunit	0.003	0.0241	0.0387
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0707	1
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0241	0.3413
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0141	0.1988
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.0707	0.1201
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0161	0.0425
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Mycobacterium leprae	Probable lipase LipE	0.0075	0.0707	0.5
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0161	0.0258
Loa Loa (eye worm)	Smad1	0.0009	0.0026	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0707	0.1135
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.0707	0.1201
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Brugia malayi	MH2 domain containing protein	0.0009	0.0026	0.0043
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0313	0.3055
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0504	0.0479
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0141	0.0226
Trypanosoma brucei	unspecified product	0.002	0.0141	0.1988
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0313	0.0503
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0141	0.1988
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0161	0.2276
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0241	0.3413
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0026	0.0083
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0707	0.1135
Entamoeba histolytica	hypothetical protein	0.0024	0.0184	0.2492
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0313	0.0908
Trypanosoma brucei	unspecified product	0.0014	0.0077	0.1094
Plasmodium vivax	importin-beta 2, putative	0.003	0.0241	0.3413
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0313	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0707	0.1135
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0707	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0141	0.0441
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0313	0.0288
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0161	0.2276
Leishmania major	hypothetical protein, conserved	0.0075	0.0707	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0313	0.4436
Onchocerca volvulus		0.0075	0.0707	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.0707	0.5
Schistosoma mansoni	importin beta-1	0.003	0.0241	0.0757
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0184	0.0761
Echinococcus granulosus	snurportin 1	0.0316	0.3187	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.0707	0.1201
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0141	0.1988

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.6511 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1316022

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1235090