Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2041 | 0.379 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.3574 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.3574 | 1 |
Loa Loa (eye worm) | twinkle helicase | 0.0206 | 0.2399 | 0.524 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0182 | 0.2041 | 0.5712 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.1106 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.0721 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.0721 | 1 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0218 | 0.0218 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.0721 | 1 | 0.5 |
Entamoeba histolytica | dual specificity protein phosphatase, putative | 0.0649 | 0.8936 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.3574 | 1 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.0721 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0218 | 0.0218 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0218 | 0.0611 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.0721 | 1 | 0.5 |
Trichomonas vaginalis | pps1 dual specificty phosphatase, putative | 0.0649 | 0.8936 | 0.5 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.0721 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0118 | 0.1106 | 0.3094 |
Onchocerca volvulus | Huntingtin homolog | 0.0118 | 0.1106 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.3574 | 1 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0182 | 0.2041 | 0.379 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 195 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | = 0.1585 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.