Detailed information for compound 1243867

Basic information

Technical information
  • TDR Targets ID: 1243867
  • Name: methyl 5-(5-chloro-2-hydroxybenzoyl)-2-iminop yran-3-carboxylate
  • MW: 307.686 | Formula: C14H10ClNO5
  • H donors: 1 H acceptors: 3 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cc(coc1=N)C(=O)c1cc(Cl)ccc1O
  • InChi: 1S/C14H10ClNO5/c1-20-14(19)10-4-7(6-21-13(10)16)12(18)9-5-8(15)2-3-11(9)17/h2-6,16-17H,1H3
  • InChiKey: SAUGGVWONKHPJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 5-(5-chloro-2-hydroxy-benzoyl)-2-imino-pyran-3-carboxylate
  • 5-[(5-chloro-2-hydroxyphenyl)-oxomethyl]-2-imino-3-pyrancarboxylic acid methyl ester
  • 5-(5-chloro-2-hydroxy-benzoyl)-2-imino-pyran-3-carboxylic acid methyl ester
  • methyl 5-(5-chloro-2-hydroxy-phenyl)carbonyl-2-imino-pyran-3-carboxylate
  • MLS000775724
  • ZINC06490479
  • SMR000369283
  • T0517-2788

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Temporarily assigned gene name protein 44 0.003 0.0437 0.0275
Schistosoma mansoni cpg binding protein 0.0062 0.1127 0.1336
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0435 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Loa Loa (eye worm) tumor suppressor 0.0355 0.7407 0.7405
Brugia malayi larval opioid receptor 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0447 0.053
Echinococcus granulosus fmrfamide receptor 0.0031 0.0447 0.0322
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Onchocerca volvulus 0.0287 0.5949 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0215 0.0087
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0447 0.053
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.2029 0.2817
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0447 0.053
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0447 0.0322
Schistosoma mansoni opsin-like receptor 0.0031 0.0447 0.053
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.2169 0.6105
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Echinococcus multilocularis survival motor neuron protein 1 0.0476 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2029 0.3323
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0008 0.001
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0215 0.0017
Echinococcus multilocularis serotonin receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis serotonin receptor 0.0031 0.0447 0.0322
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0215 0.0061
Schistosoma mansoni hypothetical protein 0.0048 0.0822 0.0975
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0537 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0593 0.0703
Brugia malayi GnHR receptor homolog 0.0031 0.0447 0.0285
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0447 0.0322
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Schistosoma mansoni neuropeptide receptor 0.0031 0.0447 0.053
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.2169 0.3032
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0447 0.053
Echinococcus granulosus orexin receptor type 2 0.0031 0.0447 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.2169 0.5
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0008 0.0138
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2169 1
Schistosoma mansoni hypothetical protein 0.0048 0.0822 0.0975
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0822 0.0667
Mycobacterium ulcerans hypothetical protein 0.0169 0.3422 1
Toxoplasma gondii hypothetical protein 0.0052 0.0904 0.4088
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.2169 0.2066
Brugia malayi Pre-SET motif family protein 0.0253 0.5205 0.5124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0204 0.0293
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0447 0.0285
Schistosoma mansoni lamin 0.0033 0.0491 0.0582
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0447 0.0322
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0447 0.0322
Brugia malayi RE15519p 0.0031 0.0447 0.0285
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0447 0.053
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2169 0.2571
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0447 0.0322
Schistosoma mansoni neuropeptide receptor 0.0031 0.0447 0.053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2778 0.2683
Schistosoma mansoni neuropeptide receptor 0.0031 0.0447 0.053
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0447 0.053
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2169 0.2162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0447 0.053
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0447 0.053
Echinococcus granulosus g protein coupled receptor 0.0031 0.0447 0.0322
Brugia malayi Dopamine receptor 0.0031 0.0447 0.0285
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.2778 0.2655
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0476 1 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0135 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0079 0.00000000029662
Schistosoma mansoni cpg binding protein 0.0059 0.1055 0.1251
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0215 0.031
Loa Loa (eye worm) hypothetical protein 0.003 0.0437 0.0429
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0447 0.0439
Schistosoma mansoni cpg binding protein 0.0062 0.1127 0.1336
Schistosoma mansoni adenoreceptor 0.0031 0.0447 0.053
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0447 0.0322
Brugia malayi G-protein coupled receptor 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus neuropeptide receptor 0.0031 0.0447 0.0322
Brugia malayi CXXC zinc finger family protein 0.0059 0.1055 0.0903
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0135 0.0005
Echinococcus granulosus g protein coupled receptor 0.0031 0.0447 0.0322
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0447 0.0322
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0135 0.0005
Loa Loa (eye worm) hypothetical protein 0.0104 0.2017 0.201
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0435 0.7334
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Loa Loa (eye worm) hypothetical protein 0.0016 0.013 0.0122
Toxoplasma gondii exonuclease III APE 0.0019 0.0204 0.0922
Schistosoma mansoni hypothetical protein 0.003 0.0437 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0593 0.0703
Onchocerca volvulus 0.0097 0.1875 0.2595
Schistosoma mansoni intermediate filament proteins 0.0033 0.0491 0.0582
Echinococcus multilocularis cpg binding protein 0.0062 0.1127 0.101
Schistosoma mansoni hypothetical protein 0.0048 0.0822 0.0975
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2778 0.2683
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0215 0.0485
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.6683 1
Brugia malayi follicle stimulating hormone receptor 0.0031 0.0447 0.0285
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.2169 0.2066
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0215 0.0232
Schistosoma mansoni amine GPCR 0.0031 0.0447 0.053
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0447 0.0439
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.2029 0.1925
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0822 0.0702
Schistosoma mansoni hypothetical protein 0.0031 0.0447 0.053
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0822 0.0702
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.00000000017426
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0593 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.3054 0.4563
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0447 0.0322
Onchocerca volvulus 0.0033 0.0491 0.0079
Schistosoma mansoni hypothetical protein 0.0031 0.0447 0.053
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0491 0.0483
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Brugia malayi putative neuropeptide receptor 0.0031 0.0447 0.0285
Brugia malayi 6-phosphofructokinase 0.0111 0.2169 0.2036
Brugia malayi hypothetical protein 0.003 0.0437 0.0275
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus survival motor neuron protein 1 0.0476 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0079 0.00000000029662
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.2017 0.1881
Loa Loa (eye worm) hypothetical protein 0.0037 0.0593 0.0585
Schistosoma mansoni hypothetical protein 0.003 0.0437 0.0518
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0447 0.0322
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0435 0.1975
Brugia malayi Pre-SET motif family protein 0.0037 0.0593 0.0433
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2169 0.356
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0447 0.0322
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0435 0.1965
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2169 0.3032
Brugia malayi tumor suppressor. 0.0355 0.7407 0.7363
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0031 0.0447 0.0439
Schistosoma mansoni survival motor neuron protein 0.0097 0.1875 0.2223
Schistosoma mansoni hypothetical protein 0.0031 0.0447 0.053
Schistosoma mansoni DNA helicase recq5 0.002 0.0215 0.0255
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0447 0.053
Schistosoma mansoni amine GPCR 0.0031 0.0447 0.053
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.3054 0.4398
Echinococcus multilocularis lamin 0.0033 0.0491 0.0366
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0204 0.5
Onchocerca volvulus 0.0037 0.0593 0.0265
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0037
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Brugia malayi ORL1-like opioid receptor 0.0031 0.0447 0.0285
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0447 0.0322
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0447 0.053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0822 0.0702
Brugia malayi phosphofructokinase 0.0111 0.2169 0.2036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0135 0.016
Trypanosoma brucei polo-like protein kinase 0.0104 0.2029 0.2817
Echinococcus multilocularis lamin dm0 0.0033 0.0491 0.0366
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2029 0.3028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0447 0.0285
Onchocerca volvulus 0.0059 0.1055 0.1104
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0447 0.0322
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2169 0.356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0079 0.00000000029662
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0447 0.0322
Brugia malayi hypothetical protein 0.0161 0.324 0.3126
Echinococcus granulosus allatostatin A receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus multilocularis bloom syndrome protein 0.002 0.0215 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0167 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Schistosoma mansoni hypothetical protein 0.0048 0.0822 0.0975
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0447 0.0322
Echinococcus granulosus hypothetical protein 0.003 0.0437 0.0311
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0079 0.00000000029662
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0002 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0135 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0593 0.0469
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0447 0.0439
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0447 0.0322
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.2169 0.3237
Schistosoma mansoni biogenic amine receptor 0.0031 0.0447 0.053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0447 0.0322
Brugia malayi neuropeptide F receptor 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0161 0.324 0.3235
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0822 0.0702
Schistosoma mansoni ap endonuclease 0.0019 0.0204 0.0242
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.2498 0.2962
Echinococcus multilocularis musashi 0.0033 0.0491 0.0366
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0447 0.0322
Echinococcus granulosus neuropeptide s receptor 0.0031 0.0447 0.0322
Echinococcus granulosus neuropeptide receptor A26 0.0031 0.0447 0.0322
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0435 0.0606
Schistosoma mansoni opsin-like receptor 0.0031 0.0447 0.053
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0215 0.0232
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0447 0.0322
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0204 0.0213
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0974 0.1447
Echinococcus granulosus cpg binding protein 0.0062 0.1127 0.101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.3422 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.6683 1
Schistosoma mansoni hypothetical protein 0.0097 0.1875 0.2223
Echinococcus granulosus g protein coupled receptor 0.0031 0.0447 0.0322
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.2029 0.2875
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0435 0.7334
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0762 0.1129
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Echinococcus granulosus somatostatin receptor 0.0031 0.0447 0.0322
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0435 0.0606
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0435 0.0606
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Schistosoma mansoni amine GPCR 0.0031 0.0447 0.053
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2029 0.3323
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0079 0.00000000029662
Brugia malayi 6-phosphofructokinase 0.0111 0.2169 0.2036
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2029 0.3323
Schistosoma mansoni hypothetical protein 0.0031 0.0447 0.053
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0447 0.053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus multilocularis somatostatin receptor 0.0031 0.0447 0.0322
Onchocerca volvulus 0.0033 0.0491 0.0079
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.2029 0.1894
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0215 0.0207
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0762 0.0861
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0204 0.3441
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0447 0.0322
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0447 0.0285
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0447 0.053
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2169 1
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0447 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2029 0.3323
Giardia lamblia Kinase, PLK 0.0104 0.2029 1
Schistosoma mansoni neuropeptide receptor 0.0031 0.0447 0.053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0079 0.00000000029662
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.2169 0.2571
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.6683 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2778 0.2683
Brugia malayi Dopamine receptor protein 1 0.0031 0.0447 0.0285
Echinococcus granulosus protein quaking 0.003 0.0437 0.0311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0593 0.0703
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0447 0.053
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2029 0.3323
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.3046 0.2928
Plasmodium vivax SET domain protein, putative 0.0037 0.0593 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2778 0.3293
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.09 0.1399
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.2029 0.9357
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0762 0.1129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0447 0.0285
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0822 0.0815
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0593 0.0469
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0215 0.0049
Echinococcus granulosus GPCR family 2 0.0048 0.0822 0.0702
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0447 0.053
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0215 0.0087
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0204 0.0038
Loa Loa (eye worm) histone methyltransferase 0.002 0.0212 0.0204
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0447 0.053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2029 0.3323
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0215 0.0049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0079 0.00000000029662
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0435 0.1965
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0447 0.0322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0447 0.0322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0447 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Brugia malayi Serotonin receptor 0.0031 0.0447 0.0285
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0212 0.0083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0491 0.0329
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Trichomonas vaginalis set domain proteins, putative 0.0287 0.5949 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0447 0.0322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2778 0.3293
Loa Loa (eye worm) RecQ helicase 0.002 0.0215 0.0207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0212 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0079 0.00000000029662
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0447 0.0439
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0435 0.1965
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0015 0.0117 0.0109
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.002 0.0215 0.0207
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.2029 0.2023
Brugia malayi AKH receptor 0.0031 0.0447 0.0285
Echinococcus granulosus dnaJ subfamily B 0.0403 0.8435 0.8415
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0762 0.1129
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0447 0.0322
Schistosoma mansoni biogenic amine receptor 0.0031 0.0447 0.053
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0435 0.0606
Echinococcus multilocularis neuropeptide receptor A26 0.0031 0.0447 0.0322
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0447 0.0285
Brugia malayi G-protein coupled receptor 0.0031 0.0447 0.0285
Echinococcus multilocularis sex peptide receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.1055 0.1048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0593 0.0703
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0435 0.2005
Brugia malayi Melatonin receptor type 1A 0.0031 0.0447 0.0285
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0215 0.0485
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0447 0.0322
Schistosoma mansoni opsin-like receptor 0.0031 0.0447 0.053
Echinococcus granulosus sex peptide receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0215 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0447 0.0322
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0435 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2778 0.3293
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0204 0.0941
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0435 0.0606
Echinococcus multilocularis G protein coupled receptor 139 0.0031 0.0447 0.0322
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0447 0.0285
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0435 0.0606
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0215 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0491 0.0483
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.2169 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2169 0.356
Schistosoma mansoni kinase 0.0053 0.093 0.1102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2778 0.2683
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0215 0.0232
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0435 1
Loa Loa (eye worm) phosphofructokinase 0.0111 0.2169 0.2162
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0204 0.0906
Brugia malayi Serotonin receptor 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0048 0.0822 0.0815
Echinococcus granulosus neuropeptide receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0447 0.0322
Schistosoma mansoni amine GPCR 0.0031 0.0447 0.053
Entamoeba histolytica recQ family helicase, putative 0.002 0.0215 0.0992
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0435 0.0606
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0215 0.0973
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0593 0.268
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.6683 1
Echinococcus granulosus serotonin receptor 0.0031 0.0447 0.0322
Brugia malayi Dopamine receptor protein 2 0.0031 0.0447 0.0285
Echinococcus granulosus lamin 0.0033 0.0491 0.0366
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0447 0.0322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Echinococcus granulosus hypothetical protein 0.0031 0.0447 0.0322
Schistosoma mansoni hypothetical protein 0.0403 0.8435 1
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.8435 0.8415
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0204 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0215 0.0049
Entamoeba histolytica recQ family DNA helicase 0.001 0.0008 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0447 0.0322
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0447 0.0322
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Brugia malayi G protein-coupled receptor 0.0031 0.0447 0.0285
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Brugia malayi hypothetical protein 0.0031 0.0447 0.0285
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0447 0.0322
Schistosoma mansoni histamine h1 receptor 0.0031 0.0447 0.053
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.2212 1
Echinococcus granulosus bloom syndrome protein 0.002 0.0215 0.0087
Brugia malayi sulfakinin receptor protein 0.0031 0.0447 0.0285
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0447 0.0285
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0447 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.2169 0.356
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0447 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.09 0.1399
Onchocerca volvulus 0.0161 0.324 0.5077
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0447 0.053
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0204 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.2029 0.2406
Echinococcus multilocularis GPCR, family 2 0.0048 0.0822 0.0702
Schistosoma mansoni amine GPCR 0.0031 0.0447 0.053
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0822 0.0667
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.3046 0.2928
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0447 0.0322
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0207 0.0041
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0447 0.0439
Schistosoma mansoni lamin 0.0033 0.0491 0.0582
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0447 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.3046 0.304
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2029 0.3323
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0447 0.053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.3054 0.4398
Loa Loa (eye worm) hypothetical protein 0.0152 0.3046 0.304
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0447 0.053
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0447 0.053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0204 0.0196
Schistosoma mansoni hypothetical protein 0.0104 0.2017 0.2391
Loa Loa (eye worm) hypothetical protein 0.0032 0.0478 0.047
Brugia malayi intermediate filament protein 0.0033 0.0491 0.0329
Schistosoma mansoni DNA helicase recq1 0.002 0.0215 0.0255
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0435 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.2029 0.1925
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0447 0.0439
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.5205 0.5201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0447 0.0322
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0447 0.0322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0447 0.053
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2029 0.3028
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0447 0.0322
Schistosoma mansoni myosin xvIII 0.0031 0.0447 0.053
Schistosoma mansoni biogenic amine receptor 0.0031 0.0447 0.053
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0447 0.0439
Echinococcus granulosus lamin dm0 0.0033 0.0491 0.0366
Echinococcus granulosus intermediate filament protein 0.0033 0.0491 0.0366
Schistosoma mansoni ap endonuclease 0.0019 0.0204 0.0242
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0435 0.1264
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1875 0.1737
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Echinococcus multilocularis neuropeptide s receptor 0.0031 0.0447 0.0322
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0447 0.0322
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0215 0.0973
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.2169 0.6105
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0204 0.0075
Brugia malayi neuropeptide F receptor 0.0031 0.0447 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.2778 0.2772
Loa Loa (eye worm) hypothetical protein 0.0033 0.0491 0.0483
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0447 0.053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0447 0.0439
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.2169 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0447 0.0322
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.2169 0.2162
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0204 0.0293
Echinococcus multilocularis protein quaking 0.003 0.0437 0.0311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0117 0.0109
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0215 0.0087

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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