TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 569.638 | Formula: C30H30F3N3O3S
H donors: 2 H acceptors: 4 LogP: 5.93 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: N#C[C@H](Cc1ccccc1)NC(=O)[C@H](CC1CC1)N[C@H](C(F)(F)F)c1ccc(cc1)c1ccc(cc1)S(=O)(=O)C
InChi: 1S/C30H30F3N3O3S/c1-40(38,39)26-15-13-23(14-16-26)22-9-11-24(12-10-22)28(30(31,32)33)36-27(18-21-7-8-21)29(37)35-25(19-34)17-20-5-3-2-4-6-20/h2-6,9-16,21,25,27-28,36H,7-8,17-18H2,1H3,(H,35,37)/t25-,27-,28-/m0/s1
InChiKey: JNRFQDUMCHRUFL-MYKRZTLLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	References
Homo sapiens	cathepsin F	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Mycobacterium ulcerans	pyruvate kinase	0.0037	0.083	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.1941	0.4128
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Loa Loa (eye worm)	hypothetical protein	0.0037	0.083	0.083
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.1204	0.1204
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0037	0.083	0.083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0043	0.1204	0.1388
Leishmania major	cathepsin L-like protease	0.0079	0.3523	0.4235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0136	0.7188	0.7188
Brugia malayi	Cathepsin L-like precursor	0.0079	0.3523	0.3523
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Echinococcus multilocularis	cysteine protease	0.0079	0.3523	0.3307
Giardia lamblia	Cathepsin B precursor	0.0068	0.2832	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.3523	0.3307
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0068	0.2832	0.3149
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.1204	0.1204
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.1941	0.538
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1725	0.145
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0037	0.083	0.5
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0037	0.083	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.3523	0.3307
Brugia malayi	Cathepsin L-like precursor	0.0055	0.1941	0.1941
Leishmania major	cathepsin L-like protease	0.0136	0.7188	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0079	0.3523	0.3523
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0079	0.3523	0.2937
Leishmania major	cathepsin L-like protease	0.0079	0.3523	0.4235
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0055	0.1941	0.1941
Brugia malayi	Cathepsin L-like precursor	0.0055	0.1941	0.1941
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1725	0.1725
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Leishmania major	cathepsin L-like protease	0.0079	0.3523	0.4235
Onchocerca volvulus		0.0079	0.3523	1
Entamoeba histolytica	cysteine protease, putative	0.0079	0.3523	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Leishmania major	cathepsin L-like protease	0.0079	0.3523	0.4235
Plasmodium vivax	vivapain-2	0.0079	0.3523	1
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.3523	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0037	0.083	0.083
Echinococcus granulosus	cathepsin l1	0.0079	0.3523	0.2937
Brugia malayi	Cathepsin L-like precursor	0.0079	0.3523	0.3523
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Brugia malayi	Cathepsin L-like precursor	0.0079	0.3523	0.3523
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1941	0.1941
Onchocerca volvulus		0.0079	0.3523	1
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0037	0.083	0.083
Chlamydia trachomatis	pyruvate kinase	0.0037	0.083	0.5
Echinococcus multilocularis	pyruvate kinase	0.0037	0.083	0.0525
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.1204	0.1204
Brugia malayi	Cathepsin L-like precursor	0.0079	0.3523	0.3523
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Echinococcus granulosus	cysteine protease	0.0043	0.1204	0.0408
Brugia malayi	cathepsin L-like precursor	0.0055	0.1941	0.1941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Giardia lamblia	Cathepsin B precursor	0.0068	0.2832	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.3523	0.3307
Loa Loa (eye worm)	ctsf protein	0.0079	0.3523	0.3523
Brugia malayi	Cathepsin L-like precursor	0.0079	0.3523	0.3523
Plasmodium vivax	unspecified product	0.0043	0.1204	0.3417
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.1204	0.3224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Schistosoma mansoni	pyruvate kinase	0.0037	0.083	0.083
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.1204	0.3224
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1941	0.1941
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.3523	0.3523
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0079	0.3523	1
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.083	0.083
Loa Loa (eye worm)	hypothetical protein	0.018	1	1
Echinococcus granulosus	cathepsin b	0.018	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1725	0.1725
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.018	1	1
Echinococcus multilocularis	cathepsin b	0.018	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0043	0.1204	0.1204
Plasmodium vivax	pyruvate kinase, putative	0.0037	0.083	0.2355
Onchocerca volvulus		0.0055	0.1941	0.4128
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Echinococcus multilocularis	cathepsin L	0.0043	0.1204	0.0911
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0079	0.3523	1
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.3523	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.1725	0.1725
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0043	0.1204	0.1388
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0043	0.1204	0.1388
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0075	0.3288	0.3288
Echinococcus granulosus	cathepsin l1	0.0055	0.1941	0.1212
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0068	0.2832	0.3149
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.7188	0.7188
Brugia malayi	Cathepsin L-like precursor	0.0079	0.3523	0.3523
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Loa Loa (eye worm)	cathepsin B	0.0068	0.2832	0.2832
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0079	0.3523	0.2937
Onchocerca volvulus		0.0079	0.3523	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0055	0.1941	0.1941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.1204	0.1204
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.7188	0.7188
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.3523	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0043	0.1204	0.0408
Trypanosoma cruzi	cysteine peptidase, putative	0.0043	0.1204	0.1204
Echinococcus granulosus	cathepsin b	0.018	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Onchocerca volvulus		0.0079	0.3523	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.3523	0.3523
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.1204	0.0588
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.3523	0.3523
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0079	0.3523	1
Onchocerca volvulus		0.0079	0.3523	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.3523	0.3523
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Entamoeba histolytica	cysteine proteinase 2	0.0043	0.1204	0.3224
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.1204	0.3224
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1941	0.1941
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0037	0.083	0.083
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.7188	0.7188
Toxoplasma gondii	cathepsin CPL	0.0079	0.3523	1
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Loa Loa (eye worm)	pyruvate kinase-PB	0.0026	0.01	0.01
Schistosoma mansoni	pyruvate kinase	0.0037	0.083	0.083
Onchocerca volvulus	Cathepsin F homolog	0.0079	0.3523	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Toxoplasma gondii	cathepsin B	0.0068	0.2832	0.7435
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.1204	0.0588
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.3523	0.3307
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Leishmania major	cathepsin L-like protease	0.0136	0.7188	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1725	0.0976
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.1204	0.1204
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.2832	0.2832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.1725	0.1725
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0068	0.2832	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0079	0.3523	0.3523
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0068	0.2832	0.7435
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.3523	1
Trypanosoma cruzi	cysteine protease, putative	0.0043	0.1204	0.1204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Giardia lamblia	Cathepsin B precursor	0.0068	0.2832	1
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.3523	1
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.083	0.083
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1725	0.0976
Leishmania major	cathepsin L-like protease	0.0136	0.7188	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.3523	1
Loa Loa (eye worm)	fibroinase	0.0079	0.3523	0.3523
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Entamoeba histolytica	cysteine proteinase, putative	0.0043	0.1204	0.3224
Loa Loa (eye worm)	hypothetical protein	0.0026	0.01	0.01
Echinococcus multilocularis	pyruvate kinase	0.0037	0.083	0.0525
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0111	0.5607	0.5607
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.1204	0.1204
Plasmodium vivax	vivapain-2	0.0079	0.3523	1
Echinococcus multilocularis	cysteine protease	0.0079	0.3523	0.3307
Loa Loa (eye worm)	cysteine protease	0.0079	0.3523	0.3523
Leishmania major	cathepsin L-like protease	0.0079	0.3523	0.4235
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.1941	0.4128
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.7188	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.3523	1
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.3523	1
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.1204	0.1204
Echinococcus granulosus	cathepsin L	0.0043	0.1204	0.0408
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1725	0.145
Onchocerca volvulus		0.0079	0.3523	1
Echinococcus multilocularis	cathepsin b	0.018	1	1
Plasmodium vivax	vivapain-1	0.0043	0.1204	0.3417
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.3523	0.3523
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.018	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1725	0.1725
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0043	0.1204	0.3224
Onchocerca volvulus		0.0079	0.3523	1
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Entamoeba histolytica	cysteine protease, putative	0.0043	0.1204	0.3224
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.083	0.083
Leishmania major	cysteine peptidase A (CPA)	0.0079	0.3523	0.4235
Plasmodium vivax	vivapain-3	0.0043	0.1204	0.3417
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 16 nM	Inhibition of Trypanosoma cruzi Cruzipain	ChEMBL.	21041084
IC50 (binding)	= 147 nM	Inhibition of human Cat F expressed in rabbit HIG82 cells	ChEMBL.	21041084
IC50 (binding)	= 231 nM	Inhibition of human Cat B in HepG2 cells	ChEMBL.	21041084
IC50 (binding)	= 5246 nM	Inhibition of human Cat L	ChEMBL.	21041084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1289988

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1258985