TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 501.519 | Formula: C26H27F4N5O
H donors: 3 H acceptors: 3 LogP: 4.83 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: N#C[C@@H](NC(=O)[C@H](CC(F)(C)C)N[C@H](C(F)(F)F)c1ccc(cc1)c1cn[nH]c1)Cc1ccccc1
InChi: 1S/C26H27F4N5O/c1-25(2,27)13-22(24(36)34-21(14-31)12-17-6-4-3-5-7-17)35-23(26(28,29)30)19-10-8-18(9-11-19)20-15-32-33-16-20/h3-11,15-16,21-23,35H,12-13H2,1-2H3,(H,32,33)(H,34,36)/t21-,22-,23-/m0/s1
InChiKey: CGAOFGCVDRGRSC-VABKMULXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	References
Homo sapiens	cathepsin F	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0068	0.0758	0.1317
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0942	0.3004
Giardia lamblia	Cathepsin B precursor	0.0068	0.0758	0.5
Onchocerca volvulus		0.0235	0.3629	1
Plasmodium vivax	vivapain-2	0.0079	0.0942	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Entamoeba histolytica	cysteine protease, putative	0.0079	0.0942	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0068	0.0758	0.0758
Onchocerca volvulus	Cathepsin F homolog	0.0079	0.0942	0.2413
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0942	0.3004
Plasmodium vivax	vivapain-1	0.0043	0.0322	0.3417
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0322	0.1026
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0322	0.0597
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0088	0.069
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0286	0.451	0.4509
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.0942	0.1612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Echinococcus multilocularis	cathepsin b	0.018	0.2675	0.488
Plasmodium vivax	SET domain protein, putative	0.003	0.0088	0.093
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0346	0.0521
Trypanosoma cruzi	cysteine peptidase, putative	0.0043	0.0322	0.0322
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.0322	0.0322
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0085	0.1043	0.1043
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0942	0.3004
Echinococcus multilocularis	cathepsin L	0.0043	0.0322	0.0442
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0079	0.0942	0.3004
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.0942	0.3004
Toxoplasma gondii	hypothetical protein	0.0097	0.1258	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Trypanosoma cruzi	cysteine protease, putative	0.0043	0.0322	0.0322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.0942	0.1876
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.1923	0.1923
Leishmania major	cathepsin L-like protease	0.0136	0.1923	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0519	0.1656
Mycobacterium ulcerans	hypothetical protein	0.0318	0.5067	0.5
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0519	0.1656
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0346	0.0488
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.2675	0.4964
Brugia malayi	Pre-SET motif family protein	0.0206	0.3137	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Trypanosoma cruzi	major cysteine proteinase, putative	0.0075	0.0879	0.0879
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0519	0.0597
Loa Loa (eye worm)	fibroinase	0.0079	0.0942	0.3004
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0286	0.451	0.4509
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.0942	0.1748
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.2675	0.4964
Toxoplasma gondii	cathepsin CPL	0.0079	0.0942	0.7488
Leishmania major	cathepsin L-like protease	0.0136	0.1923	0.1922
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0346	0.1104
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0085	0.1043	0.1042
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.0942	0.3004
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0346	0.0643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0322	0.0597
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0286	0.451	0.451
Brugia malayi	Pre-SET motif family protein	0.003	0.0088	0.0279
Echinococcus granulosus	cysteine protease	0.0043	0.0322	0.0476
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.0942	0.1612
Schistosoma mansoni	hypothetical protein	0.0337	0.5389	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.0942	0.1876
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0318	0.5067	0.5
Giardia lamblia	Cathepsin B precursor	0.0068	0.0758	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0346	0.1104
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0068	0.0758	0.0757
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Onchocerca volvulus		0.0055	0.0519	0.1219
Brugia malayi	Papain family cysteine protease containing protein	0.0043	0.0322	0.1026
Schistosoma mansoni	hypothetical protein	0.0337	0.5389	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0079	0.0942	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Brugia malayi	cathepsin L-like precursor	0.0055	0.0519	0.1656
Echinococcus granulosus	cathepsin b	0.018	0.2675	0.4898
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.1923	0.1923
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Echinococcus granulosus	geminin	0.0337	0.5389	1
Loa Loa (eye worm)	ctsf protein	0.0079	0.0942	0.3004
Onchocerca volvulus		0.0079	0.0942	0.2413
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0519	0.1656
Onchocerca volvulus		0.0079	0.0942	0.2413
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0942	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0104	0.1363	0.1363
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0085	0.1043	0.1043
Echinococcus granulosus	cathepsin L	0.0043	0.0322	0.0476
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0942	0.3004
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0079	0.0942	0.1642
Echinococcus granulosus	cathepsin l1	0.0055	0.0519	0.0847
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.0942	0.0942
Onchocerca volvulus		0.0079	0.0942	0.2413
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.018	0.2675	0.2675
Loa Loa (eye worm)	hypothetical protein	0.003	0.0088	0.0279
Giardia lamblia	Cathepsin B precursor	0.0068	0.0758	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0088	0.0163
Leishmania major	cathepsin L-like protease	0.0136	0.1923	0.1922
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Loa Loa (eye worm)	cathepsin B	0.0068	0.0758	0.2415
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.0942	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0346	0.0521
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0079	0.0942	0.1642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.1923	0.1923
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.0942	0.1612
Onchocerca volvulus		0.0079	0.0942	0.2413
Leishmania major	cathepsin L-like protease	0.0079	0.0942	0.0941
Leishmania major	cathepsin L-like protease	0.0079	0.0942	0.0941
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0043	0.0322	0.0597
Onchocerca volvulus		0.0079	0.0942	0.2413
Leishmania major	cathepsin L-like protease	0.0079	0.0942	0.0941
Echinococcus granulosus	cathepsin b	0.018	0.2675	0.4898
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.0322	0.0321
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0942	0.3004
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0088	0.0163
Toxoplasma gondii	cathepsin B	0.0068	0.0758	0.6018
Leishmania major	cathepsin L-like protease	0.0079	0.0942	0.0941
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.0942	0.2413
Trypanosoma cruzi	cruzipain precursor, putative	0.0136	0.1923	0.1923
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.3629	1
Echinococcus multilocularis	cysteine protease	0.0079	0.0942	0.1612
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Echinococcus granulosus	cathepsin l1	0.0079	0.0942	0.1642
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0079	0.0942	1
Onchocerca volvulus		0.0079	0.0942	0.2413
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0346	0.0643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0001	0.0003
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0043	0.0322	0.0322
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0043	0.0322	0.341
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0001	0.001
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0079	0.0942	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0085	0.1043	0.1043
Echinococcus multilocularis	cathepsin b	0.018	0.2675	0.488
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0001	0.0001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.018	0.2675	0.4964
Onchocerca volvulus		0.0079	0.0942	0.2413
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0519	0.1656
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0068	0.0758	0.0757
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.0942	0.1748
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0088	0.0163
Brugia malayi	cathepsin B-like cysteine proteinase	0.018	0.2675	0.8527
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Trypanosoma cruzi	cysteine proteinase, putative	0.0043	0.0322	0.0322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0519	0.0597
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0068	0.0758	0.1406
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0604	1	1
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0519	0.1656
Echinococcus multilocularis	geminin	0.0337	0.5389	1
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.0942	0.2413
Brugia malayi	hypothetical protein	0.0025	0.0001	0.0003
Loa Loa (eye worm)	cysteine protease	0.0079	0.0942	0.3004
Schistosoma mansoni	cathepsin F (C01 family)	0.0055	0.0519	0.0964
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0604	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.018	0.2675	0.4964
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0604	1	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.3137	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0043	0.0322	0.0321
Leishmania major	cysteine peptidase A (CPA)	0.0079	0.0942	0.0941
Plasmodium vivax	vivapain-3	0.0043	0.0322	0.3417
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0346	0.0643
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Plasmodium vivax	unspecified product	0.0043	0.0322	0.3417
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0136	0.1923	0.1922
Echinococcus granulosus	cathepsin L cysteine protease	0.0043	0.0322	0.0476
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.0942	0.1612
Brugia malayi	Cathepsin L-like precursor	0.0079	0.0942	0.3004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.0942	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0942	0.3004
Echinococcus multilocularis	cysteine protease	0.0079	0.0942	0.1612
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0055	0.0519	0.1656
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0519	0.3182
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0001	0.0001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0346	0.0488
Leishmania major	cathepsin L-like protease	0.0079	0.0942	0.0941
Loa Loa (eye worm)	hypothetical protein	0.018	0.2675	0.8527
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0111	0.15	0.15
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.0942	0.1876
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0088	0.0035
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0088	0.0163
Plasmodium vivax	vivapain-2	0.0079	0.0942	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 24 nM	Inhibition of human Cat F expressed in rabbit HIG82 cells	ChEMBL.	21041084
IC50 (binding)	= 33 nM	Inhibition of Trypanosoma cruzi Cruzipain	ChEMBL.	21041084
IC50 (binding)	= 59 nM	Inhibition of human Cat B in HepG2 cells	ChEMBL.	21041084
IC50 (binding)	= 379 nM	Inhibition of human Cat L	ChEMBL.	21041084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1289764

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1259150