Detailed information for compound 1262252

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 621.588 | Formula: C31H29F2N5O7
  • H donors: 2 H acceptors: 6 LogP: 2.41 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1n1nnc(c1)COc1ccc(cc1OC)/C=C/C(=O)/C=C/c1ccc(cc1F)F)n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C31H29F2N5O7/c1-18-14-37(31(42)34-30(18)41)29-13-25(28(16-39)45-29)38-15-22(35-36-38)17-44-26-10-4-19(11-27(26)43-2)3-8-23(40)9-6-20-5-7-21(32)12-24(20)33/h3-12,14-15,25,28-29,39H,13,16-17H2,1-2H3,(H,34,41,42)/b8-3+,9-6+/t25-,28+,29+/m0/s1
  • InChiKey: VWYWUMNQDIUWMA-JIOQABLESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0012 0.0012
Plasmodium falciparum glutathione reductase 0.0055 0.048 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0398 0.0583
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.1239 0.8837
Plasmodium vivax SET domain protein, putative 0.0036 0.0283 0.5488
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0012
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.048 0.0469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0431 0.0431
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1021 0.1011
Plasmodium vivax glutathione reductase, putative 0.0055 0.048 1
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0369 0.0358
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0355 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0283 0.0283
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0121 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.393 0.6469
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0069 0.0638 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0283 0.0467
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0346 0.0555
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.1239 0.8837
Echinococcus multilocularis dnaJ subfamily B 0.093 1 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0039 0.0028
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0233 0.0222
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0069 0.0638 0.0638
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0567 0.6049 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1623 0.1614
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1305 0.2142
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.6049 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.048 0.0777
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0092 0.1122
Brugia malayi CXXC zinc finger family protein 0.0065 0.0597 0.0987
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0092 0.1122
Schistosoma mansoni autophagin-1 (C54 family) 0.0069 0.0638 0.0638
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.1239 0.8837
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0077 0.0066
Brugia malayi Peptidase family C54 containing protein 0.0069 0.0638 0.1055
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0012
Plasmodium falciparum glutathione reductase 0.0019 0.0092 0.1122
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0027 0.018 0.1396
Loa Loa (eye worm) hypothetical protein 0.0165 0.1677 0.2758
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0069 0.0638 0.0984
Onchocerca volvulus Glucosylceramidase homolog 0.0372 0.393 0.7077
Schistosoma mansoni elf1 0.0011 0.0012 0.0012
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0346 0.0335
Echinococcus granulosus geminin 0.0384 0.4059 0.4052
Echinococcus granulosus cpg binding protein 0.0069 0.0637 0.0627
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.139 1
Schistosoma mansoni cpg binding protein 0.0069 0.0637 0.0637
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0092 0.0716
Loa Loa (eye worm) glutathione reductase 0.0055 0.048 0.0775
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1623 0.2684
Brugia malayi glutathione reductase 0.0055 0.048 0.0793
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.393 0.6469
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.393 0.6469
Plasmodium falciparum thioredoxin reductase 0.0055 0.048 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.1239 0.8837
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0398 0.3085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0431 0.0713
Mycobacterium tuberculosis Probable reductase 0.0124 0.1239 0.8837
Schistosoma mansoni ets-related 0.0011 0.0012 0.0012
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0346 0.0346
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0092 0.1445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0431 0.042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0038 0.0062
Brugia malayi Thioredoxin reductase 0.0055 0.048 0.0793
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0449
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0069 0.0638 0.0984
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.393 0.6469
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.6049 1
Onchocerca volvulus Phospholipase A2 homolog 0.0108 0.1059 0.1582
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.019 0.019
Echinococcus multilocularis muscleblind protein 1 0.0165 0.1677 0.1667
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0092 0.5
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0121 0.018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.048 0.2985
Onchocerca volvulus Phospholipase A2 homolog 0.0512 0.5456 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0821 0.1341
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.1239 0.8837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0283 0.0283
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.1575 0.1565
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.048 0.0469
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0027 0.018 0.1605
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0027 0.018 0.2818
Loa Loa (eye worm) hypothetical protein 0.0512 0.5456 0.9019
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0431 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.6049 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0027 0.018 0.1605
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0431 0.042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0283 0.0271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0233 0.0367
Schistosoma mansoni cpg binding protein 0.0069 0.0637 0.0637
Onchocerca volvulus 0.0065 0.0597 0.0697
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0747 0.1218
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.048 0.0775
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0069 0.0638 1
Schistosoma mansoni cpg binding protein 0.0065 0.0597 0.0597
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0398 0.0386
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0231 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0283 0.0283
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0788 0.0788
Schistosoma mansoni hypothetical protein 0.0032 0.0233 0.0233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0431 0.042
Schistosoma mansoni hypothetical protein 0.0384 0.4059 0.4059
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.393 0.6469
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0012 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0398 0.3085
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.139 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0821 0.1341
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0092 0.0716
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0069 0.0638 0.0984
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0092 0.0074
Schistosoma mansoni ets 0.0011 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.4147 0.6832
Treponema pallidum NADH oxidase 0.0019 0.0092 0.5
Brugia malayi MH2 domain containing protein 0.013 0.1305 0.2157
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1623 0.1623
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0398 0.0583
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0077 0.0066
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0092 0.1445
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0038 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0129 0.1289 1
Plasmodium falciparum phd finger protein, putative 0.0032 0.0233 0.435
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0253 0.0242
Brugia malayi Fli-1 protein 0.024 0.2498 0.413
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.6049 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0233 0.0233
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0398 0.8119
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.048 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0233 0.1809
Schistosoma mansoni gabp alpha 0.0079 0.0747 0.0747
Leishmania major trypanothione reductase 0.0055 0.048 0.7093
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0069 0.0638 0.0638
Brugia malayi PHD-finger family protein 0.0032 0.0233 0.0385
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0597 0.097
Echinococcus multilocularis peregrin 0.0036 0.0276 0.0264
Brugia malayi transcription factor E74 isoform 0.0011 0.0012 0.0019
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0747 0.0736
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.2554 0.4212
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0233 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.393 0.6469
Entamoeba histolytica peptidase, C54 family 0.0069 0.0638 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0092 0.1122
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.1407 0.1407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0283 0.0283
Trichomonas vaginalis glucosylceramidase, putative 0.0392 0.4147 0.6832
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0346 0.0346
Giardia lamblia PHD finger protein 15 0.0032 0.0233 0.5361
Brugia malayi jmjC domain containing protein 0.0042 0.0346 0.0573
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.6049 1
Schistosoma mansoni eyes absent homolog 0.0086 0.0821 0.0821
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0077 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0431 0.0695
Brugia malayi hypothetical protein 0.0086 0.0821 0.1357
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0092 0.5
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0077 0.0066
Brugia malayi Ets-domain containing protein 0.0079 0.0747 0.1235
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0121 0.0109
Brugia malayi jmjC domain containing protein 0.0104 0.1021 0.1688
Loa Loa (eye worm) hypothetical protein 0.0108 0.1059 0.1736
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0039 0.0028
Echinococcus multilocularis geminin 0.0384 0.4059 0.4052
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0747 0.0736
Echinococcus multilocularis Peptidase C54 0.0069 0.0638 0.0627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0431 0.0431
Brugia malayi Pre-SET motif family protein 0.0245 0.2554 0.4223
Brugia malayi Ets-domain containing protein 0.0079 0.0747 0.1235
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0069 0.0638 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.139 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0602 0.0978
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.048 0.7093
Loa Loa (eye worm) hypothetical protein 0.0165 0.1677 0.2758
Echinococcus multilocularis cysteine protease atg4b 0.0069 0.0638 0.0627
Plasmodium falciparum thioredoxin reductase 0.0019 0.0092 0.1122
Echinococcus granulosus muscleblind protein 0.0165 0.1677 0.1667
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0092 0.0074
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0355 0.7144
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0048
Echinococcus multilocularis muscleblind protein 0.0165 0.1677 0.1667
Loa Loa (eye worm) hypothetical protein 0.0068 0.0622 0.1011
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0283 0.0271
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0092 0.5
Brugia malayi Muscleblind-like protein 0.0165 0.1677 0.2772
Schistosoma mansoni hypothetical protein 0.093 1 1
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0027 0.018 0.1605
Brugia malayi Ets-domain containing protein 0.0011 0.0012 0.0019
Brugia malayi Bromodomain containing protein 0.0036 0.0276 0.0456
Onchocerca volvulus 0.0279 0.2921 0.5146
Brugia malayi PHD-finger family protein 0.0014 0.004 0.0067
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0069 0.0638 0.0984
Loa Loa (eye worm) fli-1 protein 0.024 0.2498 0.4119
Loa Loa (eye worm) hypothetical protein 0.0069 0.0638 0.1038
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0355 0.3819
Schistosoma mansoni hypothetical protein 0.0384 0.4059 0.4059
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0567 0.6049 1
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.6049 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0233 0.435
Echinococcus granulosus peregrin 0.0036 0.0276 0.0264
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1305 0.2142
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0306 0.0295
Toxoplasma gondii thioredoxin reductase 0.0055 0.048 0.3722
Loa Loa (eye worm) acetyltransferase 0.016 0.1623 0.267
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0233 0.1809
Echinococcus multilocularis cpg binding protein 0.0069 0.0637 0.0627
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0092 0.1445
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0233 0.0367
Trypanosoma brucei trypanothione reductase 0.0055 0.048 0.7513
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.139 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0092 0.5
Brugia malayi Phospholipase A2 family protein 0.0108 0.1059 0.1751
Trichomonas vaginalis set domain proteins, putative 0.0279 0.2921 0.4788
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.393 0.6469
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0092 0.5
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0092 0.1445
Echinococcus granulosus cysteine protease atg4b 0.0069 0.0638 0.0627
Plasmodium falciparum cysteine protease ATG4, putative 0.0027 0.018 0.3131
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1021 0.1011
Echinococcus granulosus Peptidase C54 0.0069 0.0638 0.0627
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0283 0.2194
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0069 0.0638 0.0984
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0431 0.0431
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0369 0.0358
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0092 0.5
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0092 0.1122
Schistosoma mansoni ets-related 0.024 0.2498 0.2498
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0283 0.0271
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0092 0.0152
Onchocerca volvulus 0.0036 0.0283 0.0095

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.4 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs ChEMBL. 21044845
IC50 (functional) = 1.7 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 48 hrs ChEMBL. 21044845
IC50 (functional) = 12.4 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by FACS analysis in presence of 10 % human serum ChEMBL. 21044845

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21044845

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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