Detailed information for compound 1265250

Basic information

Technical information
  • TDR Targets ID: 1265250
  • Name: 3-[(4-fluorophenyl)sulfanylmethyl]-5-(propan- 2-ylcarbamoyl)-1,2-oxazole-4-carboxylic acid
  • MW: 338.354 | Formula: C15H15FN2O4S
  • H donors: 2 H acceptors: 4 LogP: 2.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)c1onc(c1C(=O)O)CSc1ccc(cc1)F)C
  • InChi: 1S/C15H15FN2O4S/c1-8(2)17-14(19)13-12(15(20)21)11(18-22-13)7-23-10-5-3-9(16)4-6-10/h3-6,8H,7H2,1-2H3,(H,17,19)(H,20,21)
  • InChiKey: WECRAQBVMVLLQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(4-fluorophenyl)sulfanylmethyl]-5-(isopropylcarbamoyl)isoxazole-4-carboxylic acid
  • 3-[[(4-fluorophenyl)thio]methyl]-5-[(isopropylamino)-oxomethyl]-4-isoxazolecarboxylic acid
  • 3-[[(4-fluorophenyl)thio]methyl]-5-(isopropylcarbamoyl)isoxazole-4-carboxylic acid
  • MLS000560784
  • SMR000155797

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aurora kinase 0.0057 0.0821 0.8259
Brugia malayi Protein kinase domain containing protein 0.0025 0.0109 0.0109
Echinococcus granulosus epidermal growth factor receptor 0.015 0.2892 0.2889
Giardia lamblia G2/mitotic-specific cyclin B 0.0134 0.2527 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0511 0.0508
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0024 0.0086 0.0082
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.0535 0.2118
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0152
Loa Loa (eye worm) hypothetical protein 0.0134 0.2527 0.2623
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0641 0.2527
Trichomonas vaginalis STE family protein kinase 0.0075 0.1206 0.4765
Loa Loa (eye worm) hypothetical protein 0.0029 0.018 0.0184
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0022 0.0042 0.004
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0075 0.1206 0.1247
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0049 0.0641 0.2527
Echinococcus multilocularis geminin 0.0205 0.4098 0.4096
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0535 0.0532
Onchocerca volvulus 0.0025 0.0109 0.0344
Loa Loa (eye worm) cyclin domain-containing protein 0.0249 0.5096 0.5294
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0057 0.0821 0.3241
Brugia malayi Ets-domain containing protein 0.0087 0.1489 0.154
Echinococcus granulosus tyrosine protein kinase shark 0.0231 0.4689 0.4687
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0817 0.0814
Echinococcus multilocularis Glutaredoxin protein 5 0.0026 0.0131 0.0128
Brugia malayi Fibronectin type III domain containing protein 0.0029 0.018 0.0183
Schistosoma mansoni cyclins 0.0086 0.1456 0.1453
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0641 0.2527
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0535 0.0532
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0273 0.5613 0.5832
Schistosoma mansoni hypothetical protein 0.0205 0.4098 0.4096
Echinococcus granulosus protein kinase shaggy 0.0049 0.0641 0.0638
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1645 0.5367
Entamoeba histolytica protein kinase, putative 0.0057 0.0821 0.3241
Loa Loa (eye worm) TK/ALK protein kinase 0.0245 0.4993 0.5187
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0131 0.0128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0511 0.0526
Brugia malayi serine/threonine kinase 12 0.0057 0.0821 0.0848
Brugia malayi Ets-domain containing protein 0.0087 0.1489 0.154
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0057 0.0817 0.0814
Echinococcus granulosus insulin receptor 0.0188 0.3731 0.3729
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0704 0.2775
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0505 0.1986
Brugia malayi protein kinase C II. 0.0033 0.0268 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0313 0.1225
Onchocerca volvulus 0.0025 0.0109 0.0344
Brugia malayi Protein kinase domain containing protein 0.0025 0.0109 0.0109
Schistosoma mansoni tyrosine kinase 0.0029 0.0188 0.0184
Brugia malayi Cyclin, N-terminal domain containing protein 0.0134 0.2527 0.2617
Schistosoma mansoni tyrosine kinase 0.0223 0.45 0.4498
Trichomonas vaginalis cyclins, putative 0.0134 0.2527 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.0535 0.2107
Onchocerca volvulus Tyrosine kinase homolog 0.0158 0.3063 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0115 0.0442
Trypanosoma cruzi rac serine-threonine kinase, putative 0.003 0.0204 0.0795
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0025 0.0109 0.0105
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0821 0.3241
Brugia malayi Stress-activated protein kinase jnk-1 0.0226 0.4576 0.4742
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1489 0.1486
Schistosoma mansoni tyrosine kinase 0.0217 0.438 0.4378
Loa Loa (eye worm) plexin A 0.0032 0.0262 0.0269
Echinococcus granulosus serine threonine protein kinase nrc 0.003 0.0204 0.0201
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0704 0.07
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0817 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1456 0.5755
Trichomonas vaginalis STE family protein kinase 0.0075 0.1206 0.4765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.1027
Trypanosoma cruzi Protein kinase B 0.003 0.0204 0.0795
Onchocerca volvulus 0.0134 0.2527 0.8248
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.0188 0.0184
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0057 0.0821 0.3241
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0535 0.2107
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0033 0.0268 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1645 0.1643
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0511 0.2011
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0194 0.3856 0.3853
Trichomonas vaginalis cyclin B, putative 0.0086 0.1456 0.5755
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.0535 0.2107
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0617 0.2429
Onchocerca volvulus 0.0025 0.0109 0.0344
Brugia malayi SRC-1 0.0057 0.0817 0.0843
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0078
Schistosoma mansoni protein kinase 0.0057 0.0821 0.0818
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0084 0.0084
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0024 0.0077 0.0073
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0511 0.2011
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0704 0.07
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0024 0.0084 0.0081
Echinococcus multilocularis plexin a4 0.0032 0.0262 0.0259
Loa Loa (eye worm) raf kinase 0.0453 0.9622 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0313 0.124
Echinococcus multilocularis Immunoglobulin 0.0024 0.0077 0.0073
Echinococcus granulosus roundabout 2 0.0043 0.0494 0.0491
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.003 0.0204 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1645 0.6507
Echinococcus granulosus serine/threonine protein kinase 0.003 0.0204 0.0201
Schistosoma mansoni atypical protein kinase C 0.0033 0.0268 0.0265
Echinococcus multilocularis tyrosine protein kinase shark 0.0231 0.4689 0.4687
Schistosoma mansoni tyrosine kinase 0.0188 0.3731 0.3729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0313 0.1225
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.003 0.0204 0.0201
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0535 0.2107
Echinococcus granulosus neuroglian 0.0032 0.0243 0.024
Echinococcus granulosus cyclins 0.0086 0.1456 0.1453
Brugia malayi intracellular kinase 0.0049 0.0641 0.0661
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.036 0.0357
Brugia malayi hypothetical protein 0.0027 0.0149 0.0151
Echinococcus granulosus plexin a4 0.0032 0.0262 0.0259
Echinococcus granulosus cyclins 0.0086 0.1456 0.1453
Trypanosoma cruzi cyclin, putative 0.0134 0.2527 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0204 0.0795
Schistosoma mansoni tyrosine kinase 0.0057 0.0817 0.0814
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0535 0.2107
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1645 0.6507
Brugia malayi SH2 domain containing protein 0.0025 0.0109 0.0109
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0817 0.0814
Brugia malayi Tyrosine-protein kinase abl-1 0.0029 0.0188 0.0191
Loa Loa (eye worm) hypothetical protein 0.0029 0.018 0.0184
Brugia malayi SH2 domain containing protein 0.0025 0.0109 0.0109
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0263 0.2616
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0057 0.0817 0.0814
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0505 0.1986
Echinococcus granulosus protein tyrosine kinase 0.0261 0.5348 0.5347
Echinococcus granulosus cyclin B 0.0134 0.2527 0.2524
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1645 0.1703
Schistosoma mansoni tyrosine kinase 0.0029 0.0188 0.0184
Onchocerca volvulus 0.0025 0.0109 0.0344
Entamoeba histolytica cyclin family protein 0.0086 0.1456 0.5755
Giardia lamblia Aurora kinase 0.0057 0.0821 0.3241
Brugia malayi Cyclin, N-terminal domain containing protein 0.0134 0.2527 0.2617
Loa Loa (eye worm) hypothetical protein 0.0029 0.018 0.0184
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0181 0.3579 0.3717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0064 0.0241
Echinococcus multilocularis neuroglian 0.0032 0.0243 0.024
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.0535 0.2107
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0821 0.3241
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0057 0.0817 0.0814
Trypanosoma cruzi cyclin, putative 0.0134 0.2527 1
Trichomonas vaginalis cyclins, putative 0.0134 0.2527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.1027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0121 0.0465
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0076
Entamoeba histolytica cyclin, putative 0.0086 0.1456 0.5755
Echinococcus granulosus cyclin B3 1 0.0086 0.1456 0.1453
Echinococcus multilocularis tyrosine protein kinase HCK 0.0045 0.0548 0.0545
Giardia lamblia Kinase, AGC PKA 0.003 0.0204 0.0795
Loa Loa (eye worm) hypothetical protein 0.0048 0.0613 0.0633
Brugia malayi plexin A 0.0032 0.0262 0.0268
Schistosoma mansoni plexin 0.0025 0.0109 0.0105
Loa Loa (eye worm) hypothetical protein 0.0075 0.1206 0.125
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0025 0.0109 0.0105
Schistosoma mansoni nephrin 0.0036 0.0347 0.0343
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0043 0.0505 0.0521
Echinococcus granulosus tyrosine protein kinase ABL1 0.0025 0.0109 0.0105
Trichomonas vaginalis cyclins, putative 0.0069 0.1075 0.4245
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0024 0.0077 0.0073
Loa Loa (eye worm) TK/INSR protein kinase 0.0188 0.3731 0.3875
Trichomonas vaginalis cyclins, putative 0.0134 0.2527 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.0109 0.0109
Echinococcus multilocularis aurora kinase A 0.0057 0.0821 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.1027
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1645 0.1643
Loa Loa (eye worm) hypothetical protein 0.0201 0.4007 0.4163
Entamoeba histolytica protein kinase , putative 0.0057 0.0821 0.3241
Echinococcus granulosus defective proboscis extension response 0.0024 0.0077 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0076
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0535 0.0532
Brugia malayi Plexin repeat family protein 0.0025 0.0109 0.0109
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0226 0.4576 0.4575
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0057 0.0821 0.3241
Brugia malayi Protein kinase domain containing protein 0.0045 0.0535 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0064 0.0241
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0704 0.2775
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1645 0.6507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0369 0.1449
Brugia malayi MAP kinase sur-1 0.0052 0.0704 0.0726
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0704 0.2775
Trichomonas vaginalis cyclins, putative 0.0134 0.2527 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0029 0.0188 0.0184
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1489 0.1544
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0535 0.0553
Schistosoma mansoni cell adhesion molecule 0.0035 0.0327 0.0324
Echinococcus granulosus aurora kinase A 0.0057 0.0821 0.0818
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0821 0.0818
Plasmodium vivax glycogen synthase kinase 3, putative 0.0049 0.0641 0.7795
Schistosoma mansoni tyrosine kinase 0.0134 0.2514 0.2511
Schistosoma mansoni hypothetical protein 0.0205 0.4098 0.4096
Schistosoma mansoni tyrosine kinase 0.0188 0.3731 0.3729
Loa Loa (eye worm) AUR protein kinase 0.0057 0.0821 0.085
Trichomonas vaginalis cyclin B, putative 0.0134 0.2527 1
Plasmodium falciparum cyclin 0.0086 0.1456 1
Plasmodium vivax protein kinase Crk2 0.0045 0.0535 0.6501
Loa Loa (eye worm) TK protein kinase 0.0248 0.5063 0.526
Trypanosoma cruzi aurora B kinase, putative 0.0057 0.0821 0.3241
Loa Loa (eye worm) TK protein kinase 0.0054 0.0738 0.0763
Trypanosoma brucei aurora B kinase 0.0057 0.0821 0.3251
Brugia malayi hypothetical protein 0.0029 0.018 0.0183
Trypanosoma cruzi cyclin 6, putative 0.0134 0.2527 1
Schistosoma mansoni cyclin B 0.0134 0.2527 0.2524
Schistosoma mansoni protein kinase 0.0075 0.1206 0.1203
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0817 0.0814
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0112 0.2046 0.2043
Entamoeba histolytica protein kinase, putative 0.0043 0.0505 0.1986
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0511 0.0508
Brugia malayi Immunoglobulin I-set domain containing protein 0.0181 0.3579 0.3708
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1645 0.6507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0121 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0121 0.0465
Echinococcus granulosus tyrosine kinase 0.0054 0.0738 0.0734
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0704 0.2775
Echinococcus multilocularis Immunoglobulin 0.0024 0.0077 0.0073
Schistosoma mansoni tyrosine kinase 0.0231 0.4689 0.4687
Schistosoma mansoni tyrosine kinase 0.015 0.2892 0.2889
Echinococcus multilocularis cyclins 0.0086 0.1456 0.1453
Echinococcus multilocularis N chimaerin 0.0024 0.0084 0.0081
Echinococcus granulosus tyrosine protein kinase Src64B 0.0057 0.0817 0.0814
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0024 0.0084 0.0081
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0535 0.2107
Echinococcus granulosus cyclin b3 0.0086 0.1456 0.1453
Echinococcus granulosus fibroblast growth factor receptor 4 0.0112 0.2046 0.2043
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0535 0.0532
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.2892 0.2889
Brugia malayi Protein kinase domain containing protein 0.0264 0.5413 0.5609
Entamoeba histolytica protein kinase domain containing protein 0.0024 0.0073 0.0274
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0042 0.004
Echinococcus granulosus protein kinase c epsilon type 0.0033 0.0268 0.0265
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0704 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0244
Echinococcus granulosus dual specificity mitogen activated protein 0.0075 0.1206 0.1203
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0024 0.0077 0.0073
Echinococcus multilocularis tyrosine protein kinase 0.0248 0.5063 0.5061
Echinococcus multilocularis protein kinase c epsilon type 0.0033 0.0268 0.0265
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.015 0.2892 0.2889
Giardia lamblia Cyclin A 0.0086 0.1456 0.5755
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0057 0.0817 0.0814
Loa Loa (eye worm) TK/EGFR protein kinase 0.0217 0.438 0.455
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0535 0.0532
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0152
Loa Loa (eye worm) TK/FAK protein kinase 0.0264 0.5413 0.5624
Echinococcus granulosus Immunoglobulin 0.0024 0.0077 0.0073
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0204 0.0201
Trypanosoma cruzi CYC2-like cyclin, putative 0.0134 0.2527 1
Loa Loa (eye worm) TK protein kinase 0.012 0.2212 0.2296
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0641 0.0663
Toxoplasma gondii hypothetical protein 0.0065 0.0994 1
Schistosoma mansoni tyrosine kinase 0.015 0.2892 0.2889
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0193 0.3835 0.3832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0171 0.0663
Schistosoma mansoni tyrosine kinase 0.0057 0.0817 0.0814
Echinococcus granulosus tyrosine kinase 0.0025 0.0109 0.0105
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1645 0.6507
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0024 0.0084 0.0084
Echinococcus multilocularis insulin receptor 0.0188 0.3731 0.3729
Echinococcus multilocularis protein tyrosine kinase 0.0261 0.5348 0.5347
Leishmania major cyclin 0.0134 0.2527 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0057 0.0817 0.0814
Loa Loa (eye worm) hypothetical protein 0.0134 0.2527 0.2623
Echinococcus multilocularis cyclin B 0.0134 0.2527 0.2524
Echinococcus granulosus tyrosine protein kinase Blk 0.0054 0.0738 0.0734
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0511 0.0508
Brugia malayi cell division control protein 2 homolog 0.0045 0.0535 0.0551
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0704 0.2775
Echinococcus granulosus Glutaredoxin protein 5 0.0026 0.0131 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.1027
Brugia malayi Protein kinase domain containing protein 0.0086 0.1459 0.151
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0024 0.0084 0.0081
Trypanosoma brucei mitotic cyclin 6 0.0134 0.2527 1
Plasmodium falciparum glycogen synthase kinase 3 0.0049 0.0641 0.439
Onchocerca volvulus 0.0134 0.2519 0.8221
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0511 0.2022
Trypanosoma brucei mitotic cyclin 0.0021 0.0003 0.0014
Brugia malayi Protein kinase domain containing protein 0.0025 0.0109 0.0109
Schistosoma mansoni vesicular amine transporter 0.0024 0.0077 0.0073
Brugia malayi Cyclin, N-terminal domain containing protein 0.0194 0.3856 0.3995
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0057 0.0817 0.0814
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Entamoeba histolytica cyclin family protein 0.0086 0.1456 0.5755
Schistosoma mansoni gabp alpha 0.0087 0.1489 0.1486
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1645 0.1707
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0535 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0115 0.0442
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.0402
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0075 0.1206 0.125
Loa Loa (eye worm) hypothetical protein 0.0041 0.0462 0.0477
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0131 0.0128
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0054 0.0738 0.0734
Echinococcus multilocularis cyclins 0.0086 0.1456 0.1453
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0817 0.0814
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0535 0.2107
Onchocerca volvulus 0.0027 0.0149 0.0476
Brugia malayi Raf kinase 0.0454 0.9647 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0029 0.0188 0.0184
Echinococcus granulosus c-Jun N-terminal kinases 0.0226 0.4576 0.4575
Schistosoma mansoni cyclin B3 0.0194 0.3856 0.3853
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0112 0.2046 0.2043
Entamoeba histolytica protein kinase, putative 0.0045 0.0548 0.2159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.1027
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1645 0.6507
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0535 0.0532
Brugia malayi Protein kinase domain containing protein 0.0248 0.5063 0.5246
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0075 0.1206 0.4765
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0821 0.3241
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0057 0.0821 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0511 0.2011
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0049 0.0641 0.0663
Trypanosoma brucei cyclin 3 0.0021 0.0003 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0057 0.0817 0.0814
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0704 0.2785
Echinococcus multilocularis roundabout 2 0.0043 0.0494 0.0491
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0313 0.1228
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0535 0.2107
Brugia malayi Protein kinase domain containing protein 0.0025 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0109
Giardia lamblia GTOR 0.0044 0.0511 0.2011
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0704 0.2775
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0505 0.1986
Loa Loa (eye worm) TK protein kinase 0.0045 0.0548 0.0566
Loa Loa (eye worm) hypothetical protein 0.0031 0.0224 0.0229
Echinococcus granulosus nervana 2 0.0026 0.0131 0.0128
Schistosoma mansoni tyrosine kinase 0.0112 0.2046 0.2043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0313 0.1225
Loa Loa (eye worm) TK/ABL protein kinase 0.0025 0.0109 0.0109
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0025 0.0109 0.0417
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0029 0.0188 0.0184
Echinococcus multilocularis nervana 2 0.0026 0.0131 0.0128
Plasmodium falciparum protein kinase 5 0.0045 0.0535 0.3662
Toxoplasma gondii AGC kinase 0.0043 0.0505 0.5061
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1645 0.6507
Entamoeba histolytica protein kinase, putative 0.0049 0.0641 0.2527
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0617 0.2429
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0193 0.3835 0.3832
Trypanosoma cruzi rac serine-threonine kinase, putative 0.003 0.0204 0.0795
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0535 0.2107
Onchocerca volvulus 0.0025 0.0109 0.0344
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0049 0.0641 0.6438
Echinococcus multilocularis protein kinase shaggy 0.0049 0.0641 0.0638
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0535 0.0532
Entamoeba histolytica protein kinase 2, putative 0.003 0.0204 0.0795
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0057 0.0817 0.0814
Echinococcus granulosus twitchin 0.0035 0.0316 0.0313
Echinococcus multilocularis nervana 2 0.0026 0.0131 0.0128
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0704 0.2775
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0086 0.0086
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0024 0.0084 0.0081
Echinococcus multilocularis epidermal growth factor receptor 0.0217 0.438 0.4378
Schistosoma mansoni hypothetical protein 0.0027 0.0149 0.0146
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0022 0.0032 0.0029
Brugia malayi Protein kinase domain containing protein 0.0043 0.0505 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0192 0.0746
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.018 0.0183
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0075 0.1206 0.4772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0511 0.2011
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0505 0.1986
Schistosoma mansoni hypothetical protein 0.0027 0.0149 0.0146
Schistosoma mansoni tyrosine kinase 0.0261 0.5348 0.5347
Entamoeba histolytica cyclin, putative 0.0134 0.2527 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0704 0.2775
Onchocerca volvulus 0.0049 0.0641 0.2084
Trichomonas vaginalis cyclin D, putative 0.0086 0.1456 0.5755
Loa Loa (eye worm) cyclin domain-containing protein 0.0194 0.3856 0.4005
Trypanosoma brucei polo-like protein kinase 0.0094 0.1645 0.6512
Entamoeba histolytica protein kinase, putative 0.0043 0.0505 0.1986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0511 0.2011
Loa Loa (eye worm) hypothetical protein 0.0231 0.4685 0.4867
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0821 0.3241
Onchocerca volvulus 0.0032 0.0253 0.0814
Giardia lamblia Hypothetical protein 0.0086 0.1456 0.5755
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0268 0.0265
Schistosoma mansoni ephrin receptor 0.0022 0.0023 0.0019
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.003 0.0204 0.2452
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0313 0.1228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0313 0.1225
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0505 0.1986
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0134 0.2527 1
Trichomonas vaginalis cyclin B3, putative 0.0086 0.1456 0.5755
Echinococcus granulosus tyrosine protein kinase Lyn 0.0061 0.089 0.0887
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0511 0.0528
Trichomonas vaginalis STE family protein kinase 0.0075 0.1206 0.4765
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0021 0.0003 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Echinococcus granulosus protein kinase c iota type 0.0033 0.0268 0.0265
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0204 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0064 0.0241
Echinococcus granulosus tyrosine protein kinase Src42A 0.0057 0.0817 0.0814
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.0188 0.0184
Plasmodium falciparum serine/threonine protein kinase, putative 0.0057 0.0821 0.5632
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0049 0.0641 0.2527
Schistosoma mansoni tyrosine kinase 0.0025 0.0109 0.0105
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.0535 0.2118
Echinococcus granulosus tyrosine protein kinase Srms 0.0025 0.0109 0.0105
Echinococcus granulosus cyclins 0.0086 0.1456 0.1453
Echinococcus multilocularis cyclins 0.0086 0.1456 0.1453
Echinococcus multilocularis tyrosine protein kinase Srms 0.0054 0.0738 0.0734
Brugia malayi hypothetical protein 0.0025 0.0109 0.0109
Echinococcus granulosus cyclins 0.0086 0.1456 0.1453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0244
Echinococcus multilocularis cyclin B3 1 0.0086 0.1456 0.1453
Echinococcus granulosus tyrosine protein kinase 0.0248 0.5063 0.5061
Loa Loa (eye worm) SRC-1 0.0057 0.0817 0.0846
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0226 0.4576 0.4754
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Trypanosoma brucei rac serine-threonine kinase, putative 0.0043 0.0505 0.1997
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0704 0.0728
Echinococcus multilocularis 0.0061 0.0906 0.0903
Echinococcus granulosus c src tyrosine kinase 0.0029 0.0188 0.0184
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0821 0.3241
Echinococcus multilocularis raf serine:threonine protein kinase 0.047 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0024 0.0086 0.0082
Loa Loa (eye worm) AGC/AKT protein kinase 0.0043 0.0505 0.0521
Schistosoma mansoni serine/threonine protein kinase 0.047 1 1
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0535 0.0532
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0505 0.1986
Echinococcus multilocularis cyclin b3 0.0086 0.1456 0.1453
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0641 0.2527
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0025 0.0109 0.0105
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0224 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0704 0.07
Echinococcus multilocularis cyclins 0.0086 0.1456 0.1453
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0738 0.0734
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0057 0.0821 0.0818
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0049 0.0641 0.0638
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.2212 0.2291
Giardia lamblia Kinase, STE STE20 0.0075 0.1206 0.4765
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Brugia malayi Cyclin, N-terminal domain containing protein 0.0249 0.5096 0.5281
Brugia malayi Furin-like cysteine rich region family protein 0.0217 0.438 0.4539
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1645 0.6507
Echinococcus granulosus MAM 0.0027 0.0149 0.0146
Echinococcus granulosus N chimaerin 0.0024 0.0084 0.0081
Schistosoma mansoni kinase 0.0049 0.0643 0.064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0313 0.1225
Echinococcus multilocularis rac serine:threonine kinase 0.003 0.0204 0.0201
Brugia malayi serine/threonine protein kinase 6 0.0057 0.0821 0.0848
Echinococcus multilocularis cyclins 0.0086 0.1456 0.1453
Trichomonas vaginalis cyclins, putative 0.0086 0.1456 0.5755
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0057 0.0821 0.0818
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.0402
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0049 0.0641 0.0638
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0641 0.2527
Brugia malayi p70 ribosomal S6 kinase beta 0.0043 0.0505 0.052
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0535 0.2107
Trichomonas vaginalis cyclin B, putative 0.0134 0.2527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0065 0.0244
Onchocerca volvulus 0.0025 0.0109 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.1027
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1489 0.1486
Schistosoma mansoni tyrosine kinase 0.0134 0.2514 0.2511
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1645 0.6507
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0112 0.2046 0.2043
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0194 0.3856 0.3853
Trichomonas vaginalis cyclin A, putative 0.0134 0.2527 1
Echinococcus granulosus geminin 0.0205 0.4098 0.4096
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0049 0.0641 0.0638
Loa Loa (eye worm) AUR protein kinase 0.0057 0.0821 0.085
Giardia lamblia Kinase, CMGC GSK 0.0049 0.0641 0.2527
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0268 0.0265
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0704 0.2775
Entamoeba histolytica tyrosin kinase, putative 0.0024 0.0073 0.0274
Trichomonas vaginalis cyclin B, putative 0.0134 0.2527 1
Schistosoma mansoni tyrosine kinase 0.0031 0.0233 0.023
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0704 0.707
Echinococcus granulosus nervana 2 0.0026 0.0131 0.0128
Echinococcus multilocularis protein kinase c iota type 0.0033 0.0268 0.0265
Brugia malayi Protein kinase domain containing protein 0.0188 0.3731 0.3866
Trichomonas vaginalis cyclin D, putative 0.0086 0.1456 0.5755
Schistosoma mansoni serine/threonine protein kinase 0.0226 0.4576 0.4575
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.003 0.0204 0.1381
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0511 0.2022
Echinococcus multilocularis MAM 0.0027 0.0149 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0535 0.2107
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.036 0.0357
Brugia malayi Fli-1 protein 0.0265 0.5453 0.5651
Trichomonas vaginalis cyclin B, putative 0.0134 0.2527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0263 0.1027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0511 0.2011
Giardia lamblia Kinase, PLK 0.0094 0.1645 0.6507
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.0535 0.537
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0511 0.2011
Echinococcus granulosus cyclins 0.0086 0.1456 0.1453
Echinococcus granulosus Protein kinase C brain isozyme 0.0033 0.0268 0.0265
Schistosoma mansoni tyrosine kinase 0.0134 0.2514 0.2511
Echinococcus multilocularis cyclins 0.0086 0.1456 0.1453
Loa Loa (eye worm) fli-1 protein 0.0265 0.5453 0.5666
Echinococcus multilocularis tyrosine protein kinase Blk 0.0054 0.0738 0.0734
Schistosoma mansoni ets-related 0.0265 0.5453 0.5452
Trypanosoma brucei cyclin 9 0.0021 0.0003 0.0014
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0204 0.0201
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0075 0.1206 0.4765
Echinococcus granulosus tyrosine protein kinase HCK 0.0045 0.0548 0.0545
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0511 0.2011
Entamoeba histolytica protein kinase, putative 0.0043 0.0505 0.1986
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0704 0.2775
Brugia malayi serine/threonine-protein kinase 6 0.0057 0.0821 0.0848
Brugia malayi protein-tyrosine kinase 0.0054 0.0738 0.0761
Loa Loa (eye worm) hypothetical protein 0.0069 0.1081 0.1121
Loa Loa (eye worm) AUR protein kinase 0.0057 0.0821 0.085
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0511 0.2011
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0109 0.0109
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1645 0.6507
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0535 0.0553
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0704 0.07
Echinococcus multilocularis cyclins 0.0086 0.1456 0.1453
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0109
Echinococcus granulosus epidermal growth factor receptor 0.0217 0.438 0.4378
Brugia malayi RhoGAP domain containing protein 0.0024 0.0084 0.0084
Trypanosoma brucei protein kinase, putative 0.0049 0.0641 0.2537
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0704 0.2775
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0505 0.1986
Onchocerca volvulus 0.0025 0.0109 0.0344
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0817 0.0814
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0641 0.2527
Echinococcus multilocularis dual specificity mitogen activated protein 0.0075 0.1206 0.1203
Brugia malayi Protein kinase domain containing protein 0.0245 0.4994 0.5176
Echinococcus multilocularis tyrosine kinase 0.0025 0.0109 0.0105
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0535 0.0553
Trypanosoma brucei protein kinase, putative 0.0052 0.0704 0.2785
Leishmania major protein kinase, putative 0.0057 0.0821 0.3241
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1645 0.6507
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0268 0.0265
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1645 0.1643
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0535 0.0532
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0033 0.0268 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0152
Entamoeba histolytica protein kinase, putative 0.0057 0.0821 0.3241
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.0535 0.2107
Schistosoma mansoni vav2 0.0024 0.0084 0.0081

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2311 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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