Detailed information for compound 1267419

Basic information

Technical information
  • TDR Targets ID: 1267419
  • Name: 2-[(4-ethoxyphenyl)-pyridin-3-ylsulfonylamino ]acetic acid
  • MW: 336.363 | Formula: C15H16N2O5S
  • H donors: 1 H acceptors: 5 LogP: 1.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)N(S(=O)(=O)c1cccnc1)CC(=O)O
  • InChi: 1S/C15H16N2O5S/c1-2-22-13-7-5-12(6-8-13)17(11-15(18)19)23(20,21)14-4-3-9-16-10-14/h3-10H,2,11H2,1H3,(H,18,19)
  • InChiKey: GBWHATWHNVMJFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-ethoxyphenyl)-(3-pyridylsulfonyl)amino]acetic acid
  • 2-[(4-ethoxyphenyl)-pyridin-3-ylsulfonyl-amino]ethanoic acid
  • MLS000120780
  • SMR000097622
  • 2-[(4-ethoxyphenyl)-pyridin-1-ium-3-ylsulfonylamino]acetate
  • 2-[(4-ethoxyphenyl)-pyridin-1-ium-3-ylsulfonyl-amino]acetate
  • 2-[(4-ethoxyphenyl)-(3-pyridin-1-iumylsulfonyl)amino]acetate
  • 2-[(4-ethoxyphenyl)-pyridin-1-ium-3-ylsulfonyl-amino]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0822 0.31
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 1 1
Echinococcus multilocularis dna polymerase eta 0.0046 0.0822 0.0822
Loa Loa (eye worm) hypothetical protein 0.0311 0.9804 0.9804
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.1074 0.1074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.2651 1
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Echinococcus multilocularis cysteine protease 0.0053 0.1074 0.1074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0567 0.214
Brugia malayi Cathepsin L-like precursor 0.0053 0.1074 0.1095
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.2651 0.2651
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0567 0.214
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0331 0.3083
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0286 0.8962 0.8962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0331 0.1249
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0277 0.0277
Echinococcus granulosus cysteine protease 0.0032 0.0331 0.0331
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0277 0.0277
Plasmodium falciparum importin beta, putative 0.003 0.0266 0.2474
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Plasmodium vivax vivapain-3 0.0032 0.0331 0.3083
Echinococcus multilocularis snurportin 1 0.0316 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0567 0.0579
Loa Loa (eye worm) hypothetical protein 0.0053 0.1074 0.1074
Giardia lamblia Cathepsin B precursor 0.01 0.2651 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0277 0.1044
Schistosoma mansoni hypothetical protein 0.0316 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Onchocerca volvulus 0.0053 0.1074 0.0836
Brugia malayi Cathepsin L-like precursor 0.0053 0.1074 0.1095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0266 0.1002
Brugia malayi jmjC domain containing protein 0.0098 0.2591 0.2643
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0491 0.0491
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0331 0.0369
Plasmodium vivax unspecified product 0.0032 0.0331 0.3083
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.136 0.136
Echinococcus multilocularis cathepsin L 0.0032 0.0331 0.0331
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.1074 0.1074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.1074 0.1074
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0331 0.3083
Onchocerca volvulus 0.0053 0.1074 0.0836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Loa Loa (eye worm) hypothetical protein 0.0039 0.0567 0.0567
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Echinococcus granulosus cathepsin l1 0.0039 0.0567 0.0567
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0567 0.0567
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Loa Loa (eye worm) cathepsin B 0.01 0.2651 0.2651
Plasmodium vivax vivapain-2 0.0053 0.1074 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0266 0.1002
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0331 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0053 0.1074 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0491 0.0491
Leishmania major cysteine peptidase A (CPA) 0.0053 0.1074 0.405
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Echinococcus multilocularis cysteine protease 0.0053 0.1074 0.1074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.1074 1
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0331 0.3083
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.1074 0.1074
Onchocerca volvulus Cathepsin F homolog 0.0053 0.1074 0.0836
Echinococcus granulosus cathepsin L 0.0032 0.0331 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Echinococcus multilocularis importin subunit beta 1 0.003 0.0266 0.0266
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.2591 0.2591
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0331 0.0331
Giardia lamblia Cathepsin B precursor 0.01 0.2651 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.1074 0.405
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Brugia malayi hypothetical protein 0.0091 0.2334 0.2381
Loa Loa (eye worm) fibroinase 0.0053 0.1074 0.1074
Leishmania major importin beta-1 subunit, putative 0.0024 0.0075 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0053 0.1074 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0277 0.1044
Onchocerca volvulus 0.0053 0.1074 0.0836
Echinococcus granulosus cathepsin b 0.0286 0.8962 0.8962
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.1074 0.405
Loa Loa (eye worm) hypothetical protein 0.0091 0.2334 0.2334
Brugia malayi Cathepsin L-like precursor 0.0053 0.1074 0.1095
Schistosoma mansoni eyes absent homolog 0.0091 0.2334 0.2334
Loa Loa (eye worm) cysteine protease 0.0053 0.1074 0.1074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0331 0.1249
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0357 0.1348
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0075 0.0284
Entamoeba histolytica cysteine protease, putative 0.0053 0.1074 1
Brugia malayi Cathepsin L-like precursor 0.0053 0.1074 0.1095
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.1074 0.1074
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0277 0.0277
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0822 0.0917
Plasmodium falciparum cysteine proteinase falcipain 3 0.0053 0.1074 1
Brugia malayi Bromodomain containing protein 0.003 0.0277 0.0282
Giardia lamblia PHD finger protein 15 0.003 0.0277 0.1044
Brugia malayi Importin beta-1 subunit 0.003 0.0266 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0357 0.0399
Giardia lamblia Cathepsin B precursor 0.01 0.2651 1
Echinococcus granulosus cathepsin l1 0.0053 0.1074 0.1074
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0491 0.0491
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.1074 0.1198
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0491 0.0491
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0331 0.0369
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0331 0.0338
Onchocerca volvulus 0.0311 0.9804 1
Schistosoma mansoni DNA polymerase eta 0.0046 0.0822 0.0822
Echinococcus multilocularis cathepsin b 0.0286 0.8962 0.8962
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Brugia malayi jmjC domain containing protein 0.0036 0.0491 0.0501
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0039 0.0567 0.0633
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0075 0.0084
Onchocerca volvulus Cathepsin L homolog 0.0053 0.1074 0.0836
Brugia malayi cathepsin B-like cysteine proteinase 0.0286 0.8962 0.9141
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0331 0.3083
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0331 0.0369
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Plasmodium vivax importin-beta 2, putative 0.003 0.0266 0.2474
Toxoplasma gondii cathepsin CPL 0.0053 0.1074 0.405
Onchocerca volvulus 0.0039 0.0567 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Loa Loa (eye worm) hypothetical protein 0.0091 0.2334 0.2334
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.01 0.2651 1
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.1074 0.1074
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0822 0.0838
Brugia malayi Cathepsin L-like precursor 0.0039 0.0567 0.0579
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0266 0.1002
Loa Loa (eye worm) hypothetical protein 0.0286 0.8962 0.8962
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Brugia malayi cathepsin L-like precursor 0.0039 0.0567 0.0579
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.2591 0.2591
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0331 0.3083
Plasmodium falciparum phd finger protein, putative 0.003 0.0277 0.2578
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Onchocerca volvulus Cathepsin L homolog 0.0053 0.1074 0.0836
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0331 0.0338
Brugia malayi hypothetical protein 0.0311 0.9804 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.1074 0.1074
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0075 0.0284
Brugia malayi Cathepsin L-like precursor 0.0053 0.1074 0.1095
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0675 0.0675
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0331 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.1074 0.1198
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0286 0.8962 0.8962
Echinococcus granulosus peregrin 0.003 0.0277 0.0277
Echinococcus multilocularis peregrin 0.003 0.0277 0.0277
Echinococcus granulosus dna polymerase eta 0.0046 0.0822 0.0822
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.1074 0.1074
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.1074 0.1074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0331 0.0331
Leishmania major DNA polymerase eta, putative 0.0032 0.0357 0.1348
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.1074 0.1074
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0702
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0277 0.0277
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.1074 0.1198
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0331 0.3083
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.1074 0.1198
Leishmania major DNA polymerase eta, putative 0.0046 0.0822 0.31
Echinococcus granulosus cathepsin b 0.0286 0.8962 0.8962
Loa Loa (eye worm) hypothetical protein 0.0046 0.0822 0.0822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.1074 0.1095
Loa Loa (eye worm) hypothetical protein 0.003 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.1004 0.1004
Schistosoma mansoni hypothetical protein 0.003 0.0277 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0331 0.1249
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0567 0.5284
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Onchocerca volvulus 0.0053 0.1074 0.0836
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0331 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0331 0.1249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0286 0.8962 0.8962
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.01 0.2651 0.2958
Plasmodium vivax hypothetical protein, conserved 0.003 0.0277 0.2578
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Plasmodium vivax vivapain-1 0.0032 0.0331 0.3083
Entamoeba histolytica cysteine protease, putative 0.0032 0.0331 0.3083
Brugia malayi RNA, U transporter 1 0.0084 0.2121 0.2163
Schistosoma mansoni jumonji domain containing protein 0.0078 0.1906 0.1906
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0675 0.0675
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0286 0.8962 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0567 0.0567
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Loa Loa (eye worm) ctsf protein 0.0053 0.1074 0.1074
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0331 0.0369
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0075 0.0284
Leishmania major cathepsin L-like protease 0.0053 0.1074 0.405
Onchocerca volvulus 0.0053 0.1074 0.0836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Brugia malayi PHD-finger family protein 0.003 0.0277 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0331 0.3083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.1074 0.405
Echinococcus multilocularis cathepsin b 0.0286 0.8962 0.8962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.1074 0.405
Trypanosoma brucei cysteine peptidase C (CPC) 0.01 0.2651 1
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.1074 0.1198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.1074 0.405
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.1074 1
Onchocerca volvulus 0.0053 0.1074 0.0836
Brugia malayi Cathepsin L-like precursor 0.0053 0.1074 0.1095
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0491 0.0491
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0286 0.8962 0.8962
Brugia malayi Cathepsin L-like precursor 0.0039 0.0567 0.0579
Toxoplasma gondii cathepsin B 0.01 0.2651 1
Plasmodium vivax vivapain-2 0.0053 0.1074 1
Onchocerca volvulus 0.0053 0.1074 0.0836
Loa Loa (eye worm) hypothetical protein 0.0039 0.0567 0.0567
Schistosoma mansoni importin beta-1 0.003 0.0266 0.0266
Echinococcus granulosus importin subunit beta 1 0.003 0.0266 0.0266

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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