Detailed information for compound 1269900

Basic information

Technical information
  • TDR Targets ID: 1269900
  • Name: 4-(4-acetamidophenyl)-3-amino-N-butan-2-yl-N' -(2,4-dimethylphenyl)-6-methylthieno[4,5-e]py ridine-2,5-dicarboxamide
  • MW: 543.68 | Formula: C30H33N5O3S
  • H donors: 4 H acceptors: 4 LogP: 5.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC(NC(=O)c1sc2c(c1N)c(c1ccc(cc1)NC(=O)C)c(c(n2)C)C(=O)Nc1ccc(cc1C)C)C
  • InChi: 1S/C30H33N5O3S/c1-7-17(4)32-29(38)27-26(31)25-24(20-9-11-21(12-10-20)34-19(6)36)23(18(5)33-30(25)39-27)28(37)35-22-13-8-15(2)14-16(22)3/h8-14,17H,7,31H2,1-6H3,(H,32,38)(H,34,36)(H,35,37)
  • InChiKey: CMVADEVKRBVJFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(4-acetamidophenyl)-3-amino-N'-(2,4-dimethylphenyl)-6-methyl-N-sec-butyl-thieno[4,5-e]pyridine-2,5-dicarboxamide
  • 4-(4-acetamidophenyl)-3-amino-N'-(2,4-dimethylphenyl)-6-methyl-N-sec-butylthieno[4,5-e]pyridine-2,5-dicarboxamide
  • 4-(4-acetamidophenyl)-3-amino-N-butan-2-yl-N'-(2,4-dimethylphenyl)-6-methyl-thieno[4,5-e]pyridine-2,5-dicarboxamide
  • C291-0074
  • NCGC00106996-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0642 0.0878 0.3856
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Loa Loa (eye worm) hypothetical protein 0.0246 0.022 0.0951
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.126 0.1905 0.8033
Leishmania major hypothetical protein, conserved 0.2338 0.3696 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.0234 0.0375
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0799 0.1138 0.2977
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.126 0.1905 0.4982
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0797 0.1136 0.5399
Echinococcus granulosus serine protein kinase ATM 0.1053 0.1561 0.1359
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0642 0.0878 0.3098
Echinococcus multilocularis Zinc finger, PHD finger 0.0305 0.0318 0.0086
Leishmania major phosphatidylinositol 3-kinase, putative 0.0305 0.0318 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0717 0.1002 0.2623
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0465 0.0584 0.1314
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0642 0.0878 0.2297
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0465 0.0584 0.0358
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0813 0.1161 0.2584
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0234 0.101
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1506 0.2314 0.6008
Toxoplasma gondii FATC domain-containing protein 0.1053 0.1561 0.7942
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0368 0.0423 0.0909
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.0234 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0717 0.1002 0.3696
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2414 0.3823 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0318 0.0404
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.0234 0.0375
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0368 0.0423 0.0909
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0318 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0717 0.1002 0.3696
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1053 0.1561 0.4083
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0963 0.1412 0.705
Brugia malayi FAT domain containing protein 0.0543 0.0713 0.166
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0234 0.101
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1506 0.2314 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1053 0.1561 0.638
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0545 0.0717 0.2324
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.059 0.0792 0.2072
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1196 0.0985
Mycobacterium leprae conserved hypothetical protein 0.0254 0.0234 0.5
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0717 0.1002 0.0787
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.0423 0.1132
Onchocerca volvulus 0.0254 0.0234 0.5
Toxoplasma gondii target of rapamycin (TOR), putative 0.126 0.1905 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.126 0.1905 0.4826
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0368 0.0423 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0254 0.0234 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0717 0.1002 0.3696
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0305 0.0318 0.0234
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0305 0.0318 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0254 0.0234 0.0611
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.126 0.1905 0.4826
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Loa Loa (eye worm) phosphatidylinositol 3 0.0749 0.1056 0.4564
Schistosoma mansoni fkbp-rapamycin associated protein 0.0717 0.1002 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.1506 0.2314 1
Loa Loa (eye worm) phosphatidylinositol 3 0.1506 0.2314 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0254 0.0234 0.0611
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0482 0.0612 0.2265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0463 0.058 0.1664
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0305 0.0318 1
Entamoeba histolytica hypothetical protein 0.0579 0.0773 0.3228
Onchocerca volvulus 0.0254 0.0234 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0963 0.1412 0.5663
Trypanosoma cruzi hypothetical protein, conserved 0.2084 0.3273 0.8563
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1053 0.1561 0.3934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0717 0.1002 0.3696
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0579 0.0773 0.3228
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.126 0.1905 1
Loa Loa (eye worm) hypothetical protein 0.0717 0.1002 0.4333
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0305 0.0318 0.0503
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0305 0.0318 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0717 0.1002 0.3696
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Schistosoma mansoni hypothetical protein 0.0543 0.0713 0.1336
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0642 0.0878 0.2103
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.0423 0.1132
Loa Loa (eye worm) phosphatidylinositol kinase 0.0254 0.0234 0.101
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0305 0.0318 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0543 0.0713 0.0491
Loa Loa (eye worm) hypothetical protein 0.0797 0.1136 0.4909
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0642 0.0878 0.2297
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Leishmania major phosphatidylinositol kinase related protein, putative 0.059 0.0792 0.1613
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0402 0.0479 0.1467
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0717 0.1002 0.0787
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.126 0.1905 0.1711
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0797 0.1136 0.4337
Loa Loa (eye worm) hypothetical protein 0.0177 0.0105 0.0455
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0717 0.1002 0.2437
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.126 0.1905 0.4826
Loa Loa (eye worm) hypothetical protein 0.0246 0.022 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0465 0.0584 0.0358
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0305 0.0318 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis conserved hypothetical protein 0.0797 0.1136 0.4337
Echinococcus multilocularis serine protein kinase ATM 0.1053 0.1561 0.1359
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2414 0.3823 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0813 0.1161 0.095
Giardia lamblia GTOR 0.126 0.1905 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0305 0.0318 0.0086
Loa Loa (eye worm) hypothetical protein 0.0799 0.1138 0.4918
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0388 0.0455 0.1326
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.0423 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.126 0.1905 0.1711
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.126 0.1905 0.8033
Loa Loa (eye worm) phosphatidylinositol 3 0.126 0.1905 0.8231
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6132 1 1
Entamoeba histolytica hypothetical protein 0.1053 0.1561 0.7942
Trichomonas vaginalis conserved hypothetical protein 0.0543 0.0713 0.2304
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0254 0.0234 0.0611
Loa Loa (eye worm) hypothetical protein 0.0465 0.0584 0.2523
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2414 0.3823 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0368 0.0423 0.0909
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1196 0.268
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2414 0.3823 0.3675
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.126 0.1905 0.4982
Trichomonas vaginalis conserved hypothetical protein 0.0463 0.058 0.1664
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0543 0.0713 0.0491
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1053 0.1561 0.638
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0642 0.0878 0.3098
Loa Loa (eye worm) hypothetical protein 0.0254 0.0234 0.101
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0305 0.0318 0.0234
Entamoeba histolytica protein kinase rad3, putative 0.0717 0.1002 0.4601
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0318 0.0831
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1053 0.1561 0.3698
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.126 0.1905 0.4826
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0305 0.0318 0.0243
Trypanosoma cruzi target of rapamycin kinase 3 0.126 0.1905 0.4982
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0368 0.0423 0.0909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0717 0.1002 0.3696
Trypanosoma brucei target of rapamycin kinase 3, putative 0.126 0.1905 0.8033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0797 0.1136 0.4337
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.126 0.1905 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0642 0.0878 0.3098
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2414 0.3823 0.3675
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0368 0.0423 0.1106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0254 0.0234 0.5
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0305 0.0318 0.1373
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0234 0.101
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0813 0.1161 0.095
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0305 0.0318 0.0503
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1196 0.0985
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0545 0.0717 0.2324
Loa Loa (eye worm) hypothetical protein 0.0543 0.0713 0.3082
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0234 0.101
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0305 0.0318 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0305 0.0318 0.0503
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.126 0.1905 0.4656
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.126 0.1905 0.4856
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0305 0.0318 0.06
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0305 0.0318 0.0086
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2414 0.3823 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0305 0.0318 0.0404
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0318 0.0339 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.1905 0.8033

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.