TDR Targets

Basic information

Technical information

TDR Targets ID: 1270397
Name: 2-(4-oxo-[1]benzoxolo[3,2-d]pyrimidin-3-yl)-N -(oxolan-2-ylmethyl)acetamide
MW: 327.335 | Formula: C17H17N3O4
H donors: 1 H acceptors: 2 LogP: 1.38 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1cnc2c(c1=O)oc1c2cccc1)NCC1CCCO1
InChi: 1S/C17H17N3O4/c21-14(18-8-11-4-3-7-23-11)9-20-10-19-15-12-5-1-2-6-13(12)24-16(15)17(20)22/h1-2,5-6,10-11H,3-4,7-9H2,(H,18,21)
InChiKey: NGSKGHZLBPGYRP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-oxobenzofurano[3,2-d]pyrimidin-3-yl)-N-(tetrahydrofuran-2-ylmethyl)acetamide
2-(4-oxo-3-benzofurano[3,2-d]pyrimidinyl)-N-(2-tetrahydrofuranylmethyl)acetamide
2-(4-ketobenzofurano[3,2-d]pyrimidin-3-yl)-N-(tetrahydrofurfuryl)acetamide
2-(4-oxo-[1]benzoxolo[3,2-d]pyrimidin-3-yl)-N-(oxolan-2-ylmethyl)ethanamide
2-(4-oxo[1]benzofuro[3,2-d]pyrimidin-3(4H)-yl)-N-(tetrahydrofuran-2-ylmethyl)acetamide
MLS000094541
SMR000030093

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	relaxin/insulin-like family peptide receptor 1	Starlite/ChEMBL	No references
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	arginine vasopressin receptor 1B	Starlite/ChEMBL	No references
Homo sapiens	relaxin/insulin-like family peptide receptor 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0015	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0015	0	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0134	0.1191	0.1191
Leishmania major	cytochrome p450-like protein	0.0052	0.0373	0.376
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0015	0	0.5
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Echinococcus multilocularis	dro:myosuppressin receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	g protein coupled receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	TYRA-2 protein	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0015	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Brugia malayi	Dopamine receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0134	0.1191	0.1191
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0015	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	fmrfamide receptor	0.0134	0.1191	0.1191
Brugia malayi	neuropeptide F receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	g-protein coupled receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Trypanosoma cruzi	cytochrome P450, putative	0.0052	0.0373	0.376
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.0016	0.0016
Brugia malayi	Dopamine receptor protein 2	0.0134	0.1191	0.1191
Echinococcus multilocularis	g protein coupled receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0024	0.0093	0.0093
Echinococcus granulosus	neuropeptide receptor	0.0134	0.1191	0.1191
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	neuropeptide Y receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	CYP4Cod1	0.0052	0.0373	0.0373
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0015	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.0016	0.0016
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0134	0.1191	0.1191
Mycobacterium leprae	Conserved hypothetical protein	0.0015	0	0.5
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0016	0.0016
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0015	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	voltage-gated potassium channel	0.0092	0.0768	0.0768
Brugia malayi	G protein-coupled receptor	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0015	0	0.5
Schistosoma mansoni	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	neuropeptide receptor A26	0.069	0.6753	0.6753
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	allatostatin A receptor	0.0134	0.1191	0.1191
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0134	0.1191	0.1191
Brugia malayi	ORL1-like opioid receptor	0.0134	0.1191	0.1191
Trypanosoma brucei	polo-like protein kinase	0.0114	0.0992	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus granulosus	g protein coupled receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0093	0.0093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Echinococcus granulosus	neuropeptide Y receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.0016	0.0016
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0134	0.1191	0.1191
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.0992	1
Schistosoma mansoni	kinase	0.0058	0.043	0.043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0015	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus granulosus	tm gpcr rhodopsin	0.0134	0.1191	0.1191
Trypanosoma brucei	cytochrome P450, putative	0.0052	0.0373	0.376
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	neuropeptide Y receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus granulosus	tm gpcr rhodopsin	0.0134	0.1191	0.1191
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	G protein coupled receptor 139	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0373	0.0373
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Loa Loa (eye worm)	ceramide glucosyltransferase	0.1014	1	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.0016	0.0016
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.0635	0.6348
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus granulosus	sex peptide receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	allatostatin A receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	orexin receptor type 2	0.0134	0.1191	0.1191
Echinococcus granulosus	neuropeptides capa receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0084	0.0691	0.0691
Onchocerca volvulus		0.0134	0.1191	0.0221
Schistosoma mansoni	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	hypothetical protein	0.0134	0.1191	0.1191
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0024	0.0093	0.0093
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.0016	0.0016
Schistosoma mansoni	neuropeptide receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	serotonin receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	orexin receptor type 2	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.1014	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0015	0	0.5
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0017	0.0016	0.0016
Schistosoma mansoni	ceramide glucosyltransferase	0.1014	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus granulosus	serotonin receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	ceramide glucosyltransferase	0.1014	1	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.0992	0.0992
Schistosoma mansoni	opsin-like receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	neuropeptide s receptor	0.069	0.6753	0.6753
Echinococcus granulosus	ceramide glucosyltransferase	0.1014	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0992	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Brugia malayi	putative neuropeptide receptor NPR1	0.0134	0.1191	0.1191
Schistosoma mansoni	opsin-like receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0015	0	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.069	0.6753	0.6753
Onchocerca volvulus		0.0134	0.1191	0.0221
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0402	0.0402
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0052	0.0373	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0134	0.1191	0.1191
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0134	0.1191	0.1191
Brugia malayi	AKH receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	neuropeptide F-like receptor	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0015	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0078	0.0635	0.6348
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0992	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.0992	0.0992
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0402	0.0402
Brugia malayi	Serotonin receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0093	0.0093
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0402	0.0402
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Echinococcus multilocularis	sex peptide receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	fmrfamide receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0134	0.1191	0.1191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Loa Loa (eye worm)	neuropeptide F receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0015	0	0.5
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0024	0.0093	0.0093
Echinococcus granulosus	7TM GPCR rhodopsin	0.0134	0.1191	0.1191
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus granulosus	7tm_1 domain containing protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0134	0.1191	0.1191
Giardia lamblia	Ceramide glucosyltransferase	0.046	0.4451	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.0992	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Schistosoma mansoni	neuropeptide F-like receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0402	0.0402
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0017	0.0016	0.0016
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0992	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0134	0.1191	0.0221
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0015	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Trypanosoma cruzi	cytochrome P450, putative	0.0052	0.0373	0.376
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Brugia malayi	larval opioid receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	G-protein coupled receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine receptor	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0134	0.1191	0.1191
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0373	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.0016	0.0016
Schistosoma mansoni	adenoreceptor	0.0134	0.1191	0.1191
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0134	0.1191	0.1191
Brugia malayi	neuropeptide F receptor	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0402	0.0402
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0015	0	0.5
Schistosoma mansoni	amine GPCR	0.0134	0.1191	0.1191
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0073	0.058	0.058
Echinococcus granulosus	biogenic amine 5HT receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Schistosoma mansoni	amine GPCR	0.0134	0.1191	0.1191
Brugia malayi	follicle stimulating hormone receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.0016	0.0016
Brugia malayi	RE15519p	0.0134	0.1191	0.1191
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0017	0.0016	0.0016
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.0992	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus granulosus	hypothetical protein	0.0134	0.1191	0.1191
Brugia malayi	putative neuropeptide receptor	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Schistosoma mansoni	neuropeptide receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	dro:myosuppressin receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	G protein coupled receptor 139	0.0134	0.1191	0.1191
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0017	0.0016	0.0016
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0134	0.1191	0.1191
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus granulosus	somatostatin receptor	0.0134	0.1191	0.1191
Brugia malayi	Dopamine receptor protein 1	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0373	0.0373
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0134	0.1191	0.1191
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0017	0.0016	0.0016
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.0992	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	amine GPCR	0.0134	0.1191	0.1191
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0016	0.0016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Echinococcus multilocularis	neuropeptide receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Brugia malayi	G-protein coupled receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	neuropeptide receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	amine GPCR	0.0134	0.1191	0.1191
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	growth hormone secretagogue receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	serotonin receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	biogenic amine receptor	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0015	0	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0092	0.0768	0.0768
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0015	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0134	0.1191	0.1191
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0134	0.1191	0.1191
Schistosoma mansoni	ceramide glucosyltransferase	0.1014	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus granulosus	voltage gated potassium channel	0.0024	0.0093	0.0093
Echinococcus granulosus	neuropeptides capa receptor	0.0134	0.1191	0.1191
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0992	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	neuropeptide F receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0084	0.0691	0.0691
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0134	0.1191	0.1191
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0084	0.0691	0.0691
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0222
Schistosoma mansoni	amine GPCR	0.0134	0.1191	0.1191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0134	0.1191	0.1191
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Echinococcus granulosus	fmrfamide receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0134	0.1191	0.1191
Schistosoma mansoni	histamine h1 receptor	0.0134	0.1191	0.1191
Brugia malayi	Melatonin receptor type 1A	0.0134	0.1191	0.1191
Mycobacterium leprae	putative cytochrome p450	0.0015	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0134	0.1191	0.1191
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0084	0.0691	0.0691
Brugia malayi	G-protein coupled receptor	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0134	0.1191	0.0221
Onchocerca volvulus		0.0134	0.1191	0.0221
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0093	0.0093
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0402	0.0402
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	opsin-like receptor	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0015	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	tm gpcr rhodopsin	0.0134	0.1191	0.1191
Schistosoma mansoni	neuropeptide receptor	0.0134	0.1191	0.1191
Schistosoma mansoni	myosin xvIII	0.0134	0.1191	0.1191
Echinococcus multilocularis	neuropeptide Y receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0134	0.1191	0.1191
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0015	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0134	0.1191	0.1191
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0415	0.4089
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0373	0.0373
Schistosoma mansoni	neuropeptide f receptor 76f	0.0134	0.1191	0.1191
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0134	0.1191	0.1191
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0015	0	0.5
Onchocerca volvulus		0.0134	0.1191	0.0221
Echinococcus multilocularis	somatostatin receptor	0.0134	0.1191	0.1191
Onchocerca volvulus		0.0134	0.1191	0.0221
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0415	0.4089
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0992	1
Echinococcus granulosus	g-protein coupled receptor	0.0134	0.1191	0.1191
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.0992	0.0992
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0015	0	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0016	0.0016
Brugia malayi	GnHR receptor homolog	0.0134	0.1191	0.1191
Echinococcus granulosus	rhodopsin orphan GPCR	0.0134	0.1191	0.1191
Brugia malayi	sulfakinin receptor protein	0.0134	0.1191	0.1191
Schistosoma mansoni	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.0016	0.0016
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0134	0.1191	0.1191
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0992	1
Brugia malayi	hypothetical protein	0.0134	0.1191	0.1191
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0134	0.1191	0.1191
Brugia malayi	G protein-coupled receptor F59B2.13	0.0134	0.1191	0.1191
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0017	0.0016	0.0016
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0992	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus granulosus	neuropeptide FF receptor 2	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Echinococcus multilocularis	voltage gated potassium channel	0.0024	0.0093	0.0093
Echinococcus granulosus	g protein coupled receptor	0.0134	0.1191	0.1191
Echinococcus granulosus	neuropeptide receptor A26	0.069	0.6753	0.6753
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191
Brugia malayi	Serotonin receptor	0.0134	0.1191	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1191	0.1191

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	6.9134 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.7614 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.4405 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012]	ChEMBL.	No reference
Potency (functional)	15.4405 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948]	ChEMBL.	No reference
Potency (functional)	18.8876 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1375857

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1270397