Detailed information for compound 1279054

Basic information

Technical information
  • TDR Targets ID: 1279054
  • Name: N-tert-butyl-2-[[4-(phenylmethyl)-5-pyridin-2 -yl-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • MW: 381.495 | Formula: C20H23N5OS
  • H donors: 1 H acceptors: 4 LogP: 2.82 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C)(C)C)CSc1nnc(n1Cc1ccccc1)c1ccccn1
  • InChi: 1S/C20H23N5OS/c1-20(2,3)22-17(26)14-27-19-24-23-18(16-11-7-8-12-21-16)25(19)13-15-9-5-4-6-10-15/h4-12H,13-14H2,1-3H3,(H,22,26)
  • InChiKey: HJOZZWSHMJHAKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-tert-butyl-2-[[4-(phenylmethyl)-5-(2-pyridyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • N-tert-butyl-2-[[4-(phenylmethyl)-5-(2-pyridyl)-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[4-(benzyl)-5-(2-pyridyl)-1,2,4-triazol-3-yl]thio]-N-tert-butyl-acetamide
  • N-tert-butyl-2-[[4-(phenylmethyl)-5-pyridin-2-yl-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • 2-(4-Benzyl-5-pyridin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-N-tert-butyl-acetamide
  • MLS000121937
  • SMR000119377
  • ZINC01362683
  • ASN 05944737

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0086 0.0174
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0378 0.5386
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0086 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1155 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0813 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0813 0.1603
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0378 0.5386
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1554 0.2096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0086 0.0116
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0378 0.0509
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0813 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1627 0.2195
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.5074 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0378 0.0509
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0378 0.2731
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1627 0.3206
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0292 0.0593
Loa Loa (eye worm) loechrig isoform VII 0.011 0.3075 0.4149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Brugia malayi Pre-SET motif family protein 0.0036 0.0813 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0813 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0292 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0129 0.0129
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1286 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0378 0.5386
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0116
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0773 0.1569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0086 0.0169
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0378 0.0744
Echinococcus granulosus serine protein kinase ATM 0.003 0.0628 0.1275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0379 0.541
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.011 0.3075 0.6246
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0378 0.0744
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1627 0.2195
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0378 0.5386
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.011 0.3075 0.6061
Schistosoma mansoni hypothetical protein 0.0019 0.0292 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1554 0.2096
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0378 0.0767
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0378 0.4987
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1155 0.288
Schistosoma mansoni protein kinase subunit gamma 0.011 0.3075 0.6061
Schistosoma mansoni hypothetical protein 0.0019 0.0292 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0378 0.4987
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0813 0.1603
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0378 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1627 0.2195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0086 0.0086
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1286 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0378 0.2731
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0292 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Brugia malayi loechrig isoform VII 0.011 0.3075 0.4149
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0292 0.0394
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0378 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1627 0.3206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0129 0.0129
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.011 0.3075 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1627 0.3206
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0292 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0813 0.1652
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1627 0.3206
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0378 0.4987
Schistosoma mansoni hypothetical protein 0.0019 0.0292 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0378 0.0509
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0813 0.1603
Loa Loa (eye worm) RNA binding protein 0.0063 0.1627 0.2195
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0103 0.2867 0.565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0292 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.4923 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8477 0.8477
Loa Loa (eye worm) acetyltransferase 0.0175 0.5074 0.6845
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0628 0.0847
Brugia malayi Pre-SET motif family protein 0.0251 0.7413 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1286 0.2612
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1627 0.3206
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0379 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7413 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.097 0.1308
Entamoeba histolytica hypothetical protein 0.003 0.0628 0.5071
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0378 0.0509
Loa Loa (eye worm) hypothetical protein 0.006 0.1554 0.2096
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0628 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0378 0.0744
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.5074 0.6845
Loa Loa (eye worm) hypothetical protein 0.0041 0.097 0.1308
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1286 0.1286
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0378 0.4987
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0378 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Schistosoma mansoni hypothetical protein 0.0041 0.097 0.1911
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1554 0.2096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0378 0.0744
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0378 0.215
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1286 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Schistosoma mansoni hypothetical protein 0.0019 0.0292 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0292 0.0593
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0628 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0628 0.1237
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0628 0.1237
Loa Loa (eye worm) hypothetical protein 0.0019 0.0292 0.0394
Loa Loa (eye worm) hypothetical protein 0.0026 0.0499 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0086 0.0086
Echinococcus multilocularis GPCR, family 2 0.0019 0.0292 0.0576
Echinococcus granulosus GPCR family 2 0.0019 0.0292 0.0593
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.5074 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0499 0.7623
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1286 1
Brugia malayi TAR-binding protein 0.0063 0.1627 0.2195
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1155 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1627 0.3206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0086 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0628 0.0628
Onchocerca volvulus 0.0286 0.8477 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0813 0.1603
Brugia malayi RNA binding protein 0.0063 0.1627 0.2195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0378 0.0378
Echinococcus granulosus tar DNA binding protein 0.0063 0.1627 0.3304
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0813 0.5914
Toxoplasma gondii FATC domain-containing protein 0.003 0.0628 0.4311

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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