Detailed information for compound 1282618

Basic information

Technical information
  • TDR Targets ID: 1282618
  • Name: T5568358
  • MW: 330.353 | Formula: C18H19FN2O3
  • H donors: 1 H acceptors: 2 LogP: 2.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)F)COC(=O)c1cc(n(c1C)C1CC1)C
  • InChi: 1S/C18H19FN2O3/c1-11-8-16(12(2)21(11)15-6-7-15)18(23)24-10-17(22)20-14-5-3-4-13(19)9-14/h3-5,8-9,15H,6-7,10H2,1-2H3,(H,20,22)
  • InChiKey: NHRFFDNXDYJGTQ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1369 0.1347
Plasmodium falciparum serine repeat antigen 7 0.0039 0.0264 0.0209
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0039 0.0264 0.0209
Toxoplasma gondii cathepsin CPC2 0.0039 0.0264 0.0737
Plasmodium falciparum serine repeat antigen 4 0.0039 0.0264 0.0209
Giardia lamblia Cathepsin B precursor 0.0169 0.3275 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0039 0.0264 0.024
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0039 0.0264 0.0808
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0039 0.0264 0.024
Plasmodium falciparum serine repeat antigen 5 0.0039 0.0264 0.0209
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0039 0.0264 0.0808
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0264 0.024
Onchocerca volvulus Cathepsin F homolog 0.0156 0.2988 0.6301
Onchocerca volvulus 0.0156 0.2988 0.6301
Plasmodium vivax vivapain-2 0.0156 0.2988 1
Plasmodium vivax vivapain-3 0.0087 0.1369 0.4534
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0169 0.3275 0.3134
Brugia malayi MH2 domain containing protein 0.0116 0.2059 0.2039
Brugia malayi hypothetical protein 0.0036 0.0178 0.0154
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1687 0.1666
Onchocerca volvulus 0.0156 0.2988 0.6301
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0025 0.0025
Echinococcus granulosus cathepsin b 0.0457 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0087 0.0062
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0206 0.0611
Trypanosoma cruzi major cysteine proteinase, putative 0.0181 0.3574 0.3439
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0039 0.0264 0.0209
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0087 0.0087
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.2988 0.2971
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1369 0.1347
Toxoplasma gondii cathepsin CPL 0.0156 0.2988 0.9117
Brugia malayi Cathepsin L-like precursor 0.0109 0.1884 0.1864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.1884 0.3629
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0039 0.0264 0.0808
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0218 0.0193
Trypanosoma cruzi cruzipain precursor, putative 0.0298 0.6298 0.6221
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1307 0.553
Brugia malayi Cathepsin L-like precursor 0.0109 0.1884 0.1864
Onchocerca volvulus 0.0039 0.0264 0.0509
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0268 0.0243
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.6298 0.6221
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Onchocerca volvulus 0.0147 0.2779 0.5857
Echinococcus multilocularis cysteine protease 0.0156 0.2988 0.2971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0156 0.2988 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 0.3275 0.3259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2059 0.2039
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.2197 0.6682
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0431 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.2988 0.2971
Plasmodium vivax glutathione reductase, putative 0.0037 0.0206 0.0611
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.1369 0.1187
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.1369 0.1187
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Plasmodium falciparum serine repeat antigen 3 0.0039 0.0264 0.0209
Brugia malayi Thioredoxin reductase 0.0037 0.0206 0.0182
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0039 0.0264 0.0808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.1369 0.1908
Schistosoma mansoni cathepsin F (C01 family) 0.0109 0.1884 0.1864
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1494 0.1494
Loa Loa (eye worm) fibroinase 0.0156 0.2988 0.2971
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1494 0.1473
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1526 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1494 0.1473
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Schistosoma mansoni hypothetical protein 0.0176 0.3451 0.3435
Onchocerca volvulus Cathepsin L homolog 0.0156 0.2988 0.6301
Onchocerca volvulus 0.0156 0.2988 0.6301
Plasmodium falciparum serine repeat antigen 6 0.0039 0.0264 0.0209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1687 0.1666
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0218 0.0218
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Trypanosoma brucei cysteine peptidase C (CPC) 0.0169 0.3275 0.5038
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0264 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0087 0.0062
Trypanosoma cruzi cysteine protease, putative 0.0087 0.1369 0.1187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0087 0.1369 0.1187
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0039 0.0264 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.1369 0.2474
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0156 0.2988 0.2971
Schistosoma mansoni hypothetical protein 0.0176 0.3451 0.3435
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Giardia lamblia Cathepsin B precursor 0.0169 0.3275 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0206 0.0182
Trypanosoma cruzi cysteine peptidase, putative 0.0156 0.2988 0.2841
Leishmania major cathepsin L-like protease 0.0298 0.6298 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.2197 0.2197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 1 1
Echinococcus granulosus cathepsin b 0.0457 1 1
Brugia malayi glutathione reductase 0.0037 0.0206 0.0182
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0039 0.0264 0.0808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0087 0.1369 0.1908
Echinococcus granulosus cathepsin l1 0.0109 0.1884 0.1884
Brugia malayi cathepsin F-like cysteine proteinase 0.0047 0.0451 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.1369 0.2474
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.6298 0.6221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1307 0.553
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Toxoplasma gondii preprocathepsin c precursor, putative 0.0039 0.0264 0.0737
Loa Loa (eye worm) hypothetical protein 0.0047 0.0451 0.0427
Plasmodium falciparum serine repeat antigen 9 0.0039 0.0264 0.0209
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.2988 0.2971
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0087 0.0062
Echinococcus granulosus cathepsin L cysteine proteinase 0.0156 0.2988 0.2988
Trichomonas vaginalis set domain proteins, putative 0.0231 0.4728 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1526 0.6628
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0268 0.0243
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0946 0.0924
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0039 0.0264 0.024
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0264 0.024
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2197 0.2177
Echinococcus granulosus cathepsin L 0.0087 0.1369 0.1369
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0156 0.2988 0.2971
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1526 0.6628
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0268 0.0243
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0062
Brugia malayi Pre-SET motif family protein 0.0203 0.4075 0.406
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0431 0.0407
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0264 0.0808
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0264 0.024
Plasmodium vivax unspecified product 0.0087 0.1369 0.4534
Leishmania major cathepsin L-like protease 0.0298 0.6298 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.2779 0.2761
Brugia malayi hypothetical protein 0.0036 0.0178 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni cathepsin F (C01 family) 0.0156 0.2988 0.2971
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Toxoplasma gondii thioredoxin reductase 0.0037 0.0206 0.0557
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Echinococcus multilocularis cathepsin b 0.0457 1 1
Brugia malayi cathepsin L-like precursor 0.0109 0.1884 0.1864
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0251 0.5194 0.5093
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Leishmania major cysteine peptidase A (CPA) 0.0156 0.2988 0.4567
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1307 0.553
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0268 0.0221
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.2988 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1494 0.1473
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.2988 0.2971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0264 0.024
Loa Loa (eye worm) hypothetical protein 0.0109 0.1884 0.1864
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0431 0.081
Brugia malayi fibroinase precursor 0.0039 0.0264 0.024
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0047 0.0451 0.0427
Trypanosoma cruzi cysteine proteinase, putative 0.0087 0.1369 0.1187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Plasmodium vivax vivapain-1 0.0087 0.1369 0.4534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0431 0.1372
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0268 0.0243
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.1369 0.1347
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1494 0.1473
Loa Loa (eye worm) hypothetical protein 0.0457 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0451 0.0427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.2197 1
Onchocerca volvulus 0.0156 0.2988 0.6301
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0264 0.024
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0264 0.024
Schistosoma mansoni hypothetical protein 0.0032 0.0087 0.0062
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0039 0.0264 0.0209
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1526 0.6628
Brugia malayi Cathepsin L-like cysteine proteinase 0.0109 0.1884 0.1864
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2197 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0451 0.025
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0457 1 1
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Loa Loa (eye worm) hypothetical protein 0.0156 0.2988 0.2971
Plasmodium vivax unspecified product 0.0039 0.0264 0.0808
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0087 0.0087
Echinococcus multilocularis expressed protein 0.0047 0.0431 0.0407
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.6298 0.6221
Schistosoma mansoni hypothetical protein 0.004 0.0268 0.0243
Onchocerca volvulus 0.0109 0.1884 0.3953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0264 0.024
Echinococcus granulosus expressed protein 0.0047 0.0431 0.0431
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0169 0.3275 0.6746
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0156 0.2988 1
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Echinococcus multilocularis geminin 0.0176 0.3451 0.3435
Echinococcus granulosus geminin 0.0176 0.3451 0.3451
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0264 0.024
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0457 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.2197 0.2177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1687 0.1666
Echinococcus granulosus cysteine protease 0.0087 0.1369 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0264 0.0509
Loa Loa (eye worm) hypothetical protein 0.01 0.1687 0.1666
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0264 0.024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.2197 0.3268
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0264 0.0808
Loa Loa (eye worm) cysteine protease 0.0156 0.2988 0.2971
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1307 0.553
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0039 0.0264 0.024
Entamoeba histolytica cysteine proteinase, putative 0.0087 0.1369 0.4054
Loa Loa (eye worm) glutathione reductase 0.0037 0.0206 0.0182
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.2988 0.2971
Echinococcus granulosus cathepsin l cysteine peptidase 0.0156 0.2988 0.2988
Loa Loa (eye worm) hypothetical protein 0.0047 0.0451 0.0427
Schistosoma mansoni cathepsin s 0.0047 0.0451 0.0427
Brugia malayi Cathepsin L-like precursor 0.0047 0.0451 0.0427
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0039 0.0264 0.0808
Onchocerca volvulus Cathepsin L homolog 0.0156 0.2988 0.6301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1494 0.1473
Echinococcus granulosus cathepsin L 0.0039 0.0264 0.0264
Leishmania major cathepsin L-like protease 0.0298 0.6298 1
Mycobacterium tuberculosis Probable reductase 0.0084 0.1307 0.553
Echinococcus granulosus cathepsin l1 0.0156 0.2988 0.2988
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Plasmodium falciparum serine repeat antigen 2 0.0039 0.0264 0.0209
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Toxoplasma gondii cathepsin CPC1 0.0039 0.0264 0.0737
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0087 0.0062
Echinococcus granulosus cathepsin L cysteine protease 0.0087 0.1369 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0431 0.125
Entamoeba histolytica cysteine proteinase 1, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.1884 0.5946
Loa Loa (eye worm) hypothetical protein 0.0109 0.1884 0.1864
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2197 0.5
Plasmodium falciparum serine repeat antigen 8 0.0039 0.0264 0.0209
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.2197 0.2177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.1884 0.3629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0109 0.1884 0.1864
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0268 0.0746
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0039 0.0264 0.0808
Echinococcus multilocularis GPCR, family 2 0.0032 0.0087 0.0062
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0264 0.0059
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2059 0.2039
Entamoeba histolytica cysteine protease, putative 0.0156 0.2988 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0457 1 1
Brugia malayi Cathepsin L-like precursor 0.0156 0.2988 0.2971
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0451 0.025
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0087 0.0062
Echinococcus multilocularis cathepsin b 0.0457 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0039 0.0264 0.024
Plasmodium vivax unspecified product 0.0047 0.0451 0.1438
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Plasmodium falciparum cysteine proteinase falcipain 3 0.0156 0.2988 1
Toxoplasma gondii cathepsin B 0.0169 0.3275 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0087 0.1369 0.1347
Plasmodium falciparum serine repeat antigen 1 0.0039 0.0264 0.0209
Brugia malayi hypothetical protein 0.0147 0.2779 0.2761
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.2197 0.5
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0039 0.0264 0.0808
Entamoeba histolytica cysteine proteinase 2 0.0087 0.1369 0.4054
Loa Loa (eye worm) hypothetical protein 0.0069 0.0946 0.0924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.6298 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4075 0.406
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0156 0.2988 0.6103
Loa Loa (eye worm) ctsf protein 0.0156 0.2988 0.2971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1494 0.1473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1494 0.1473
Echinococcus granulosus GPCR family 2 0.0032 0.0087 0.0087
Echinococcus multilocularis cathepsin L cysteine protease 0.0156 0.2988 0.2971
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0431 0.125
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0451 0.0427
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.024
Entamoeba histolytica cysteine protease, putative 0.0087 0.1369 0.4054
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0169 0.3275 0.5038
Echinococcus multilocularis cathepsin L 0.0039 0.0264 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Giardia lamblia Cathepsin B precursor 0.0169 0.3275 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0087 0.1369 0.4179
Onchocerca volvulus 0.0156 0.2988 0.6301
Leishmania major cathepsin L-like protease 0.0156 0.2988 0.4567
Plasmodium vivax vivapain-2 0.0156 0.2988 1
Echinococcus multilocularis cathepsin L 0.0087 0.1369 0.1347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0264 0.0808
Loa Loa (eye worm) cathepsin B 0.0169 0.3275 0.3259
Onchocerca volvulus 0.0156 0.2988 0.6301
Entamoeba histolytica cysteine proteinase, putative 0.0156 0.2988 1
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0431 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0268 0.0819
Echinococcus multilocularis cysteine protease 0.0156 0.2988 0.2971
Schistosoma mansoni hypothetical protein 0.0069 0.0946 0.0924
Onchocerca volvulus 0.0156 0.2988 0.6301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Schistosoma mansoni cathepsin S (C01 family) 0.0039 0.0264 0.024
Onchocerca volvulus 0.0231 0.4728 1
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.1369 0.1347
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0264 0.0808
Brugia malayi cathepsin L precursor 0.0039 0.0264 0.024
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0264 0.024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1307 0.553
Schistosoma mansoni cathepsin C 0.0039 0.0264 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.2988 0.6103
Loa Loa (eye worm) hypothetical protein 0.004 0.0268 0.0243

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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