Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 3 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0711 | 0.2288 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0285 | 0.0917 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2895 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0424 | 0.0424 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1114 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0035 | 0.1114 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1114 | 0.3586 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3106 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0035 | 0.1114 | 0.3846 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3543 | 0.3543 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0035 | 0.1114 | 0.3846 |
Onchocerca volvulus | 0.0035 | 0.1114 | 0.1114 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1498 | 0.5173 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0536 | 0.1852 |
Schistosoma mansoni | brg-1 associated factor | 0.0035 | 0.1114 | 0.3586 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0021 | 0.0388 | 0.1339 |
Chlamydia trachomatis | SWIB complex protein | 0.0035 | 0.1114 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0021 | 0.0388 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1641 | 0.1641 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0598 | 0.0598 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0388 | 0.1249 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0035 | 0.1114 | 0.3846 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0388 | 0.0388 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0388 | 0.1249 |
Brugia malayi | brahma associated protein 60 kDa | 0.0035 | 0.1114 | 0.1114 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0285 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0035 | 0.1114 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0035 | 0.1114 | 0.3846 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0536 | 0.1852 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0035 | 0.1114 | 0.1114 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.085 | 0.085 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2895 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0285 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1114 | 0.3586 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0711 | 0.2454 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0035 | 0.1114 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1637 | 0.1637 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0711 | 0.2454 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0035 | 0.1114 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0021 | 0.0388 | 0.1339 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0035 | 0.1114 | 0.3846 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3795 | 0.3795 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1893 | 0.1893 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0388 | 0.1249 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0285 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0035 | 0.1114 | 0.5 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0.0285 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1498 | 0.5173 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0388 | 0.1249 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.1114 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.0035 | 0.1114 | 0.1114 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0598 | 0.1926 |
Brugia malayi | brahma associated protein 60 kDa | 0.0035 | 0.1114 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.178 | 0.178 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0035 | 0.1114 | 0.3846 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0035 | 0.1114 | 0.1114 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0285 | 0.0917 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0536 | 0.1726 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0035 | 0.1114 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1114 | 0.3586 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0021 | 0.0388 | 0.1339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.