TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 340.482 | Formula: C20H24N2OS
H donors: 0 H acceptors: 1 LogP: 3.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(C(=O)CC1)[C@@H](c1ccccc1)CSc1ccccc1
InChi: 1S/C20H24N2OS/c1-21-13-12-20(23)22(15-14-21)19(17-8-4-2-5-9-17)16-24-18-10-6-3-7-11-18/h2-11,19H,12-16H2,1H3/t19-/m1/s1
InChiKey: MMBVRZOCPGIYRT-LJQANCHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	sodium:hydrogen exchanger 7	0.0065	0.0937	0.09
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0064	0.0023
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0064	0.0023
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0038	0.0431	0.0404
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0064	0.0023
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0064	0.0023
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0125	0.2063	0.2031
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0064	0.0037
Trypanosoma cruzi	Na/H antiporter-like protein, putative	0.0065	0.0937	1
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	hypothetical protein	0.0019	0.0064	0.0037
Mycobacterium ulcerans	potassium/proton antiporter	0.0065	0.0937	1
Echinococcus granulosus	sodium:hydrogen exchanger	0.0341	0.6145	0.6129
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0064	0.0023
Entamoeba histolytica	protein kinase, putative	0.0038	0.0431	0.2782
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0051	0.0011
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0028	0.0235	0.2168
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.0064	0.0025
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0024	0.0156	0.1285
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0064	0.0037
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0355	0.0315
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0064	0.0023
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0064	0.0069
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0038	0.0431	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0038	0.0431	0.0391
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0028	0.0235	0.2168
Toxoplasma gondii	protein kinase, putative	0.0353	0.6359	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0064	0.0069
Schistosoma mansoni	opsin-like receptor	0.0019	0.0064	0.0037
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0064	0.0069
Trichomonas vaginalis	sugar transporter, putative	0.0039	0.044	0.0834
Brugia malayi	putative neuropeptide receptor	0.0019	0.0064	0.0025
Loa Loa (eye worm)	sodium/hydrogen exchanger	0.0341	0.6145	0.6648
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0064	0.0037
Schistosoma mansoni	histamine h1 receptor	0.0019	0.0064	0.0037
Onchocerca volvulus		0.0019	0.0064	0.0037
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0331	0.0291
Onchocerca volvulus		0.0019	0.0064	0.0037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	opsin-like receptor	0.0019	0.0064	0.0037
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0039	0.044	0.445
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0787	0.0851
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	NHE-3	0.0341	0.6145	0.6648
Onchocerca volvulus		0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Entamoeba histolytica	protein kinase, putative	0.0038	0.0431	0.2782
Plasmodium falciparum	protein kinase 6	0.053	0.9698	1
Loa Loa (eye worm)	sugar transporter	0.0018	0.0041	0.0044
Brugia malayi	AKH receptor	0.0019	0.0064	0.0025
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0341	0.6145	0.6129
Onchocerca volvulus		0.0034	0.0355	0.0514
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0028	0.0235	0.0406
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.0064	0.0037
Brugia malayi	Pre-SET motif family protein	0.0034	0.0355	0.0341
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0125	0.2063	0.2031
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.0341	0.6145	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Brugia malayi	GnHR receptor homolog	0.0019	0.0064	0.0025
Echinococcus granulosus	sodium:hydrogen exchanger 7	0.0065	0.0937	0.09
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0044	0.0533	1
Brugia malayi	Cytochrome P450 family protein	0.0073	0.1085	0.1134
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0064	0.0023
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0064	0.0025
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0039	0.044	0.8107
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0064	0.0023
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0028	0.0235	0.1013
Echinococcus granulosus	calcium dependent protein kinase	0.0036	0.0386	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0466
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0125	0.2063	0.2031
Schistosoma mansoni	glucose transport protein	0.0125	0.2063	0.3313
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0038	0.0431	0.0423
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0064	0.0023
Echinococcus multilocularis	calcium dependent protein kinase	0.0036	0.0386	0.0347
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0064	0.0023
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0416	0.045
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0125	0.2063	0.2031
Plasmodium vivax	SET domain protein, putative	0.0034	0.0355	0.0325
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0044	0.0533	0.0779
Schistosoma mansoni	amine GPCR	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Brugia malayi	RE15519p	0.0019	0.0064	0.0025
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.0064	0.0037
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0064	0.0025
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0039	0.044	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0038	0.0431	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0937	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0037	0.0416	0.3327
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0064	0.0023
Schistosoma mansoni	hypothetical protein	0.0065	0.0937	0.1468
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0037	0.0416	0.0377
Echinococcus multilocularis	lysyl tRNA synthetase	0.0028	0.0235	0.0195
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0341	0.6145	0.6129
Echinococcus multilocularis	serotonin receptor	0.0019	0.0064	0.0023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Schistosoma mansoni	amine GPCR	0.0019	0.0064	0.0037
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Echinococcus multilocularis	sodium:hydrogen exchanger	0.0341	0.6145	0.6129
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Plasmodium vivax	lysine--tRNA ligase, putative	0.0028	0.0235	0.0201
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein YjcE	0.0065	0.0937	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0937	0.1014
Onchocerca volvulus		0.0065	0.0937	0.1468
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0044	0.0533	0.549
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0064	0.0037
Trichomonas vaginalis	CAMK family protein kinase	0.0038	0.0431	0.0814
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0051	0.001
Toxoplasma gondii	Na+/H+ exchanger NHE3	0.0065	0.0937	0.1419
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0064	0.0023
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0038	0.0431	0.0466
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0064	0.0025
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0037	0.0416	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Echinococcus granulosus	hypothetical protein	0.0019	0.0064	0.0023
Onchocerca volvulus		0.0019	0.0064	0.0037
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Schistosoma mansoni	hypothetical protein	0.0205	0.3567	0.5776
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0064	0.0023
Loa Loa (eye worm)	sodium-hydrogen exchanger NHE1	0.0065	0.0937	0.1014
Schistosoma mansoni	opsin-like receptor	0.0019	0.0064	0.0037
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0064	0.0037
Brugia malayi	hypothetical protein	0.0506	0.9244	1
Onchocerca volvulus		0.0019	0.0064	0.0037
Giardia lamblia	Prolyl-tRNA synthetase	0.0037	0.0416	0.0614
Brugia malayi	hypothetical protein	0.0065	0.0937	0.0974
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.0341	0.6145	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0937	0.1468
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0506	0.9244	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0037	0.0416	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0341	0.6145	0.6648
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.0341	0.6145	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0038	0.0431	0.0391
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0051	0.0055
Brugia malayi	Cam kinase protein 1	0.0038	0.0431	0.0423
Trypanosoma cruzi	hexose transporter, putative	0.0039	0.044	0.445
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0355	0.0497
Brugia malayi	Serotonin receptor	0.0019	0.0064	0.0025
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.0064	0.0037
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0064	0.0023
Leishmania major	protein kinase, putative	0.0038	0.0431	0.4347
Trichomonas vaginalis	glucose transporter, putative	0.0039	0.044	0.0834
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0064	0.0023
Giardia lamblia	Lysyl-tRNA synthetase	0.0028	0.0235	0.0318
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0064	0.0025
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.0064	0.0023
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0064	0.0025
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0355	0.0514
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0064	0.0023
Schistosoma mansoni	sodium/hydrogen exchanger 2 (nhe2)	0.0341	0.6145	1
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0064	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.044	0.0834
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0038	0.0431	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0235	0.0255
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0038	0.0431	0.0404
Schistosoma mansoni	hypothetical protein	0.0019	0.0064	0.0037
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Trichomonas vaginalis	set domain proteins, putative	0.0271	0.4826	1
Echinococcus multilocularis	serotonin receptor	0.0019	0.0064	0.0023
Onchocerca volvulus		0.0019	0.0064	0.0037
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0064	0.0037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Onchocerca volvulus		0.0065	0.0937	0.1468
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Leishmania major	glucose transporter, lmgt1	0.0039	0.044	0.445
Leishmania major	glucose transporter, lmgt3	0.0039	0.044	0.445
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0064	0.0023
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.0064	0.0037
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Echinococcus granulosus	geminin	0.0205	0.3567	0.354
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Brugia malayi	Pre-SET motif family protein	0.0239	0.4205	0.4525
Loa Loa (eye worm)	sugar transporter	0.0125	0.2063	0.2232
Schistosoma mansoni	adenoreceptor	0.0019	0.0064	0.0037
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0038	0.0431	0.7919
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.0341	0.6145	0.6129
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0064	0.0023
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0065	0.0937	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Brugia malayi	lysyl-tRNA synthetase	0.0028	0.0235	0.0211
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0064	0.0023
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.0064	0.0069
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0064	0.0023
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0038	0.0431	0.0617
Toxoplasma gondii	sodium/hydrogen exchanger NHE2	0.0065	0.0937	0.1419
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Schistosoma mansoni	hypothetical protein	0.0205	0.3567	0.5776
Entamoeba histolytica	sodium/proton antiporter, putative	0.0065	0.0937	1
Schistosoma mansoni	glucose transport protein	0.0125	0.2063	0.3313
Schistosoma mansoni	lysyl-tRNA synthetase	0.0028	0.0235	0.0318
Brugia malayi	sulfakinin receptor protein	0.0506	0.9244	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0064	0.0023
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0044	0.0533	0.549
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0064	0.0023
Plasmodium falciparum	hexose transporter	0.0125	0.2063	0.2094
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0037	0.0416	0.0614
Schistosoma mansoni	hypothetical protein	0.0125	0.2063	0.3313
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.0064	0.0025
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0341	0.6145	0.6129
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0202	0.3513	0.3595
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0038	0.0431	0.0391
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0171	0.0271
Mycobacterium ulcerans	ion antiporter, NhaP	0.0065	0.0937	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0038	0.0431	0.0617
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0038	0.0431	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0064	0.0023
Onchocerca volvulus		0.0019	0.0064	0.0037
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.003	0.0284	0.0307
Plasmodium vivax	hexose transporter	0.0125	0.2063	0.2094
Onchocerca volvulus		0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0038	0.0431	0.0391
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0064	0.0025
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Onchocerca volvulus		0.0019	0.0064	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.044	0.0834
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0064	0.0023
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0051	0.001
Leishmania major	lysyl-tRNA synthetase, putative	0.0028	0.0235	0.2168
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0064	0.0023
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.0064	0.0037
Onchocerca volvulus		0.0019	0.0064	0.0037
Schistosoma mansoni	protein kinase	0.0038	0.0431	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0125	0.2063	0.2031
Schistosoma mansoni	hypothetical protein	0.0018	0.0051	0.0016
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0239	0.4205	0.4549
Toxoplasma gondii	lysine-tRNA ligase	0.0028	0.0235	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0051	0.001
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0446	0.0483
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0064	0.0023
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0019	0.0064	0.0037
Trypanosoma cruzi	hexose transporter	0.0039	0.044	0.445
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Schistosoma mansoni	amine GPCR	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Plasmodium vivax	sodium/hydrogen exchanger 1, putative	0.0065	0.0937	0.0928
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0355	0.0315
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2063	0.4226
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0044	0.0533	0.549
Brugia malayi	G-protein coupled receptor	0.0019	0.0064	0.0025
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0064	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0064	0.0023
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0202	0.3513	0.3595
Trypanosoma cruzi	hexose transporter, putative	0.0039	0.044	0.445
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0355	0.0514
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0037	0.0416	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0064	0.0023
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Mycobacterium ulcerans	membrane transporter	0.0065	0.0937	1
Echinococcus granulosus	sodium:hydrogen exchanger	0.0341	0.6145	0.6129
Entamoeba histolytica	sodium/proton antiporter, putative	0.0065	0.0937	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0038	0.0431	0.0404
Schistosoma mansoni	hypothetical protein	0.0018	0.0051	0.0016
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0028	0.0235	0.395
Echinococcus granulosus	somatostatin receptor	0.0019	0.0064	0.0023
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0038	0.0431	0.0391
Schistosoma mansoni	hypothetical protein	0.0039	0.0446	0.0664
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0355	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0037	0.0416	0.0377
Brugia malayi	Sodium/hydrogen exchanger 8	0.0065	0.0937	0.0974
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0051	0.001
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0064	0.0025
Onchocerca volvulus		0.0019	0.0064	0.0037
Trypanosoma cruzi	sodium/hydrogen exchanger, putative	0.0065	0.0937	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0018	0.0041	0.0044
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0355	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Echinococcus granulosus	GPCR family 2	0.0018	0.0051	0.001
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0028	0.0235	0.2168
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0038	0.0431	0.0617
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.2427	0.2626
Onchocerca volvulus		0.0019	0.0064	0.0037
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0064	0.0069
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	protein kinase	0.0038	0.0431	0.0638
Onchocerca volvulus		0.0019	0.0064	0.0037
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.0064	0.0037
Echinococcus granulosus	General substrate transporter	0.0107	0.1733	0.1698
Brugia malayi	sodium/hydrogen exchanger 3 family protein	0.0065	0.0937	0.0974
Echinococcus granulosus	lysyl tRNA synthetase	0.0028	0.0235	0.0195
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0064	0.0069
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0064	0.0025
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Trypanosoma brucei	glucose transporter, putative	0.0039	0.044	0.8107
Trypanosoma cruzi	hexose transporter, putative	0.0039	0.044	0.445
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0064	0.0023
Echinococcus granulosus	sex peptide receptor	0.0019	0.0064	0.0023
Brugia malayi	G-protein coupled receptor	0.0019	0.0064	0.0025
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0064	0.0023
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0064	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0064	0.0023
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0787	0.081
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0064	0.0037
Trypanosoma cruzi	sodium/hydrogen exchanger, putative	0.0065	0.0937	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0038	0.0431	0.0391
Schistosoma mansoni	hypothetical protein	0.0018	0.0051	0.0016
Schistosoma mansoni	hypothetical protein	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Plasmodium falciparum	proline--tRNA ligase	0.0044	0.0533	0.051
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0039	0.044	0.8107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Schistosoma mansoni	protein kinase	0.0038	0.0431	0.0638
Brugia malayi	Dopamine receptor	0.0019	0.0064	0.0025
Onchocerca volvulus		0.0019	0.0064	0.0037
Trypanosoma cruzi	Na/H antiporter-like protein, putative	0.0065	0.0937	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0064	0.0023
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0125	0.2063	0.2031
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0051	0.001
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0446	0.044
Toxoplasma gondii	sodium/hydrogen exchanger 3 protein	0.0065	0.0937	0.1419
Trypanosoma cruzi	hexose transporter, putative	0.0021	0.0109	0.0759
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0037	0.0416	0.0784
Brugia malayi	Serotonin receptor	0.0019	0.0064	0.0025
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0064	0.0023
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0018	0.0041	0.0044
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0064	0.0023
Trypanosoma brucei	glucose transporter 2A	0.0039	0.044	0.8107
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.0341	0.6145	0.6129
Trichomonas vaginalis	glucose transporter, putative	0.0039	0.044	0.0834
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0038	0.0431	0.0391
Onchocerca volvulus		0.0019	0.0064	0.0037
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0024	0.0156	0.1285
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0038	0.0431	0.0391
Chlamydia trachomatis	lysine--tRNA ligase	0.0028	0.0235	0.5
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0064	0.0037
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	Slc9a7 protein	0.0065	0.0937	0.1468
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0051	0.0055
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0064	0.0069
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Mycobacterium leprae	probable conserved integral membrane transport protein	0.0065	0.0937	1
Giardia lamblia	Sodium/hydrogen exchanger 3	0.0341	0.6145	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0073	0.1085	0.1174
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Toxoplasma gondii	facilitative glucose transporter GT1	0.0125	0.2063	0.3201
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.2427	0.2626
Brugia malayi	neuropeptide F receptor	0.0019	0.0064	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Plasmodium vivax	CDK-related protein kinase 6, putative	0.053	0.9698	1
Loa Loa (eye worm)	hypothetical protein	0.0341	0.6145	0.6648
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	glucose transport protein	0.0125	0.2063	0.3313
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0355	0.0514
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0064	0.0023
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0355	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0064	0.0023
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0064	0.0069
Echinococcus multilocularis	geminin	0.0205	0.3567	0.354
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0416	0.045
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0202	0.3513	0.5495
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0019	0.0064	0.0037
Echinococcus multilocularis	General substrate transporter	0.0107	0.1733	0.1698
Brugia malayi	sodium/hydrogen exchanger 3 family protein	0.0341	0.6145	0.6633
Loa Loa (eye worm)	sodium/hydrogen exchanger 3 family protein	0.0341	0.6145	0.6648
Brugia malayi	larval opioid receptor	0.0019	0.0064	0.0025
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0064	0.0069
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.0064	0.0037
Schistosoma mansoni	lysyl-tRNA synthetase	0.0028	0.0235	0.0318
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0064	0.0023
Echinococcus granulosus	serotonin receptor	0.0019	0.0064	0.0023
Trypanosoma brucei	glucose transporter 1E	0.0039	0.044	0.8107
Onchocerca volvulus		0.0271	0.4826	0.7839
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0064	0.0023
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0037	0.0416	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0051	0.0011
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0787	0.0851
Schistosoma mansoni	sodium/hydrogen exchanger	0.0341	0.6145	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0064	0.0037
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0125	0.2063	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Brugia malayi	G protein-coupled receptor	0.0019	0.0064	0.0025
Schistosoma mansoni	sodium/hydrogen exchanger 3 (nhe3)	0.0065	0.0937	0.1468
Schistosoma mansoni	myosin xvIII	0.0019	0.0064	0.0037
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0064	0.0037
Echinococcus granulosus	mitochondrial sodium:hydrogen exchanger 9B2	0.0065	0.0937	0.09
Schistosoma mansoni	amine GPCR	0.0019	0.0064	0.0037
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0064	0.0037
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0064	0.0023
Toxoplasma gondii	Na+/H+ exchanger NHE1	0.0065	0.0937	0.1419
Echinococcus multilocularis	sodium:hydrogen exchanger	0.0341	0.6145	0.6129
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0431	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Trichomonas vaginalis	sugar transporter, putative	0.0039	0.044	0.0834
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0064	0.0023
Brugia malayi	neuropeptide F receptor	0.0019	0.0064	0.0025
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0064	0.0023
Echinococcus granulosus	sodium:hydrogen exchanger 2 (nhe2)	0.0276	0.4918	0.4897
Plasmodium falciparum	lysine--tRNA ligase	0.0028	0.0235	0.0201
Brugia malayi	hypothetical protein	0.0019	0.0064	0.0025
Schistosoma mansoni	hypothetical protein	0.0019	0.0064	0.0037
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0064	0.0023
Brugia malayi	Sugar transporter family protein	0.0125	0.2063	0.2198
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.0276	0.4918	0.4897
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0064	0.0069
Plasmodium vivax	proline--tRNA ligase, putative	0.0044	0.0533	0.051
Echinococcus multilocularis	mitochondrial sodium:hydrogen exchanger 9B2	0.0065	0.0937	0.09
Leishmania major	Na/H antiporter-like protein	0.0065	0.0937	1
Plasmodium falciparum	sodium/hydrogen exchanger, Na+, H+ antiporter	0.0065	0.0937	0.0928
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0064	0.0023
Leishmania major	hypothetical protein, conserved	0.0065	0.0937	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0787	0.081
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Schistosoma mansoni	hypothetical protein	0.0018	0.0051	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0041	0.0044
Wolbachia endosymbiont of Brugia malayi	Kef-type K+ transport system, membrane component	0.0065	0.0937	1
Schistosoma mansoni	amine GPCR	0.0019	0.0064	0.0037
Plasmodium falciparum	protein kinase 7	0.0353	0.6359	0.6542
Brugia malayi	MH2 domain containing protein	0.0144	0.2427	0.2593
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0064	0.0023
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0038	0.0431	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0064	0.0037
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0064	0.0037
Onchocerca volvulus		0.0019	0.0064	0.0037
Onchocerca volvulus		0.0019	0.0064	0.0037
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0064	0.0025
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0064	0.0037
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0038	0.0431	0.0404
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0064	0.0023
Trichomonas vaginalis	sugar transporter, putative	0.0039	0.044	0.0834
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0044	0.0533	0.549
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0125	0.2063	0.2031
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0038	0.0431	0.0404
Leishmania major	glucose transporter, lmgt2	0.0039	0.044	0.445
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0069
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0064	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0341	0.6145	0.6648
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0064	0.0023
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0064	0.0023
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.0341	0.6145	0.6129

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.4654 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 56.2341 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1398297

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1295424