Detailed information for compound 1308925

Basic information

Technical information
  • TDR Targets ID: 1308925
  • Name: 3-[4-(2,2-dimethoxyethyl)-5-sulfanylidene-1H- 1,2,4-triazol-3-yl]-N,N-dimethylbenzenesulfon amide
  • MW: 372.463 | Formula: C14H20N4O4S2
  • H donors: 0 H acceptors: 4 LogP: 0.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(Cn1c(S)nnc1c1cccc(c1)S(=O)(=O)N(C)C)OC
  • InChi: 1S/C14H20N4O4S2/c1-17(2)24(19,20)11-7-5-6-10(8-11)13-15-16-14(23)18(13)9-12(21-3)22-4/h5-8,12H,9H2,1-4H3,(H,16,23)
  • InChiKey: XRJMUPRFQUGPSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-(2,2-dimethoxyethyl)-5-thioxo-1H-1,2,4-triazol-3-yl]-N,N-dimethyl-benzenesulfonamide
  • 3-[4-(2,2-dimethoxyethyl)-5-thioxo-1H-1,2,4-triazol-3-yl]-N,N-dimethylbenzenesulfonamide
  • 3-[4-(2,2-dimethoxyethyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]-N,N-dimethyl-benzenesulfonamide
  • ZINC03239380
  • MLS000773971
  • SMR000364788

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0286 0.2641 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0569 0.5723 0.5634
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0323 0.3039 0.3039
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0062 0.0203 0.0203
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0062 0.0203 0.0203
Entamoeba histolytica hypothetical protein 0.0062 0.0203 0.0203
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2263 0.2119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0624 0.6326 0.625
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0832 0.0642
Brugia malayi FAT domain containing protein 0.0141 0.1058 0.1058
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0962 1 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.1661 0.1506
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0062 0.0203 0.0203
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0323 0.3039 0.2895
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0962 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0821 0.8469 0.8437
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0203 0.0203
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0062 0.0203 0.0203
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0062 0.0203 0.0203
Giardia lamblia GTOR 0.0962 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0323 0.3039 0.2895
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0062 0.0203 0.0203
Echinococcus multilocularis 0.0062 0.0203 0.0203
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0062 0.0203 0.0203
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0203 0.0021
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0455 0.448 0.4366
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0203 0.0203
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0765 0.7857 0.7813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5182 0.5082
Loa Loa (eye worm) hypothetical protein 0.012 0.0832 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.7316 0.7261
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0203 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0062 0.0203 0.0203
Loa Loa (eye worm) phosphatidylinositol kinase 0.0062 0.0203 0.0021
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0962 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0182 0.0182
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0203 0.1734 0.2153
Entamoeba histolytica hypothetical protein 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.1508 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0765 0.7857 0.7813
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0182 0.1508 0.1332
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0062 0.0203 0.0203
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0062 0.0203 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5182 0.5082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.3039 0.2895
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0182 0.1508 0.1332
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0062 0.0203 0.0203
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0182 0.1508 0.1508
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0318 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0765 0.7857 0.7813
Toxoplasma gondii FATC domain-containing protein 0.0182 0.1508 0.1835
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0062 0.0203 0.5
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.7316 0.7261
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0962 1 1
Entamoeba histolytica hypothetical protein 0.0182 0.1508 0.1508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5173 0.5074
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0782 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5182 0.5082
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0832 0.0642
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0203 0.5
Plasmodium vivax hypothetical protein 0.0062 0.0203 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0569 0.5723 0.5634
Loa Loa (eye worm) hypothetical protein 0.006 0.0184 0.0002
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0062 0.0203 0.0203
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0766 0.7866 0.7822
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0575 0.5785 0.5698
Echinococcus granulosus serine protein kinase ATM 0.0182 0.1508 0.1508
Schistosoma mansoni hypothetical protein 0.0141 0.1058 0.1058
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0062 0.0203 0.0203
Brugia malayi Pre-SET motif family protein 0.0251 0.2263 0.2263
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0962 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.0021
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0062 0.0203 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0062 0.0203 0.0203
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.1508 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0962 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0062 0.0203 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.3039 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0575 0.5785 0.5698
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.3039 0.3039
Leishmania major phosphatidylinositol 3-kinase, putative 0.0323 0.3039 0.2895
Loa Loa (eye worm) phosphatidylinositol 3 0.0323 0.3039 0.291
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0182 0.1508 0.1508
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0962 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.3039 0.2895
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0062 0.0203 0.0203
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0182 0.1508 0.1508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0765 0.7857 0.7813
Loa Loa (eye worm) hypothetical protein 0.0141 0.1058 0.0892
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0323 0.3039 0.2895
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0062 0.0203 0.0203
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0323 0.3039 0.2895
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0203 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.7316 0.7261
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.7316 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0575 0.5785 0.5698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5182 0.5082
Loa Loa (eye worm) phosphatidylinositol 3 0.0962 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0062 0.0203 0.0203
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0062 0.0203 0.0203
Entamoeba histolytica hypothetical protein 0.0062 0.0203 0.0203
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.1508 0.1508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.7316 0.7261
Schistosoma mansoni hypothetical protein 0.0062 0.0203 0.0203
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0323 0.3039 0.3039
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0062 0.0203 0.0203
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0203 0.0203
Mycobacterium leprae conserved hypothetical protein 0.0062 0.0203 0.5
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.006 0.006
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0141 0.1058 0.1058
Entamoeba histolytica protein kinase rad3, putative 0.0182 0.1508 0.1508
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0524 0.0524
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0962 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0766 0.7866 0.7822
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2641 0.2489
Echinococcus multilocularis Zinc finger, PHD finger 0.0062 0.0203 0.0203
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0062 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0203 0.1734 0.1581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0258 0.2337 0.2178
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0962 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0182 0.1508 0.1332
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0962 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0962 1 1
Echinococcus granulosus jumonji domain containing protein 0.0049 0.006 0.006
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0062 0.0203 0.0203
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0062 0.0203 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0203 0.0021
Toxoplasma gondii target of rapamycin (TOR), putative 0.0715 0.7316 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0645 0.6552 0.6481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.7316 0.7261
Echinococcus multilocularis serine protein kinase ATM 0.0182 0.1508 0.1508
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0182 0.1508 0.1508
Trypanosoma cruzi target of rapamycin kinase 3 0.0766 0.7866 0.7822
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0203 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0203 0.0021
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0782 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182 0.1508 0.1332
Brugia malayi jmjC domain containing protein 0.0115 0.0782 0.0782
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0062 0.0203 0.5
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0062 0.0203 0.5
Loa Loa (eye worm) hypothetical protein 0.0182 0.1508 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0715 0.7316 0.7261
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0182 0.1508 0.1508
Schistosoma mansoni fkbp-rapamycin associated protein 0.0182 0.1508 0.1508
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0323 0.3039 0.3039
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0323 0.3039 0.2895
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.012 0.0832 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0765 0.7857 0.7813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5173 0.5074
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0962 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0519 0.5173 0.5074
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0062 0.0203 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1734 0.1563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.3039 0.2895
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1058 0.0873
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0062 0.0203 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0182 0.0182
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.04 0.3877 0.375
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0962 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0062 0.0203 0.0203
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0062 0.0203 0.5
Entamoeba histolytica hypothetical protein 0.0062 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.3039 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0962 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0062 0.0203 0.0203
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0062 0.0203 0.0203
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0141 0.1058 0.1058
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0062 0.0203 0.0203

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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