Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | solute carrier family 5 (sodium/choline cotransporter), member 7 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0378 | 0.8898 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0877 | 0.0877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0877 | 0.0877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0877 | 0.0877 |
Brugia malayi | Sodium:solute symporter family protein | 0.0046 | 0.0075 | 0.0075 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0046 | 0.0075 | 0.0075 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4283 | 0.4283 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.042 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.6434 | 0.6434 |
Onchocerca volvulus | 0.0182 | 0.3694 | 0.4152 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0877 | 0.0877 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0046 | 0.0075 | 0.0075 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0378 | 0.8898 | 0.5 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.042 | 1 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0046 | 0.0075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0392 | 0.0392 |
Giardia lamblia | Hypothetical protein | 0.0378 | 0.8898 | 0.5 |
Onchocerca volvulus | 0.0378 | 0.8898 | 1 | |
Mycobacterium tuberculosis | Long conserved protein | 0.0378 | 0.8898 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4283 | 0.4283 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0392 | 0.0392 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0378 | 0.8898 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.6434 | 0.6434 |
Echinococcus granulosus | Transglutaminase | 0.0378 | 0.8898 | 0.8898 |
Onchocerca volvulus | 0.0058 | 0.0392 | 0.0441 | |
Brugia malayi | hypothetical protein | 0.0182 | 0.3694 | 0.3694 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.0075 | 0.0075 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0877 | 0.0877 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0378 | 0.8898 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0877 | 0.0877 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0392 | 0.0392 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0378 | 0.8898 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.6227 | 0.6998 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0378 | 0.8898 | 1 |
Schistosoma mansoni | inositol transporter | 0.0046 | 0.0075 | 0.0075 |
Mycobacterium ulcerans | hypothetical protein | 0.0378 | 0.8898 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0378 | 0.8898 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.0075 | 0.0075 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0877 | 0.0877 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0877 | 0.0877 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0378 | 0.8898 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.0046 | 0.0075 | 0.0075 |
Schistosoma mansoni | high-affinity choline transporter | 0.042 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0877 | 0.0877 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0877 | 0.0877 |
Onchocerca volvulus | 0.0046 | 0.0075 | 0.0084 | |
Schistosoma mansoni | inositol transporter | 0.0046 | 0.0075 | 0.0075 |
Brugia malayi | Thioredoxin family protein | 0.0378 | 0.8898 | 0.8898 |
Mycobacterium tuberculosis | Conserved protein | 0.0378 | 0.8898 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.6434 | 0.6434 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0877 | 0.0877 |
Schistosoma mansoni | hypothetical protein | 0.0378 | 0.8898 | 0.8898 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0075 | 0.0075 |
Mycobacterium ulcerans | hypothetical protein | 0.0378 | 0.8898 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0046 | 0.0075 | 0.0075 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0046 | 0.0075 | 0.0075 |
Echinococcus multilocularis | solute carrier family 5 | 0.0046 | 0.0075 | 0.0075 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0877 | 0.0877 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4283 | 0.4283 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | Transglutaminase | 0.0378 | 0.8898 | 0.8898 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.6434 | 0.6434 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0378 | 0.8898 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3694 | 0.3694 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0046 | 0.0075 | 0.0075 |
Echinococcus granulosus | geminin | 0.0205 | 0.4283 | 0.4283 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0877 | 0.0877 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0046 | 0.0075 | 0.0075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 1.584893192 uM | PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 10 point CRC. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 3.835166213 uM | PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488975, AID488997, AID493221, AID493222] | ChEMBL. | No reference |
IC50 (functional) | > 66 uM | PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 66 uM | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.