Detailed information for compound 1317289

Basic information

Technical information
  • TDR Targets ID: 1317289
  • Name: [2-(ethoxycarbonylamino)-2-oxoethyl] naphthal ene-1-carboxylate
  • MW: 301.294 | Formula: C16H15NO5
  • H donors: 1 H acceptors: 3 LogP: 2.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)NC(=O)COC(=O)c1cccc2c1cccc2
  • InChi: 1S/C16H15NO5/c1-2-21-16(20)17-14(18)10-22-15(19)13-9-5-7-11-6-3-4-8-12(11)13/h3-9H,2,10H2,1H3,(H,17,18,20)
  • InChiKey: JQXAHHIVULCVNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(ethoxycarbonylamino)-2-oxo-ethyl] naphthalene-1-carboxylate
  • 1-naphthalenecarboxylic acid [2-(ethoxycarbonylamino)-2-oxoethyl] ester
  • naphthalene-1-carboxylic acid [2-(carbethoxyamino)-2-keto-ethyl] ester
  • MLS001010710
  • SMR000352796
  • T5256213

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0676 0.4046 1
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0363 0.2554
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0018 0.0077
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0067
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0185
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.017 0.002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0187 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.1198
Echinococcus multilocularis GPCR, family 2 0.0015 0.0044 0.0044
Loa Loa (eye worm) beta-lactamase 0.0036 0.017 0.1346
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0363 0.2554
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0039 0.0154
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.02 0.1342
Plasmodium falciparum peptide deformylase 0.0676 0.4046 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0254 0.1062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0254 0.2053
Brugia malayi RNA binding protein 0.0076 0.0414 0.3405
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0353 0.0473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0057 0.0288
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0638
Schistosoma mansoni chromobox protein 0.0068 0.0363 0.1518
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0036 0.0133
Schistosoma mansoni hypothetical protein 0.0166 0.0956 0.3993
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.017 0.002
Loa Loa (eye worm) hypothetical protein 0.0149 0.0853 0.71
Echinococcus multilocularis chromobox protein 1 0.0068 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0049 0.0246 0.1984
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.0185
Schistosoma mansoni inositol monophosphatase 0.0039 0.0187 0.0782
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0067
Plasmodium vivax SET domain protein, putative 0.003 0.0133 0.0284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0057 0.0288
Onchocerca volvulus 0.0041 0.02 0.1347
Mycobacterium tuberculosis Conserved protein 0.0036 0.017 0.002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0187 0.0419
Schistosoma mansoni hypothetical protein 0.0166 0.0956 0.3993
Brugia malayi hypothetical protein 0.0036 0.017 0.135
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.017 0.1125
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.017 0.002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0353 0.0353
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0057 0.0288
Echinococcus granulosus chromobox protein 1 0.0068 0.0363 0.1518
Schistosoma mansoni hypothetical protein 0.0403 0.2393 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.017 0.1346
Onchocerca volvulus 0.0234 0.1369 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.0044
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0185
Brugia malayi chromobox protein homolog 3 0.0038 0.0182 0.1451
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0555
Onchocerca volvulus 0.0011 0.0018 0.000000055278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0555
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0018 0.0072
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0676 0.4046 1
Echinococcus multilocularis geminin 0.0166 0.0956 0.0956
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0414 0.3405
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.1446
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0414 0.173
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0414 0.173
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0133 0.0133
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Echinococcus multilocularis cpg binding protein 0.003 0.0132 0.0132
Loa Loa (eye worm) helicase 0.0011 0.0018 0.0067
Schistosoma mansoni cpg binding protein 0.0028 0.0122 0.0511
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0126
Brugia malayi hypothetical protein 0.0149 0.0853 0.7102
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0246 0.1989
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0044 0.0284
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0258 0.1513 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0353 0.1364
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1353 0.3065
Schistosoma mansoni chromobox protein 0.0011 0.0018 0.0077
Brugia malayi beta-lactamase family protein 0.0036 0.017 0.1351
Mycobacterium ulcerans peptide deformylase 0.0676 0.4046 1
Brugia malayi Pre-SET motif family protein 0.003 0.0133 0.1036
Echinococcus granulosus tar DNA binding protein 0.0076 0.0414 0.173
Plasmodium vivax hypothetical protein, conserved 0.0036 0.017 0.0377
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0028 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0555
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.017 0.1351
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0115 0.0712
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.1346
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.1031
Toxoplasma gondii ABC1 family protein 0.0036 0.017 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0182 0.1212
Chlamydia trachomatis peptide deformylase 0.0676 0.4046 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0254 0.2057
Echinococcus granulosus Chromobox protein 3 0.0011 0.0018 0.0077
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0187 0.125
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0187 0.125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0254 0.1062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0254 0.1062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0057 0.0288
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.017 0.0711
Loa Loa (eye worm) RNA binding protein 0.0076 0.0414 0.3401
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0414 0.0414
Treponema pallidum polypeptide deformylase (def) 0.0676 0.4046 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0321 0.1342
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0676 0.4046 1
Plasmodium vivax peptide deformylase, putative 0.0676 0.4046 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0133 0.0555
Schistosoma mansoni chromobox protein 0.0068 0.0363 0.1518
Brugia malayi beta-lactamase 0.0036 0.017 0.1351
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0018 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.017 0.1125
Mycobacterium leprae Probable lipase LipE 0.0036 0.017 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0254 0.1062
Schistosoma mansoni inositol monophosphatase 0.0039 0.0187 0.0782
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.017 0.1125
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.1346
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0284
Trypanosoma cruzi Peptide deformylase 2, putative 0.0258 0.1513 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0182 0.1212
Echinococcus granulosus cpg binding protein 0.003 0.0132 0.0552
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0067
Echinococcus granulosus Chromo domain 0.0011 0.0018 0.0077
Brugia malayi hypothetical protein 0.0011 0.0018 0.0072
Brugia malayi SET domain containing protein 0.0013 0.0029 0.0159
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0414 0.3401
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0246 0.1989
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0258 0.1513 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0414 0.173
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0353 0.0832
Entamoeba histolytica hypothetical protein 0.0036 0.017 0.8988
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.017 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0067
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0018 0.0072
Trypanosoma brucei Polypeptide deformylase 1 0.0258 0.1513 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.017 0.0711
Echinococcus multilocularis chromobox protein 1 0.0068 0.0363 0.0363
Brugia malayi Heterochromatin protein 1 0.0068 0.0363 0.2977
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.017 0.0711
Onchocerca volvulus 0.0149 0.0853 0.6181
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0187 0.0782
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.1346
Brugia malayi Pre-SET motif family protein 0.0206 0.1197 1
Brugia malayi Inositol-1 0.0039 0.0187 0.1494
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0254 0.0254
Entamoeba histolytica hypothetical protein 0.0036 0.017 0.8988
Trichomonas vaginalis chromobox protein, putative 0.0041 0.02 0.1342
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0028 0.0118
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0133 0.0284
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0028 0.0028
Trypanosoma brucei Peptide deformylase 2 0.0258 0.1513 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0044 0.029
Onchocerca volvulus 0.0036 0.017 0.1125
Brugia malayi beta-lactamase family protein 0.0036 0.017 0.1351
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.017 0.1125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0126
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.017 0.002
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0185
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.017 0.017
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0187 0.0187
Echinococcus granulosus dnaJ subfamily B 0.0403 0.2393 1
Schistosoma mansoni hypothetical protein 0.0036 0.017 0.0711
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0057 0.0288
Loa Loa (eye worm) hypothetical protein 0.003 0.0132 0.1025
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.017 0.002
Schistosoma mansoni chromobox protein 0.0011 0.0018 0.0077
Brugia malayi TAR-binding protein 0.0076 0.0414 0.3405
Trichomonas vaginalis chromobox protein, putative 0.0041 0.02 0.1342
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0153 0.1203
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0028 0.0149
Brugia malayi Protein cec-1. 0.0011 0.0018 0.0072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0057 0.0288
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0353 0.1477
Loa Loa (eye worm) inositol-1 0.0039 0.0187 0.1489
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0044 0.029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.017 0.0711
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0126
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.0044
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0363 0.2973
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.017 0.002
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0018 0.0077
Onchocerca volvulus 0.0036 0.017 0.1125
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.017 0.1125
Mycobacterium tuberculosis Conserved protein 0.0036 0.017 0.002
Onchocerca volvulus 0.0028 0.0122 0.077
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.1346
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.017 0.017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0123 0.0512
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0414 0.3401
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0067
Echinococcus granulosus GPCR family 2 0.0015 0.0044 0.0185
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1369 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0282 0.0655
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0414 0.173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0246 0.1984
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.2393 0.2393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0254 0.1062
Mycobacterium tuberculosis Conserved protein 0.0036 0.017 0.002
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0187 0.125
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0057 0.0288
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0182 0.1212
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0018 0.0018
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0057 0.0288
Echinococcus granulosus chromobox protein 2 0.0011 0.0018 0.0077
Toxoplasma gondii hypothetical protein 0.0676 0.4046 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.017 0.0711
Trypanosoma cruzi Peptide deformylase 2, putative 0.0258 0.1513 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0353 0.0492
Mycobacterium leprae conserved hypothetical protein 0.0036 0.017 0.002
Schistosoma mansoni cpg binding protein 0.003 0.0132 0.0552
Echinococcus granulosus geminin 0.0166 0.0956 0.3993
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0353 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0115 0.0712
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.0044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0039 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0414 0.173
Leishmania major polypeptide deformylase-like protein, putative 0.0258 0.1513 1
Echinococcus multilocularis chromobox protein 2 0.0011 0.0018 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0353 0.0473
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.1346
Entamoeba histolytica hypothetical protein 0.0036 0.017 0.8988
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0254 0.0254
Echinococcus multilocularis Chromo domain 0.0011 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0077
Trichomonas vaginalis esterase, putative 0.0036 0.017 0.1125
Brugia malayi CXXC zinc finger family protein 0.0028 0.0122 0.0948
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0353 0.1477
Loa Loa (eye worm) hypothetical protein 0.0036 0.017 0.1346
Onchocerca volvulus 0.003 0.0132 0.0842
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0353 0.1477
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0018 0.0077
Brugia malayi CHD4 protein 0.0013 0.0028 0.0155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1197 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.02 0.0837
Onchocerca volvulus 0.0036 0.017 0.1125
Schistosoma mansoni cpg binding protein 0.003 0.0132 0.0552
Echinococcus granulosus chromobox protein 1 0.0068 0.0363 0.1518
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0122 0.0943
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0018 0.0077
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0018 0.0072
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0036 0.017 0.8988

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 37.6505 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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