Detailed information for compound 1320940

Basic information

Technical information
  • TDR Targets ID: 1320940
  • Name: 3-[3-(thiophen-2-ylmethyl)imidazo[5,4-b]pyrid in-2-yl]-N-(3,4,5-trimethoxyphenyl)propanamid e
  • MW: 452.526 | Formula: C23H24N4O4S
  • H donors: 1 H acceptors: 3 LogP: 3.03 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(NC(=O)CCc2nc3c(n2Cc2cccs2)nccc3)cc(c1OC)OC
  • InChi: 1S/C23H24N4O4S/c1-29-18-12-15(13-19(30-2)22(18)31-3)25-21(28)9-8-20-26-17-7-4-10-24-23(17)27(20)14-16-6-5-11-32-16/h4-7,10-13H,8-9,14H2,1-3H3,(H,25,28)
  • InChiKey: JBZCAHGGAZOCRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[3-(2-thienylmethyl)imidazo[5,4-b]pyridin-2-yl]-N-(3,4,5-trimethoxyphenyl)propanamide
  • 3-[3-(2-thienylmethyl)-2-imidazo[5,4-b]pyridinyl]-N-(3,4,5-trimethoxyphenyl)propanamide
  • 3-[3-(2-thienylmethyl)imidazo[5,4-b]pyridin-2-yl]-N-(3,4,5-trimethoxyphenyl)propionamide
  • C614-6403
  • NCGC00111075-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis integrin alpha ps 0.0069 0.0342 0.0339
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0868 0.1683
Schistosoma mansoni hypothetical protein 0.0036 0.0141 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.035 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0768 0.1484
Loa Loa (eye worm) integrin alpha pat-2 0.0237 0.1376 0.326
Echinococcus multilocularis integrin alpha ps 0.0069 0.0342 0.0339
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.005
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.035 0.0803
Loa Loa (eye worm) hypothetical protein 0.0053 0.0245 0.058
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0567
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.035 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.1833 1
Schistosoma mansoni lamin 0.0029 0.0095 0.0146
Brugia malayi hypothetical protein 0.0035 0.0135 0.0291
Brugia malayi Histone deacetylase 1 0.0041 0.0171 0.0377
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0072 0.1233
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0081
Echinococcus multilocularis musashi 0.0029 0.0095 0.0091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0065 0.0321 0.076
Echinococcus granulosus intermediate filament protein 0.0029 0.0095 0.0137
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0171 0.0768
Brugia malayi hypothetical protein 0.0025 0.0072 0.0141
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0492
Loa Loa (eye worm) hypothetical protein 0.0033 0.0123 0.0291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0021 0.005
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0072 0.1233
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0072 0.2382
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0033 0.0064
Brugia malayi histone deacetylase 3 (HD3) 0.0041 0.0171 0.0377
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.035 1
Leishmania major hypothetical protein, conserved 0.0025 0.0072 0.1233
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0034 0.0065
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0033 0.0078
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0567
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0768 0.1795
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.1833 1
Echinococcus multilocularis histone deacetylase 1 0.0041 0.0171 0.0168
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0567
Brugia malayi MH2 domain containing protein 0.0144 0.0806 0.1886
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0168 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0306 0.0567
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0034 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0095 0.0224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0768 0.0765
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0144
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0217
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0329
Brugia malayi Integrin alpha pat-2 precursor 0.0154 0.0864 0.2023
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0135 0.0226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0245 0.058
Echinococcus granulosus integrin alpha 3 0.0118 0.0643 0.0955
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Echinococcus multilocularis geminin 0.0514 0.3087 0.3085
Brugia malayi TAR-binding protein 0.0063 0.0306 0.0698
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0117 0.064 0.1518
Onchocerca volvulus 0.0065 0.0321 0.0597
Onchocerca volvulus 0.0029 0.0095 0.0051
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.0853 1
Loa Loa (eye worm) histone deacetylase 1 0.0041 0.0171 0.0406
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0174 0.0783
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0171 0.4353
Loa Loa (eye worm) hypothetical protein 0.028 0.1641 0.3888
Brugia malayi hypothetical protein 0.0016 0.0017 0.0012
Schistosoma mansoni hypothetical protein 0.0035 0.0135 0.0226
Brugia malayi hypothetical protein 0.0105 0.0566 0.1314
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0171 0.0768
Toxoplasma gondii histone deacetylase HDAC2 0.0041 0.0171 0.8414
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0135 0.0197
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0073 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0768 0.1142
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0033 0.5
Brugia malayi ephrin receptor 1 precursor 0.0032 0.0112 0.0237
Echinococcus granulosus Solute carrier family 22 5 0.1101 0.6701 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0066 0.0325 0.0481
Leishmania major histone deacetylase, putative 0.0041 0.0171 0.4353
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0492
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0073 0.0492
Echinococcus granulosus histone deacetylase 1 0.0041 0.0171 0.0251
Echinococcus granulosus geminin 0.0514 0.3087 0.4604
Echinococcus granulosus histone deacetylase 3 0.0041 0.0171 0.0251
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0171 0.4353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0768 0.1142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0081
Loa Loa (eye worm) hypothetical protein 0.0698 0.422 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0081
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5051 0.7537
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0034 0.5
Schistosoma mansoni hypothetical protein 0.0514 0.3087 0.6095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0121 0.0287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0768 0.1484
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0073 0.0552
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0306 0.0567
Schistosoma mansoni integrin alpha 0.0154 0.0864 0.1675
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0806 0.191
Entamoeba histolytica histone deacetylase, putative 0.0041 0.0171 0.0768
Leishmania major histone deacetylase, putative 0.0041 0.0171 0.4353
Loa Loa (eye worm) hypothetical protein 0.0085 0.044 0.1042
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0034 0.0077
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0197 0.0913
Treponema pallidum fructose-bisphosphate aldolase 0.0311 0.1833 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.035 1
Echinococcus multilocularis histone deacetylase 3 0.0041 0.0171 0.0168
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0013 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.127
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0171 0.0768
Giardia lamblia Fructose-bisphosphate aldolase 0.0311 0.1833 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0174
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0073 0.0492
Schistosoma mansoni intermediate filament proteins 0.0029 0.0095 0.0146
Schistosoma mansoni integrin alpha-ps 0.0036 0.0139 0.0233
Onchocerca volvulus Phospholipase A2 homolog 0.028 0.1641 0.378
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0168 0.0165
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0174
Loa Loa (eye worm) hypothetical protein 0.0121 0.066 0.1565
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.0841 0.1251
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0335
Loa Loa (eye worm) TK/EPH protein kinase 0.0084 0.0436 0.1032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.0853 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5051 0.5049
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0073 0.0224
Loa Loa (eye worm) acetyltransferase 0.0154 0.0868 0.2056
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0245 0.0551
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0095 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0224
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0072 0.1233
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0034 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0306 0.0567
Loa Loa (eye worm) RNA binding protein 0.0063 0.0306 0.0726
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0081
Onchocerca volvulus Phospholipase A2 homolog 0.0698 0.422 1
Loa Loa (eye worm) histone deacetylase 3 0.0041 0.0171 0.0406
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0072 0.2776
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0072 0.2776
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0174
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0197 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0245 0.0551
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0073 0.0224
Plasmodium vivax histone deacetylase 1, putative 0.0041 0.0171 0.8414
Echinococcus multilocularis integrin alpha ps 0.0033 0.0121 0.0118
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.035 0.0655
Schistosoma mansoni hypothetical protein 0.0033 0.0121 0.0199
Echinococcus granulosus lamin 0.0029 0.0095 0.0137
Echinococcus granulosus lamin dm0 0.0029 0.0095 0.0137
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0868 0.2032
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0095 0.0224
Schistosoma mansoni histone deacetylase 0.0041 0.0171 0.0298
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0135 0.0132
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0306 0.0726
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0306 0.0726
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0171 0.0768
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0868 0.0865
Schistosoma mansoni hypothetical protein 0.0514 0.3087 0.6095
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0116 0.0633 0.1475
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0141 0.0306
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0768 0.0765
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.0023
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.035 0.0831
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0197 0.0913
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.035 0.0519
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0306 0.0567
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0171 0.0768
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0144
Brugia malayi Phospholipase A2 family protein 0.0698 0.422 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0306 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0768 0.1484
Echinococcus granulosus tar DNA binding protein 0.0063 0.0306 0.0452
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0021 0.0021
Echinococcus multilocularis lamin 0.0029 0.0095 0.0091
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0033 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0306 0.0567
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0073 0.0492
Entamoeba histolytica hypothetical protein 0.0035 0.0135 0.0567
Onchocerca volvulus 0.0029 0.0095 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Echinococcus granulosus GPCR family 2 0.0017 0.0021 0.0027
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0171 0.0768
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0117 0.064 0.0637
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.035 0.0347
Schistosoma mansoni ephrin receptor 0.0066 0.0325 0.0604
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066 0.0325 0.0322
Echinococcus granulosus leukotriene A 4 hydrolase 0.0117 0.064 0.0952
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.0853 1
Schistosoma mansoni histone deacetylase 0.0041 0.0171 0.0298
Echinococcus multilocularis integrin alpha 3 0.0118 0.0643 0.064
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5051 1
Brugia malayi RNA binding protein 0.0063 0.0306 0.0698
Trypanosoma brucei histone deacetylase 1 0.0041 0.0171 0.4353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0806 0.191
Schistosoma mansoni integrin alpha-ps 0.0069 0.0342 0.0637
Echinococcus granulosus integrin alpha ps 0.0069 0.0342 0.0506
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0197 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0073 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0073 0.0492
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0033 0.0048
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0171 0.0768
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0171 0.0768
Toxoplasma gondii histone deacetylase HDAC3 0.0041 0.0171 0.8414
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0174 1
Brugia malayi histone deacetylase 1 (HD1) 0.0041 0.0171 0.0377
Giardia lamblia Histone deacetylase 0.0041 0.0171 0.0768
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0174 0.0783
Echinococcus multilocularis lamin dm0 0.0029 0.0095 0.0091
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0072 0.2382
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0073 0.0552
Brugia malayi intermediate filament protein 0.0029 0.0095 0.0195
Schistosoma mansoni lamin 0.0029 0.0095 0.0146
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0306 0.0698
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.035 0.1764
Mycobacterium ulcerans hypothetical protein 0.0025 0.0073 0.0492
Loa Loa (eye worm) hypothetical protein 0.0116 0.0633 0.1501
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0117 0.064 0.1231
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0073 0.127
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0406
Echinococcus granulosus integrin alpha ps 0.0033 0.0121 0.0176
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0171 0.0768
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0073 0.0492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0018
Echinococcus multilocularis GPCR, family 2 0.0017 0.0021 0.0018
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0197 0.029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0768 0.182
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.1833 1
Plasmodium falciparum histone deacetylase 1 0.0041 0.0171 0.9802

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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