Detailed information for compound 1323985

Basic information

Technical information
  • TDR Targets ID: 1323985
  • Name: 6-chloro-7-[3-oxo-3-(4-phenylpiperazin-1-yl)p ropyl]sulfonyl-4H-1,4-benzoxazin-3-one
  • MW: 463.934 | Formula: C21H22ClN3O5S
  • H donors: 1 H acceptors: 4 LogP: 1.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1COc2c(N1)cc(c(c2)S(=O)(=O)CCC(=O)N1CCN(CC1)c1ccccc1)Cl
  • InChi: 1S/C21H22ClN3O5S/c22-16-12-17-18(30-14-20(26)23-17)13-19(16)31(28,29)11-6-21(27)25-9-7-24(8-10-25)15-4-2-1-3-5-15/h1-5,12-13H,6-11,14H2,(H,23,26)
  • InChiKey: MYSRABLWBDDEDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-chloro-7-[3-oxo-3-(4-phenyl-1-piperazinyl)propyl]sulfonyl-4H-1,4-benzoxazin-3-one
  • 6-chloro-7-[3-keto-3-(4-phenylpiperazin-1-yl)propyl]sulfonyl-4H-1,4-benzoxazin-3-one
  • E511-0573
  • NCGC00121918-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0111 0.0991 0.1544
Brugia malayi nuclear receptor NHR-67 0.0053 0.0257 0.0391
Loa Loa (eye worm) hypothetical protein 0.0111 0.0991 0.1554
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0346 0.3922 0.3918
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0111 0.0991 0.1544
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Loa Loa (eye worm) hypothetical protein 0.0269 0.2963 0.4648
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0543 0.6375 0.6373
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.0257 0.0249
Brugia malayi photoreceptor-specific nuclear receptor 0.0111 0.0991 0.1544
Loa Loa (eye worm) hypothetical protein 0.006 0.0346 0.0543
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0053 0.0257 0.0249
Loa Loa (eye worm) acetyltransferase 0.0148 0.1449 0.2273
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0111 0.0991 0.0984
Onchocerca volvulus 0.006 0.0346 0.1146
Brugia malayi nuclear hormone receptor 0.0111 0.0991 0.1544
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0007 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0257 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0111 0.0991 0.1544
Schistosoma mansoni nuclear receptor 0.0053 0.0257 0.0249
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0326 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.019 0.1969 0.2716
Brugia malayi hypothetical protein 0.0059 0.0335 0.0515
Schistosoma mansoni pyruvate dehydrogenase 0.0513 0.5999 0.5996
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0111 0.0991 0.0984
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0111 0.0991 0.0984
Echinococcus multilocularis ecdysone induced protein 78C 0.0111 0.0991 0.0984
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.0257 0.0403
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.0257 0.0249
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Brugia malayi MAP kinase sur-1 0.0058 0.0326 0.0501
Brugia malayi nuclear receptor NHR-88 0.0053 0.0257 0.0391
Brugia malayi nuclear receptor NHR-88 0.0111 0.0991 0.1544
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.0257 0.0249
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Loa Loa (eye worm) hypothetical protein 0.0033 0.0007 0.0012
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0543 0.6375 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Brugia malayi conserved hypotetical protein 0.0053 0.0257 0.0391
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0111 0.0991 0.0984
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0111 0.0991 0.1544
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.0257 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0263 0.2888 0.2883
Schistosoma mansoni pyruvate dehydrogenase 0.0513 0.5999 0.5996
Brugia malayi tailless protein 0.0053 0.0257 0.0391
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0326 0.0825
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0053 0.0257 0.0843
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0326 0.0512
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0326 1
Loa Loa (eye worm) hypothetical protein 0.0543 0.6375 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.0257 0.0391
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.1397 0.1391
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0053 0.0257 0.0843
Leishmania major developmentally regulated phosphoprotein-like protein 0.0543 0.6375 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0346 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0111 0.0991 0.1544
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0111 0.0991 0.0984
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0326 0.0319
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1449 0.1443
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0111 0.0991 0.0984
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0387 0.038
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0059 0.0335 0.0328
Brugia malayi ecdysteroid receptor 0.0269 0.2963 0.4642
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0111 0.0991 0.0984
Schistosoma mansoni steroid hormone receptor ad4bp 0.0111 0.0991 0.0984
Echinococcus multilocularis tumor protein p63 0.0408 0.4693 0.4689
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0257 0.0249
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0111 0.0991 0.0984
Echinococcus multilocularis thyroid hormone receptor alpha 0.0263 0.2888 0.2883
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Brugia malayi hypothetical protein 0.0053 0.0257 0.0391
Brugia malayi Steroid receptor seven-up type 2 0.0111 0.0991 0.1544
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0111 0.0991 0.0984
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.0257 0.0249
Brugia malayi nuclear hormone receptor 0.0053 0.0257 0.0391
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1449 0.2264
Onchocerca volvulus Bile acid receptor homolog 0.0269 0.2963 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0059 0.0335 0.0328
Onchocerca volvulus 0.0053 0.0257 0.0843
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Echinococcus granulosus geminin 0.0173 0.1762 0.1756
Loa Loa (eye worm) hypothetical protein 0.0059 0.0335 0.0526
Loa Loa (eye worm) hypothetical protein 0.0111 0.0991 0.1554
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0257 0.0249
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.019 0.1969 0.2716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0111 0.0991 0.1554
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0111 0.0991 0.1544
Loa Loa (eye worm) hypothetical protein 0.0111 0.0991 0.1554
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0326 0.0319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0111 0.0991 0.0984
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0111 0.0991 0.1544
Schistosoma mansoni nuclear receptor 0.0053 0.0257 0.0249
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0257 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0111 0.0991 0.1544
Onchocerca volvulus 0.0111 0.0991 0.3327
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0111 0.0991 0.0984
Brugia malayi hypothetical protein 0.0059 0.0335 0.0515
Schistosoma mansoni RAR-like nuclear receptor 0.0111 0.0991 0.0984
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0111 0.0991 0.1554
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Loa Loa (eye worm) hypothetical protein 0.0059 0.0335 0.0526
Echinococcus multilocularis geminin 0.0173 0.1762 0.1756
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0326 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0111 0.0991 0.1554
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0326 0.0319
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0346 0.3922 0.6152
Schistosoma mansoni pyruvate dehydrogenase 0.0543 0.6375 0.6373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0111 0.0991 0.1554
Brugia malayi nuclear receptor RXR 0.0059 0.0335 0.0515
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0326 1
Echinococcus granulosus FTZ F1 alpha 0.0111 0.0991 0.0984
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0543 0.6375 0.6373
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0099 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0111 0.0991 0.1554
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0257 0.0249
Trypanosoma brucei developmentally regulated phosphoprotein 0.0543 0.6375 1
Schistosoma mansoni coup transcription factor 0.0111 0.0991 0.0984
Schistosoma mansoni zinc finger protein 0.0053 0.0257 0.0249
Loa Loa (eye worm) steroid hormone receptor 0.0111 0.0991 0.1554
Schistosoma mansoni nuclear hormone receptor 0.0111 0.0991 0.0984
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0111 0.0991 0.0984
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0257 0.0391
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1449 0.1443
Schistosoma mansoni hypothetical protein 0.0152 0.1498 0.1492
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0111 0.0991 0.1544
Schistosoma mansoni thyroid hormone receptor 0.0263 0.2888 0.2883
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.0257 0.0249
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.0257 0.0391
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0111 0.0991 0.0984
Brugia malayi steroid hormone receptor 0.0111 0.0991 0.1544
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0326 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0257 0.0249
Loa Loa (eye worm) hypothetical protein 0.0111 0.0991 0.1554
Schistosoma mansoni retinoic acid receptor RXR 0.0111 0.0991 0.0984
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0111 0.0991 0.0984
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0111 0.0991 0.1554
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0346 0.3922 0.3918
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0543 0.6375 0.6373
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0387 0.038
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.019 0.1969 0.2716
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Loa Loa (eye worm) hypothetical protein 0.0111 0.0991 0.1554
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0059 0.0335 0.0328
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.022 0.2346 1
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0335 0.0515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0111 0.0991 0.0984
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0059 0.0335 0.0526
Loa Loa (eye worm) DR-78 0.0053 0.0257 0.0403
Brugia malayi ecdysone receptor 0.0053 0.0257 0.0391
Loa Loa (eye worm) hypothetical protein 0.0059 0.0335 0.0526
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0346 0.3922 0.6148
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0059 0.0335 0.0328
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0099 0.5
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0326 0.0319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0257 0.0249
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0111 0.0991 0.3327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0111 0.0991 0.0984
Brugia malayi Nuclear hormone receptor-like 1 0.0111 0.0991 0.1544
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0111 0.0991 0.1544
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0403
Echinococcus multilocularis FTZ F1 alpha 0.0111 0.0991 0.0984
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.0257 0.0391
Schistosoma mansoni hypothetical protein 0.0173 0.1762 0.1756
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0335 0.0515
Loa Loa (eye worm) hypothetical protein 0.0059 0.0335 0.0526
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.0257 0.0403
Brugia malayi kinase, mitochondrial precursor 0.0543 0.6375 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.0257 0.0249
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0111 0.0991 0.0984
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0111 0.0991 0.0984
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0111 0.0991 0.1544
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.0257 0.0403
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0007 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0111 0.0991 0.3327
Loa Loa (eye worm) hypothetical protein 0.0059 0.0335 0.0526
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0145 0.0137
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0346 0.3922 0.3918
Loa Loa (eye worm) hypothetical protein 0.0111 0.0991 0.1554
Schistosoma mansoni hypothetical protein 0.0173 0.1762 0.1756
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0111 0.0991 0.1544
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.0257 0.0391
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1498 0.1492
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.019 0.1969 0.8288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0111 0.0991 0.1554
Loa Loa (eye worm) hypothetical protein 0.0111 0.0991 0.1554
Echinococcus granulosus tumor protein p63 0.0408 0.4693 0.4689
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0111 0.0991 0.0984
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0326 1
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0257 0.0391
Onchocerca volvulus 0.0053 0.0257 0.0843
Brugia malayi hypothetical protein 0.0053 0.0257 0.0391
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1498 0.1492
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.0257 0.0249
Schistosoma mansoni lipoxygenase 0.0063 0.0387 0.038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0257 0.0249
Echinococcus granulosus ecdysone induced protein 78C 0.0111 0.0991 0.0984
Brugia malayi nuclear receptor RXR 0.0053 0.0257 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0111 0.0991 0.1544

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0032 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.2239 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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