Detailed information for compound 1329296

Basic information

Technical information
  • TDR Targets ID: 1329296
  • Name: N,N,2-trimethyl-4-nitroaniline
  • MW: 180.204 | Formula: C9H12N2O2
  • H donors: 0 H acceptors: 2 LogP: 2.24 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1C)[N+](=O)[O-])C
  • InChi: 1S/C9H12N2O2/c1-7-6-8(11(12)13)4-5-9(7)10(2)3/h4-6H,1-3H3
  • InChiKey: WQMWMGANNDSYBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N,2-trimethyl-4-nitro-aniline
  • dimethyl-(2-methyl-4-nitro-phenyl)amine
  • 32417-74-6
  • AE-562/12222770
  • Benzenamine, N,N,2-trimethyl-4-nitro-
  • ZINC04115616
  • Oprea1_832311
  • MLS000702173
  • SMR000224805
  • Benzenamine,N,N,2-trimethyl-4-nitro-
  • NSC227943

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0304 0.0785 0.1762
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0068 0.0153
Brugia malayi Probable ClpP-like protease 0.009 0.0219 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0121 0.0121
Entamoeba histolytica hypothetical protein 0.0053 0.0121 0.0121
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0219 1
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0018
Schistosoma mansoni tar DNA-binding protein 0.034 0.0881 0.1978
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0053 0.0121 0.3729
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.169 0.4454 0.4453
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0037 0.0037
Brugia malayi TAR-binding protein 0.034 0.0881 0.0881
Schistosoma mansoni tar DNA-binding protein 0.034 0.0881 0.1978
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0008 0.0018
Echinococcus granulosus peptidase Clp S14 family 0.0059 0.0137 0.0307
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.169 0.4454 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0121 0.0121
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.169 0.4454 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0024 0.0053
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0068 0.0153
Loa Loa (eye worm) Smad1 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0062 0.0062
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.009 0.0219 0.0491
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0024 0.0053
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.3785 1 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.3785 1 1
Echinococcus granulosus tar DNA binding protein 0.034 0.0881 0.1978
Onchocerca volvulus 0.002 0.0034 0.0034
Schistosoma mansoni cpg binding protein 0.0021 0.0037 0.0084
Loa Loa (eye worm) hypothetical protein 0.0207 0.053 0.053
Brugia malayi MH2 domain containing protein 0.0236 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0008
Schistosoma mansoni glutaminase 0.0286 0.0738 0.1656
Echinococcus multilocularis lamin dm0 0.002 0.0034 0.0076
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0219 0.0474
Loa Loa (eye worm) hypothetical protein 0.0398 0.1034 0.1034
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0863 0.2265 0.5086
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.3785 1 1
Echinococcus multilocularis Smad4 0.0016 0.0024 0.0053
Trichomonas vaginalis glutaminase, putative 0.0286 0.0738 0.0738
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0053 0.0121 0.0136
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0219 0.0099
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0053 0.0121 0.0271
Plasmodium vivax replication factor C subunit 1, putative 0.0053 0.0121 0.0136
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0219 1
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0304 0.0785 0.1762
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0863 0.2265 0.5086
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0034 0.0034
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.3785 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.034 0.0881 0.1978
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0863 0.2265 0.5018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.009 0.0219 1
Brugia malayi MH1 domain containing protein 0.0016 0.0024 0.0024
Echinococcus granulosus lamin dm0 0.002 0.0034 0.0076
Brugia malayi MH2 domain containing protein 0.0016 0.0024 0.0024
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0219 0.0358
Schistosoma mansoni DNA ligase IV 0.0053 0.0121 0.0272
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.169 0.4454 0.4453
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0024 0.0053
Schistosoma mansoni hypothetical protein 0.0184 0.0468 0.1051
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.3785 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0582 0.1521 0.1521
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0008 0.0018
Schistosoma mansoni dishevelled 0.001 0.0008 0.0018
Echinococcus multilocularis musashi 0.002 0.0034 0.0076
Brugia malayi hypothetical protein 0.001 0.0008 0.0008
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0005
Loa Loa (eye worm) intermediate filament protein 0.002 0.0034 0.0034
Echinococcus multilocularis peptidase Clp (S14 family) 0.0059 0.0137 0.0307
Trypanosoma cruzi FHA domain containing protein, putative 0.0053 0.0121 0.0271
Brugia malayi MH2 domain containing protein 0.0016 0.0024 0.0024
Schistosoma mansoni topbp1 0.0053 0.0121 0.0272
Schistosoma mansoni smad1 5 8 and 0.0016 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0008
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0008 0.0008
Schistosoma mansoni topbp1 0.0053 0.0121 0.0272
Echinococcus granulosus intermediate filament protein 0.002 0.0034 0.0076
Onchocerca volvulus 0.0053 0.0121 0.0121
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0008 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0018
Brugia malayi ubiquitin conjugating enzyme protein 13 0.169 0.4454 0.4454
Brugia malayi hypothetical protein 0.0053 0.0121 0.0121
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.009 0.0219 1
Schistosoma mansoni tar DNA-binding protein 0.034 0.0881 0.1978
Brugia malayi Smad1 0.0016 0.0024 0.0024
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0068 0.0015
Schistosoma mansoni smad1 5 8 and 0.0016 0.0024 0.0053
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.3785 1 1
Echinococcus multilocularis tar DNA binding protein 0.034 0.0881 0.1978
Echinococcus granulosus cpg binding protein 0.0023 0.0041 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0034
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0053 0.0121 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0121 0.0121
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0184 0.0468 0.1051
Echinococcus multilocularis nibrin 0.0053 0.0121 0.0272
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.169 0.4454 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0059 0.0137 0.4744
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0863 0.2265 0.5086
Schistosoma mansoni cpg binding protein 0.0023 0.0041 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0062 0.0138
Plasmodium falciparum replication factor C subunit 1, putative 0.0053 0.0121 0.0136
Echinococcus multilocularis cpg binding protein 0.0023 0.0041 0.0091
Schistosoma mansoni smad1 5 8 and 0.0016 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0582 0.1521 0.1521
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.0009 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0184 0.0468 0.0468
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0068 0.0153
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0034 0.0034
Toxoplasma gondii hypothetical protein 0.0031 0.0063 0.0124
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0219 0.0358
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.169 0.4454 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.3785 1 1
Echinococcus multilocularis GPCR, family 2 0.0184 0.0468 0.1051
Loa Loa (eye worm) hypothetical protein 0.009 0.0219 0.0219
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.009 0.0219 0.0099
Echinococcus granulosus replication factor c subunit 1 0.0053 0.0121 0.0272
Schistosoma mansoni smad 0.0016 0.0024 0.0053
Onchocerca volvulus 0.001 0.0008 0.0008
Brugia malayi DIX domain containing protein 0.001 0.0008 0.0008
Brugia malayi CXXC zinc finger family protein 0.0021 0.0037 0.0037
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0018
Echinococcus multilocularis smad 0.0016 0.0024 0.0053
Mycobacterium ulcerans glutaminase 0.0286 0.0738 0.0624
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.169 0.4454 0.4454
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0068 0.0015
Loa Loa (eye worm) hypothetical protein 0.0053 0.0121 0.0121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0582 0.1521 0.1521
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.0606 0.0606
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0008 0.0008
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0207 0.053 0.053
Brugia malayi hypothetical protein 0.003 0.0062 0.0062
Brugia malayi topoisomerase 0.0053 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0038
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.001 0.0007 0.0015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0068 0.0152
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0063 0.0003
Onchocerca volvulus 0.0021 0.0037 0.0037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0059 0.0137 0.0069
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0008
Schistosoma mansoni lamin 0.002 0.0034 0.0076
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0008 0.0018
Brugia malayi hypothetical protein 0.001 0.0008 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0068 0.0153
Schistosoma mansoni hypothetical protein 0.0184 0.0468 0.1051
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0053 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0053 0.0121 0.0121
Echinococcus granulosus cytoplasmic intermediate filament protein 0.001 0.0007 0.0015
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0017 0.0038
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0017 0.0038
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0062 0.012
Schistosoma mansoni cpg binding protein 0.0023 0.0041 0.0091
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0068 0.0135
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0068 0.0152
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0008 0.0008
Brugia malayi DKFZp564C0469 protein 0.0053 0.0121 0.0121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0184 0.0468 0.1051
Loa Loa (eye worm) RNA binding protein 0.034 0.0881 0.0881
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0053 0.0121 0.0121
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0018
Schistosoma mansoni lamin 0.002 0.0034 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0121 0.0121
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0.0009 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0184 0.0468 0.1051
Echinococcus granulosus GPCR family 2 0.0184 0.0468 0.1051
Brugia malayi latrophilin 2 splice variant baaae 0.0398 0.1034 0.1034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0184 0.0468 0.0468
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0053 0.0121 0.0121
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.169 0.4454 1
Echinococcus granulosus smad 0.0016 0.0024 0.0053
Treponema pallidum DNA ligase (lig) 0.0053 0.0121 0.3729
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0863 0.2265 0.5086
Brugia malayi N-terminal motif family protein 0.0207 0.053 0.053
Schistosoma mansoni peptidase Clp (S14 family) 0.009 0.0219 0.0491
Schistosoma mansoni hypothetical protein 0.0184 0.0468 0.1051
Schistosoma mansoni hypothetical protein 0.0184 0.0468 0.1051
Brugia malayi RNA recognition motif domain containing protein 0.034 0.0881 0.0881
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.3785 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0863 0.2265 0.5018
Loa Loa (eye worm) nuclear factor I 0.0009 0.0005 0.0005
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0053 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0101 0.0226
Brugia malayi isocitrate dehydrogenase 0.0033 0.0068 0.0068
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0068 0.0153
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.169 0.4454 1
Brugia malayi hypothetical protein 0.002 0.0033 0.0033
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.009 0.0219 0.0474
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0068 0.0015
Trichomonas vaginalis replication factor C large subunit, putative 0.0053 0.0121 0.0121
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.034 0.0881 0.0881
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0121 0.0121
Echinococcus granulosus dnaJ subfamily B 0.0304 0.0785 0.1762
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.009 0.0219 1
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0068 0.0068
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.3785 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0121 0.0121
Echinococcus multilocularis lamin 0.002 0.0034 0.0076
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0018
Echinococcus granulosus lamin 0.002 0.0034 0.0076
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0121 0.0271
Schistosoma mansoni dep domain containing protein 0.001 0.0008 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0063 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0184 0.0468 0.0468
Entamoeba histolytica protein tyrosine phosphatase, putative 0.3785 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0863 0.2265 0.5018
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0068 0.0153
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0068 0.0015
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0024 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0582 0.1521 0.1521
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0088 0.018
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0062 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0121 0.0271
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.169 0.4454 0.4453
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0059 0.0137 0.0069
Onchocerca volvulus 0.002 0.0034 0.0034
Brugia malayi glutaminase DH11.1 0.0286 0.0738 0.0738
Toxoplasma gondii ATPase, AAA family protein 0.0053 0.0121 0.0254
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0068 0.0153
Trypanosoma brucei ubiquitin-protein ligase, putative 0.169 0.4454 1
Schistosoma mansoni intermediate filament proteins 0.002 0.0034 0.0076
Mycobacterium tuberculosis Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) 0.0322 0.0834 0.0771
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0018
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.169 0.4454 0.4454
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.009 0.0219 0.0491
Brugia malayi hypothetical protein 0.0053 0.0121 0.0121
Brugia malayi RNA binding protein 0.034 0.0881 0.0881
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0053 0.0121 0.0121
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0863 0.2265 0.5086
Echinococcus granulosus Smad4 0.0016 0.0024 0.0053
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.3785 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0024 0.0053
Onchocerca volvulus 0.3785 1 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.3785 1 1
Echinococcus granulosus nibrin 0.0053 0.0121 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0184 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0053 0.0121 0.0121
Schistosoma mansoni Smad4 0.0016 0.0024 0.0053
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0068 0.0135
Schistosoma mansoni dishevelled 0.001 0.0008 0.0018
Brugia malayi MH1 domain containing protein 0.0016 0.0024 0.0024
Brugia malayi intermediate filament protein 0.002 0.0034 0.0034
Loa Loa (eye worm) glutaminase 0.0286 0.0738 0.0738
Echinococcus multilocularis replication factor c subunit 1 0.0053 0.0121 0.0272
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0018
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0024 0.0053
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0053 0.0121 0.0254
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.169 0.4454 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0008 0.0018
Schistosoma mansoni hypothetical protein 0.0398 0.1034 0.2321
Loa Loa (eye worm) TAR-binding protein 0.034 0.0881 0.0881
Schistosoma mansoni chromosome transmission fidelity factor 0.0053 0.0121 0.0272
Schistosoma mansoni regulator of G protein signaling 0.001 0.0008 0.0018
Schistosoma mansoni tar DNA-binding protein 0.034 0.0881 0.1978
Loa Loa (eye worm) glutaminase 2 0.0286 0.0738 0.0738
Brugia malayi Pax transcription activation domain interacting protein 0.0053 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0053 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0008 0.0008
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.169 0.4454 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.0606 0.0606
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.169 0.4454 1
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0033
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0068 0.0015
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.169 0.4454 0.4454
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0184 0.0468 0.1051

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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