Detailed information for compound 1334983

Basic information

Technical information
  • TDR Targets ID: 1334983
  • Name: methyl (2S)-3-methyl-2-[(4-methylpiperidine-1 -carbonyl)amino]pentanoate
  • MW: 270.368 | Formula: C14H26N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC([C@@H](C(=O)OC)NC(=O)N1CCC(CC1)C)C
  • InChi: 1S/C14H26N2O3/c1-5-11(3)12(13(17)19-4)15-14(18)16-8-6-10(2)7-9-16/h10-12H,5-9H2,1-4H3,(H,15,18)/t11?,12-/m0/s1
  • InChiKey: VMIPSTCBMXIGQX-KIYNQFGBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-3-methyl-2-[[(4-methyl-1-piperidinyl)-oxomethyl]amino]pentanoic acid methyl ester
  • (2S)-3-methyl-2-[(4-methylpiperidine-1-carbonyl)amino]valeric acid methyl ester
  • methyl (2S)-3-methyl-2-[(4-methylpiperidin-1-yl)carbonylamino]pentanoate
  • STOCK1N-64079
  • MLS000758798
  • SMR000440087
  • (S)-3-Methyl-2-[(4-methyl-piperidine-1-carbonyl)-amino]-pentanoic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0971 0.1135
Schistosoma mansoni hypothetical protein 0.0126 0.3227 0.3227
Toxoplasma gondii ABC1 family protein 0.0036 0.075 0.5014
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0036 0.0036
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0183 0.0183
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.075 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0717 0.4287
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.075 0.068
Schistosoma mansoni nuclear hormone receptor 0.001 0.0036 0.0036
Loa Loa (eye worm) beta-lactamase 0.0036 0.075 0.075
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0036 0.0045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0971 0.1214
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0535 0.5449
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.1495 0.1979
Echinococcus granulosus protein cereblon 0.0299 0.7998 0.7998
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0359 0.0359
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0359 0.2404
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.075 0.7686
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0724 0.4335
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0036 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0678 0.0848
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.075 0.4505
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0036 0.0045
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Onchocerca volvulus 0.0036 0.075 0.0896
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0183 0.0183
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.6141 0.6141
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0359 0.2404
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0483 0.4901
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0359 0.1913
Brugia malayi steroid hormone receptor 0.001 0.0036 0.0045
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0359 0.0449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0035 0.0717 0.0717
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0971 0.0971
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0359 0.1913
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.0045
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0359 0.1913
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0535 0.5449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0036 0.0036
Echinococcus granulosus transcription factor Dp 1 0.0038 0.081 0.081
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0359 0.3614
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.075 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0083 0.0729
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0971 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.1577 0.1577
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0183 0.0183
Leishmania major hypothetical protein, conserved 0.0036 0.075 0.4505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.1495 0.9457
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.075 0.068
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0345 0.3467
Brugia malayi follicle stimulating hormone receptor 0.0232 0.6141 0.7678
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Schistosoma mansoni peroxidasin 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Mycobacterium tuberculosis Conserved protein 0.0036 0.075 0.068
Loa Loa (eye worm) RecQ helicase 0.0021 0.0345 0.0345
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0036 0.0036
Brugia malayi glutathione reductase 0.0063 0.1495 0.1869
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1577 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.075 0.075
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0359 0.1913
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0164 0.0618
Onchocerca volvulus Dual oxidase homolog 0.0156 0.4061 0.5056
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0359 0.1526
Mycobacterium leprae conserved hypothetical protein 0.0036 0.075 1
Trypanosoma brucei trypanothione reductase 0.0063 0.1495 0.9457
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0717 0.4287
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Plasmodium falciparum glutathione reductase 0.0063 0.1495 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Plasmodium falciparum thioredoxin reductase 0.0063 0.1495 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0359 0.1913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.075 0.068
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0535 0.3082
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0036 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0036 0.0036
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0345 0.0432
Mycobacterium ulcerans beta-lactamase 0.0036 0.075 1
Onchocerca volvulus 0.0156 0.4061 0.5056
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0036 0.0045
Onchocerca volvulus 0.0156 0.4061 0.5056
Brugia malayi ecdysteroid receptor 0.001 0.0036 0.0045
Plasmodium falciparum thioredoxin reductase 0.0022 0.0359 0.2404
Echinococcus multilocularis peroxidasin 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0036 0.0045
Mycobacterium leprae Probable lipase LipE 0.0036 0.075 1
Brugia malayi beta-lactamase family protein 0.0036 0.075 0.0937
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.1495 0.1495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.075 0.075
Plasmodium falciparum glutathione reductase 0.0022 0.0359 0.2404
Leishmania major importin beta-1 subunit, putative 0.0028 0.0535 0.3082
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0463 0.2604
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0036 0.0036
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.1577 0.1577
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0169 0.4427 0.4427
Plasmodium vivax hypothetical protein, conserved 0.0036 0.075 0.4438
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.4771
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Loa Loa (eye worm) glutathione reductase 0.0063 0.1495 0.1495
Brugia malayi beta-lactamase 0.0036 0.075 0.0937
Onchocerca volvulus 0.0036 0.075 0.0896
Brugia malayi RNA, U transporter 1 0.0099 0.2486 0.3108
Schistosoma mansoni peroxidasin 0.0156 0.4061 0.4061
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0164 0.0164
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0164 0.0164
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.1577 0.1577
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0331 0.1727
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0359 0.1913
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0475 0.4826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.075 1
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.1577 0.1971
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0971 0.5979
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0971 0.5979
Brugia malayi Peroxidasin 0.0156 0.4061 0.5078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0483 0.4901
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0971 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0359 0.1526
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0036 0.0045
Schistosoma mansoni thyroid hormone receptor 0.0136 0.3505 0.3505
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0036 0.0036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.015 0.1005
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0717 0.4794
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0359 0.3614
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0036 0.0045
Echinococcus granulosus FTZ F1 alpha 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0317 0.8501 0.8501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4161
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4161
Schistosoma mansoni hypothetical protein 0.0015 0.0183 0.0183
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0036 0.0045
Entamoeba histolytica hypothetical protein, conserved 0.0299 0.7998 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.075 0.068
Echinococcus multilocularis protein cereblon 0.0299 0.7998 0.7998
Onchocerca volvulus 0.0036 0.075 0.0896
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0036 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.075 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.02 0.0249
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0036 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.075 0.075
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0036 0.0045
Brugia malayi Blistered cuticle protein 3 0.0156 0.4061 0.5078
Trichomonas vaginalis ran, putative 0.0026 0.0463 0.4699
Brugia malayi hypothetical protein 0.0122 0.3112 0.3891
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Schistosoma mansoni hypothetical protein 0.0299 0.7998 0.7998
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0036 0.0036
Mycobacterium ulcerans hypothetical protein 0.0036 0.075 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.1495 0.1495
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.1495 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0971 0.5979
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.075 0.7686
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.3227 0.3227
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0036 0.0036
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0463 0.0463
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0036 0.0036
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0971 0.0971
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0036 0.0036
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0463 0.2604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0483 0.4901
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0036 0.0036
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0463 0.2302
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0164 0.0206
Leishmania major trypanothione reductase 0.0063 0.1495 0.9457
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1104 0.1104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0226 0.0226
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0036 0.0036
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Echinococcus multilocularis snurportin 1 0.0372 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0475 0.4826
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0261 0.1263
Echinococcus granulosus GPCR family 2 0.0015 0.0183 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0136 0.3505 0.3505
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.00000000011056 0.00000000073963
Echinococcus granulosus bloom syndrome protein 0.0021 0.0345 0.0345
Onchocerca volvulus Peroxidase homolog 0.0156 0.4061 0.5056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4161
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0164 0.0164
Echinococcus multilocularis geminin 0.0169 0.4427 0.4427
Echinococcus multilocularis GPCR, family 2 0.0015 0.0183 0.0183
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.075 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0971 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0359 0.1913
Onchocerca volvulus Peroxidase homolog 0.0156 0.4061 0.5056
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.081 0.081
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0971 0.5979
Echinococcus granulosus geminin 0.0169 0.4427 0.4427
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0359 0.1913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Echinococcus granulosus peroxidasin 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Brugia malayi Importin beta-1 subunit 0.0035 0.0717 0.0896
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.3505 0.3505
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0036 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0036 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.075 0.4505
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.075 0.068
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0971 0.1135
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.1577 0.1577
Entamoeba histolytica hypothetical protein 0.0028 0.0535 0.0585
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.066 0.4416
Onchocerca volvulus Peroxidasin homolog 0.0156 0.4061 0.5056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0036 0.0045
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0359 0.1913
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0183 0.0229
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.1577 0.1899
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0222 0.0222
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0164 0.0618
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0183 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Schistosoma mansoni ran 0.0026 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Plasmodium vivax importin-beta 2, putative 0.0035 0.0717 0.4193
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.6097 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Brugia malayi hypothetical protein 0.0299 0.7998 1
Schistosoma mansoni coup transcription factor 0.001 0.0036 0.0036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.1104 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Echinococcus granulosus importin subunit beta 1 0.0035 0.0717 0.0717
Brugia malayi Thioredoxin reductase 0.0063 0.1495 0.1869
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1104 0.138
Onchocerca volvulus Protein cereblon homolog 0.0299 0.7998 1
Schistosoma mansoni hypothetical protein 0.0169 0.4427 0.4427
Toxoplasma gondii thioredoxin reductase 0.0063 0.1495 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0535 0.5449
Schistosoma mansoni importin beta-1 0.0035 0.0717 0.0717
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0971 0.5979
Onchocerca volvulus Peroxidasin homolog 0.0156 0.4061 0.5056
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.075 0.7686
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0036 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0036 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0463 0.2604
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0359 0.2404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0164 0.1579
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0033 0.0678 0.0678
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0723 0.7408
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.075 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0794 0.8147
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0717 0.0717
Brugia malayi nuclear receptor NHR-88 0.001 0.0036 0.0045
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0724 0.4335
Plasmodium falciparum importin beta, putative 0.0035 0.0717 0.4794
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0359 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.3227 0.3227
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0724 0.4335
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0036 0.0045
Brugia malayi Animal haem peroxidase family protein 0.0156 0.4061 0.5078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Schistosoma mansoni hypothetical protein 0.0033 0.0678 0.0678
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0463 0.31
Leishmania major GTP-binding protein, putative 0.0026 0.0463 0.2604
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0359 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0036 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1104 0.138
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0164 0.0164
Mycobacterium ulcerans lipase LipD 0.0036 0.075 1
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0359 0.2404
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.1577 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1577 1
Brugia malayi hypothetical protein 0.0156 0.4061 0.5078
Loa Loa (eye worm) hypothetical protein 0.0036 0.075 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0572 0.5829
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0971 0.5979
Loa Loa (eye worm) hypothetical protein 0.0015 0.0183 0.0183
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0274 0.1832
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0359 0.1913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0545 0.5555
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0036 0.0036
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0463 0.0463
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0036 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.075 0.075
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0164 0.0618
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.075 0.7686
Loa Loa (eye worm) animal heme peroxidase 0.0156 0.4061 0.4061
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0359 0.0359
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0345 0.3467
Loa Loa (eye worm) hypothetical protein 0.0299 0.7998 0.7998
Loa Loa (eye worm) blistered cuticle protein 3 0.0156 0.4061 0.4061
Schistosoma mansoni ran 0.0026 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Plasmodium vivax glutathione reductase, putative 0.0063 0.1495 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.31
Brugia malayi nuclear hormone receptor 0.001 0.0036 0.0045
Onchocerca volvulus 0.0156 0.4061 0.5056
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1577 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Trichomonas vaginalis esterase, putative 0.0036 0.075 0.7686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.066 0.6753
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.075 0.068
Onchocerca volvulus Chorion peroxidase homolog 0.0156 0.4061 0.5056
Entamoeba histolytica Ran family GTPase 0.0026 0.0463 0.0495
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.075 0.4505
Schistosoma mansoni hypothetical protein 0.0372 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0463 0.0463
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0071 0.0609
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0359 0.0359
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0013 0.0088
Brugia malayi beta-lactamase family protein 0.0036 0.075 0.0937
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.075 0.7686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0036 0.0036
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0359 0.37
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0413 0.4171
Giardia lamblia GTOR 0.0044 0.0971 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.075 0.068
Loa Loa (eye worm) hypothetical protein 0.0156 0.4061 0.4061
Treponema pallidum NADH oxidase 0.0022 0.0359 0.5
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.02 0.0249
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0971 0.0971
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0359 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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