Detailed view for LOAG_04229

Basic information

TDR Targets ID: 938564
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.848 | Length (AA): 433 | MW (Da): 49202 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02190   ATP-dependent protease La (LON) substrate-binding domain
PF03226   Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
39 413 4ci2 (B) 49 426 30.00 0 1 1.07585 0.48
91 413 5fqd (B) 75 424 34.00 0 1 1.11916 -0.1
312 413 5yj0 (t) 323 427 39.00 0 1 0.606366 -0.33
312 416 5amh (A) 21 123 31.00 0 0.96 0.722294 -1.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130671)

Species Accession Gene Product
Arabidopsis thaliana AT2G25740   ATP-dependent protease La (LON) domain protein
Brugia malayi Bm1_28415   hypothetical protein
Caenorhabditis elegans CELE_M18.6   Protein M18.6
Drosophila melanogaster Dmel_CG3925   CG3925 gene product from transcript CG3925-RA
Echinococcus granulosus EgrG_000609800   protein cereblon
Entamoeba histolytica EHI_148120   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000609800   protein cereblon
Homo sapiens ENSG00000113851   cereblon
Loa Loa (eye worm) LOAG_04229   hypothetical protein
Mus musculus 58799   cereblon
Oryza sativa 4339355   Os05g0521500
Oryza sativa 4326165   Os01g0743600
Onchocerca volvulus OVOC1354   Protein cereblon homolog
Schistosoma japonicum Sjp_0077580   expressed protein
Schistosoma mansoni Smp_094340   hypothetical protein
Schmidtea mediterranea mk4.011701.00  
Schmidtea mediterranea mk4.002385.07  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Magnetospirillum gryphiswaldense Cereblon isoform 4 Compounds References
Homo sapiens cereblon Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0319 0.2524 0.5026
0.0295 0.4288 0.4534
0.0495 1 0.5
0.0297 0.9409 0.9409
0.0361 0.4186 0.4186
0.0353 0.2866 0.588
0.0315 0.5558 0.9416
0.0306 0.3398 0.9414
0.0294 0.9408 0.9408
0.0292 0.5092 0.5079
0.0315 0.9417 0.9414
0.0319 0.4685 0.627
0.0324 0.2663 0.6631
0.0312 0.9408 0.9408
0.0322 0.9406 0.9406
0.0305 0.9406 0.9406
0.0292 0.5092 0.5079
0.0302 0.3559 0.7276
0.0296 0.4837 0.4837
0.0294 0.9408 0.9408
0.0308 0.5626 0.5626
0.0308 0.3698 0.3687
0.0353 0.2866 0.588
0.0302 0.2548 0.541
0.0342 0.4186 0.4186
0.0303 0.9408 0.9408
0.0305 0.3583 0.9406
0.0312 0.9408 0.9408
0.0298 0.3567 0.577
0.0325 0.9402 0.9401
0.033 1 1
0.0294 0.4205 0.6351
0.0299 0.7998 0.7998
0.0292 0.5092 0.5079
0.034 0.6815 0.9402
0.0318 0.6306 0.6306
0.0315 0.4367 0.4575
0.0337 0.3329 0.9397
0.0316 0.5 0.5
0.0329 0.6746 0.7895
0.0313 0.2672 0.4704
0.0292 1 1
0.0313 0.4279 0.6516
0.0306 0.3776 0.6465
0.0297 0.3101 0.4664
0.0292 0.5092 0.5079
0.0357 0.4737 0.7017
0.0296 0.4837 0.4837
0.0303 0.3485 0.7232
0.0325 0.4164 0.4116
0.0342 0.4186 0.4186
0.033 1 1
0.0312 0.3114 0.9407
0.0299 0.9406 0.9406
0.0353 0.2866 0.588
0.0292 0.5092 0.5079
0.0315 0.2537 0.5044
0.0325 0.4164 0.4116
0.0308 0.3777 0.461
0.029 0.5094 0.9405
0.0296 0.4837 0.4837
0.0292 0.5092 0.5079
0.0297 0.3414 0.9408
0.0297 0.8229 0.9407
0.0293 0.4159 0.4205
0.0302 0.3559 0.7276
0.0315 0.4687 0.6266
0.0329 0.682 0.9401
0.0315 0.4367 0.4575
0.0296 0.2508 0.6253
0.0312 0.9409 0.9409
0.0305 0.3085 0.9414
0.0299 0.7998 0.7998
0.0302 0.3559 0.7276
0.0302 0.3559 0.7276
0.0312 0.5461 0.9409
0.0306 0.9409 0.9409
0.0329 0.3284 0.9406
0.0297 0.8229 0.9407
0.0315 0.9409 0.9409
0.0297 0.9409 0.9409

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_04229 (Loa Loa (eye worm)), hypothetical protein
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