Detailed information for compound 1339658

Basic information

Technical information
  • TDR Targets ID: 1339658
  • Name: N-butyl-4-[(4-fluorophenyl)methyl]piperazine- 1-carboxamide
  • MW: 293.38 | Formula: C16H24FN3O
  • H donors: 1 H acceptors: 1 LogP: 2.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)N1CCN(CC1)Cc1ccc(cc1)F
  • InChi: 1S/C16H24FN3O/c1-2-3-8-18-16(21)20-11-9-19(10-12-20)13-14-4-6-15(17)7-5-14/h4-7H,2-3,8-13H2,1H3,(H,18,21)
  • InChiKey: GRUJVHAPBLHDMT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-4-[(4-fluorophenyl)methyl]-1-piperazinecarboxamide
  • N-butyl-4-(4-fluorobenzyl)piperazine-1-carboxamide
  • SMR000297656
  • MLS000679484
  • N-butyl-4-(4-fluorobenzyl)-1-piperazinecarboxamide
  • IVK/0016990

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MAP kinase sur-1 0.0062 0.0249 0.0249
Chlamydia trachomatis phospholipase D superfamily protein 0.017 0.1306 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Echinococcus multilocularis neuropeptide receptor A26 0.1057 0.9962 0.9962
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0046 0.0098 0.0177
Chlamydia trachomatis phospholipase D superfamily protein 0.017 0.1306 0.5
Echinococcus multilocularis sorting nexin 4 0.0046 0.0098 0.0098
Brugia malayi Phospholipase D. Active site motif family protein 0.02 0.1601 0.1601
Loa Loa (eye worm) hypothetical protein 0.0114 0.076 0.0911
Leishmania major phosphoinositide-binding protein, putative 0.0046 0.0098 0.0366
Trypanosoma cruzi cardiolipin synthetase, putative 0.037 0.3258 1
Schistosoma mansoni hypothetical protein 0.0056 0.0198 0.0198
Brugia malayi beta-lactamase family protein 0.004 0.0041 0.0041
Loa Loa (eye worm) TRAF4-associated factor 2 0.0046 0.0098 0.0117
Brugia malayi PXA domain containing protein 0.0046 0.0098 0.0098
Brugia malayi Phospholipase D. Active site motif family protein 0.037 0.3258 0.3258
Brugia malayi beta-lactamase 0.004 0.0041 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0339 0.0339
Brugia malayi Sorting nexin 12 0.0046 0.0098 0.0098
Trypanosoma cruzi hypothetical protein 0.0046 0.0098 0.0177
Mycobacterium ulcerans beta-lactamase 0.004 0.0041 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.2345 0.2345
Trypanosoma brucei differentiation inhibitory kinase 0.0047 0.0103 0.0194
Trypanosoma cruzi PX domain containing protein, putative 0.0046 0.0098 0.0177
Echinococcus multilocularis phospholipase d3 0.02 0.1601 0.1601
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.2345 0.2345
Trypanosoma brucei Autophagy-related protein 24 0.0046 0.0098 0.0177
Leishmania major zinc finger protein kinase-like 0.0047 0.0103 0.04
Trypanosoma cruzi hypothetical protein 0.0046 0.0098 0.0177
Brugia malayi PX domain containing protein 0.0046 0.0098 0.0098
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.076 0.0911
Onchocerca volvulus 0.0046 0.0098 0.0366
Brugia malayi beta-lactamase family protein 0.004 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Schistosoma mansoni sortingnexin-related 0.0046 0.0098 0.0098
Entamoeba histolytica phospholipase D, putative 0.1061 1 1
Chlamydia trachomatis phospholipase D endonuclease family protein 0.017 0.1306 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0098 0.0117
Echinococcus granulosus phospholipase D 0.0937 0.8792 0.8792
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0041 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0041 0.0049
Echinococcus multilocularis sorting nexin 2 0.0046 0.0098 0.0098
Trypanosoma brucei PX domain containing protein, putative 0.0046 0.0098 0.0177
Entamoeba histolytica hypothetical protein 0.0066 0.0287 0.0192
Leishmania major hypothetical protein, conserved 0.0046 0.0098 0.0366
Echinococcus granulosus neuropeptide receptor A26 0.1057 0.9962 0.9962
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.017 0.1306 0.1306
Echinococcus granulosus phospholipase D1 0.1061 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0041 0.5
Brugia malayi PX domain containing protein 0.0046 0.0098 0.0098
Brugia malayi PX domain containing protein 0.0046 0.0098 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0339 0.0339
Mycobacterium ulcerans lipase LipD 0.004 0.0041 0.5
Trypanosoma cruzi Autophagy-related protein 24 0.0046 0.0098 0.0177
Brugia malayi Protein K4 0.017 0.1306 0.1306
Onchocerca volvulus 0.0046 0.0098 0.0366
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0249 0.0647
Loa Loa (eye worm) PX domain-containing protein 0.0046 0.0098 0.0117
Trypanosoma brucei cardiolipin synthetase 0.037 0.3258 1
Loa Loa (eye worm) PX domain-containing protein 0.0046 0.0098 0.0117
Schistosoma mansoni hypothetical protein 0.0189 0.1495 0.1495
Schistosoma mansoni sorting nexin 0.0046 0.0098 0.0098
Trypanosoma cruzi PX domain containing protein, putative 0.0046 0.0098 0.0177
Leishmania major phosphatidylglycerophosphate synthase, putative 0.02 0.1601 1
Chlamydia trachomatis phospholipase D endonuclease family protein 0.017 0.1306 0.5
Mycobacterium leprae conserved hypothetical protein 0.004 0.0041 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0198 0.0198
Echinococcus granulosus Phox 0.0046 0.0098 0.0098
Trypanosoma cruzi cardiolipin synthetase, putative 0.037 0.3258 1
Echinococcus granulosus neuropeptide s receptor 0.1057 0.9962 0.9962
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0249 0.0298
Leishmania major cardiolipin synthetase, putative 0.017 0.1306 0.8107
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0249 1
Plasmodium vivax WD domain, G-beta repeat domain containing protein 0.0046 0.0098 0.0451
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.017 0.1306 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0249 0.0249
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0046 0.0098 0.0098
Echinococcus multilocularis 0.0046 0.0098 0.0098
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.2155 1
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.017 0.1306 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0339 0.0339
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0339 0.0406
Loa Loa (eye worm) RNA binding protein 0.0071 0.0339 0.0406
Loa Loa (eye worm) hypothetical protein 0.0276 0.2345 0.2811
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0249 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0339 0.0339
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Toxoplasma gondii phospholipase D active site domain-containing protein 0.037 0.3258 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0339 0.0339
Echinococcus multilocularis sorting nexin 0.0046 0.0098 0.0098
Schistosoma mansoni sorting nexin 0.0046 0.0098 0.0098
Loa Loa (eye worm) PX domain-containing protein 0.0046 0.0098 0.0117
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0249 1
Brugia malayi TRAF4-associated factor 2 0.0046 0.0098 0.0098
Trypanosoma cruzi PX domain containing protein, putative 0.0046 0.0098 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Loa Loa (eye worm) hypothetical protein 0.0691 0.639 0.7659
Trypanosoma cruzi Autophagy-related protein 24 0.0046 0.0098 0.0177
Echinococcus granulosus ribosomal protein S6 kinase delta 1 0.0047 0.0103 0.0103
Echinococcus multilocularis sorting nexin 6 0.0046 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0098 0.0098
Trypanosoma brucei PX domain containing protein, putative 0.0046 0.0098 0.0177
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0041 0.0041
Trypanosoma cruzi zinc finger protein kinase, putative 0.0047 0.0103 0.0194
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0049
Echinococcus granulosus sorting nexin 0.0046 0.0098 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0408 0.0408
Echinococcus granulosus sorting nexin 2 0.0046 0.0098 0.0098
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0249 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Loa Loa (eye worm) beta-lactamase 0.004 0.0041 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.076 0.076
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.017 0.1306 1
Brugia malayi PX domain containing protein 0.0046 0.0098 0.0098
Toxoplasma gondii hypothetical protein 0.0046 0.0098 0.0177
Trypanosoma brucei cardiolipin synthetase, putative 0.037 0.3258 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0049
Schistosoma mansoni sorting nexin 0.0046 0.0098 0.0098
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0046 0.0098 0.0117
Echinococcus multilocularis ribosomal protein S6 kinase delta 1 0.0047 0.0103 0.0103
Chlamydia trachomatis phospholipase D endonuclease family protein 0.017 0.1306 0.5
Echinococcus multilocularis Phox 0.0046 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0691 0.639 0.7659
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0046 0.0098 0.0117
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0249 0.0647
Echinococcus multilocularis neuropeptide s receptor 0.1057 0.9962 0.9962
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0249 0.0249
Trypanosoma brucei protein kinase, putative 0.0062 0.0249 0.0647
Plasmodium vivax cardiolipin synthetase, putative 0.017 0.1306 1
Loa Loa (eye worm) hypothetical protein 0.0891 0.8343 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0046 0.0098 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Echinococcus granulosus nischarin 0.0046 0.0098 0.0098
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0249 0.0647
Brugia malayi Variant SH3 domain containing protein 0.0046 0.0098 0.0098
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.017 0.1306 0.3931
Loa Loa (eye worm) PXA domain-containing protein 0.0046 0.0098 0.0117
Echinococcus granulosus tar DNA binding protein 0.0071 0.0339 0.0339
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0339 0.0339
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0249 0.0647
Brugia malayi hypothetical protein 0.017 0.1306 0.1306
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0891 0.8343 0.8326
Echinococcus multilocularis geminin 0.0189 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0046 0.0098 0.0117
Schistosoma mansoni phospholipase D 0.1061 1 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0249 0.1334
Trypanosoma cruzi hypothetical protein 0.0046 0.0098 0.0177
Brugia malayi hypothetical protein 0.0276 0.2345 0.2345
Wolbachia endosymbiont of Brugia malayi cardiolipin synthase 0.017 0.1306 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0046 0.0098 0.0117
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0049
Brugia malayi TAR-binding protein 0.0071 0.0339 0.0339
Echinococcus granulosus geminin 0.0189 0.1495 0.1495
Brugia malayi RNA binding protein 0.0071 0.0339 0.0339
Schistosoma mansoni survival motor neuron protein 0.0056 0.0198 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0041 0.0041
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0249 0.0249
Mycobacterium leprae Probable lipase LipE 0.004 0.0041 0.5
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0249 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0098 0.2742
Echinococcus multilocularis sorting nexin 0.0046 0.0098 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0098 0.0451
Echinococcus granulosus sorting nexin 6 0.0046 0.0098 0.0098
Echinococcus granulosus sorting nexin 4 0.0046 0.0098 0.0098
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0339 0.0339
Loa Loa (eye worm) phospholipase D 0.02 0.1601 0.1919
Loa Loa (eye worm) sorting nexin 12 0.0046 0.0098 0.0117
Echinococcus granulosus sorting nexin 13 0.0046 0.0098 0.0098
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0249 0.0647
Brugia malayi PX domain containing protein 0.0046 0.0098 0.0098
Schistosoma mansoni sorting nexin 0.0046 0.0098 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0249 1
Echinococcus multilocularis nischarin 0.0046 0.0098 0.0098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.076 0.076
Chlamydia trachomatis phospholipase D endonuclease family protein 0.017 0.1306 0.5
Echinococcus granulosus phospholipase d3 0.02 0.1601 0.1601
Echinococcus multilocularis phospholipase D 0.0937 0.8792 0.8792
Loa Loa (eye worm) hypothetical protein 0.0078 0.0408 0.0489
Onchocerca volvulus 0.0056 0.0198 0.1011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0339 0.0406
Loa Loa (eye worm) hypothetical protein 0.017 0.1306 0.1565
Schistosoma mansoni hypothetical protein 0.0189 0.1495 0.1495
Loa Loa (eye worm) hypothetical protein 0.0891 0.8343 1
Echinococcus multilocularis sorting nexin 14 0.0046 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0078 0.0408 0.0408
Onchocerca volvulus Putative phospholipase D 0.02 0.1601 1
Entamoeba histolytica phospholipase D, putative 0.1061 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.02 0.1601 0.1919
Echinococcus granulosus sorting nexin 14 0.0046 0.0098 0.0098
Echinococcus granulosus sorting nexin 0.0046 0.0098 0.0098
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0249 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0041 0.0049
Brugia malayi PX domain containing protein 0.0046 0.0098 0.0098
Mycobacterium ulcerans hypothetical protein 0.004 0.0041 0.5
Brugia malayi PXA domain containing protein 0.0046 0.0098 0.0098
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0249 0.1334
Echinococcus multilocularis phospholipase D1 0.1061 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0041 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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