Detailed information for compound 13417

Basic information

Technical information
  • TDR Targets ID: 13417
  • Name: N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2- yl]oxybutoxy]naphthalen-1-yl]ethyl]acetamide
  • MW: 512.639 | Formula: C32H36N2O4
  • H donors: 2 H acceptors: 2 LogP: 5.92 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2
  • InChi: 1S/C32H36N2O4/c1-23(35)33-17-15-27-9-5-7-25-11-13-29(21-31(25)27)37-19-3-4-20-38-30-14-12-26-8-6-10-28(32(26)22-30)16-18-34-24(2)36/h5-14,21-22H,3-4,15-20H2,1-2H3,(H,33,35)(H,34,36)
  • InChiKey: AGGOYESCDGTCOY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[7-[4-[[8-(2-acetamidoethyl)-2-naphthyl]oxy]butoxy]-1-naphthyl]ethyl]acetamide
  • N-[2-[7-[4-[8-(2-acetamidoethyl)naphthalen-2-yl]oxybutoxy]naphthalen-1-yl]ethyl]ethanamide
  • N-[2-[7-[4-[8-(2-acetamidoethyl)-2-naphthoxy]butoxy]-1-naphthyl]ethyl]acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melatonin receptor 1B Starlite/ChEMBL References
Homo sapiens melatonin receptor 1A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melatonin receptor 1B 362 aa 329 aa 18.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0176 0.1594 0.4829
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0437 0.1328
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0045
Mycobacterium ulcerans sugar transporter 0.0049 0.0326 0.2001
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0347 0.33 0.8549
Leishmania major protein kinase, putative 0.0074 0.0573 0.1742
Schistosoma mansoni hypothetical protein 0.004 0.0239 0.0725
Schistosoma mansoni protein kinase 0.0074 0.0573 0.1736
Loa Loa (eye worm) major facilitator superfamily transporter 0.0049 0.0326 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Brugia malayi Major Facilitator Superfamily protein 0.0049 0.0326 0.0989
Plasmodium falciparum DNA gyrase subunit A 0.0066 0.0501 0.0501
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0084 0.0677 0.2059
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0215 0.0556
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.003 0.0135 0.0408
Loa Loa (eye worm) hypothetical protein 0.0055 0.0393 0.1191
Plasmodium falciparum lysine--tRNA ligase 0.0054 0.0374 0.0374
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0215 0.0651
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0393 0.1191
Onchocerca volvulus 0.0049 0.0326 0.1679
Trichomonas vaginalis myo-inositol transporter, putative 0.0049 0.0326 0.0989
Schistosoma mansoni transient receptor potential channel 4 0.0108 0.0917 0.2779
Echinococcus multilocularis dna polymerase eta 0.0038 0.0215 0.0556
Plasmodium vivax CDK-related protein kinase 6, putative 0.1019 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.012 0.0364
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0074 0.0573 0.1736
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0049 0.0326 0.2001
Plasmodium vivax hexose transporter 0.0347 0.33 0.33
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0288 0.0876
Chlamydia trachomatis DNA gyrase subunit A 0.0066 0.0501 0.3069
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Schistosoma mansoni glucose transport protein 0.0347 0.33 1
Trypanosoma brucei DNA topoisomerase III, putative 0.0017 0.0006 0.0017
Echinococcus multilocularis calcium dependent protein kinase 0.0069 0.0528 0.1367
Plasmodium vivax calcium-dependent protein kinase, putative 0.0074 0.0573 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0172 0.0522
Echinococcus granulosus dna polymerase kappa 0.0067 0.051 0.1321
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.018 0.1632 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0072 0.0558 0.1691
Plasmodium vivax proline--tRNA ligase, putative 0.0084 0.0677 0.0677
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0072 0.0558 0.1691
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0326 0.0989
Entamoeba histolytica DNA topoisomerase II, putative 0.0308 0.2913 0.7876
Loa Loa (eye worm) hypothetical protein 0.0074 0.0573 0.1736
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0241 0.0623
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0089 0.0724 0.2194
Schistosoma mansoni patched 1 0.0047 0.0309 0.0936
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0066 0.0501 0.3069
Echinococcus multilocularis solute carrier family 22 0.0049 0.0326 0.0846
Brugia malayi Major Facilitator Superfamily protein 0.0049 0.0326 0.0989
Echinococcus multilocularis dna polymerase kappa 0.0067 0.051 0.1321
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Entamoeba histolytica protein kinase, putative 0.0074 0.0573 0.1549
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0573 0.1484
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0794
Brugia malayi GRF zinc finger family protein 0.0017 0.0006 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0239 0.0725
Giardia lamblia DINP protein human, muc B family 0.0045 0.0288 0.0779
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0933 0.2416
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.051 0.155
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trypanosoma brucei DNA topoisomerase IA, putative 0.0017 0.0006 0.0017
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0074 0.0573 0.1736
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.1165 0.353
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0017 0.0006 0.009
Leishmania major DNA topoisomerase III, putative 0.0017 0.0006 0.0017
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0045
Giardia lamblia Hexose transporter 0.0049 0.0326 0.0883
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.018 0.1632 1
Schistosoma mansoni DNA polymerase eta 0.0038 0.0215 0.0651
Entamoeba histolytica hypothetical protein 0.004 0.0239 0.0647
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0049 0.0147
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0017 0.0006 0.0035
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0129 0.0392
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0084 0.0677 0.2059
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0326 0.0989
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1426 0.4337
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0049 0.0326 0.2001
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0129 0.0349
Entamoeba histolytica hypothetical protein 0.011 0.0938 0.2536
Echinococcus granulosus voltage dependent calcium channel subunit 0.0403 0.386 1
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0072 0.0558 0.1691
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0074 0.0573 0.0573
Trypanosoma cruzi DNA topoisomerase III, putative 0.0017 0.0006 0.0017
Giardia lamblia DNA repair protein RAD52 0.0387 0.3698 1
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0049 0.0326 0.2001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.051 0.155
Onchocerca volvulus 0.0049 0.0326 0.1679
Loa Loa (eye worm) hypothetical protein 0.0068 0.0517 0.1565
Schistosoma mansoni sugar transporter 0.0049 0.0326 0.0989
Toxoplasma gondii DNA topoisomerase family protein 0.0017 0.0006 0.0009
Toxoplasma gondii transporter, major facilitator family protein 0.0049 0.0326 0.0494
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0049 0.0132
Echinococcus granulosus Sugar transporter ERD6 protein 0.0049 0.0326 0.0846
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0309 0.08
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0015 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Brugia malayi Transient-receptor-potential like protein 0.004 0.0241 0.0729
Toxoplasma gondii sugar transporter ST3 0.0049 0.0326 0.0494
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0573 0.1736
Schistosoma mansoni protein kinase 0.0074 0.0573 0.1736
Giardia lamblia DNA topoisomerase III 0.0017 0.0006 0.0015
Schistosoma mansoni sugar transporter 0.0049 0.0326 0.0989
Leishmania major mitochondrial DNA polymerase beta 0.0336 0.3192 0.9705
Schistosoma mansoni lysyl-tRNA synthetase 0.0054 0.0374 0.1134
Leishmania major glucose transporter, lmgt3 0.0108 0.0913 0.2776
Schistosoma mansoni hypothetical protein 0.0045 0.0292 0.0885
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0049 0.0298
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0208 0.1917 1
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0308 0.2913 0.7545
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0017 0.0006 0.0017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.004
Echinococcus granulosus solute carrier family 22 0.0049 0.0326 0.0846
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0241 0.0623
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0129 0.0195
Mycobacterium ulcerans hypothetical protein 0.0177 0.1606 0.9839
Brugia malayi isocitrate dehydrogenase 0.0018 0.0015 0.0046
Toxoplasma gondii lysine-tRNA ligase 0.0054 0.0374 0.0567
Schistosoma mansoni hypothetical protein 0.0095 0.0784 0.2376
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0049 0.0148
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0074 0.0573 0.1736
Plasmodium vivax sugar transporter, putative 0.0049 0.0326 0.0326
Plasmodium falciparum DNA gyrase subunit B 0.018 0.1632 0.1632
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0403 0.386 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0015 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.051 0.155
Echinococcus granulosus General substrate transporter 0.0298 0.2814 0.7289
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0015 0.0023
Schistosoma mansoni DNA topoisomerase II 0.0308 0.2913 0.8826
Trypanosoma cruzi DNA topoisomerase II, putative 0.0291 0.2747 0.8352
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0326 0.0989
Trichomonas vaginalis sugar transporter, putative 0.0108 0.0913 0.2767
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0072 0.0558 0.1691
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.051 0.155
Echinococcus granulosus transient receptor potential ion channel A 0.0104 0.0881 0.2283
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.008 0.0638 1
Brugia malayi Flap endonuclease-1 0.0029 0.0129 0.0391
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.012 0.0181
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Echinococcus multilocularis lysyl tRNA synthetase 0.0054 0.0374 0.0969
Echinococcus granulosus lysyl tRNA synthetase 0.0054 0.0374 0.0969
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0017 0.0006 0.0017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0049 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.051 0.155
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0311 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0172 0.0522
Treponema pallidum DNA topoisomerase I (topA) 0.0017 0.0006 0.0035
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.012 0.012
Trichomonas vaginalis DNA polymerase eta, putative 0.0067 0.051 0.1545
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0054 0.0374 0.1134
Echinococcus granulosus solute carrier family 22 0.0049 0.0326 0.0846
Onchocerca volvulus 0.0049 0.0326 0.1679
Onchocerca volvulus 0.0049 0.0326 0.1679
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.0552 0.1431
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0208 0.1917 1
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.0552 0.1431
Trichomonas vaginalis sugar transporter, putative 0.0108 0.0913 0.2767
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0039
Entamoeba histolytica hypothetical protein 0.004 0.0239 0.0647
Loa Loa (eye worm) DNA topoisomerase III 0.0017 0.0006 0.0017
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0049 0.0326 0.2001
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.012 0.0364
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.1402 0.3631
Schistosoma mansoni ap endonuclease 0.0021 0.0049 0.0147
Mycobacterium ulcerans DNA gyrase subunit A 0.0066 0.0501 0.3069
Mycobacterium ulcerans DNA topoisomerase I 0.0017 0.0006 0.0035
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0015 0.0046
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0015 0.0046
Schistosoma mansoni transient receptor potential channel 0.0108 0.0917 0.2779
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.051 0.3125
Plasmodium falciparum proline--tRNA ligase 0.0084 0.0677 0.0677
Brugia malayi Cache domain containing protein 0.0081 0.0649 0.1968
Loa Loa (eye worm) hypothetical protein 0.0072 0.0558 0.1691
Schistosoma mansoni hypothetical protein 0.0045 0.0292 0.0885
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0215 0.0581
Schistosoma mansoni sugar transporter 0.0049 0.0326 0.0989
Brugia malayi DNA topoisomerase III beta-1 0.0017 0.0006 0.0017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0049 0.0298
Trypanosoma cruzi DNA topoisomerase III, putative 0.0017 0.0006 0.0017
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0015 0.004
Brugia malayi hypothetical protein 0.004 0.0239 0.0725
Trypanosoma brucei unspecified product 0.0026 0.0098 0.0299
Leishmania major DNA polymerase kappa, putative 0.0045 0.0288 0.0876
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Brugia malayi CHE-14 protein 0.0047 0.0309 0.0936
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0308 0.2913 0.8826
Echinococcus granulosus expressed conserved protein 0.0103 0.0866 0.2244
Leishmania major glucose transporter/membrane transporter D2, putative 0.0108 0.0913 0.2776
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0251 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0017 0.0006 0.0017
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0049 0.0326 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0251 0.0764
Echinococcus multilocularis transient receptor potential ion channel A 0.0104 0.0881 0.2283
Trypanosoma brucei THT1 - hexose transporter, putative 0.0108 0.0913 0.2776
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0311 0.0946
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.011 0.0938 0.2536
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0017 0.0006 0.0017
Giardia lamblia Sugar-proton symporter 0.0049 0.0326 0.0883
Trypanosoma brucei glucose transporter 2A 0.0108 0.0913 0.2776
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0084 0.0677 0.1025
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0049 0.0126
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0015 0.0046
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0933 0.2826
Brugia malayi hypothetical protein 0.0049 0.0326 0.0989
Schistosoma mansoni hypothetical protein 0.0189 0.1721 0.5213
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0311 0.0946
Echinococcus multilocularis protein dispatched 1 0.0054 0.0375 0.0972
Brugia malayi major facilitator superfamily protein 0.0049 0.0326 0.0989
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0084 0.0677 0.2059
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0347 0.33 0.8549
Leishmania major hypothetical protein, conserved 0.0049 0.0326 0.0993
Loa Loa (eye worm) hypothetical protein 0.0047 0.0309 0.0936
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0074 0.0573 0.1484
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0017 0.0006 0.0015
Onchocerca volvulus 0.0049 0.0326 0.1679
Trypanosoma brucei THT1 - hexose transporter, putative 0.0108 0.0913 0.2776
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0066 0.0501 0.3069
Leishmania major DNA topoisomerase III, putative 0.0017 0.0006 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.33 1
Echinococcus granulosus voltage dependent calcium channel subunit 0.0183 0.1668 0.4322
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0015 0.0046
Schistosoma mansoni transient receptor potential channel 0.0071 0.0552 0.1674
Trichomonas vaginalis sugar transport protein, putative 0.0049 0.0326 0.0989
Brugia malayi polk-prov protein 0.0041 0.0251 0.0762
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0215 0.0651
Loa Loa (eye worm) sugar transporter 0.0049 0.0326 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0172 0.0522
Echinococcus multilocularis synaptic vesicle 2 protein 0.0049 0.0326 0.0846
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0387 0.3698 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0347 0.33 0.8549
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0183 0.1668 0.4322
Plasmodium vivax DNA topoisomerase II, putative 0.0308 0.2913 0.2913
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0326 0.0989
Plasmodium falciparum calcium-dependent protein kinase 1 0.0074 0.0573 0.0573
Entamoeba histolytica hypothetical protein 0.004 0.0239 0.0647
Giardia lamblia Lysyl-tRNA synthetase 0.0054 0.0374 0.1012
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.012 0.012
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Chlamydia trachomatis DNA gyrase subunit A 0.0066 0.0501 0.3069
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.3192 0.9705
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0049 0.0326 0.0993
Loa Loa (eye worm) hypothetical protein 0.0038 0.0215 0.0651
Trypanosoma brucei DNA topoisomerase III, putative 0.0017 0.0006 0.0017
Chlamydia trachomatis lysine--tRNA ligase 0.0054 0.0374 0.2294
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0309 0.0936
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0347 0.33 0.8549
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Leishmania major DNA topoisomerase 1A 0.0017 0.0006 0.0017
Echinococcus multilocularis protein patched 0.0047 0.0309 0.08
Schistosoma mansoni glucose transporter 0.0049 0.0326 0.0989
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0046 0.0294 0.18
Loa Loa (eye worm) hypothetical protein 0.0125 0.109 0.3302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0015 0.0039
Schistosoma mansoni sugar transporter 0.0049 0.0326 0.0989
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Plasmodium falciparum calcium-dependent protein kinase 3 0.0074 0.0573 0.0573
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.012 0.0364
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0045
Brugia malayi hypothetical protein 0.0168 0.1517 0.4596
Trichomonas vaginalis sugar transporter, putative 0.0108 0.0913 0.2767
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0015 0.0015
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Trypanosoma cruzi hexose transporter, putative 0.0108 0.0913 0.2776
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0054 0.0374 0.1134
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0573 0.1484
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0046 0.0294 0.18
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Leishmania major glucose transporter, lmgt1 0.0108 0.0913 0.2776
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0015 0.0039
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Leishmania major myo-inositol/proton symporter (MIT) 0.0049 0.0326 0.0993
Brugia malayi Sugar transporter family protein 0.0049 0.0326 0.0989
Schistosoma mansoni glucose transport protein 0.0347 0.33 1
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0347 0.33 0.8549
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0393 0.1191
Brugia malayi hypothetical protein 0.0049 0.0326 0.0989
Entamoeba histolytica DNA topoisomerase III, putative 0.0017 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0209 0.1919 0.5816
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0309 0.08
Onchocerca volvulus 0.0168 0.1517 0.7909
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0933 0.2416
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Onchocerca volvulus 0.0049 0.0326 0.1679
Schistosoma mansoni protein kinase 0.0074 0.0573 0.1736
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0015 0.0094
Echinococcus multilocularis solute carrier family 22 0.0049 0.0326 0.0846
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.0552 0.1431
Plasmodium falciparum calcium-dependent protein kinase 4 0.0074 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Trypanosoma cruzi sugar transporter, putative 0.0049 0.0326 0.0993
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0308 0.0934
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0388 0.3708 0.5616
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0015 0.004
Echinococcus granulosus solute carrier family 22 0.0049 0.0326 0.0846
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0215 0.0651
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.051 0.3125
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0347 0.33 0.8549
Echinococcus granulosus synaptic vesicle 2 protein 0.0049 0.0326 0.0846
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0015 0.0045
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0129 0.0391
Trichomonas vaginalis glucose transporter, putative 0.0108 0.0913 0.2767
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0129 0.0334
Brugia malayi major facilitator superfamily protein 0.0049 0.0326 0.0989
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0017 0.0006 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Trypanosoma brucei DNA topoisomerase ii 0.0346 0.3289 1
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.051 0.155
Loa Loa (eye worm) hypothetical protein 0.0058 0.0414 0.1255
Leishmania major hypothetical protein, conserved 0.0028 0.012 0.0364
Loa Loa (eye worm) hypothetical protein 0.0209 0.1919 0.5816
Brugia malayi hypothetical protein 0.0049 0.0326 0.0989
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0129 0.0391
Leishmania major glucose transporter, lmgt2 0.0108 0.0913 0.2776
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.1165 0.353
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Trypanosoma cruzi hexose transporter, putative 0.0049 0.0326 0.0993
Giardia lamblia Prolyl-tRNA synthetase 0.0072 0.0558 0.1509
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0015 0.0046
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0046 0.0294 0.4601
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0241 0.0729
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0794
Echinococcus granulosus transient receptor potential gamma protein 0.0108 0.0917 0.2376
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.004
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0208 0.1917 1
Giardia lamblia DNA topoisomerase II 0.0292 0.2753 0.7443
Onchocerca volvulus 0.0049 0.0326 0.1679
Toxoplasma gondii sugar transporter ST1 0.0049 0.0326 0.0494
Onchocerca volvulus 0.0049 0.0326 0.1679
Loa Loa (eye worm) hypothetical protein 0.0038 0.0218 0.0661
Mycobacterium ulcerans integral membrane transport protein 0.0049 0.0326 0.2001
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0072 0.0558 0.1509
Echinococcus multilocularis transient receptor potential gamma protein 0.0108 0.0917 0.2376
Loa Loa (eye worm) hypothetical protein 0.0125 0.109 0.3302
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0072 0.0558 0.8742
Trichomonas vaginalis glucose transporter, putative 0.0049 0.0326 0.0989
Loa Loa (eye worm) sugar transporter 0.0347 0.33 1
Brugia malayi DNA topoisomerase III 0.0017 0.0006 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0393 0.1191
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.1426 0.4337
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0215 0.0651
Echinococcus multilocularis expressed conserved protein 0.0103 0.0866 0.2244
Brugia malayi Sugar transporter family protein 0.0347 0.33 1
Treponema pallidum prolyl-tRNA synthetase 0.0025 0.0094 0.0574
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0309 0.08
Plasmodium vivax DNA topoisomerase 3, putative 0.0017 0.0006 0.0006
Brugia malayi MH2 domain containing protein 0.0133 0.1165 0.353
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0049 0.0148
Echinococcus granulosus GPCR family 2 0.0018 0.0015 0.0039
Trypanosoma brucei sugar transporter, putative 0.0049 0.0326 0.0993
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0049 0.0326 0.2001
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0074 0.0573 0.0868
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Brugia malayi hypothetical protein 0.0028 0.012 0.0363
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0015 0.0045
Toxoplasma gondii DNA topoisomerase 2, putative 0.0308 0.2913 0.4411
Echinococcus multilocularis GPCR, family 2 0.0018 0.0015 0.0039
Giardia lamblia DNA topoisomerase III 0.0017 0.0006 0.0015
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0215 0.0653
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0072 0.0558 0.1446
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0239 0.062
Toxoplasma gondii hypothetical protein 0.0054 0.0381 0.0576
Plasmodium falciparum protein kinase 7 0.0678 0.6603 0.6603
Mycobacterium ulcerans DNA gyrase subunit B 0.018 0.1632 1
Leishmania major mitochondrial DNA topoisomerase II 0.0346 0.3289 1
Onchocerca volvulus 0.0049 0.0326 0.1679
Toxoplasma gondii facilitative glucose transporter GT1 0.0347 0.33 0.4998
Chlamydia trachomatis DNA topoisomerase I 0.0017 0.0006 0.0035
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0573 0.1484
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0049 0.0147
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0049 0.0326 0.0846
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0015 0.0046
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0573 0.1484
Plasmodium falciparum calcium-dependent protein kinase 2 0.0074 0.0573 0.0573
Schistosoma mansoni hypothetical protein 0.0038 0.0218 0.0661
Schistosoma mansoni hypothetical protein 0.0045 0.0292 0.0885
Trypanosoma cruzi hexose transporter, putative 0.0108 0.0913 0.2776
Echinococcus multilocularis rho GTPase activating protein 20 0.0017 0.0006 0.0015
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0347 0.33 0.8549
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0084 0.0677 0.2059
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0049 0.0326 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.004
Brugia malayi Major Facilitator Superfamily protein 0.0049 0.0326 0.0989
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.095 0.2877
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0015 0.004
Trypanosoma brucei glucose transporter 1E 0.0108 0.0913 0.2776
Brugia malayi Sugar transporter family protein 0.0049 0.0326 0.0989
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.012 0.012
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.3192 0.9705
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Schistosoma mansoni ap endonuclease 0.0021 0.0049 0.0147
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0347 0.33 0.8549
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Loa Loa (eye worm) hypothetical protein 0.0081 0.0649 0.1968
Onchocerca volvulus Putative transporter 0.0049 0.0326 0.1679
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.062
Echinococcus granulosus flap endonuclease 1 0.0029 0.0129 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Entamoeba histolytica DNA topoisomerase III, putative 0.0017 0.0006 0.0015
Onchocerca volvulus 0.0049 0.0326 0.1679
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0308 0.2913 0.7545
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.1402 0.3631
Schistosoma mansoni glucose transport protein 0.0347 0.33 1
Trypanosoma cruzi glucose transporter, putative 0.0049 0.0326 0.0993
Trypanosoma cruzi DNA topoisomerase II, putative 0.0291 0.2747 0.8352
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0215 0.0653
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0066 0.0501 0.0758
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.1426 0.4337
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0054 0.0374 0.1138
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0074 0.0573 0.0573
Echinococcus multilocularis solute carrier family 22 0.0049 0.0326 0.0846
Entamoeba histolytica protein kinase, putative 0.0074 0.0573 0.1549
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Brugia malayi Cam kinase protein 1 0.0074 0.0573 0.1736
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0129 0.0349
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0049 0.0298
Brugia malayi hypothetical protein 0.0018 0.0021 0.0062
Leishmania major lysyl-tRNA synthetase, putative 0.0054 0.0374 0.1138
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0291 0.2747 0.8352
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0074 0.0573 0.1742
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0291 0.2747 0.8352
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0066 0.0501 0.3069
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0215 0.0556
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0025 0.0094 0.0574
Onchocerca volvulus 0.0049 0.0326 0.1679
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0336 0.3192 0.9705
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0017 0.0006 0.0017
Trypanosoma cruzi hexose transporter 0.0108 0.0913 0.2776
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0049 0.0147
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0218 0.0661
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0913 0.2767
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.018 0.1632 0.2471
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0072 0.0558 0.1691
Trichomonas vaginalis DNA topoisomerase II, putative 0.0308 0.2913 0.8826
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0054 0.0374 0.2294
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0326 0.0989
Trypanosoma cruzi hexose transporter, putative 0.0059 0.0427 0.1297
Schistosoma mansoni hypothetical protein 0.0347 0.33 1
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0168 0.1517 0.4596
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0573 0.1484
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0017 0.0006 0.0015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0311 0.0946
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0049 0.0148
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.0552 0.1431
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0129 0.0392
Schistosoma mansoni transient receptor potential channel 0.0071 0.0552 0.1674
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0045
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0049 0.0148
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0054 0.0374 0.5862
Loa Loa (eye worm) hypothetical protein 0.0108 0.0917 0.2779
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0573 0.1736
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Echinococcus granulosus geminin 0.0189 0.1721 0.4457
Brugia malayi lysyl-tRNA synthetase 0.0054 0.0374 0.1134
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0074 0.0573 0.0868
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0054 0.0374 0.2294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0262 0.0794
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Onchocerca volvulus 0.0049 0.0326 0.1679
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.051 0.155
Entamoeba histolytica hypothetical protein 0.0054 0.0374 0.1012
Toxoplasma gondii sugar transporter ST2 0.0049 0.0326 0.0494
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0015 0.0039
Toxoplasma gondii exonuclease III APE 0.0021 0.0049 0.0074
Plasmodium falciparum calcium-dependent protein kinase 5 0.0074 0.0573 0.0573
Trichomonas vaginalis glucose transporter, putative 0.0108 0.0913 0.2767
Echinococcus granulosus dna polymerase eta 0.0038 0.0215 0.0556
Loa Loa (eye worm) major facilitator superfamily transporter 0.0049 0.0326 0.0989
Chlamydia trachomatis proline--tRNA ligase 0.0025 0.0094 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0309 0.0936
Loa Loa (eye worm) hypothetical protein 0.0041 0.0251 0.0762
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0074 0.0573 0.0868
Plasmodium falciparum flap endonuclease 1 0.0029 0.0129 0.0129
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0288 0.0876
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0049 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0045
Plasmodium vivax DNA gyrase subunit B, putative 0.018 0.1632 0.1632
Plasmodium vivax DNA gyrase subunit A, putative 0.0066 0.0501 0.0501
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0072 0.0558 0.1446
Trypanosoma brucei unspecified product 0.0026 0.0098 0.0299
Trypanosoma cruzi hexose transporter, putative 0.0108 0.0913 0.2776
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0049 0.0298
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0067 0.051 0.1545
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0049 0.0049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.1606 0.9839
Loa Loa (eye worm) hypothetical protein 0.0059 0.0423 0.1283
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0074 0.0573 0.0573
Chlamydia trachomatis DNA gyrase subunit B 0.018 0.1632 1
Plasmodium falciparum DNA topoisomerase 3, putative 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0288 0.1765
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0215 0.1316
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Echinococcus granulosus calcium dependent protein kinase 0.0069 0.0528 0.1367
Loa Loa (eye worm) TOPoisomerase family member 0.0308 0.2913 0.8826
Leishmania major DNA polymerase eta, putative 0.0038 0.0215 0.0653
Leishmania major DNA topoisomerase ii 0.0291 0.2747 0.8352
Plasmodium falciparum DNA topoisomerase 2 0.0308 0.2913 0.2913
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0388 0.3708 0.3708
Toxoplasma gondii protein kinase, putative 0.0678 0.6603 1
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Schistosoma mansoni lysyl-tRNA synthetase 0.0054 0.0374 0.1134
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0308 0.2913 0.8826
Loa Loa (eye worm) hypothetical protein 0.0072 0.0558 0.1691
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0054 0.0374 0.1138
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.0363
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0015 0.0045
Schistosoma mansoni serine-rich repeat protein 0.0095 0.0784 0.2376
Trypanosoma brucei glucose transporter, putative 0.0108 0.0913 0.2776
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0129 0.0392
Echinococcus multilocularis geminin 0.0189 0.1721 0.4457
Plasmodium falciparum hexose transporter 0.0347 0.33 0.33
Echinococcus multilocularis solute carrier family 22 0.0049 0.0326 0.0846
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.018 0.1632 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989
Chlamydia trachomatis DNA gyrase subunit B 0.0142 0.1256 0.7695
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0017 0.0006 0.0009
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0346 0.3289 1
Trypanosoma brucei unspecified product 0.006 0.0437 0.1328
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0084 0.0677 0.2059
Onchocerca volvulus 0.0049 0.0326 0.1679
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0239 0.062
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0346 0.3289 1
Schistosoma mansoni hypothetical protein 0.0189 0.1721 0.5213
Trypanosoma cruzi DNA topoisomerase III, putative 0.0017 0.0006 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0215 0.0651
Trypanosoma brucei THT1 - hexose transporter, putative 0.0108 0.0913 0.2776
Onchocerca volvulus 0.0049 0.0326 0.1679
Entamoeba histolytica hypothetical protein 0.004 0.0239 0.0647
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0933 0.2522
Echinococcus granulosus solute carrier family 22 0.0049 0.0326 0.0846
Loa Loa (eye worm) hypothetical protein 0.011 0.0933 0.2826
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0017 0.0006 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Onchocerca volvulus 0.0049 0.0326 0.1679
Schistosoma mansoni flap endonuclease-1 0.0026 0.0101 0.0307
Brugia malayi Probable DNA topoisomerase II 0.0308 0.2913 0.8826
Plasmodium falciparum mitogen-activated protein kinase 2 0.0388 0.3708 0.3708
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0049 0.0147
Plasmodium vivax lysine--tRNA ligase, putative 0.0054 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.0045 0.0292 0.0885
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0414 0.126
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0074 0.0573 0.1484
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0017 0.0006 0.0017
Onchocerca volvulus 0.0049 0.0326 0.1679
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trichomonas vaginalis sugar transporter, putative 0.0049 0.0326 0.0989
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0913 0.2767
Echinococcus multilocularis General substrate transporter 0.0298 0.2814 0.7289
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0074 0.0573 0.1484
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0989

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 73 nM Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay ChEMBL. 20444610
EC50 (functional) = 405 nM Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay ChEMBL. 20444610
Emax (functional) = 25 % Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay relative to melatonin ChEMBL. 20444610
Emax (functional) = 39 % Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay relative to melatonin ChEMBL. 20444610
Imax (functional) = 68 % Antagonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of melatonin-induced response by [35S]GTPgamma binding assay relative to control ChEMBL. 20444610
Imax (functional) = 80 % Antagonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of melatonin-induced response by [35S]GTPgamma binding assay relative to control ChEMBL. 20444610
Kb (functional) = 11 nM Antagonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of melatonin-induced response by [35S]GTPgamma binding assay ChEMBL. 20444610
Kb (functional) = 29 nM Antagonist activity at human MT2 receptor expressed in CHO cells assessed as inhibition of melatonin-induced response by [35S]GTPgamma binding assay ChEMBL. 20444610
Ki (binding) = 0.6 nM Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as radioligand ChEMBL. 12646022
Ki (binding) = 0.6 nM Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as radioligand ChEMBL. 12646022
Ki (binding) = 0.6 nM Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells ChEMBL. 20444610
Ki (binding) = 0.6 nM Binding affinity to MT1 receptor (unknown origin) expressed in HEK cells ChEMBL. 24228714
Ki (binding) = 0.6 nM Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins ChEMBL. No reference
Ki (binding) = 3.1 nM Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells ChEMBL. 24228714
Ki (binding) = 72.7 nM Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as radioligand ChEMBL. 12646022
Ki (binding) = 72.7 nM Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as radioligand ChEMBL. 12646022
Ki (binding) = 72.7 nM Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cells ChEMBL. 20444610
Ki (binding) = 73.2 nM Binding affinity to MT2 receptor (unknown origin) expressed in HEK cells ChEMBL. 24228714
Ki (binding) = 73.2 nM Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT2 expressed in HEK293 cells after 120 mins ChEMBL. No reference
Ki (binding) = 167 nM Displacement of [125I]2-iodomelatonin from human MT2 receptor expressed in CHO cells ChEMBL. 24228714
Ratio (binding) = 120 Selectivity ratio for inhibition of human MT2 receptor to that of human MT1 receptor was determined ChEMBL. 12646022
Ratio (binding) = 120 Selectivity ratio for inhibition of human MT2 receptor to that of human MT1 receptor was determined ChEMBL. 12646022

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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