Detailed information for compound 1346718

Basic information

Technical information
  • TDR Targets ID: 1346718
  • Name: 2-fluoro-N-[4-(4-methylpiperidin-1-yl)sulfony lphenyl]benzamide
  • MW: 376.445 | Formula: C19H21FN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)S(=O)(=O)c1ccc(cc1)NC(=O)c1ccccc1F
  • InChi: 1S/C19H21FN2O3S/c1-14-10-12-22(13-11-14)26(24,25)16-8-6-15(7-9-16)21-19(23)17-4-2-3-5-18(17)20/h2-9,14H,10-13H2,1H3,(H,21,23)
  • InChiKey: HHHRIXHCTYILMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-fluoro-N-[4-[(4-methyl-1-piperidyl)sulfonyl]phenyl]benzamide
  • 2-fluoro-N-[4-[(4-methyl-1-piperidinyl)sulfonyl]phenyl]benzamide
  • AJ-292/41694134
  • STK085973
  • ZINC00792547
  • 2-Fluoro-N-[4-(4-methyl-piperidine-1-sulfonyl)-phenyl]-benzamide
  • BAS 05276983

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0437 0.0867
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0437 0.0822
Schistosoma mansoni coup transcription factor 0.0012 0.0437 0.0867
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0437 0.0822
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0437 0.0822
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0437 0.0867
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0437 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0437 0.0867
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0025 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0437 0.0822
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.5035 1
Loa Loa (eye worm) RecQ helicase 0.0029 0.1637 0.1637
Brugia malayi TAR-binding protein 0.0076 0.5035 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.042 0.0788
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0671 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0437 0.0822
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1637 0.3218
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0437 0.0822
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0437 0.0822
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0437 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0437 0.0822
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.042 0.042
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.5
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1637 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0437 0.0822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0437 0.0437
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0437 0.0867
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0437 0.0822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0437 0.0437
Schistosoma mansoni DNA helicase recq5 0.0012 0.042 0.0833
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0966 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0437 0.0822
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0025 0.0025
Schistosoma mansoni DNA helicase recq1 0.0012 0.042 0.0833
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.042 0.0788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0437 0.0437
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0437 0.0822
Loa Loa (eye worm) RNA binding protein 0.0076 0.5035 0.5035
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.042 0.5
Brugia malayi ecdysteroid receptor 0.0012 0.0437 0.0822
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0437 0.0822
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0025
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0437 0.0867
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0788
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0437 0.0822
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0437 0.0822
Brugia malayi steroid hormone receptor 0.0012 0.0437 0.0822
Echinococcus granulosus bloom syndrome protein 0.0029 0.1637 0.3218
Schistosoma mansoni tar DNA-binding protein 0.0076 0.5035 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.1201 0.2385
Brugia malayi RNA binding protein 0.0076 0.5035 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0437 0.0822
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0437 0.5
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0437 0.0867
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0437 0.0822
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0437 0.0437
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0437 0.0822
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0437 0.0822
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0437 0.0822
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0437 0.0822
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0437 0.0867
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0437 0.0822
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.4422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0437 0.0437
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1637 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0437 0.0822
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0437 0.0822
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.042 0.0788
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0437 0.0867
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.4422
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0437 0.0822
Loa Loa (eye worm) hypothetical protein 0.0012 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0025
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1637 0.3218
Onchocerca volvulus 0.0012 0.0437 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0437 0.0822
Loa Loa (eye worm) hypothetical protein 0.0006 0.0025 0.0025
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0788
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0437 0.0867
Loa Loa (eye worm) hypothetical protein 0.0012 0.042 0.042
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0437 0.0867
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0437 0.0822
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0437 0.0822
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1385 1
Brugia malayi nuclear hormone receptor 0.0012 0.0437 0.0822
Loa Loa (eye worm) TAR-binding protein 0.0076 0.5035 0.5035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0437 0.0822
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0437 0.0822
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0025 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0437 0.0437
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0437 0.0822
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.5035 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0437 0.0822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0437 0.0437
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0437 0.0867
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0437 0.0867
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0437 0.0822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0437 0.0437
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.0000000003529 0.5
Echinococcus granulosus tar DNA binding protein 0.0076 0.5035 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0949 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0437 0.0822
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0437 0.0822
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.5035 0.5035
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.042 0.0788

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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