TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 519.546 | Formula: C28H29N3O7
H donors: 5 H acceptors: 5 LogP: 2.77 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@H]1Cc2ccc(c(c2)Oc2ccc(C[C@@H](C(=O)N[C@H](C(=O)N1)Cc1ccc(cc1)O)N)cc2)O
InChi: 1S/C28H29N3O7/c1-37-28(36)23-14-18-6-11-24(33)25(15-18)38-20-9-4-16(5-10-20)12-21(29)26(34)30-22(27(35)31-23)13-17-2-7-19(32)8-3-17/h2-11,15,21-23,32-33H,12-14,29H2,1H3,(H,30,34)(H,31,35)/t21-,22-,23+/m0/s1
InChiKey: OYUVAYNPMPDLBV-RJGXRXQPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Angiotensin-converting enzyme	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Angiotensin-converting enzyme family protein	Get druggable targets OG5_131988	All targets in OG5_131988
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	Get druggable targets OG5_131988	All targets in OG5_131988

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.013	0.0631	0.3733
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0111	0.021
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0258	0.1348	0.3273
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0474	0.112
Brugia malayi	Pre-SET motif family protein	0.0064	0.0267	0.0615
Echinococcus granulosus	peregrin	0.0032	0.009	0.0204
Plasmodium vivax	SET domain protein, putative	0.0064	0.0267	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0247	0.0562
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.009	0.0204
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0111	0.0292
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0057	0.0225	0.0225
Echinococcus granulosus	cpg binding protein	0.006	0.0242	0.055
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.017	0.0377
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0144	0.0712	0.4311
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0077	0.2814
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0122	0.0591	0.1306
Leishmania major	hypothetical protein, conserved	0.003	0.0077	0.2814
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0111	0.4456
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0144	0.0712	0.4664
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0111	0.062
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.017	0.0372
Plasmodium vivax	thioredoxin reductase, putative	0.0057	0.0225	0.8324
Plasmodium falciparum	glutathione reductase	0.0057	0.0225	1
Brugia malayi	Pre-SET motif family protein	0.0441	0.2366	0.5779
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.009	0.286
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.017	0.0387
Schistosoma mansoni	hypothetical protein	0.0806	0.44	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0028	0.0468
Schistosoma mansoni	hypothetical protein	0.0189	0.096	0.2149
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0441	0.2366	0.5777
Mycobacterium tuberculosis	Probable oxidoreductase	0.0144	0.0712	0.4664
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0077	0.2343
Trichomonas vaginalis	set domain proteins, putative	0.0502	0.2705	0.8506
Brugia malayi	F/Y-rich N-terminus family protein	0.003	0.0077	0.0147
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Plasmodium vivax	glutathione reductase, putative	0.0057	0.0225	0.8324
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0111	0.023
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.0904	0.2803
Loa Loa (eye worm)	thioredoxin reductase	0.0057	0.0225	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0474	0.2551	0.623
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0111	0.0225
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0111	0.062
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0111	0.0292
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0339	0.0339
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0111	0.062
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0309	0.1631	0.3966
Toxoplasma gondii	hypothetical protein	0.0171	0.0863	1
Plasmodium falciparum	phd finger protein, putative	0.0032	0.009	0.3436
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.016	0.0365
Brugia malayi	jmjC domain containing protein	0.0042	0.0146	0.0316
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.009	0.0173
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0064	0.0267	0.2943
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0064	0.0267	0.0567
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.017	0.017
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0128	0.0128
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0111	0.3709
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0028	0.0468
Entamoeba histolytica	hypothetical protein	0.0077	0.0339	0.0986
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0111	0.4456
Schistosoma mansoni	hypothetical protein	0.0077	0.0339	0.0731
Onchocerca volvulus	Glucosylceramidase homolog	0.0169	0.0853	0.2918
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0289	0.0618
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0148	0.0736	0.1768
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0111	0.0292
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0853	0.2642
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0111	0.0225
Brugia malayi	beta-lactamase family protein	0.0036	0.0111	0.023
Brugia malayi	beta-lactamase	0.0036	0.0111	0.023
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0028	0.0468
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0111	0.021
Echinococcus granulosus	histone lysine methyltransferase setb	0.0064	0.0267	0.0607
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0028	0.0468
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0853	0.2642
Giardia lamblia	Fructose-bisphosphate aldolase	0.0586	0.3177	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0111	0.0225
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0111	0.062
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0289	0.0665
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0586	0.3177	1
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0289	0.0618
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0309	0.1631	0.3706
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0309	0.1631	0.1631
Onchocerca volvulus		0.0064	0.0267	0.0679
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.1348	0.4208
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0111	0.0225
Onchocerca volvulus		0.0057	0.0224	0.0514
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0586	0.3177	1
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0111	0.062
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0111	0.062
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0064	0.0267	0.0267
Schistosoma mansoni	hypothetical protein	0.0047	0.017	0.0347
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0146	0.029
Schistosoma mansoni	cpg binding protein	0.006	0.0242	0.051
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0267	0.061
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.1348	0.4208
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0028	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0047	0.017	0.0372
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Loa Loa (eye worm)	glutathione reductase	0.0057	0.0225	0.0508
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.002	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0111	0.0225
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0064	0.0267	0.0267
Echinococcus granulosus	lysine specific demethylase 5A	0.0042	0.0146	0.0331
Brugia malayi	glutathione reductase	0.0057	0.0225	0.0512
Mycobacterium tuberculosis	Probable reductase	0.013	0.0631	0.4122
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0111	0.062
Leishmania major	hypothetical protein, conserved	0.0036	0.0111	0.4456
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0111	0.0252
Echinococcus multilocularis	geminin	0.0189	0.096	0.096
Echinococcus granulosus	GPCR family 2	0.0047	0.017	0.0387
Brugia malayi	latrophilin 2 splice variant baaae	0.0101	0.0474	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0032	0.009	0.0173
Echinococcus multilocularis	peregrin	0.0032	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0219	0.0491
Brugia malayi	TAR-binding protein	0.0068	0.0289	0.067
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0077	0.2814
Brugia malayi	RNA binding protein	0.0068	0.0289	0.067
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0111	0.062
Mycobacterium ulcerans	lipase LipD	0.0036	0.0111	0.062
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0309	0.1631	0.3706
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.0282	0.0647
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0267	0.0567
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.0904	0.2803
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.013	0.0631	0.4122
Schistosoma mansoni	ap endonuclease	0.0021	0.0028	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0111	0.0225
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0853	0.2642
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0028	0.0468
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.013	0.0631	0.4122
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0289	0.0665
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.009	0.0842
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0224	0.0509
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0111	0.062
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.002	0.0018	0.0018
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.016	0.016
Onchocerca volvulus		0.0036	0.0111	0.0081
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0289	0.0658
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0309	0.1631	0.3679
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0111	0.062
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.009	0.0162
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0028	0.0028
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0286	0.1505	1
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0289	0.0618
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0028	0.0065
Brugia malayi	Bromodomain containing protein	0.0032	0.009	0.0178
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0853	0.2642
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0148	0.0736	0.1768
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0853	0.2642
Schistosoma mansoni	cpg binding protein	0.006	0.0242	0.051
Plasmodium falciparum	thioredoxin reductase	0.0057	0.0225	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0028	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0077	0.2814
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Toxoplasma gondii	thioredoxin reductase	0.0057	0.0225	0.245
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.1348	0.4208
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.009	0.009
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0474	0.2551	0.623
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0258	0.1348	0.3269
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0144	0.0712	0.4664
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0853	0.2642
Echinococcus granulosus	geminin	0.0189	0.096	0.2182
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0111	0.0225
Onchocerca volvulus		0.0502	0.2705	1
Schistosoma mansoni	hypothetical protein	0.0047	0.017	0.0347
Brugia malayi	PHD-finger family protein	0.0032	0.009	0.0178
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0148	0.0736	0.1764
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0146	0.0311
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0027	0.0059	0.0093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0309	0.1631	0.3679
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.002	0.0019	0.0044
Brugia malayi	jmjC domain containing protein	0.0106	0.0501	0.119
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0028	0.0389
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0339	0.0731
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.017	0.0387
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.009	0.0842
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0267	0.0567
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0111	0.4456
Echinococcus multilocularis	cpg binding protein	0.006	0.0242	0.0242
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.002	0.0018	0.0003
Onchocerca volvulus		0.0036	0.0111	0.0081
Onchocerca volvulus		0.0036	0.0111	0.0081
Toxoplasma gondii	exonuclease III APE	0.0021	0.0028	0.0115
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0077	0.2814
Schistosoma mansoni	ap endonuclease	0.0021	0.0028	0.0022
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0146	0.029
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0028	0.0031
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0289	0.0665
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0028	0.0031
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Trypanosoma brucei	trypanothione reductase	0.0057	0.0225	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0111	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0736	0.1764
Brugia malayi	Angiotensin-converting enzyme family protein	0.0749	0.4083	1
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0028	0.0031
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Echinococcus granulosus	dnaJ subfamily B	0.0806	0.44	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.1199	0.7942
Echinococcus multilocularis	dnaJ subfamily B	0.0806	0.44	0.44
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0286	0.1505	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0309	0.1631	0.3679
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0309	0.1631	0.1631
Schistosoma mansoni	hypothetical protein	0.0047	0.017	0.0347
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0077	0.069
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0339	0.077
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.1348	0.4208
Schistosoma mansoni	hypothetical protein	0.0189	0.096	0.2149
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0749	0.4083	1
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.017	0.0377
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.013	0.0631	0.4122
Brugia malayi	hypothetical protein	0.003	0.0077	0.0146
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0028	0.0065
Brugia malayi	beta-lactamase family protein	0.0036	0.0111	0.023
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0111	0.0111
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0057	0.0225	0.1392
Entamoeba histolytica	hypothetical protein	0.0077	0.0339	0.0986
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0028	0.0064
Brugia malayi	hypothetical protein	0.0077	0.0339	0.0791
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0106	0.0501	0.1139
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0224	0.0504
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0111	0.0292
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0289	0.0618
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0077	0.2814
Schistosoma mansoni	hypothetical protein	0.0101	0.0474	0.104
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.0519	0.5927
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0309	0.1631	0.3969
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0111	0.062
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0863	0.2077
Schistosoma mansoni	jumonji domain containing protein	0.0084	0.0379	0.0824
Brugia malayi	Thioredoxin reductase	0.0057	0.0225	0.0512
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.017	0.017
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0267	0.0567
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0289	0.0618
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0111	0.062
Entamoeba histolytica	hypothetical protein	0.0077	0.0339	0.0986
Schistosoma mansoni	hypothetical protein	0.0047	0.017	0.0347
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0289	0.067
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0106	0.0501	0.0501
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.1348	0.4208
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.002	0.0018	0.0042
Loa Loa (eye worm)	hypothetical protein	0.003	0.0077	0.0142
Mycobacterium tuberculosis	Probable dehydrogenase	0.013	0.0631	0.4122
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0853	0.2642
Leishmania major	trypanothione reductase	0.0057	0.0225	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.002	0.0018	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0289	0.0289
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0028	0.0031
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0286	0.1505	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0863	0.2077
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0111	0.0225
Schistosoma mansoni	hypothetical protein	0.0032	0.009	0.0162
Giardia lamblia	PHD finger protein 15	0.0032	0.009	0.0225
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0111	0.0292
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0586	0.3177	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0111	0.062
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0111	0.062
Trypanosoma cruzi	trypanothione reductase, putative	0.0057	0.0225	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0586	0.3177	1
Echinococcus multilocularis	GPCR, family 2	0.0047	0.017	0.017
Trichomonas vaginalis	esterase, putative	0.0036	0.0111	0.0292
Schistosoma mansoni	cpg binding protein	0.0057	0.0224	0.0469
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0028	0.0022
Echinococcus granulosus	thioredoxin glutathione reductase	0.0057	0.0225	0.0512
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.013	0.0631	0.4122
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.1348	0.4208
Entamoeba histolytica	hypothetical protein	0.0077	0.0339	0.0986

Activities

Activity type	Activity value	Assay description	Source	Reference
I50 (binding)	= 0.6 ug ml-1	Inhibitory concentration against Angiotensin I converting enzyme obtained from rabbit lung acetone powder extract	ChEMBL.	No reference
IC50 (binding)	= 0.6 ug ml-1	Inhibitory concentration against Angiotensin I converting enzyme obtained from rabbit lung acetone powder extract	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 135264