Detailed information for compound 1360893

Basic information

Technical information
  • TDR Targets ID: 1360893
  • Name: E565-0204
  • MW: 493.558 | Formula: C23H19N5O4S2
  • H donors: 1 H acceptors: 5 LogP: 4.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(ccc1C)S(=O)(=O)c1nnn2c1nc(NCc1ccc3c(c1)OCO3)c1c2ccs1
  • InChi: 1S/C23H19N5O4S2/c1-13-3-5-16(9-14(13)2)34(29,30)23-22-25-21(20-17(7-8-33-20)28(22)27-26-23)24-11-15-4-6-18-19(10-15)32-12-31-18/h3-10H,11-12H2,1-2H3,(H,24,25)
  • InChiKey: POEIRBWVSVWOHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCGC00122798-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.2983 0.6965 0.6965
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.4281 1 1
Trypanosoma cruzi lanosterol synthase, putative 0.1129 0.2627 0.4255
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.4281 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0071 0.0071
Echinococcus multilocularis Ras protein Rap 1b 0.004 0.0079 0.0079
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0131 0.0131
Echinococcus multilocularis ras gtpase 0.0054 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.006 0.0127 0.0127
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.2983 0.6965 0.6965
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0207 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0071 0.0071
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.2983 0.6965 0.6965
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.4281 1 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.2646 0.6175 0.6175
Plasmodium vivax geranylgeranyltransferase, putative 0.1129 0.2627 0.3773
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0773 0.1795 0.2908
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0031 0.0031
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0207 0.5
Plasmodium falciparum geranylgeranyltransferase, putative 0.1129 0.2627 0.3773
Echinococcus multilocularis Ras protein Rap 1b 0.004 0.0079 0.0079
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.1129 0.2627 0.2627
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.2646 0.6175 0.6175
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0071 0.0114
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0773 0.1795 0.1795
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.4281 1 1
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0773 0.1795 0.2908
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.2646 0.6175 0.6175
Trypanosoma brucei protein farnesyltransferase beta subunit 0.2646 0.6175 1
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.1129 0.2627 0.4255
Entamoeba histolytica Ras family GTPase 0.004 0.0079 0.0079
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0773 0.1795 0.1795
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.2983 0.6965 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0773 0.1795 0.1795
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.1129 0.2627 0.2627
Loa Loa (eye worm) hypothetical protein 0.0054 0.0112 0.0112
Trichomonas vaginalis GTP-binding protein rit, putative 0.0054 0.0112 0.0112
Trypanosoma cruzi protein farnesyltransferase, putative 0.2646 0.6175 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.2983 0.6965 0.6965
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0071 0.0071
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.2983 0.6965 0.6965
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.1129 0.2627 0.2627
Echinococcus granulosus Ras protein Rap 1b 0.004 0.0079 0.0079
Trichomonas vaginalis Rab6, putative 0.004 0.0079 0.0079
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.2646 0.6175 0.6175
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0031 0.0031
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0773 0.1795 0.2908
Schistosoma mansoni hsp40 subfamily A members 124 0.0006 0.000000000030189 0.000000000030189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0071 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0127 0.0127
Trichomonas vaginalis rap1 and, putative 0.0054 0.0112 0.0112
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0031 0.0031
Brugia malayi Ras protein let-60 0.0054 0.0112 0.0112
Entamoeba histolytica ras-1, putative 0.0054 0.0112 0.0112
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.4281 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0031 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0088 0.0088
Trichomonas vaginalis rheb, putative 0.0054 0.0112 0.0112
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.1129 0.2627 0.4255
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.1129 0.2627 1
Loa Loa (eye worm) hypothetical protein 0.1129 0.2627 0.2627
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.1129 0.2627 0.4255
Giardia lamblia Rab geranylgeranyltransferase 0.1129 0.2627 0.3773
Plasmodium falciparum protein farnesyltransferase subunit beta 0.2646 0.6175 0.8866
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1935 0.1935
Leishmania major geranylgeranyltransferase, putative 0.1129 0.2627 0.4255
Plasmodium vivax SET domain protein, putative 0.0036 0.0071 0.0101
Loa Loa (eye worm) hypothetical protein 0.1129 0.2627 0.2627
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.2983 0.6965 0.6965
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0079 0.0079
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.1129 0.2627 0.2627
Schistosoma mansoni rap1 and 0.004 0.0079 0.0079
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.4281 1 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.2646 0.6175 1
Trypanosoma cruzi lanosterol synthase, putative 0.1129 0.2627 0.4255
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.2646 0.6175 0.6175
Entamoeba histolytica hypothetical protein 0.0043 0.0088 0.0088
Toxoplasma gondii hypothetical protein 0.221 0.5155 0.8349
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.2646 0.6175 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0131 0.4744
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0131 0.0131
Giardia lamblia Prenyltransferase 0.2646 0.6175 0.8866
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0067 0.0067
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0773 0.1795 0.1795
Plasmodium vivax conserved Plasmodium protein, unknown function 0.1517 0.3534 0.5074
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0574 0.0574
Trypanosoma brucei hypothetical protein, conserved 0.0773 0.1795 0.2908
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0031 0.0031
Schistosoma mansoni hsp40 subfamily A members 124 0.0006 0.000000000030189 0.000000000030189
Giardia lamblia Rab geranylgeranyltransferase 0.0773 0.1795 0.2578
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1935 0.1935
Loa Loa (eye worm) Ras protein let-60 0.0054 0.0112 0.0112
Echinococcus multilocularis rho GTPase activating protein 190 0.004 0.0079 0.0079
Echinococcus granulosus ras gtpase 0.0054 0.0112 0.0112
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0207 0.0207
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0127 0.0127
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.2646 0.6175 0.6175
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.1129 0.2627 0.3773
Schistosoma mansoni hypothetical protein 0.0041 0.0082 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0071 0.0071
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0773 0.1795 0.1795
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0207 0.0207
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.1129 0.2627 0.4255
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.2983 0.6965 0.6965
Brugia malayi Ras-related protein R-Ras2 0.0054 0.0112 0.0112
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0031 0.0031
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0207 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0071 0.0071
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.2646 0.6175 0.6175
Trypanosoma cruzi hypothetical protein, conserved 0.0773 0.1795 0.2908
Loa Loa (eye worm) hypothetical protein 0.0036 0.0071 0.0071
Brugia malayi RAP1B, member of RAS oncogene family 0.004 0.0079 0.0079
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.2646 0.6175 0.6175
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1935 0.1935
Brugia malayi hypothetical protein 0.0043 0.0088 0.0088
Entamoeba histolytica Ras family GTPase 0.0054 0.0112 0.0112
Toxoplasma gondii hypothetical protein 0.0773 0.1795 0.2908
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0207 0.0297
Schistosoma mansoni hypothetical protein 0.0043 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0031
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0773 0.1795 0.2908
Echinococcus multilocularis GPCR, family 2 0.0019 0.0031 0.0031
Leishmania major farnesyltransferase beta subunit 0.2646 0.6175 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0088 0.0088
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0207 1
Onchocerca volvulus 0.0773 0.1795 1
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0773 0.1795 0.2908
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0079
Echinococcus granulosus rho GTPase activating protein 190 0.004 0.0079 0.0079
Giardia lamblia Rab geranylgeranyltransferase 0.2983 0.6965 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0207 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.0207 0.0207
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.4281 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.1129 0.2627 0.4255
Entamoeba histolytica hypothetical protein 0.0043 0.0088 0.0088
Echinococcus granulosus Ras protein Rap 1b 0.004 0.0079 0.0079
Plasmodium vivax farnesyltransferase beta subunit, putative 0.2646 0.6175 0.8866
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0773 0.1795 0.1795
Entamoeba histolytica hypothetical protein 0.0043 0.0088 0.0088
Brugia malayi Probable ClpP-like protease 0.0094 0.0207 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.1129 0.2627 0.4255
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0773 0.1795 0.2908
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.1129 0.2627 0.3773
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0207 0.5
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0773 0.1795 0.2578
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.2983 0.6965 0.6965
Trichomonas vaginalis ral, putative 0.0054 0.0112 0.0112
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0062 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0071 0.0071
Onchocerca volvulus 0.0286 0.0655 0.339
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.221 0.5155 0.5155
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0207 0.0297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0031 0.0031
Plasmodium vivax prenyltransferase alpha subunit, putative 0.2983 0.6965 1
Entamoeba histolytica Ras family GTPase 0.0054 0.0112 0.0112
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0207 0.0335
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0127 0.0127
Schistosoma mansoni rap1 and 0.004 0.0079 0.0079
Onchocerca volvulus 0.004 0.0079 0.0047
Trichomonas vaginalis dexras1, putative 0.0054 0.0112 0.0112
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0088 0.0088
Echinococcus granulosus protein farnesyltransferase subunit beta 0.2646 0.6175 0.6175
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0207 0.0335
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0773 0.1795 0.1795
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.1129 0.2627 0.2627
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0082 0.0082
Brugia malayi Pre-SET motif family protein 0.0036 0.0071 0.0071
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.2646 0.6175 0.6175
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0773 0.1795 0.1795
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0207 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0773 0.1795 0.1795
Echinococcus granulosus GPCR family 2 0.0019 0.0031 0.0031
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0062 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0082 0.0082
Trypanosoma brucei lanosterol synthase 0.1129 0.2627 0.4255
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0207 0.0207
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.2646 0.6175 0.6175
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0655 0.0655
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.2983 0.6965 0.6965
Schistosoma mansoni protein farnesyltransferase subunit beta 0.2646 0.6175 0.6175
Trichomonas vaginalis ras-dva small GTPase, putative 0.0054 0.0112 0.0112
Brugia malayi Pre-SET motif family protein 0.0251 0.0574 0.0574
Toxoplasma gondii hypothetical protein 0.0033 0.0062 0.0101
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0773 0.1795 0.2578
Trypanosoma cruzi hypothetical protein, conserved 0.0773 0.1795 0.2908
Loa Loa (eye worm) hypothetical protein 0.2983 0.6965 0.6965
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0773 0.1795 0.2908
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.1129 0.2627 0.2627

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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