Detailed information for compound 1374967

Basic information

Technical information
  • TDR Targets ID: 1374967
  • Name: ZINC00357808
  • MW: 303.315 | Formula: C18H13N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.35 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cccc(c1)n1c(=O)c2cccc3c2c(c1=O)ccc3N
  • InChi: 1S/C18H13N3O2/c19-10-3-1-4-11(9-10)21-17(22)13-6-2-5-12-15(20)8-7-14(16(12)13)18(21)23/h1-9H,19-20H2
  • InChiKey: BQCZGIQILFZTOZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • Oprea1_563344
  • BAS 00398689
  • 6-Amino-2-(3-amino-phenyl)-benzo[de]isoquinoline-1,3-dione
  • Oprea1_786304

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Starlite/ChEMBL No references
Homo sapiens kelch-like ECH-associated protein 1 No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Salmonella choleraesuis (strain SC-B67) Beta-lactamase Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Human herpesvirus 8 ORF 73 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine non-variant cyst protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni notch Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Trichomonas vaginalis Involucrin, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein Group 1 Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Kelch repeat type 1 Get druggable targets OG5_134673 All targets in OG5_134673
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Neurogenic locus notch protein homolog precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K10456 kelch-like protein 19, putative Get druggable targets OG5_134673 All targets in OG5_134673
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Kelch-like ECH-associated protein 1, putative Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum IPR013091,EGF calcium-binding;IPR013111,EGF, extracellular;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic a Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica CXXC-rich protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans class a beta-lactamase, BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Echinococcus multilocularis microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum IPR006209,EGF-like;IPR013091,EGF calcium-binding;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and as Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134673 All targets in OG5_134673
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) TK/FER protein kinase Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans UDP-galactopyranose mutase Glf Get druggable targets OG5_139595 All targets in OG5_139595
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Mycobacterium tuberculosis Class a beta-lactamase BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Kelch motif family protein kelch-like ECH-associated protein 1 624 aa 565 aa 31.1 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei beta lactamase Beta-lactamase   269 aa 263 aa 98.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ferritin 0.001 0.0092 0.0312
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.161 0.623
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Echinococcus multilocularis Kelch repeat type 1 0.0114 0.1614 0.5491
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0147 0.0875
Leishmania major electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0005 0.0014 0.0043
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Giardia lamblia Kinase, PLK 0.0114 0.161 1
Entamoeba histolytica hypothetical protein 0.0004 0.0007 0.0033
Echinococcus granulosus prenylcysteine oxidase 0.0005 0.0014 0.0024
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0595 0.2027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0057 0.0331
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0005 0.0014 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0478 0.1609
Trypanosoma cruzi UDP-galactopyranose mutase 0.0005 0.0014 0.0043
Schistosoma mansoni hypothetical protein 0.0043 0.0577 0.1967
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.161 1
Loa Loa (eye worm) hypothetical protein 0.018 0.2579 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0577 0.1967
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0068 0.0208
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0577 0.1948
Schistosoma mansoni notch 0.0004 0.0007 0.0024
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Echinococcus granulosus protoporphyrinogen oxidase 0.0005 0.0014 0.0024
Plasmodium vivax unspecified product 0.0005 0.0014 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica hypothetical protein 0.0004 0.0007 0.0033
Echinococcus granulosus kelch ECH associated protein 1 0.0114 0.161 0.5475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.075 0.2555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0057 0.0331
Loa Loa (eye worm) hypothetical protein 0.0045 0.0595 0.2285
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.117 0.3973
Schistosoma mansoni ferritin light chain 0.001 0.0092 0.0312
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0595 0.3681
Trichomonas vaginalis Involucrin, putative 0.0004 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0027
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative 0.0004 0.0007 0.0033
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0007 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0057 0.0331
Echinococcus multilocularis prenylcysteine oxidase 0.0005 0.0014 0.0024
Schistosoma mansoni apoferritin-2 0.001 0.0092 0.0312
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.161 0.5475
Entamoeba histolytica hypothetical protein 0.0043 0.0577 0.3578
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Brugia malayi Muscleblind-like protein 0.018 0.2579 1
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.117 0.3973
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0007 0.0021
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0335 0.1281
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0012 0.0066
Schistosoma mansoni ferritin 0.001 0.0092 0.0312
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0012 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Schistosoma mansoni ferritin 0.001 0.0092 0.0312
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0092 0.0078
Schistosoma mansoni myst-related protein 0.0004 0.0002 0.0006
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0005 0.0014 0.0043
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0147 0.0875
Echinococcus granulosus expressed protein 0.001 0.0092 0.0289
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.161 0.5476
Leishmania major hypothetical protein, conserved 0.0027 0.0335 0.2044
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0077 0.1067 0.1054
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0688 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0057 0.0331
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Mycobacterium ulcerans lipoprotein LpqF 0.0077 0.1067 0.1054
Schistosoma mansoni apoferritin-2 0.001 0.0092 0.0312
Entamoeba histolytica hypothetical protein 0.0014 0.0147 0.0905
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0012 0.0066
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0595 0.3681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.075 0.2537
Schistosoma mansoni cpg binding protein 0.0037 0.0478 0.1629
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0005 0.0014 0.5
Loa Loa (eye worm) hypothetical protein 0.0084 0.117 0.452
Echinococcus granulosus muscleblind protein 0.018 0.2579 0.8789
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.161 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.075 0.2555
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica hypothetical protein 0.0014 0.0147 0.0905
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0577 0.1948
Entamoeba histolytica hypothetical protein 0.0043 0.0577 0.3578
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0092 0.0078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.075 0.2887
Plasmodium vivax adrenodoxin reductase, putative 0.0005 0.0014 0.5
Schistosoma mansoni hypothetical protein 0.0205 0.2934 1
Trypanosoma brucei polo-like protein kinase 0.0114 0.161 1
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.161 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1017 0.3468
Entamoeba histolytica hypothetical protein 0.0043 0.0577 0.3578
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Brugia malayi all-trans-13,14-dihydroretinol saturase 0.0005 0.0014 0.0027
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Trichomonas vaginalis hypothetical protein 0.0041 0.054 0.334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.075 0.2537
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0057 0.0331
Schistosoma mansoni cpg binding protein 0.0035 0.0449 0.153
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Trichomonas vaginalis ferritin, putative 0.001 0.0092 0.0548
Entamoeba histolytica protein kinase, putative 0.0004 0.0007 0.0033
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0077 0.1067 0.1054
Onchocerca volvulus 0.0035 0.0449 0.2758
Schistosoma mansoni ferritin light chain 0.001 0.0092 0.0312
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.161 0.623
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0768 0.4756
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0777 0.4822
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica hypothetical protein 0.0004 0.0007 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.161 1
Entamoeba histolytica hypothetical protein 0.0014 0.0147 0.0905
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.016 0.2285 0.2274
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Loa Loa (eye worm) lethal protein 721 0.0005 0.0014 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Entamoeba histolytica hypothetical protein 0.0043 0.0577 0.3578
Entamoeba histolytica hypothetical protein 0.0005 0.0012 0.0066
Echinococcus multilocularis muscleblind protein 1 0.018 0.2579 0.8789
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0688 1 1
Schistosoma mansoni tsg101-related 0.007 0.0964 0.3287
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0012 0.0066
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0005 0.0014 0.0043
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0595 0.3688
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0595 0.2009
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Brugia malayi hypothetical protein 0.0043 0.0577 0.2216
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0092 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Plasmodium vivax unspecified product 0.0005 0.0014 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0595 0.3681
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica hypothetical protein 0.0005 0.0012 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0092 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.161 1
Schistosoma mansoni ferritin 0.001 0.0092 0.0312
Trypanosoma brucei beta lactamase 0.0077 0.1067 0.6286
Entamoeba histolytica hypothetical protein 0.0004 0.0007 0.0033
Schistosoma mansoni tsg101-related 0.0057 0.0777 0.2649
Schistosoma mansoni tsg101-related 0.007 0.0964 0.3287
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0068 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.075 0.2537
Echinococcus multilocularis expressed protein 0.001 0.0092 0.0289
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0068 0.0208
Schistosoma mansoni hypothetical protein 0.0114 0.1614 0.5502
Schistosoma mansoni myst-related protein 0.0004 0.0002 0.0006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0595 0.2009
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.161 0.5475
Plasmodium vivax unspecified product 0.0005 0.0014 0.5
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0007 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.161 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0595 0.3668
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.161 1
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Onchocerca volvulus 0.0005 0.0014 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0005 0.0014 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0147 0.0895
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.161 0.5475
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0595 0.2009
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.161 0.5475
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0092 0.0078
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0007 0.0045 0.0348
Schistosoma mansoni amine oxidase 0.0005 0.0014 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.075 0.2555
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0007 0.0033
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.161 0.5476
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0449 0.1718
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.075 0.2537
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0068 0.0208
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.161 1
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0012 0.0066
Schistosoma mansoni hypothetical protein 0.0205 0.2934 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0015 0.005
Echinococcus granulosus geminin 0.0205 0.2934 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0092 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.2579 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0099 0.0314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0057 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0068 0.0208
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.161 1
Echinococcus granulosus cpg binding protein 0.0037 0.0478 0.1609
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0057 0.0331
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0099 0.0357
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0768 0.4756
Echinococcus granulosus ferritin 0.001 0.0092 0.0289
Schistosoma mansoni cpg binding protein 0.0037 0.0478 0.1629
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.075 0.2887
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.016 0.2285 0.2274
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0092 0.0078
Schistosoma mansoni hypothetical protein 0.0005 0.0014 0.0047
Entamoeba histolytica CXXC-rich protein 0.0004 0.0007 0.0033
Entamoeba histolytica hypothetical protein 0.0005 0.0012 0.0066
Onchocerca volvulus 0.0005 0.0014 0.0043
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Entamoeba histolytica hypothetical protein 0.0004 0.0007 0.0033
Echinococcus multilocularis geminin 0.0205 0.2934 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0595 0.2027
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.161 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0057 0.0331
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0007 0.0021
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0335 0.2044
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0595 0.3668
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0057 0.0331
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0099 0.0314
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0007 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0012 0.0066
Entamoeba histolytica protein kinase, putative 0.0004 0.0007 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Trichomonas vaginalis helicase, putative 0.0008 0.0057 0.0331
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.0012 0.0066
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0027
Echinococcus multilocularis ferritin 0.001 0.0092 0.0289
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0595 0.306
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.0007 0.0033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0903 1
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0007 0.0033
Entamoeba histolytica hypothetical protein 0.0014 0.0147 0.0905
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.0012 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0147 0.0895
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative 0.0004 0.0007 0.0021
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0595 0.3668
Brugia malayi hypothetical protein 0.0084 0.117 0.452
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0595 0.2285
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.161 0.5487
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0097 0.0349
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0595 0.3668
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Entamoeba histolytica protein kinase, putative 0.0005 0.0012 0.0066
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0595 0.2009
Brugia malayi CXXC zinc finger family protein 0.0035 0.0449 0.1718
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.161 1
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0595 0.2009
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0595 0.2009
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0147 0.0875
Schistosoma mansoni kinase 0.0058 0.079 0.2691
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.161 1
Echinococcus multilocularis muscleblind protein 0.018 0.2579 0.8789

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 3.13 uM PUBCHEM_BIOASSAY: Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme Measured in Biochemical System Using Plate Reader - 2105-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504439] ChEMBL. No reference
AC50 (binding) = 4.29 uM PUBCHEM_BIOASSAY: Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504540] ChEMBL. No reference
AC50 (binding) = 6.982 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
IC50 (binding) = 16.814 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 26.152 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 31.047 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
Max_Activity_Concent (functional) 50 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1836 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1052 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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