Detailed information for compound 1380139

Basic information

Technical information
  • TDR Targets ID: 1380139
  • Name: 8-[1-(4-dimethylaminophenyl)-3-morpholin-4-yl -3-oxopropyl]-5,7-dimethoxychromen-2-one
  • MW: 466.526 | Formula: C26H30N2O6
  • H donors: 0 H acceptors: 2 LogP: 2.75 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c2c(c1C(c1ccc(cc1)N(C)C)CC(=O)N1CCOCC1)oc(=O)cc2
  • InChi: 1S/C26H30N2O6/c1-27(2)18-7-5-17(6-8-18)20(15-23(29)28-11-13-33-14-12-28)25-22(32-4)16-21(31-3)19-9-10-24(30)34-26(19)25/h5-10,16,20H,11-15H2,1-4H3
  • InChiKey: FTBAUYNAXYJVGK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-[1-(4-dimethylaminophenyl)-3-morpholino-3-oxo-propyl]-5,7-dimethoxy-chromen-2-one
  • 8-[1-(4-dimethylaminophenyl)-3-morpholino-3-oxopropyl]-5,7-dimethoxy-2-chromenone
  • 8-[1-(4-dimethylaminophenyl)-3-keto-3-morpholino-propyl]-5,7-dimethoxy-coumarin
  • 8-[1-(4-dimethylaminophenyl)-3-morpholin-4-yl-3-oxo-propyl]-5,7-dimethoxy-chromen-2-one
  • MLS000879480
  • SMR000465538

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus orexin receptor type 2 0.0101 0.1649 0.4332
Schistosoma mansoni amine GPCR 0.0101 0.1649 0.4382
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0064 0.0796 1
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0389 0.0223
Brugia malayi RE15519p 0.0101 0.1649 0.1649
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0796 0.1566
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0101 0.1649 0.4332
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.1649 0.4382
Echinococcus multilocularis cyclin dependent kinase 0.0047 0.0389 0.0511
Trypanosoma cruzi cdc2-related kinase 1 0.0047 0.0389 0.4892
Schistosoma mansoni opsin-like receptor 0.0101 0.1649 0.4382
Echinococcus multilocularis neuropeptide receptor A26 0.0101 0.1649 0.4332
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus multilocularis dual specificity protein kinase clk2 0.0064 0.0796 0.1745
Loa Loa (eye worm) AGC/PKA protein kinase 0.0044 0.0322 0.0322
Brugia malayi Cytochrome P450 family protein 0.0034 0.0093 0.0093
Echinococcus granulosus neuropeptide receptor 0.0101 0.1649 0.4332
Schistosoma mansoni hypothetical protein 0.0101 0.1649 0.4382
Trypanosoma cruzi cdc2-related kinase 3 0.0047 0.0389 0.4892
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0101 0.1649 0.1649
Echinococcus multilocularis neuropeptide s receptor 0.0101 0.1649 0.4332
Echinococcus granulosus tachykinin peptides receptor 99D 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus granulosus alpha 1A adrenergic receptor 0.0101 0.1649 0.4332
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Echinococcus granulosus allatostatin A receptor 0.0101 0.1649 0.4332
Schistosoma mansoni hypothetical protein 0.0101 0.1649 0.4382
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.1649 0.4382
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0101 0.1649 0.4332
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi Dopamine receptor 0.0101 0.1649 0.1649
Echinococcus granulosus sex peptide receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi Serotonin receptor 0.0101 0.1649 0.1649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0101 0.1649 0.4332
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0505 0.0603
Trypanosoma cruzi cdc2-related kinase 3 0.0047 0.0389 0.4892
Echinococcus granulosus neuropeptide FF receptor 2 0.0101 0.1649 0.4332
Echinococcus multilocularis orexin receptor type 2 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0169 0.3248 0.3248
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Schistosoma mansoni protein kinase 0.0089 0.138 0.3494
Onchocerca volvulus 0.0101 0.1649 0.4376
Onchocerca volvulus 0.0101 0.1649 0.4376
Brugia malayi Cytochrome P450 family protein 0.0041 0.0258 0.0258
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis somatostatin receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0047 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0044 0.0322 0.0322
Brugia malayi G-protein coupled receptor 0.0101 0.1649 0.1649
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1649 0.4332
Echinococcus multilocularis dro:myosuppressin receptor 0.0101 0.1649 0.4332
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0064 0.079 0.079
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0505 0.3852
Echinococcus multilocularis muscleblind protein 0.018 0.3516 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0044 0.0322 0.4044
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0457 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi putative neuropeptide receptor NPR1 0.0101 0.1649 0.1649
Echinococcus granulosus g protein coupled receptor 0.0101 0.1649 0.4332
Onchocerca volvulus 0.0101 0.1649 0.4376
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0505 0.3852
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0101 0.1649 0.1649
Echinococcus multilocularis neuropeptide receptor 0.0101 0.1649 0.4332
Leishmania major protein kinase A catalytic subunit isoform 2 0.0044 0.0322 0.4044
Schistosoma mansoni neuropeptide receptor 0.0101 0.1649 0.4382
Schistosoma mansoni hypothetical protein 0.0101 0.1649 0.4382
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0258 0.324
Schistosoma mansoni amine GPCR 0.0101 0.1649 0.4382
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0044 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Onchocerca volvulus 0.0101 0.1649 0.4376
Brugia malayi Cytochrome P450 family protein 0.0041 0.0258 0.0258
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0163 0.3119 0.8795
Schistosoma mansoni neuropeptide F-like receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Schistosoma mansoni amine GPCR 0.0101 0.1649 0.4382
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0044 0.0322 0.4044
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Plasmodium vivax glycogen synthase kinase 3, putative 0.0052 0.0505 0.6338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Onchocerca volvulus 0.015 0.2798 0.8775
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus granulosus neuropeptide s receptor 0.0101 0.1649 0.4332
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.1649 0.4332
Brugia malayi probable protein kinase 0.0089 0.138 0.138
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0101 0.1649 0.1649
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0163 0.3119 0.3119
Entamoeba histolytica protein kinase domain containing protein 0.0173 0.3349 1
Echinococcus granulosus G protein coupled receptor 139 0.0101 0.1649 0.4332
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1649 0.4332
Brugia malayi Serotonin receptor 0.0101 0.1649 0.1649
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0064 0.0796 1
Echinococcus multilocularis g-protein coupled receptor 0.0101 0.1649 0.4332
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0389 0.1423
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0714 0.1294
Echinococcus multilocularis serotonin receptor 0.0101 0.1649 0.4332
Brugia malayi AKH receptor 0.0101 0.1649 0.1649
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1649 0.4332
Schistosoma mansoni amine GPCR 0.0101 0.1649 0.4382
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0064 0.0796 1
Echinococcus granulosus serotonin receptor 0.0101 0.1649 0.4332
Brugia malayi GnHR receptor homolog 0.0101 0.1649 0.1649
Echinococcus granulosus cyclin dependent kinase 5 0.0047 0.0389 0.0511
Onchocerca volvulus 0.0101 0.1649 0.4376
Schistosoma mansoni adenoreceptor 0.0101 0.1649 0.4382
Toxoplasma gondii AGC kinase 0.0044 0.0322 0.4044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0085 0.1279 0.321
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1649 0.4332
Schistosoma mansoni biogenic amine receptor 0.0101 0.1649 0.4382
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.1649 0.4332
Trypanosoma brucei cdc2-related kinase 1 0.0047 0.0389 0.4892
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi Protein kinase domain containing protein 0.0169 0.3248 0.3248
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0043 0.0289 0.0289
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0173 0.3349 0.3349
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0085 0.1279 0.1279
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis sex peptide receptor 0.0101 0.1649 0.4332
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0101 0.1649 0.4382
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0101 0.1649 0.4382
Echinococcus granulosus protein kinase shaggy 0.0052 0.0505 0.0861
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.1649 0.4332
Echinococcus multilocularis g protein coupled receptor 0.0101 0.1649 0.4332
Echinococcus granulosus hypothetical protein 0.0101 0.1649 0.4332
Echinococcus granulosus neuropeptide Y receptor 0.0101 0.1649 0.4332
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0163 0.3119 0.8795
Echinococcus granulosus biogenic amine 5HT receptor 0.0101 0.1649 0.4332
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0389 0.0223
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis protein kinase shaggy 0.0052 0.0505 0.0861
Leishmania major protein kinase, putative 0.0064 0.0796 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Schistosoma mansoni neuropeptide f receptor 76f 0.0101 0.1649 0.4382
Echinococcus granulosus muscleblind protein 0.018 0.3516 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0101 0.1649 0.4332
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.1649 0.1649
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus granulosus g protein coupled receptor 0.0101 0.1649 0.4332
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0052 0.0505 0.6338
Giardia lamblia Kinase, CMGC CLK 0.0064 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.1649 0.4382
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0044 0.0322 0.4044
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0173 0.3349 0.9493
Plasmodium vivax serine/threonine kinase-1, putative 0.0064 0.0796 1
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.1649 0.4332
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0052 0.0505 0.0861
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Brugia malayi Tachykinin-like peptides receptor 99D 0.0101 0.1649 0.1649
Echinococcus granulosus cyclin dependent kinase 0.0047 0.0389 0.0511
Schistosoma mansoni neuropeptide receptor 0.0101 0.1649 0.4382
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0173 0.3349 0.9493
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0101 0.1649 0.4332
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0101 0.1649 0.4382
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0505 0.0505
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0101 0.1649 0.4382
Brugia malayi G protein-coupled receptor 0.0101 0.1649 0.1649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0163 0.3119 0.3119
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Echinococcus granulosus dual specificity protein kinase clk2 0.0064 0.0796 0.1745
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0047 0.0389 0.4892
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Echinococcus granulosus 7TM GPCR rhodopsin 0.0101 0.1649 0.4332
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.1649 0.4332
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0047 0.0389 0.4892
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1649 0.4332
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) AGC/PKA protein kinase 0.0044 0.0322 0.0322
Echinococcus granulosus tm gpcr rhodopsin 0.0101 0.1649 0.4332
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0052 0.0505 0.0603
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0052 0.0505 0.6338
Echinococcus granulosus neuropeptide receptor A26 0.0101 0.1649 0.4332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0258 0.0258
Onchocerca volvulus 0.0145 0.2698 0.8389
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi Protein kinase domain containing protein 0.0061 0.0714 0.0714
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0101 0.1649 0.4332
Leishmania major protein kinase A catalytic subunit 0.0044 0.0322 0.4044
Echinococcus granulosus peptide allatostatin:somatostatin 0.0101 0.1649 0.4332
Echinococcus multilocularis cyclin dependent kinase 1 0.0047 0.0389 0.0511
Echinococcus multilocularis muscleblind protein 1 0.018 0.3516 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0064 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus granulosus hypothetical protein 0.006 0.0695 0.1439
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus granulosus rho-associated protein kinase 1 0.015 0.2798 0.7822
Schistosoma mansoni protein kinase 0.0064 0.079 0.1547
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0047 0.0389 0.0389
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0322 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0101 0.1649 0.1649
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0044 0.0322 0.4044
Plasmodium falciparum protein kinase 5 0.0047 0.0389 0.4892
Brugia malayi ORL1-like opioid receptor 0.0101 0.1649 0.1649
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0044 0.0322 0.4044
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Entamoeba histolytica protein kinase, putative 0.0052 0.0505 0.0603
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0047 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Onchocerca volvulus 0.0101 0.1649 0.4376
Brugia malayi neuropeptide F receptor 0.0101 0.1649 0.1649
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0044 0.0322 0.4044
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0505 0.0505
Echinococcus granulosus protein kinase 0.0064 0.079 0.1728
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0163 0.3119 0.3119
Schistosoma mansoni biogenic amine receptor 0.0101 0.1649 0.4382
Echinococcus multilocularis neuropeptide FF receptor 2 0.0101 0.1649 0.4332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0714 0.8259
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0101 0.1649 0.4382
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0101 0.1649 0.4382
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0389 0.1423
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Trypanosoma brucei cdc2-related kinase 3 0.0047 0.0389 0.4892
Plasmodium falciparum glycogen synthase kinase 3 0.0052 0.0505 0.6338
Schistosoma mansoni opsin-like receptor 0.0101 0.1649 0.4382
Echinococcus granulosus fmrfamide receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.1649 0.4332
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.006 0.0695 0.0695
Entamoeba histolytica cell division protein kinase 2, putative 0.0047 0.0389 0.0223
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0044 0.0322 0.0306
Loa Loa (eye worm) neuropeptide F receptor 0.0101 0.1649 0.1649
Schistosoma mansoni alpha-1 adrenergic receptor 0.0101 0.1649 0.4382
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0064 0.0796 1
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.1649 0.4332
Entamoeba histolytica cell division protein kinase 2, putative 0.0047 0.0389 0.0223
Schistosoma mansoni growth hormone secretagogue receptor 0.0101 0.1649 0.4382
Onchocerca volvulus 0.0101 0.1649 0.4376
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.3248 0.9666
Schistosoma mansoni amine GPCR 0.0101 0.1649 0.4382
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.3119 0.9239
Schistosoma mansoni hypothetical protein 0.0101 0.1649 0.4382
Schistosoma mansoni opsin-like receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0101 0.1649 0.1649
Schistosoma mansoni myosin xvIII 0.0101 0.1649 0.4382
Brugia malayi Muscleblind-like protein 0.018 0.3516 0.3516
Onchocerca volvulus 0.0061 0.0714 0.0799
Loa Loa (eye worm) hypothetical protein 0.018 0.3516 0.3516
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus granulosus neuropeptide receptor 0.0101 0.1649 0.4332
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0258 0.324
Onchocerca volvulus 0.0061 0.0714 0.0799
Brugia malayi Protein kinase domain containing protein 0.0163 0.3119 0.3119
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0101 0.1649 0.4332
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0322 0.0306
Brugia malayi sulfakinin receptor protein 0.0101 0.1649 0.1649
Echinococcus multilocularis serotonin receptor 0.0101 0.1649 0.4332
Brugia malayi Protein kinase domain containing protein 0.0064 0.0796 0.0796
Schistosoma mansoni serine/threonine protein kinase 0.015 0.2798 0.8181
Brugia malayi putative neuropeptide receptor 0.0101 0.1649 0.1649
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0101 0.1649 0.1649
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) melatonin receptor type 1A 0.0101 0.1649 0.1649
Echinococcus granulosus dro:myosuppressin receptor 0.0101 0.1649 0.4332
Schistosoma mansoni neuropeptide receptor 0.0101 0.1649 0.4382
Schistosoma mansoni neuropeptide receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.1649 0.1649
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0505 0.0603
Echinococcus granulosus g protein coupled receptor 0.0101 0.1649 0.4332
Brugia malayi follicle stimulating hormone receptor 0.0101 0.1649 0.1649
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0714 0.8259
Echinococcus multilocularis neuropeptide receptor 0.0101 0.1649 0.4332
Giardia lamblia Kinase, CDC7 0.0061 0.0714 0.8259
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0101 0.1649 0.1649
Echinococcus granulosus rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Leishmania major protein kinase, putative 0.0064 0.0796 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0101 0.1649 0.4332
Echinococcus multilocularis allatostatin A receptor 0.0101 0.1649 0.4332
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0796 0.1566
Brugia malayi cell division control protein 2 homolog 0.0047 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi G protein-coupled receptor F59B2.13 0.0101 0.1649 0.1649
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis neuropeptides capa receptor 0.0101 0.1649 0.4332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1649 0.4332
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0714 0.8259
Loa Loa (eye worm) G-protein coupled receptor 0.0101 0.1649 0.1649
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Schistosoma mansoni biogenic amine (5HT) receptor 0.0101 0.1649 0.4382
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0101 0.1649 0.1649
Schistosoma mansoni biogenic amine receptor 0.0101 0.1649 0.4382
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis G protein coupled receptor 139 0.0101 0.1649 0.4332
Toxoplasma gondii AGC kinase 0.0044 0.0322 0.4044
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0389 0.1423
Echinococcus multilocularis CDC7 cell division cycle 7 0.0061 0.0714 0.1495
Echinococcus multilocularis fmrfamide receptor 0.0101 0.1649 0.4332
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0044 0.0322 0.4044
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0101 0.1649 0.4376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Echinococcus granulosus neuropeptides capa receptor 0.0101 0.1649 0.4332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0101 0.1649 0.4332
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0173 0.3349 0.3349
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0047 0.0389 0.0511
Onchocerca volvulus 0.0101 0.1649 0.4376
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis G-protein coupled receptor, putative 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi neuropeptide F receptor 0.0101 0.1649 0.1649
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus multilocularis rho associated protein kinase 0.015 0.2798 0.7822
Brugia malayi G-protein coupled receptor 0.0101 0.1649 0.1649
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.3349 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus multilocularis cyclin dependent kinase 1 0.0047 0.0389 0.0511
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0044 0.0322 0.0306
Brugia malayi Melatonin receptor type 1A 0.0101 0.1649 0.1649
Echinococcus granulosus cyclin dependent kinase 1 0.0047 0.0389 0.0511
Echinococcus granulosus 7tm_1 domain containing protein 0.0101 0.1649 0.4332
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0044 0.0322 0.4044
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0064 0.0796 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0322 0.0306
Echinococcus granulosus CDC7 cell division cycle 7 0.0061 0.0714 0.1495
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0163 0.3119 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0047 0.0389 0.0511
Trypanosoma brucei protein kinase, putative 0.0052 0.0505 0.6338
Echinococcus multilocularis fmrfamide receptor 0.0101 0.1649 0.4332
Giardia lamblia Kinase, CMGC CDK 0.0047 0.0389 0.1423
Onchocerca volvulus Neuropeptide F receptor homolog 0.0101 0.1649 0.4376
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0044 0.0322 0.4044
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0044 0.0322 0.4044
Echinococcus granulosus somatostatin receptor 0.0101 0.1649 0.4332
Brugia malayi Dopamine receptor protein 2 0.0101 0.1649 0.1649
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0258 0.0258
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0505 0.3852
Trypanosoma cruzi cdc2-related kinase 1 0.0047 0.0389 0.4892
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0047 0.0389 0.4892
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0258 0.324
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus granulosus g-protein coupled receptor 0.0101 0.1649 0.4332
Loa Loa (eye worm) CDC7 protein kinase 0.0061 0.0714 0.0714
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0044 0.0322 0.4044
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0505 0.3852
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0093 0.0093
Brugia malayi intracellular kinase 0.0052 0.0505 0.0505
Plasmodium vivax protein kinase Crk2 0.0047 0.0389 0.4892
Loa Loa (eye worm) hypothetical protein 0.018 0.3516 0.3516
Echinococcus multilocularis rhodopsin orphan GPCR 0.0101 0.1649 0.4332
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0052 0.0505 0.6338
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0052 0.0505 0.0861
Loa Loa (eye worm) TYRA-2 protein 0.0101 0.1649 0.1649
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0322 0.0306
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Onchocerca volvulus 0.0101 0.1649 0.4376
Echinococcus multilocularis 0.006 0.0695 0.1439
Echinococcus multilocularis neuropeptide Y receptor 0.0101 0.1649 0.4332
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0064 0.0796 1
Giardia lamblia Kinase, CMGC CDK 0.0047 0.0389 0.1423
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0101 0.1649 0.1649
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0258 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0101 0.1649 0.4332
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0101 0.1649 0.4332
Leishmania major cytochrome p450-like protein 0.0041 0.0258 0.324
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0101 0.1649 0.4382
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0101 0.1649 0.1649
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0064 0.0796 0.0796
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0044 0.0322 0.0306
Echinococcus multilocularis 0.0064 0.079 0.1728
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0101 0.1649 0.4382
Loa Loa (eye worm) hypothetical protein 0.0101 0.1649 0.1649
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0101 0.1649 0.4332
Plasmodium falciparum protein serine/threonine kinase-1 0.0064 0.0796 1
Brugia malayi hypothetical protein 0.0101 0.1649 0.1649
Brugia malayi Dopamine receptor protein 1 0.0101 0.1649 0.1649
Schistosoma mansoni histamine h1 receptor 0.0101 0.1649 0.4382
Brugia malayi Protein kinase domain containing protein 0.0047 0.0389 0.0389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0101 0.1649 0.4382
Brugia malayi larval opioid receptor 0.0101 0.1649 0.1649
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0258 0.0258

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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