Detailed information for compound 1386442

Basic information

Technical information
  • TDR Targets ID: 1386442
  • Name: (12aS)-2-(3-ethoxypropyl)-6,6-dimethyl-3,7,12 ,12a-tetrahydropyrazino[4,3-b]$b-carboline-1, 4-quinone
  • MW: 369.457 | Formula: C21H27N3O3
  • H donors: 1 H acceptors: 2 LogP: 1.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCCN1CC(=O)N2[C@H](C1=O)Cc1c(C2(C)C)[nH]c2c1cccc2
  • InChi: 1S/C21H27N3O3/c1-4-27-11-7-10-23-13-18(25)24-17(20(23)26)12-15-14-8-5-6-9-16(14)22-19(15)21(24,2)3/h5-6,8-9,17,22H,4,7,10-13H2,1-3H3/t17-/m0/s1
  • InChiKey: KQQCIXXDBUVQJP-KRWDZBQOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • STOCK1N-32310
  • ZINC02129448

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0015 0.0052
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0038 0.0177
Loa Loa (eye worm) AUR protein kinase 0.0069 0.009 0.0424
Brugia malayi beta-lactamase family protein 0.0071 0.0094 0.0128
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0015 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0039 0.0185
Mycobacterium tuberculosis Conserved protein 0.0071 0.0094 0.1303
Entamoeba histolytica protein kinase domain containing protein 0.1307 0.2094 1
Trichomonas vaginalis ran, putative 0.0022 0.0015 0.0068
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.009 0.0424
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0079 0.7207
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.006 0.0076 0.0278
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.006 0.0076 0.0278
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.006 0.0076 0.0365
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0033 0.3469
Echinococcus multilocularis Zinc finger, PHD finger 0.006 0.0076 0.0361
Leishmania major hypothetical protein, conserved 0.0027 0.0022 0.0077
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0022 0.0077
Loa Loa (eye worm) beta-lactamase 0.0071 0.0094 0.0445
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0464 0.0729 0.3482
Entamoeba histolytica hypothetical protein 0.0014 0.0001 0.0003
Loa Loa (eye worm) AUR protein kinase 0.0069 0.009 0.0424
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0319 0.0494 0.2358
Loa Loa (eye worm) hypothetical protein 0.0301 0.0465 0.2218
Mycobacterium tuberculosis Conserved protein 0.0071 0.0094 0.1303
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0015 0.002
Brugia malayi Inositol-1 0.0038 0.0039 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0019 0.0085
Loa Loa (eye worm) hypothetical protein 0.0071 0.0094 0.0445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0094 0.0445
Trypanosoma brucei aurora B kinase 0.0069 0.009 0.0327
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.006 0.0076 0.0278
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.009 0.0327
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0094 0.1303
Echinococcus granulosus snurportin 1 0.0326 0.0506 0.2416
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0079 0.0287
Schistosoma mansoni hypothetical protein 0.0326 0.0506 0.2416
Schistosoma mansoni kinase 0.0061 0.0077 0.0362
Schistosoma mansoni ran 0.0022 0.0015 0.0068
Plasmodium vivax telomerase reverse transcriptase, putative 0.1692 0.2716 1
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.009 0.0428
Onchocerca volvulus 0.1307 0.2094 0.2093
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0094 0.0445
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0464 0.0729 0.2684
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0014 0.0001 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0464 0.0729 0.1004
Trichomonas vaginalis esterase, putative 0.0071 0.0094 0.0445
Brugia malayi serine/threonine kinase 12 0.0069 0.009 0.0122
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1307 0.2094 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0022 0.0077
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.009 0.0327
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1692 0.2716 1
Leishmania major GTP-binding protein, putative 0.0022 0.0015 0.0052
Trypanosoma brucei protein kinase, putative 0.1307 0.2094 0.7709
Brugia malayi hypothetical protein 0.0027 0.0022 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0094 0.0445
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0079 0.0287
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0022 0.0077
Loa Loa (eye worm) inositol-1 0.0038 0.0039 0.0185
Trichomonas vaginalis AGC family protein kinase 0.0069 0.009 0.0424
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0094 0.0343
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0094 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0094 0.1303
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0301 0.0465 0.2218
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.009 0.0428
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0464 0.0729 0.3482
Leishmania major protein kinase, putative 0.0069 0.009 0.0327
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.006 0.0076 0.0361
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0014 0.0001 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0038 0.0177
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0015 0.0052
Brugia malayi hypothetical protein 0.0037 0.0038 0.0051
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1307 0.2094 0.7709
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0094 0.0445
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0039 0.5
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.0653 0.3118
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0015 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0079 0.0372
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0301 0.0465 0.2218
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0464 0.0729 0.3482
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.009 0.0327
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0094 0.0343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0094 0.0445
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0039 0.0143
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0079 0.7207
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0094 0.1303
Schistosoma mansoni hypothetical protein 0.0417 0.0653 0.3118
Echinococcus granulosus cpg binding protein 0.0031 0.0029 0.0133
Schistosoma mansoni cpg binding protein 0.0031 0.0029 0.0133
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0155 0.023 0.0843
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0039 0.0185
Loa Loa (eye worm) hypothetical protein 0.0071 0.0094 0.0445
Leishmania major importin beta-1 subunit, putative 0.0025 0.0019 0.0066
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.006 0.0076 0.0361
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0464 0.0729 0.3484
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1692 0.2716 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.0094 1
Onchocerca volvulus Huntingtin homolog 0.0246 0.0377 0.0376
Giardia lamblia Telomerase catalytic subunit 0.1692 0.2716 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.0151 0.0721
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.0151 0.0718
Loa Loa (eye worm) hypothetical protein 0.0071 0.0094 0.0445
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0094 0.0445
Loa Loa (eye worm) hypothetical protein 0.0071 0.0094 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0151 0.0718
Onchocerca volvulus 0.0029 0.0026 0.0025
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0319 0.0494 0.2358
Onchocerca volvulus 0.0071 0.0094 0.0093
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.006 0.0076 0.0278
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0155 0.023 0.1094
Entamoeba histolytica Ran family GTPase 0.0022 0.0015 0.0071
Trypanosoma brucei polo-like protein kinase 0.0107 0.0151 0.0554
Brugia malayi Importin beta-1 subunit 0.0031 0.0028 0.0037
Entamoeba histolytica hypothetical protein 0.0014 0.0001 0.0003
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1307 0.2094 0.7709
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1307 0.2094 0.7709
Plasmodium vivax importin-beta 2, putative 0.0031 0.0028 0.01
Onchocerca volvulus 0.0071 0.0094 0.0093
Echinococcus multilocularis protein kinase shaggy 0.1307 0.2094 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0094 0.0445
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0079 0.0372
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0094 0.0445
Entamoeba histolytica protein kinase, putative 0.1307 0.2094 1
Echinococcus granulosus protein kinase shaggy 0.1307 0.2094 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0206 0.0312 0.1488
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.006 0.0076 0.0361
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.023 0.0315
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1307 0.2094 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.006 0.0076 0.0278
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.0151 0.0207
Trichomonas vaginalis CMGC family protein kinase 0.1307 0.2094 1
Schistosoma mansoni cpg binding protein 0.0029 0.0026 0.012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0094 0.0445
Trichomonas vaginalis AGC family protein kinase 0.0069 0.009 0.0424
Entamoeba histolytica protein kinase rad3, putative 0.0014 0.0001 0.0003
Schistosoma mansoni protein kinase 0.0069 0.009 0.0424
Giardia lamblia Kinase, PLK 0.0107 0.0151 0.0554
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0142 0.0207 0.0761
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0464 0.0729 0.3482
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0094 0.0343
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.0716 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0094 0.0445
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.009 0.0428
Plasmodium falciparum importin beta, putative 0.0031 0.0028 0.01
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.0151 0.0718
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1307 0.2094 1
Giardia lamblia Aurora kinase 0.0069 0.009 0.0327
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0028 0.01
Entamoeba histolytica hypothetical protein 0.0025 0.0019 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0151 0.0718
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1307 0.2094 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.006 0.0076 0.0361
Loa Loa (eye worm) hypothetical protein 0.0071 0.0094 0.0445
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0039 0.0185
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0014 0.0001 0.0003
Toxoplasma gondii ABC1 family protein 0.0071 0.0094 0.0343
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.023 0.1094
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0015 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.009 0.0424
Entamoeba histolytica protein kinase , putative 0.0069 0.009 0.0428
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0026 0.012
Loa Loa (eye worm) hypothetical protein 0.0246 0.0377 0.1799
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0464 0.0729 0.3482
Schistosoma mansoni importin beta-1 0.0031 0.0028 0.013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0079 0.0372
Schistosoma mansoni inositol monophosphatase 0.0038 0.0039 0.0185
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0464 0.0729 0.3482
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0143
Brugia malayi RNA, U transporter 1 0.0087 0.0119 0.0163
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0151 0.0718
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0079 0.109
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.006 0.0076 0.0361
Trichomonas vaginalis AGC family protein kinase 0.0069 0.009 0.0424
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0079 0.0372
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0022 0.0077
Trypanosoma brucei telomerase reverse transcriptase 0.1692 0.2716 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.009 0.0424
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0155 0.023 0.1097
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0151 0.0718
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0022 0.0077
Loa Loa (eye worm) hypothetical protein 0.0246 0.0377 0.1799
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0039 0.0185
Toxoplasma gondii RNA-directed DNA polymerase 0.1692 0.2716 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.009 0.0428
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0028 0.01
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.0506 0.2416
Brugia malayi beta-lactamase family protein 0.0071 0.0094 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0151 0.0718
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0019 0.0009 0.0032
Loa Loa (eye worm) phosphatidylinositol 3 0.0142 0.0207 0.0988
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.0151 0.0554
Mycobacterium leprae Probable lipase LipE 0.0071 0.0094 1
Entamoeba histolytica hypothetical protein 0.0037 0.0038 0.0181
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0079 0.7207
Mycobacterium ulcerans lipase LipD 0.0071 0.0094 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0015 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0155 0.023 0.1097
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0028 0.01
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0033 0.0452
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0014 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0037 0.0038 0.0181
Giardia lamblia Kinase, CMGC GSK 0.1307 0.2094 0.7709
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0155 0.023 0.1094
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0155 0.023 0.1094
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0094 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0094 0.1303
Schistosoma mansoni hypothetical protein 0.0037 0.0038 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0079 0.0374
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0094 0.0128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0301 0.0465 0.0639
Entamoeba histolytica hypothetical protein 0.0014 0.0001 0.0003
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0019 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0151 0.0718
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.0075 0.0353
Echinococcus multilocularis cpg binding protein 0.0031 0.0029 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.0075 0.0353
Plasmodium falciparum glycogen synthase kinase 3 0.1307 0.2094 0.7709
Leishmania major telomerase reverse transcriptase, putative 0.1692 0.2716 1
Echinococcus granulosus dnaJ subfamily B 0.0417 0.0653 0.3118
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1307 0.2094 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.006 0.0076 0.0278
Schistosoma mansoni ran 0.0022 0.0015 0.0068
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0151 0.0718
Entamoeba histolytica protein kinase, putative 0.0069 0.009 0.0428
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.0151 0.0554
Entamoeba histolytica hypothetical protein 0.0369 0.0576 0.2752
Plasmodium falciparum telomerase reverse transcriptase 0.1692 0.2716 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0019 0.0066
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0015 0.0068
Onchocerca volvulus 0.0071 0.0094 0.0093
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0109 0.0154 0.0565
Plasmodium vivax glycogen synthase kinase 3, putative 0.1307 0.2094 0.7709
Loa Loa (eye worm) hypothetical protein 0.0031 0.0028 0.013
Leishmania major hypothetical protein, conserved 0.0071 0.0094 0.0343
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.006 0.0076 0.0361
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0038 0.0177
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.006 0.0076 0.0361
Brugia malayi serine/threonine protein kinase 6 0.0069 0.009 0.0122
Entamoeba histolytica protein kinase, putative 0.0069 0.009 0.0428
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0464 0.0729 0.2684
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0094 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.0151 0.0554
Echinococcus multilocularis aurora kinase A 0.0069 0.009 0.0424
Leishmania major phosphatidylinositol 3-kinase, putative 0.006 0.0076 0.0278
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0151 0.0718
Echinococcus multilocularis snurportin 1 0.0326 0.0506 0.2416
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0028 0.013
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.0151 0.015
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0143
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0224 0.0341 0.1253
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0094 0.1303
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0143
Loa Loa (eye worm) AUR protein kinase 0.0069 0.009 0.0424
Schistosoma mansoni microtubule-associated protein tau 0.0704 0.1117 0.5334
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.006 0.0076 0.0278
Entamoeba histolytica hypothetical protein 0.0014 0.0001 0.0003
Brugia malayi intracellular kinase 0.1307 0.2094 0.2882
Entamoeba histolytica protein kinase domain containing protein 0.1307 0.2094 1
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.009 0.0122
Echinococcus granulosus importin subunit beta 1 0.0031 0.0028 0.013
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0094 0.1303
Brugia malayi CXXC zinc finger family protein 0.0029 0.0026 0.0035
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0015 0.0068
Brugia malayi hypothetical protein 0.0246 0.0377 0.0518
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0094 0.1303
Entamoeba histolytica hypothetical protein 0.0037 0.0038 0.0181
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.006 0.0076 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.01
Giardia lamblia Kinase, CMGC GSK 0.1307 0.2094 0.7709
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0094 0.1303
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0068 0.0249
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.045 0.0707 0.3378
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.006 0.0076 0.0361
Schistosoma mansoni phosphatidylinositol 4-kinase 0.006 0.0076 0.0361
Trichomonas vaginalis CMGC family protein kinase 0.1307 0.2094 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.006 0.0076 0.0104
Toxoplasma gondii aurora kinase 0.0069 0.009 0.0327
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0022 0.0077
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0022 0.0077
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0015 0.0052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0015 0.0052
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0039 0.0185
Echinococcus granulosus microtubule associated protein 2 0.0704 0.1117 0.5334
Brugia malayi Telomerase reverse transcriptase 0.4502 0.7263 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0094 0.0445
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0155 0.023 0.0843
Loa Loa (eye worm) hypothetical protein 0.0164 0.0243 0.1158
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0143
Entamoeba histolytica hypothetical protein 0.0037 0.0038 0.0181
Schistosoma mansoni inositol monophosphatase 0.0038 0.0039 0.0185
Echinococcus granulosus aurora kinase A 0.0069 0.009 0.0424
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0094 0.0343
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0019 0.0085
Echinococcus multilocularis microtubule associated protein 2 0.0704 0.1117 0.5334
Brugia malayi beta-lactamase 0.0071 0.0094 0.0128
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.0151 0.0718
Schistosoma mansoni cpg binding protein 0.0031 0.0029 0.0133
Loa Loa (eye worm) phosphatidylinositol 3 0.0369 0.0576 0.2749
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.006 0.0076 0.0278
Onchocerca volvulus Huntingtin homolog 0.0246 0.0377 0.0376
Mycobacterium ulcerans hypothetical protein 0.0071 0.0094 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0369 0.0576 0.2752
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0039 0.0188
Brugia malayi hypothetical protein 0.0017 0.0006 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0069 0.009 0.0424

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 199.5262 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.