Detailed information for compound 1386790

Basic information

Technical information
  • TDR Targets ID: 1386790
  • Name: N-(3-nitrophenyl)-4-phenylsulfonylpiperazine- 1-carbothioamide
  • MW: 406.479 | Formula: C17H18N4O4S2
  • H donors: 1 H acceptors: 4 LogP: 2.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N1CCN(CC1)S(=O)(=O)c1ccccc1)Nc1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C17H18N4O4S2/c22-21(23)15-6-4-5-14(13-15)18-17(26)19-9-11-20(12-10-19)27(24,25)16-7-2-1-3-8-16/h1-8,13H,9-12H2,(H,18,26)
  • InChiKey: AJUBBBGIIOBQQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-nitrophenyl)-4-phenylsulfonyl-piperazine-1-carbothioamide
  • N-(3-nitrophenyl)-4-phenylsulfonyl-1-piperazinecarbothioamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.011 0.2425 0.2425
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 0.0309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.085 0.085
Loa Loa (eye worm) peptidase family M1 containing protein 0.0303 0.7951 0.8004
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0138 0.057
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.011 0.2425 0.2441
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0039 0.0376 0.0378
Loa Loa (eye worm) hypothetical protein 0.0039 0.0376 0.0378
Schistosoma mansoni hypothetical protein 0.0372 0.9933 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.8889 0.8949
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0039 0.0376 1
Echinococcus granulosus aminopeptidase N 0.0374 1 1
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0071 0.1314 0.1322
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0376 0.0376
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 0.0309
Echinococcus multilocularis aminopeptidase N 0.0374 1 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.011 0.2425 0.2425
Brugia malayi Importin beta-1 subunit 0.0035 0.0264 0.0264
Trypanosoma brucei Aminopeptidase M1, putative 0.011 0.2425 1
Trypanosoma brucei Aminopeptidase M1, putative 0.011 0.2425 1
Plasmodium falciparum importin beta, putative 0.0035 0.0264 0.7026
Trypanosoma brucei aminopeptidase, putative 0.0039 0.0376 0.1549
Toxoplasma gondii aminopeptidase n, putative 0.0039 0.0376 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0138 0.057
Trypanosoma cruzi Aminopeptidase M1, putative 0.011 0.2425 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0039 0.0376 0.0378
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0264 0.7026
Echinococcus granulosus snurportin 1 0.0372 0.9933 0.9933
Trypanosoma cruzi aminopeptidase, putative 0.011 0.2425 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.085 0.0856
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0264 0.1088
Echinococcus granulosus importin subunit beta 1 0.0035 0.0264 0.0264
Brugia malayi Peptidase family M1 containing protein 0.0039 0.0376 0.0376
Entamoeba histolytica aminopeptidase, putative 0.011 0.2425 1
Brugia malayi hypothetical protein 0.003 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0264 0.684 0.6886
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.011 0.2425 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.085 0.0856
Brugia malayi TATA binding protein associated factor 0.0039 0.0376 0.0376
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0071 0.1314 0.1314
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0264 0.0264
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.0376 0.1549
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Toxoplasma gondii aminopeptidase N, putative 0.0039 0.0376 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0039 0.0376 0.0376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.085 0.0856
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0075 0.0309
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.011 0.2425 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0039 0.0376 0.0376
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.085 0.085
Schistosoma mansoni importin beta-1 0.0035 0.0264 0.0266
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0138 0.057
Echinococcus multilocularis snurportin 1 0.0372 0.9933 0.9933
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.085 0.085
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0138 0.3677
Loa Loa (eye worm) TATA binding protein associated factor 0.0039 0.0376 0.0378
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0138 0.3677
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0071 0.1314 0.5418
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0376 0.1549
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0039 0.0376 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.011 0.2425 0.2441
Loa Loa (eye worm) hypothetical protein 0.0039 0.0376 0.0378
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.9933 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.0376 0.0376
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Loa Loa (eye worm) aminopeptidase N 0.011 0.2425 0.2441
Brugia malayi hypothetical protein 0.0039 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0071 0.1314 0.1322
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Brugia malayi RNA, U transporter 1 0.0099 0.2106 0.2106
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0376 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0264 0.7026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.085 0.0856
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0075 0.0309
Onchocerca volvulus 0.0374 1 1
Onchocerca volvulus 0.011 0.2425 0.2129
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.0376 0.1549
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.085 0.085
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.011 0.2425 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.0376 0.1549
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.085 0.085
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Entamoeba histolytica hypothetical protein 0.0028 0.0075 0.0309
Loa Loa (eye worm) hypothetical protein 0.0039 0.0376 0.0378
Toxoplasma gondii aminopeptidase N protein 0.0039 0.0376 1
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.0376 0.1549
Leishmania major hypothetical protein, conserved 0.003 0.0138 0.057
Schistosoma mansoni aminopeptidase A (M01 family) 0.0039 0.0376 0.0378
Loa Loa (eye worm) hypothetical protein 0.0071 0.1314 0.1322
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0039 0.0376 0.0378
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.011 0.2425 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0075 0.0309
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.011 0.2425 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.0376 0.1549
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0264 0.1088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0266
Brugia malayi Peptidase family M1 containing protein 0.011 0.2425 0.2425
Loa Loa (eye worm) hypothetical protein 0.003 0.0138 0.0139
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0039 0.0376 0.1549
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0138 0.3677
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.2425 0.2425
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0138 0.3677
Mycobacterium ulcerans aminopeptidase N PepN 0.011 0.2425 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.0376 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.011 0.2425 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.0376 0.1549
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0891 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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