Detailed information for compound 1392624

Basic information

Technical information
  • TDR Targets ID: 1392624
  • Name: 4-propoxy-N-(pyridin-3-ylmethyl)benzamide
  • MW: 270.326 | Formula: C16H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.49 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1)C(=O)NCc1cccnc1
  • InChi: 1S/C16H18N2O2/c1-2-10-20-15-7-5-14(6-8-15)16(19)18-12-13-4-3-9-17-11-13/h3-9,11H,2,10,12H2,1H3,(H,18,19)
  • InChiKey: RDTGBOGQVFYUDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-propoxy-N-(3-pyridylmethyl)benzamide
  • ST063141
  • ZINC02750113
  • 4-Propoxy-N-pyridin-3-ylmethyl-benzamide
  • MLS000030184
  • SMR000011551
  • Oprea1_204940
  • BAS 02858446

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0116 0.0257 1
Schistosoma mansoni hypothetical protein 0.0116 0.0257 0.0239
Echinococcus multilocularis twik family of potassium channels 0.0116 0.0257 0.0239
Toxoplasma gondii ion channel protein 0.0116 0.0257 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0079 0.006
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0116 0.0257 1
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0116 0.0257 0.0239
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0275 0.8342
Schistosoma mansoni calcium-activated potassium channel 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0116 0.0257 0.3315
Loa Loa (eye worm) hypothetical protein 0.1193 0.3415 0.3402
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0116 0.0257 1
Schistosoma mansoni hypothetical protein 0.3438 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0079 0.0834
Loa Loa (eye worm) hypothetical protein 0.3438 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Echinococcus granulosus snurportin 1 0.0372 0.1007 0.099
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0116 0.0257 1
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Loa Loa (eye worm) uncoordinated protein 58 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.1001 0.2853 0.2839
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0116 0.0257 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0079 0.006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0275 0.8342
Trypanosoma cruzi ion transport protein, putative 0.0116 0.0257 1
Plasmodium falciparum potassium channel 0.0116 0.0257 1
Onchocerca volvulus 0.0116 0.0257 0.5
Leishmania major trypanothione reductase 0.0053 0.0074 0.2878
Brugia malayi hypothetical protein 0.0116 0.0257 0.3315
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0275 0.8342
Trypanosoma cruzi ion transport protein, putative 0.0116 0.0257 1
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Echinococcus multilocularis potassium channel subfamily K 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0116 0.0257 0.3315
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.0315 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0116 0.0257 0.3315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0079 0.006
Onchocerca volvulus 0.0116 0.0257 0.5
Brugia malayi RNA, U transporter 1 0.0099 0.0208 0.2622
Echinococcus multilocularis calcium activated potassium channel variant 0.0116 0.0257 0.0239
Loa Loa (eye worm) glutathione reductase 0.0053 0.0074 0.0055
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0275 0.8342
Echinococcus granulosus twik family of potassium channels 0.0116 0.0257 0.0239
Onchocerca volvulus 0.0116 0.0257 0.5
Echinococcus granulosus calcium activated potassium channel variant 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Mycobacterium ulcerans ion transport protein 0.0116 0.0257 0.5
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Leishmania major ion transport protein-like protein 0.0116 0.0257 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.0315 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0079 0.006
Toxoplasma gondii thioredoxin reductase 0.0053 0.0074 0.23
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0116 0.0257 0.0239
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Onchocerca volvulus 0.0116 0.0257 0.5
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0116 0.0257 1
Echinococcus granulosus potassium channel subfamily K 0.0116 0.0257 0.0239
Mycobacterium tuberculosis Probable reductase 0.0122 0.0275 0.8342
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0116 0.0257 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0074 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0257 1
Onchocerca volvulus 0.0116 0.0257 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0116 0.0257 1
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Plasmodium vivax glutathione reductase, putative 0.0053 0.0074 0.23
Loa Loa (eye worm) TWK-28 protein 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0116 0.0257 0.3315
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0116 0.0257 0.3315
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.0315 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0917 0.2607 0.2593
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0116 0.0257 0.3315
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0079 0.006
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Brugia malayi follicle stimulating hormone receptor 0.028 0.0737 1
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0074 0.2878
Toxoplasma gondii ion channel protein 0.0116 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0116 0.0257 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0116 0.0257 0.3315
Onchocerca volvulus 0.0116 0.0257 0.5
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.1128 0.3226 0.3213
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Schistosoma mansoni calcium-activated potassium channel 0.3438 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0275 0.8342
Schistosoma mansoni twik family of potassium channels-related 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Leishmania major potassium channel subunit-like protein 0.0116 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0116 0.0257 0.3315
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Mycobacterium ulcerans transmembrane cation transporter 0.0116 0.0257 0.5
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1007 0.099
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0116 0.0257 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0116 0.0257 0.3315
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0116 0.0257 0.3315
Trypanosoma brucei trypanothione reductase 0.0053 0.0074 0.23
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0116 0.0257 0.0239
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0074 0.0055
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0074 0.23
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0116 0.0257 0.3315
Leishmania major hypothetical protein, conserved 0.0116 0.0257 1
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0116 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0116 0.0257 0.3315
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Plasmodium vivax potassium channel, putative 0.0116 0.0257 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.0737 0.0719
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Echinococcus multilocularis twik family of potassium channels 0.0116 0.0257 0.0239
Plasmodium falciparum potassium channel 0.0116 0.0257 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.0315 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0079 0.006
Leishmania major calcium/potassium channel (CAKC), putative 0.0116 0.0257 1
Echinococcus multilocularis snurportin 1 0.0372 0.1007 0.099
Onchocerca volvulus 0.0116 0.0257 0.5
Echinococcus granulosus twik family of potassium channels 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Echinococcus multilocularis small conductance calcium activated potassium 0.3438 1 1
Loa Loa (eye worm) TWK-7 protein 0.0116 0.0257 0.0239
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0116 0.0257 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0116 0.0257 0.3315
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0257 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Schistosoma mansoni calcium-activated potassium channel 0.2194 0.6351 0.6344
Giardia lamblia Hypothetical protein 0.0116 0.0257 0.5
Plasmodium falciparum thioredoxin reductase 0.0053 0.0074 0.23
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0074 0.0055
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0116 0.0257 0.3315
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0079 0.006
Plasmodium falciparum glutathione reductase 0.0053 0.0074 0.23
Brugia malayi Thioredoxin reductase 0.0053 0.0074 0.0763
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0116 0.0257 0.7609
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0116 0.0257 0.3315
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0116 0.0257 0.3315
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0079 0.006
Echinococcus granulosus potassium channel subfamily K 8 0.0116 0.0257 0.0239
Echinococcus granulosus potassium channel subfamily K 8 0.0116 0.0257 0.0239
Echinococcus multilocularis potassium channel subfamily K 8 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Loa Loa (eye worm) hypothetical protein 0.0116 0.0257 0.0239
Schistosoma mansoni hypothetical protein 0.0372 0.1007 0.099
Echinococcus multilocularis potassium channel subfamily K 8 0.0116 0.0257 0.0239
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0116 0.0257 0.3315
Onchocerca volvulus 0.0116 0.0257 0.5
Plasmodium vivax potassium channel, putative 0.0116 0.0257 1
Brugia malayi glutathione reductase 0.0053 0.0074 0.0763
Trypanosoma brucei calcium-activated potassium channel, putative 0.0116 0.0257 1
Brugia malayi hypothetical protein 0.0116 0.0257 0.3315
Schistosoma mansoni calcium-activated potassium channel 0.0116 0.0257 0.0239
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0116 0.0257 0.0239

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.