TDR Targets

Basic information

Technical information

TDR Targets ID: 1397033
Name: 3-(2-methylphenyl)-1,1-di(propan-2-yl)urea
MW: 234.337 | Formula: C14H22N2O
H donors: 1 H acceptors: 1 LogP: 3.07 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(N(C(=O)Nc1ccccc1C)C(C)C)C
InChi: 1S/C14H22N2O/c1-10(2)16(11(3)4)14(17)15-13-9-7-6-8-12(13)5/h6-11H,1-5H3,(H,15,17)
InChiKey: OZOSCYRCHSTZNX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1,1-diisopropyl-3-(2-methylphenyl)urea
ZINC00271183
MLS000532619
N,N-diisopropyl-N'-(2-methylphenyl)urea
SMR000137558

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0356	0.0374	0.0801
Echinococcus granulosus	GPCR family 2	0.0066	0.002	0.0014
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0066	0.002	0.0014
Schistosoma mansoni	hypothetical protein	0.0066	0.002	0.0014
Trypanosoma brucei	phospholipase A1, putative	0.0356	0.0374	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0316	0.0325	0.032
Brugia malayi	hypothetical protein	0.0316	0.0325	0.0319
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0273	0.0273	0.834
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0316	0.0325	0.032
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0057	0.001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0008	0.0008
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0316	0.0325	0.032
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0316	0.0325	0.032
Brugia malayi	GCC2 and GCC3 family protein	0.0056	0.0008	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0316	0.0325	0.0319
Onchocerca volvulus		0.0316	0.0325	0.0695
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.0232	0.0223	0.0217
Trypanosoma cruzi	phospholipase A1, putative	0.0356	0.0374	1
Onchocerca volvulus		0.0356	0.0374	0.0801
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0019	0.0019
Echinococcus multilocularis	sodium bile acid cotransporter	0.3796	0.4575	0.4572
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Brugia malayi	Sodium Bile acid symporter family protein	0.3796	0.4575	0.4571
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0344	0.036	0.0355
Mycobacterium tuberculosis	Probable oxidoreductase	0.0174	0.0152	1
Onchocerca volvulus		0.0316	0.0325	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0208	0.0193	0.0187
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0058	0.0011	0.0005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Brugia malayi	Protein-tyrosine phosphatase	0.0344	0.036	0.0353
Brugia malayi	Nuclear hormone receptor-like 1	0.0122	0.0089	0.0082
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0007	0.0001
Giardia lamblia	Protein tyrosine phosphatase	0.0316	0.0325	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0316	0.0325	0.032
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0066	0.002	0.002
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0316	0.0325	0.0325
Echinococcus granulosus	sodium bile acid cotransporter	0.3796	0.4575	0.4572
Plasmodium falciparum	conserved protein, unknown function	0.0056	0.0008	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0362	0.0381	0.0374
Schistosoma mansoni	hypothetical protein	0.0066	0.002	0.0014
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Echinococcus granulosus	liprin alpha 2	0.0057	0.001	0.0004
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0066	0.0019	0.0014
Plasmodium vivax	cysteine repeat modular protein 2, putative	0.0056	0.0008	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Plasmodium falciparum	cysteine repeat modular protein 3	0.0056	0.0008	0.5
Onchocerca volvulus		0.0316	0.0325	0.0695
Brugia malayi	hypothetical protein	0.0316	0.0325	0.0319
Echinococcus multilocularis		0.0316	0.0325	0.032
Onchocerca volvulus		0.0316	0.0325	0.0695
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0316	0.0325	0.7938
Echinococcus multilocularis	glycogen phosphorylase	0.0058	0.0011	0.0005
Echinococcus granulosus	Glycosyl transferase family 35	0.0058	0.0011	0.0005
Onchocerca volvulus	Phospholipase A2 homolog	0.2291	0.2738	0.5976
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Plasmodium vivax	hypothetical protein, conserved	0.0056	0.0008	0.5
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0132	0.01	0.0095
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Schistosoma mansoni	pcd6 interacting protein-related	0.0316	0.0325	0.032
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0092	0.0052	0.0047
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0057	0.001	0.0004
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Schistosoma mansoni	glycogen phosphorylase	0.0058	0.0011	0.0005
Loa Loa (eye worm)	platelet-activating factor acetylhydrolase	0.0356	0.0374	0.0374
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0316	0.0325	0.032
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0133	0.0102	0.6266
Schistosoma mansoni	hypothetical protein	0.0066	0.002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0316	0.0325	0.032
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0316	0.0325	0.0325
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0316	0.0325	0.7938
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0066	0.0019	0.0013
Echinococcus granulosus	glycogen phosphorylase	0.0058	0.0011	0.0005
Onchocerca volvulus		0.0316	0.0325	0.0695
Brugia malayi	GCC2 and GCC3 family protein	0.0056	0.0008	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0576	0.0643	0.0638
Giardia lamblia	Glycogen phosphorylase	0.0058	0.0011	0.0071
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0344	0.036	0.0355
Loa Loa (eye worm)	hypothetical protein	0.1031	0.1199	0.1199
Echinococcus multilocularis	hypothetical protein	0.0316	0.0325	0.032
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0344	0.036	0.0355
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0316	0.0325	0.032
Schistosoma mansoni	thyroid hormone receptor	0.0092	0.0052	0.0047
Onchocerca volvulus		0.0316	0.0325	0.0695
Treponema pallidum	fructose-bisphosphate aldolase	0.0273	0.0273	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0344	0.036	0.0355
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0316	0.0325	0.0319
Echinococcus granulosus	expressed protein	0.0349	0.0365	0.036
Brugia malayi	Protein-tyrosine phosphatase	0.0316	0.0325	0.0319
Plasmodium falciparum	cysteine repeat modular protein 1	0.0056	0.0008	0.5
Onchocerca volvulus		0.0316	0.0325	0.0695
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0316	0.0325	0.032
Loa Loa (eye worm)	hypothetical protein	0.0057	0.001	0.001
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Loa Loa (eye worm)	acetyltransferase	0.0135	0.0105	0.0105
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Onchocerca volvulus		0.0356	0.0374	0.0801
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Echinococcus multilocularis	GPCR, family 2	0.0066	0.002	0.0014
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0066	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0383	0.0407	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0008	0.0008
Schistosoma mansoni	sodium-bile acid cotransporter related	0.1539	0.1819	0.1815
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0007	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Entamoeba histolytica	glycogen phosphorylase, putative	0.0058	0.0011	0.0071
Schistosoma mansoni	hypothetical protein	0.0066	0.002	0.0014
Brugia malayi	GCC2 and GCC3 family protein	0.0056	0.0008	0.0001
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0344	0.036	0.0355
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0057	0.001	0.0004
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0344	0.036	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0316	0.0325	0.032
Onchocerca volvulus		0.0316	0.0325	0.0695
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0007	0.0001
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0316	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0057	0.001	0.0004
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0316	0.0325	0.032
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0066	0.002	0.0014
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0058	0.0011	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0057	0.001	0.001
Brugia malayi	Nuclear hormone receptor-like 1	0.0122	0.0089	0.0082
Loa Loa (eye worm)	hypothetical protein	0.012	0.0086	0.0086
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0056	0.0008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Onchocerca volvulus		0.0316	0.0325	0.0695
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.043	0.0465	0.0465
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0316	0.0325	0.032
Trichomonas vaginalis	pten, drome, putative	0.0316	0.0325	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0007	0.0001
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0344	0.036	0.0355
Brugia malayi	Nuclear hormone receptor-like 1	0.014	0.0111	0.0104
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0057	0.001	0.0003
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0316	0.0325	0.032
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0344	0.036	0.0355
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Trypanosoma cruzi	phospholipase A1, putative	0.0356	0.0374	1
Brugia malayi	Liprin-alpha 2	0.0057	0.001	0.0003
Plasmodium falciparum	cysteine repeat modular protein 2	0.0056	0.0008	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0007	0.0001
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0122	0.0089	0.0089
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Onchocerca volvulus		0.0316	0.0325	0.0695
Schistosoma mansoni	ephrin receptor	0.0735	0.0838	0.0833
Brugia malayi	acetyltransferase, GNAT family protein	0.0135	0.0105	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0008	0.0008
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0344	0.036	0.036
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0576	0.0643	0.0638
Loa Loa (eye worm)	hypothetical protein	0.2291	0.2738	0.2738
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Echinococcus granulosus	glycogen phosphorylase	0.0058	0.0011	0.0005
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0273	0.0273	0.834
Brugia malayi	Latrophilin receptor protein 2	0.0066	0.002	0.0013
Echinococcus multilocularis	sodium bile acid cotransporter	0.3796	0.4575	0.4572
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Brugia malayi	Angiotensin-converting enzyme family protein	0.043	0.0465	0.0458
Plasmodium vivax	hypothetical protein, conserved	0.0056	0.0008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0019	0.0019
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0316	0.0325	0.032
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0316	0.0325	0.032
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Chlamydia trachomatis	glycogen phosphorylase	0.0058	0.0011	0.5
Echinococcus multilocularis	sodium bile acid cotransporter	0.3796	0.4575	0.4572
Onchocerca volvulus		0.0316	0.0325	0.0695
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0316	0.0325	1
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Echinococcus granulosus	sodium bile acid cotransporter	0.3796	0.4575	0.4572
Brugia malayi	Peptidase family M13 containing protein	0.0066	0.0019	0.0013
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0328	0.034	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0316	0.0325	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0316	0.0325	0.032
Schistosoma mansoni	sodium-bile acid cotransporter	0.2257	0.2695	0.2691
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Brugia malayi	GCC2 and GCC3 family protein	0.0056	0.0008	0.0001
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0316	0.0325	0.032
Schistosoma mansoni	protein tyrosine phosphatase	0.0316	0.0325	0.032
Onchocerca volvulus		0.0316	0.0325	0.0695
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0066	0.002	0.0013
Schistosoma mansoni	sodium-bile acid cotransporter related	0.3796	0.4575	0.4572
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Schistosoma mansoni	hypothetical protein	0.0142	0.0113	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0019	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Onchocerca volvulus		0.0316	0.0325	0.0695
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0344	0.036	0.0355
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0316	0.0325	0.032
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0344	0.036	0.0355
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Brugia malayi	hypothetical protein	0.0316	0.0325	0.0319
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0344	0.036	0.0355
Echinococcus granulosus	endothelin converting enzyme 1	0.0066	0.0019	0.0014
Echinococcus multilocularis	endothelin converting enzyme 1	0.0066	0.0019	0.0014
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0576	0.0643	0.0638
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus multilocularis	expressed protein	0.0349	0.0365	0.036
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0576	0.0643	0.0638
Echinococcus granulosus	Sterile alpha motif SAM	0.0057	0.001	0.0004
Brugia malayi	hypothetical protein	0.0316	0.0325	0.0319
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Schistosoma mansoni	thyroid hormone receptor	0.0092	0.0052	0.0047
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Echinococcus multilocularis	glycogen phosphorylase	0.0058	0.0011	0.0005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0208	0.0193	0.0187
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0576	0.0643	0.0643
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0066	0.002	0.0014
Schistosoma mansoni	protein tyrosine phosphatase	0.0344	0.036	0.0355
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0344	0.036	0.0355
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0792	0.0906	0.0901
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0316	0.0325	0.032
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0135	0.0105	0.0099
Plasmodium vivax	cysteine repeat modular protein 3, putative	0.0056	0.0008	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0576	0.0643	0.0636
Loa Loa (eye worm)	hypothetical protein	0.3796	0.4575	0.4575
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032
Onchocerca volvulus		0.0316	0.0325	0.0695
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0316	0.0325	0.032
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0316	0.0325	0.032
Entamoeba histolytica	glycogen phosphorylase, putative	0.0058	0.0011	0.0071
Echinococcus granulosus	ephrin type A receptor 4 A	0.0792	0.0906	0.0901
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0316	0.0325	0.0325
Leishmania major	phospholipase A1, putative	0.0356	0.0374	1
Echinococcus granulosus	sodium bile acid cotransporter	0.3796	0.4575	0.4572
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0316	0.0325	1
Schistosoma mansoni	glycogen phosphorylase	0.0058	0.0011	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0133	0.0102	0.6266
Onchocerca volvulus		0.3796	0.4575	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Brugia malayi	carbohydrate phosphorylase	0.0058	0.0011	0.0004
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0344	0.036	0.0355
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.1804	0.2142	0.2138
Brugia malayi	hypothetical protein	0.0316	0.0325	0.0319
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0344	0.036	0.0355
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0316	0.0325	0.6791
Brugia malayi	Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein	0.0356	0.0374	0.0367
Brugia malayi	latrophilin 2 splice variant baaae	0.0142	0.0113	0.0106
Echinococcus multilocularis	endonuclease reverse transcriptase	0.0056	0.0008	0.0003
Mycobacterium ulcerans	short chain dehydrogenase	0.0174	0.0152	1
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0316	0.0325	0.032
Loa Loa (eye worm)	hypothetical protein	0.0208	0.0193	0.0193
Brugia malayi	Protein-tyrosine phosphatase 1	0.0316	0.0325	0.0319
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0728	0.0829	0.0829
Loa Loa (eye worm)	glycogen phosphorylase	0.0058	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0113	0.0113
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0208	0.0193	0.0193
Schistosoma mansoni	hypothetical protein	0.0056	0.0008	0.0003
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0135	0.0105	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0344	0.036	0.0355
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0133	0.0102	1
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0007	0.0001
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0066	0.002	0.0014
Echinococcus granulosus	endonuclease reverse transcriptase	0.0056	0.0008	0.0003
Loa Loa (eye worm)	TK/EPH protein kinase	0.0893	0.103	0.103
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0576	0.0643	0.0638
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0057	0.001	0.001
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0007	0.0007
Toxoplasma gondii	peptidase family M13 protein	0.0066	0.0019	1
Onchocerca volvulus		0.0728	0.0829	0.1796
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0316	0.0325	0.032
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Echinococcus multilocularis	liprin alpha 2	0.0057	0.001	0.0004
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Onchocerca volvulus	Phospholipase A2 homolog	0.1031	0.1199	0.2607
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0316	0.0325	0.0325
Onchocerca volvulus		0.0316	0.0325	0.0695
Onchocerca volvulus	4.1 G protein, putative homolog	0.0316	0.0325	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0057	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Onchocerca volvulus		0.0316	0.0325	0.0695
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Brugia malayi	Phospholipase A2 family protein	0.2291	0.2738	0.2733
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0316	0.0325	0.032
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0316	0.0325	0.7938
Giardia lamblia	Fructose-bisphosphate aldolase	0.0273	0.0273	0.834
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0316	0.0325	0.032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0007	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0316	0.0325	0.0319
Brugia malayi	coiled-coil like protein 1	0.0057	0.001	0.0003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Loa Loa (eye worm)	hypothetical protein	0.0316	0.0325	0.0325
Plasmodium falciparum	cysteine repeat modular protein 4	0.0056	0.0008	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0273	0.0273	0.8328
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0316	0.0325	0.032

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1518268

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1397033