Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) | Envelope polyprotein GP160 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.029 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.029 | 0.7037 |
Leishmania major | C-14 sterol reductase, putative | 0.0054 | 0.0404 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0348 | 0.3289 |
Leishmania major | sterol C-24 reductase, putative | 0.0054 | 0.0404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.029 | 0.0543 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.029 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.029 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.5339 | 1 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0054 | 0.0404 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0412 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.029 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.029 | 0.5 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0054 | 0.0404 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0187 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0187 | 0.0351 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.029 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.029 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.029 | 0.5 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0412 | 0.0771 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0412 | 0.3887 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.029 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.029 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0412 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0412 | 0.0412 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0348 | 0.3289 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.029 | 0.0543 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.029 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.029 | 0.0543 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.106 | 1 |
Onchocerca volvulus | 0.0043 | 0.029 | 0.5 | |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.0054 | 0.0404 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.029 | 0.7037 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.029 | 0.0543 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0187 | 0.4545 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.029 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.029 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.106 | 0.1985 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.029 | 0.5 |
Echinococcus granulosus | lamin b receptor | 0.0054 | 0.0404 | 0.9807 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.029 | 0.0543 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.029 | 0.2736 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0412 | 1 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.0054 | 0.0404 | 0.9807 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.029 | 0.7037 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0412 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.2721 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.029 | 0.0543 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.106 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.029 | 0.0543 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.029 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.029 | 0.029 |
Brugia malayi | beta-lactamase | 0.0043 | 0.029 | 0.2736 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.029 | 0.2736 |
Echinococcus multilocularis | lamin b receptor | 0.0054 | 0.0404 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0348 | 0.0653 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0412 | 0.0412 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0054 | 0.0404 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0412 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0348 | 0.0653 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.029 | 0.2736 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0054 | 0.0404 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.029 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 8.447 uM | PubChem BioAssay. Counterscreen for discovery of small molecules that bind to the HIV-1-gp120 binding antibody, PG9: TR-FRET-based biochemical high throughput dose response assay to identify small molecules that bind to the control antibody, PGV04, which binds to a distinct site on the HIV envelope different from the PG9 binding site. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 8.671 uM | PubChem BioAssay. Counterscreen for discovery of small molecules that bind to the HIV-1-gp120 binding antibody, PG9: TR-FRET-based biochemical high throughput dose response assay to identify small molecules that bind to the control antibody, PG126, which binds to a distinct site on the HIV envelope different from the PG9 binding site. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 67.054 uM | PubChem BioAssay. TRFRET-based biochemical high throughput dose response assay for small molecules that bind to the HIV-1-gp120 binding antibody, PG9. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.0794 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 7.3048 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.