Detailed information for compound 1412975

Basic information

Technical information
  • TDR Targets ID: 1412975
  • Name: MLS000762731
  • MW: 367.488 | Formula: C21H29N5O
  • H donors: 1 H acceptors: 3 LogP: 4.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nc2oc3c(c2c2c1CCCC2)ncnc3NCCCN(C)C
  • InChi: 1S/C21H29N5O/c1-4-8-16-14-9-5-6-10-15(14)17-18-19(27-21(17)25-16)20(24-13-23-18)22-11-7-12-26(2)3/h13H,4-12H2,1-3H3,(H,22,23,24)
  • InChiKey: FJSUZCLTFNBECS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-Dimethyl-N'-(5-propyl-1,2,3,4-tetrahydro-7-oxa-6,9,11-triaza-benzo[c]fluoren-8-yl)-propane-1,3-dia mine
  • SMR000439741

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0252 0.0887
Loa Loa (eye worm) hypothetical protein 0.0052 0.0409 0.1648
Onchocerca volvulus 0.0039 0.0199 0.0798
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0272 0.5
Echinococcus multilocularis geminin 0.0205 0.2835 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0043 0.0272 0.0957
Echinococcus multilocularis lamin dm0 0.0027 0.0008 0.0023
Toxoplasma gondii hypothetical protein 0.0048 0.0347 0.2214
Mycobacterium tuberculosis Probable dehydrogenase 0.0136 0.1753 0.7461
Schistosoma mansoni hypothetical protein 0.0056 0.0477 0.134
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0272 0.0271
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0409 0.2608
Onchocerca volvulus 0.0182 0.2483 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0043 0.0272 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0252 0.1012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0252 0.0887
Plasmodium falciparum thioredoxin reductase 0.0125 0.1566 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0252 0.1016
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0409 0.2608
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.182 0.1819
Mycobacterium ulcerans nitroreductase 0.0058 0.0503 0.1625
Brugia malayi hypothetical protein 0.0182 0.2483 1
Mycobacterium ulcerans oxidoreductase 0.0058 0.0503 0.1625
Echinococcus granulosus muscleblind protein 0.0147 0.1921 0.6774
Loa Loa (eye worm) hypothetical protein 0.0182 0.2483 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0252 0.1012
Brugia malayi intermediate filament protein 0.0027 0.0008 0.0027
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0618 0.2488
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0252 0.0887
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0414 0.1164
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.009 0.0359
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1452 0.5847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0252 0.1016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0252 0.0708
Onchocerca volvulus 0.0042 0.0252 0.1012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0252 0.1012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Loa Loa (eye worm) hypothetical protein 0.0026 0.0001 0.0004
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0043 0.0272 0.0271
Echinococcus multilocularis musashi 0.0027 0.0008 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Giardia lamblia Nitroreductase family protein fused to ferredoxin domain Fd-NR1 0.0058 0.0503 1
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0252 0.0887
Echinococcus multilocularis thioredoxin glutathione reductase 0.0125 0.1566 0.5522
Loa Loa (eye worm) hypothetical protein 0.006 0.0542 0.2183
Schistosoma mansoni lamin 0.0027 0.0008 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0252 0.1012
Plasmodium vivax thioredoxin reductase, putative 0.0125 0.1566 1
Schistosoma mansoni single-minded 0.0052 0.0414 0.1164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0252 0.0708
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1921 0.6774
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Giardia lamblia Nitroreductase Fd-NR2 0.0058 0.0503 1
Mycobacterium ulcerans nitroreductase 0.0058 0.0503 0.1625
Mycobacterium ulcerans nitroreductase 0.0058 0.0503 0.1625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0252 0.1016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Toxoplasma gondii NADPH-glutathione reductase 0.0043 0.0272 0.1733
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0252 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0252 0.0887
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0252 0.0708
Leishmania major trypanothione reductase 0.0125 0.1566 0.1565
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0252 0.0708
Brugia malayi nitroreductase family protein 0.0058 0.0503 0.2024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.025 0.0249
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0252 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0252 0.1012
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0618 0.0617
Mycobacterium ulcerans hypothetical protein 0.0157 0.2072 1
Brugia malayi Thioredoxin reductase 0.0125 0.1566 0.6304
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0043 0.0272 0.0271
Trypanosoma cruzi nitroreductase 0.0656 1 1
Onchocerca volvulus 0.0027 0.0008 0.0027
Brugia malayi hypoxia-induced factor 1 0.0161 0.2149 0.8654
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0252 0.1012
Trichomonas vaginalis mercuric reductase, putative 0.0043 0.0272 0.5399
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0043 0.0272 0.0391
Brugia malayi ecdysteroid receptor 0.0042 0.0252 0.1012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0043 0.0272 0.0271
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0618 0.2485
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0252 0.0708
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0409 0.2608
Plasmodium falciparum thioredoxin reductase 0.0043 0.0272 0.1733
Brugia malayi steroid hormone receptor 0.0042 0.0252 0.1012
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0542 0.2183
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0252 0.0708
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0252 0.1012
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0043 0.0272 0.1733
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0409 0.0408
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Leishmania major hypothetical protein, conserved 0.0052 0.0409 0.0408
Mycobacterium tuberculosis Probable F420 biosynthesis protein FbiB 0.0058 0.0503 0.1165
Brugia malayi PAS domain containing protein 0.0052 0.0414 0.1665
Loa Loa (eye worm) thioredoxin reductase 0.0125 0.1566 0.6306
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0252 0.0887
Giardia lamblia Nitroreductase family protein 0.0058 0.0503 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0618 0.0617
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0252 0.0887
Brugia malayi nuclear receptor NHR-88 0.0042 0.0252 0.1012
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0618 0.0617
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0008 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0252 0.0887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0252 0.1016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0272 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0409 0.0408
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0409 0.2608
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0252 0.0887
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0252 0.0887
Brugia malayi Muscleblind-like protein 0.0147 0.1921 0.7734
Plasmodium vivax glutathione reductase, putative 0.0125 0.1566 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0252 0.0887
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0272 0.0271
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0043 0.0272 0.0271
Leishmania major hypothetical protein, conserved 0.0058 0.0503 0.0502
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0252 0.0887
Schistosoma mansoni coup transcription factor 0.0042 0.0252 0.0708
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.025 0.0249
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0168 0.2257 1
Trypanosoma cruzi trypanothione reductase, putative 0.0125 0.1566 0.1565
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0043 0.0272 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0252 0.1012
Schistosoma mansoni hypothetical protein 0.0205 0.2835 0.7984
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0272 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0252 0.0887
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0168 0.2257 1
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0252 0.1016
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0409 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0043 0.0272 0.1733
Mycobacterium tuberculosis Possible oxidoreductase 0.0058 0.0503 0.1165
Loa Loa (eye worm) hypothetical protein 0.0147 0.1921 0.7735
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0252 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Brugia malayi glutathione reductase 0.0125 0.1566 0.6304
Trypanosoma brucei Nitroreductase family, putative 0.0058 0.0503 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0252 0.1012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0503 0.2027
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0252 0.1012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0043 0.0272 0.0391
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0183 0.0643
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Mycobacterium ulcerans F420-0--gamma-glutamyl ligase 0.0058 0.0503 0.1625
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0252 0.0708
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0043 0.0272 0.1733
Echinococcus granulosus intermediate filament protein 0.0027 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 0.0965
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0252 0.1012
Trypanosoma brucei Nitroreductase family, putative 0.0058 0.0503 0.0502
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Mycobacterium ulcerans hypothetical protein 0.0058 0.0503 0.1625
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0136 0.1753 0.7461
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0043 0.0272 0.0391
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0542 0.2179
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0252 0.0887
Onchocerca volvulus 0.0027 0.0008 0.0027
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0043 0.0272 0.1093
Treponema pallidum NADH oxidase 0.0043 0.0272 0.5
Loa Loa (eye worm) hypothetical protein 0.0175 0.2364 0.9521
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.025 0.0249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0252 0.0887
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.4306 0.4305
Mycobacterium tuberculosis Probable oxidoreductase 0.0168 0.2257 1
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0252 0.0708
Trypanosoma brucei trypanothione reductase 0.0125 0.1566 0.1565
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0252 0.1012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0252 0.1012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0252 0.1012
Echinococcus granulosus lamin 0.0027 0.0008 0.0023
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0043 0.0272 0.1733
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Echinococcus granulosus single minded 2 0.0039 0.0199 0.0699
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.182 0.1819
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.024 0.0961
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0542 0.2179
Toxoplasma gondii thioredoxin reductase 0.0125 0.1566 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0136 0.1753 0.7461
Echinococcus multilocularis lamin 0.0027 0.0008 0.0023
Mycobacterium ulcerans nitroreductase 0.0058 0.0503 0.1625
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0043 0.0272 0.1733
Mycobacterium tuberculosis Putative oxidoreductase 0.0058 0.0503 0.1165
Mycobacterium tuberculosis Conserved protein 0.0058 0.0503 0.1165
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0618 0.2177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0252 0.1016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0125 0.1566 0.6519
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0168 0.2257 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0043 0.0272 0.0764
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0252 0.0708
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1452 0.5847
Plasmodium falciparum glutathione reductase 0.0125 0.1566 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0161 0.2149 0.8654
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0252 0.0887
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0136 0.1753 0.7126
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0618 0.1738
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4306 0.4305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0272 0.0271
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0199 0.0699
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0395 0.0394
Brugia malayi MH2 domain containing protein 0.0118 0.1452 0.5845
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0618 0.2177
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0618 1
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0252 0.1012
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.009 0.0359
Mycobacterium tuberculosis Conserved protein Acg 0.0058 0.0503 0.1165
Schistosoma mansoni lamin 0.0027 0.0008 0.0019
Mycobacterium tuberculosis Probable reductase 0.0136 0.1753 0.7461
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0252 0.1016
Loa Loa (eye worm) hypothetical protein 0.0147 0.1921 0.7735
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0252 0.1012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0252 0.0887
Mycobacterium ulcerans hypothetical protein 0.0058 0.0503 0.1625
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0125 0.1566 0.5522
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4306 0.4305
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0136 0.1753 0.7461
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0252 0.1012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.182 0.1819
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0272 0.0271
Loa Loa (eye worm) glutathione reductase 0.0125 0.1566 0.6306
Trypanosoma cruzi nitroreductase 0.0656 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.2072 0.907
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0136 0.1753 0.7461
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.4306 0.4305
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0618 0.0617
Loa Loa (eye worm) hypothetical protein 0.0026 0.0001 0.0004
Schistosoma mansoni hypothetical protein 0.0205 0.2835 0.7984
Schistosoma mansoni intermediate filament proteins 0.0027 0.0008 0.0019
Trypanosoma brucei nitroreductase 0.0656 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0252 0.1012
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0199 0.0798
Brugia malayi hypothetical protein 0.0033 0.0118 0.0469
Echinococcus granulosus geminin 0.0205 0.2835 1
Onchocerca volvulus Iodotyrosine dehalogenase 1 homolog 0.0058 0.0503 0.2024
Plasmodium falciparum glutathione reductase 0.0043 0.0272 0.1733
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Brugia malayi hypothetical protein 0.0175 0.2364 0.9521
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.025 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0252 0.0708
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0031
Loa Loa (eye worm) hypothetical protein 0.0042 0.0252 0.1016
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0183 0.0643
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0008 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0252 0.0887
Brugia malayi nuclear hormone receptor 0.0042 0.0252 0.1012
Brugia malayi hypothetical protein 0.0052 0.0409 0.1644
Trichomonas vaginalis glutathione reductase, putative 0.0043 0.0272 0.5399
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0272 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0503 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0008 0.0031
Echinococcus multilocularis muscleblind protein 0.0147 0.1921 0.6774
Echinococcus granulosus lamin dm0 0.0027 0.0008 0.0023
Schistosoma mansoni hypothetical protein 0.0041 0.024 0.0672
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0252 0.1012

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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