Detailed information for compound 1413080

Basic information

Technical information
  • TDR Targets ID: 1413080
  • Name: 6-[[4-(tert-butylamino)-6-morpholin-4-yl-1,3, 5-triazin-2-yl]oxy]-2H-pyridazin-3-one
  • MW: 347.372 | Formula: C15H21N7O3
  • H donors: 2 H acceptors: 6 LogP: 1.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(nn1)Oc1nc(nc(n1)N1CCOCC1)NC(C)(C)C
  • InChi: 1S/C15H21N7O3/c1-15(2,3)19-12-16-13(22-6-8-24-9-7-22)18-14(17-12)25-11-5-4-10(23)20-21-11/h4-5H,6-9H2,1-3H3,(H,20,23)(H,16,17,18,19)
  • InChiKey: PAOXHAYYHHZUJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[4-(tert-butylamino)-6-morpholino-1,3,5-triazin-2-yl]oxy]-2H-pyridazin-3-one
  • 6-[[4-(tert-butylamino)-6-morpholino-s-triazin-2-yl]oxy]-2H-pyridazin-3-one
  • 6-{[4-(tert-butylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]oxy}pyridazin-3-ol
  • MLS000689718
  • SMR000313322

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0601 0.4301 0.8172
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0684 0.5054 0.9603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.4058 0.7711
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0684 0.5054 0.9603
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0147 0.0169 0.0322
Loa Loa (eye worm) hypothetical protein 0.0148 0.018 0.0203
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0707 0.5262 0.8774
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.015 0.0202 0.0034
Toxoplasma gondii target of rapamycin (TOR), putative 0.0574 0.4058 1
Leishmania major hypothetical protein, conserved 0.0185 0.0521 0.0691
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.034 0.1928 0.3453
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0707 0.5262 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0451 0.2932 0.5572
Loa Loa (eye worm) hypothetical protein 0.0235 0.0972 0.1098
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0273 0.1316 0.2252
Schistosoma mansoni fkbp-rapamycin associated protein 0.0213 0.077 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.5262 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0707 0.5262 0.5181
Loa Loa (eye worm) hypothetical protein 0.0466 0.3075 0.3473
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0785 0.5974 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0466 0.3075 0.5005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0303 0.1588 0.3018
Loa Loa (eye worm) hypothetical protein 0.0217 0.0812 0.0918
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0453 0.2957 0.5473
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0213 0.077 0.1035
Entamoeba histolytica hypothetical protein 0.0213 0.077 0.118
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0707 0.5262 0.8808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.5262 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0684 0.5054 0.959
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0707 0.5262 0.5181
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0296 0.1524 0.2659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0601 0.4301 0.8172
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0684 0.5054 0.8459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0363 0.2138 0.4063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0424 0.269 0.5111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.077 0.1463
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0235 0.0972 0.2065
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0213 0.077 0.0611
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0147 0.0169 0.0322
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0684 0.5054 0.8414
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0341 0.1934 0.3465
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0273 0.1316 0.1976
Loa Loa (eye worm) hypothetical protein 0.015 0.0202 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.31 0.5891
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0369 0.2191 0.2056
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.049 0.3295 0.6261
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0363 0.2138 0.3866
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.4058 0.7711
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0785 0.5974 0.5905
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0273 0.1316 0.2203
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0707 0.5262 0.8808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.4058 0.7711
Toxoplasma gondii FATC domain-containing protein 0.0213 0.077 0.1545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.4058 0.7711
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1432 0.1284
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0147 0.0169 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.31 0.5891
Loa Loa (eye worm) phosphatidylinositol 3 0.0453 0.2957 0.334
Loa Loa (eye worm) phosphatidylinositol 3 0.0188 0.0546 0.0617
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1227 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0147 0.0169 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0273 0.1316 0.2252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.5262 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.31 0.5891
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.015 0.0202 0.0034
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0147 0.0169 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.31 0.5891
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0601 0.4305 0.8119
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0466 0.3075 0.2956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0601 0.4301 0.8172
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0273 0.1316 0.2252
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0147 0.0169 0.0191
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0273 0.1316 0.2501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.3096 0.5884
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0213 0.077 0.0611
Echinococcus multilocularis serine protein kinase ATM 0.0213 0.077 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0496 0.3343 0.6352
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0453 0.2957 0.5473
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0785 0.5974 0.5905
Loa Loa (eye worm) phosphatidylinositol 3 0.1101 0.8853 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0188 0.0546 0.0914
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0785 0.5974 1
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0202 0.0384
Schistosoma mansoni hypothetical protein 0.015 0.0202 0.0034
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.049 0.3295 0.6261
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0707 0.5262 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0147 0.0169 0.0322
Onchocerca volvulus Huntingtin homolog 0.0148 0.018 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.4058 0.7711
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0707 0.5262 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0213 0.077 0.1289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0213 0.077 0.1035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0424 0.269 0.5111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0453 0.2957 0.5619
Trypanosoma cruzi target of rapamycin kinase 3 0.0601 0.4305 0.7205
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0684 0.5054 0.9603
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0273 0.1316 0.2501
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0785 0.5974 1
Echinococcus granulosus geminin 0.0205 0.0695 0.0535
Brugia malayi FAT domain containing protein 0.015 0.0202 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0473 0.3135 0.5956
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0364 0.2148 0.3096
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0303 0.1588 0.2787
Schistosoma mansoni hypothetical protein 0.0205 0.0695 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.4058 0.7711
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0147 0.0169 0.0283
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0707 0.5262 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0363 0.2138 0.4063
Trichomonas vaginalis conserved hypothetical protein 0.0235 0.0972 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.077 0.1463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0363 0.2138 0.4063
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0707 0.5262 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0363 0.2138 0.4063
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0599 0.4283 0.8078
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0273 0.1316 0.1167
Brugia malayi hypothetical protein 0.0148 0.018 0.0018
Giardia lamblia GTOR 0.0707 0.5262 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0684 0.5054 0.8459
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0213 0.077 0.118
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0562 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0601 0.4301 0.8172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.4058 0.7711
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0273 0.1316 0.2501
Loa Loa (eye worm) hypothetical protein 0.0213 0.077 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0601 0.4301 0.8172
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1432 0.1284
Loa Loa (eye worm) hypothetical protein 0.0148 0.018 0.0203
Loa Loa (eye worm) hypothetical protein 0.0286 0.1432 0.1617
Loa Loa (eye worm) phosphatidylinositol 3 0.0707 0.5262 0.5944
Entamoeba histolytica protein kinase rad3, putative 0.0213 0.077 0.118
Echinococcus granulosus serine protein kinase ATM 0.0213 0.077 0.0611
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0213 0.077 0.0611
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1227 1 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0466 0.3075 0.2956
Entamoeba histolytica hypothetical protein 0.0558 0.3907 0.7338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0496 0.3343 0.6352
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0601 0.4305 0.8119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.3096 0.5884
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0369 0.2191 0.2056
Echinococcus multilocularis geminin 0.0205 0.0695 0.0535
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0707 0.5262 1
Schistosoma mansoni hypothetical protein 0.0205 0.0695 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.3096 0.5884
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0785 0.5974 0.5905
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0707 0.5262 0.5181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0424 0.269 0.5111
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0544 0.378 0.6221
Leishmania major phosphatidylinositol 3-kinase, putative 0.0363 0.2138 0.3866
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0213 0.077 0.1289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0556 0.3894 0.74
Onchocerca volvulus Huntingtin homolog 0.0148 0.018 0.5
Brugia malayi hypothetical protein 0.0286 0.1432 0.2175
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0558 0.3907 0.7338

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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