TDR Targets

Basic information

Technical information

TDR Targets ID: 142548
Name: methyl (6S,8aR)-6-(naphthalen-2-ylmethyl)-5-o xo-6-(phenylmethoxycarbonylamino)-2,3,7,8-tet rahydro-1H-indolizine-8a-carboxylate
MW: 486.559 | Formula: C29H30N2O5
H donors: 1 H acceptors: 3 LogP: 4.78 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@@]12CCCN2C(=O)[C@@](CC1)(NC(=O)OCc1ccccc1)Cc1ccc2c(c1)cccc2
InChi: 1S/C29H30N2O5/c1-35-26(33)29-14-7-17-31(29)25(32)28(15-16-29,30-27(34)36-20-21-8-3-2-4-9-21)19-22-12-13-23-10-5-6-11-24(23)18-22/h2-6,8-13,18H,7,14-17,19-20H2,1H3,(H,30,34)/t28-,29+/m0/s1
InChiKey: QYVOKIYUQZZVQM-URLMMPGGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl (6S,8aR)-6-(benzyloxycarbonylamino)-6-(2-naphthylmethyl)-5-oxo-2,3,7,8-tetrahydro-1H-indolizine-8a-carboxylate
(6S,8aR)-6-(benzyloxycarbonylamino)-6-(2-naphthalenylmethyl)-5-oxo-2,3,7,8-tetrahydro-1H-indolizine-8a-carboxylic acid methyl ester
(6S,8aR)-6-(benzyloxycarbonylamino)-5-keto-6-(2-naphthylmethyl)indolizidine-8a-carboxylic acid methyl ester
methyl (6S,8aR)-6-(2-naphthylmethyl)-5-oxo-6-(phenylmethoxycarbonylamino)-2,3,7,8-tetrahydro-1H-indolizine-8a-carboxylate
(6S,8aR)-6-(2-naphthylmethyl)-5-oxo-6-[[oxo-(phenylmethoxy)methyl]amino]-2,3,7,8-tetrahydro-1H-indolizine-8a-carboxylic acid methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peptidylprolyl isomerase A (cyclophilin A)-like 4C	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase	peptidylprolyl isomerase A (cyclophilin A)-like 4C	164 aa	171 aa	46.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0173	0.1453	0.1209
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Plasmodium vivax	unspecified product	0.0095	0.0462	0.1572
Entamoeba histolytica	cysteine proteinase, putative	0.0173	0.1453	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0173	0.1453	0.1453
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.009	0.039	0.039
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.0462	0.1572
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Echinococcus granulosus	survival motor neuron protein 1	0.0289	0.2933	0.2731
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0173	0.1453	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.009	0.039	0.0116
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0095	0.0462	0.1572
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0169	0.1398	0.1398
Echinococcus multilocularis	ecdysone induced protein 78C	0.009	0.039	0.0116
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.009	0.039	0.0598
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.009	0.039	0.039
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0169	0.1398	0.9535
Schistosoma mansoni	retinoic acid receptor RXR	0.021	0.1926	0.1926
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.009	0.039	0.0627
Plasmodium vivax	vivapain-1	0.0095	0.0462	0.1572
Plasmodium vivax	vivapain-2	0.0173	0.1453	1
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0081	0.0277	0.0277
Trypanosoma cruzi	cysteine proteinase, putative	0.0095	0.0462	0.0392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0095	0.0462	0.1572
Schistosoma mansoni	steroid hormone receptor ad4bp	0.009	0.039	0.039
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0173	0.1453	0.2491
Toxoplasma gondii	cathepsin B	0.0169	0.1398	0.9535
Loa Loa (eye worm)	hypothetical protein	0.012	0.0777	0.1222
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.0462	0.1572
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0095	0.0462	0.1572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Brugia malayi	PAS domain containing protein	0.0074	0.0196	0.0315
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Loa Loa (eye worm)	hypothetical protein	0.0289	0.2933	0.4696
Brugia malayi	Cathepsin L-like precursor	0.0173	0.1453	0.2334
Onchocerca volvulus		0.0173	0.1453	1
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.021	0.1926	0.1696
Onchocerca volvulus		0.0061	0.0019	0.0131
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0173	0.1453	0.2311
Loa Loa (eye worm)	hypothetical protein	0.0451	0.4997	0.8023
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0154	0.121	0.0959
Loa Loa (eye worm)	STAT protein	0.0548	0.6223	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.009	0.039	0.0627
Schistosoma mansoni	thyroid hormone receptor	0.0244	0.2352	0.2352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.0777	0.4254
Entamoeba histolytica	cysteine proteinase 2	0.0095	0.0462	0.1572
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.009	0.039	0.0627
Giardia lamblia	Cathepsin B precursor	0.0169	0.1398	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.009	0.039	0.2685
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.4997	0.4997
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.009	0.039	0.0627
Onchocerca volvulus	Cathepsin F homolog	0.0173	0.1453	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.012	0.0777	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0141	0.104	0.1646
Onchocerca volvulus		0.009	0.039	0.2685
Schistosoma mansoni	RAR-like nuclear receptor	0.009	0.039	0.039
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.012	0.0777	0.1059
Schistosoma mansoni	thyroid hormone receptor	0.0244	0.2352	0.2352
Brugia malayi	Cathepsin L-like precursor	0.0173	0.1453	0.2334
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Brugia malayi	eukaryotic initiation factor 4A	0.0081	0.0277	0.0446
Giardia lamblia	Cathepsin B precursor	0.0169	0.1398	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.009	0.039	0.0116
Schistosoma mansoni	aryl hydrocarbon receptor	0.0216	0.1996	0.1996
Onchocerca volvulus		0.0173	0.1453	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0451	0.4997	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0163	0.1323	0.1075
Brugia malayi	nuclear receptor NHR-88	0.009	0.039	0.0627
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0173	0.1453	0.1209
Trypanosoma cruzi	cruzipain precursor, putative	0.0173	0.1453	0.2491
Brugia malayi	cathepsin B-like cysteine proteinase	0.0451	0.4997	0.8029
Schistosoma mansoni	hypothetical protein	0.0154	0.121	0.121
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0095	0.0462	0.0462
Treponema pallidum	ATP-dependent RNA helicase	0.0081	0.0277	0.5
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Onchocerca volvulus		0.0173	0.1453	1
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Onchocerca volvulus		0.012	0.0777	0.5351
Trypanosoma cruzi	cysteine protease, putative	0.0095	0.0462	0.0392
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.009	0.039	0.0598
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.009	0.039	0.0116
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0081	0.0277	0.1909
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.0462	0.1572
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.009	0.039	0.039
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.009	0.039	0.0627
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Schistosoma mansoni	nuclear hormone receptor	0.009	0.039	0.039
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0154	0.121	0.0959
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0173	0.1453	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0173	0.1453	0.1209
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Brugia malayi	Papain family cysteine protease containing protein	0.0173	0.1453	0.2334
Echinococcus multilocularis	cysteine protease	0.0173	0.1453	0.1209
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Brugia malayi	Cathepsin L-like precursor	0.012	0.0777	0.1249
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0548	0.6223	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0169	0.1398	0.9535
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0161	0.1295	0.1047
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.009	0.039	0.0627
Schistosoma mansoni	cathepsin F (C01 family)	0.0173	0.1453	0.1453
Echinococcus multilocularis	cysteine protease	0.0173	0.1453	0.1209
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0081	0.0277	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.009	0.039	0.0627
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0173	0.1453	0.1209
Toxoplasma gondii	cathepsin CPL	0.0173	0.1453	1
Echinococcus granulosus	cathepsin b	0.0451	0.4997	0.4854
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0095	0.0462	0.0392
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.0462	0.1572
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0277	0.0416
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.009	0.039	0.0627
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.009	0.039	0.0116
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.009	0.039	0.0627
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0173	0.1453	0.2311
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.009	0.039	0.039
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Loa Loa (eye worm)	cysteine protease	0.0173	0.1453	0.2311
Entamoeba histolytica	cysteine proteinase, putative	0.0173	0.1453	1
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Onchocerca volvulus	Cathepsin L homolog	0.0173	0.1453	1
Echinococcus granulosus	cathepsin l1	0.0173	0.1453	0.1209
Brugia malayi	Nuclear hormone receptor-like 1	0.009	0.039	0.0627
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.009	0.039	0.0627
Onchocerca volvulus		0.0173	0.1453	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0169	0.1398	0.2375
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.009	0.039	0.039
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.009	0.039	0.0598
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0173	0.1453	0.1209
Schistosoma mansoni	cellular tumor antigen P53	0.0061	0.0019	0.0019
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Brugia malayi	Cathepsin L-like precursor	0.0173	0.1453	0.2334
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0081	0.0277	0.0277
Brugia malayi	ecdysteroid receptor	0.009	0.039	0.0627
Brugia malayi	steroid hormone receptor	0.009	0.039	0.0627
Loa Loa (eye worm)	ctsf protein	0.0173	0.1453	0.2311
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.009	0.039	0.0627
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0173	0.1453	0.2491
Brugia malayi	hypothetical protein	0.0289	0.2933	0.4713
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.0462	0.1572
Echinococcus granulosus	cathepsin l1	0.012	0.0777	0.0514
Schistosoma mansoni	cathepsin F (C01 family)	0.012	0.0777	0.0777
Giardia lamblia	Cathepsin B precursor	0.0169	0.1398	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0095	0.0462	0.0392
Loa Loa (eye worm)	hypothetical protein	0.012	0.0777	0.1222
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.009	0.039	0.0116
Brugia malayi	cathepsin L-like precursor	0.012	0.0777	0.1249
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0169	0.1398	0.9535
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.009	0.039	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1049	0.1659
Echinococcus multilocularis	microtubule associated protein 2	0.0844	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Onchocerca volvulus		0.0173	0.1453	1
Schistosoma mansoni	microtubule-associated protein tau	0.0844	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.009	0.039	0.0116
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0095	0.0462	0.1572
Brugia malayi	Papain family cysteine protease containing protein	0.0095	0.0462	0.0743
Echinococcus granulosus	FTZ F1 alpha	0.009	0.039	0.0116
Brugia malayi	Cathepsin L-like precursor	0.0173	0.1453	0.2334
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.009	0.039	0.0116
Entamoeba histolytica	cysteine protease, putative	0.0173	0.1453	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.009	0.039	0.0116
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0095	0.0462	0.0392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.009	0.039	0.0598
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0173	0.1453	1
Schistosoma mansoni	single-minded	0.0074	0.0196	0.0196
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.4997	0.4997
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1453	0.2311
Plasmodium vivax	vivapain-2	0.0173	0.1453	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.009	0.039	0.0116
Loa Loa (eye worm)	cathepsin B	0.0169	0.1398	0.2223
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.0777	0.4254
Echinococcus multilocularis	tumor protein p63	0.0413	0.4513	0.4356
Echinococcus multilocularis	cathepsin L	0.0095	0.0462	0.019
Brugia malayi	Steroid receptor seven-up type 2	0.009	0.039	0.0627
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0173	0.1453	1
Onchocerca volvulus		0.0173	0.1453	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.009	0.039	0.0627
Loa Loa (eye worm)	hypothetical protein	0.016	0.1287	0.2043
Brugia malayi	Cathepsin L-like precursor	0.0173	0.1453	0.2334
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.009	0.039	0.0116
Echinococcus multilocularis	cathepsin L cysteine protease	0.0173	0.1453	0.1209
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0095	0.0462	0.0462
Brugia malayi	photoreceptor-specific nuclear receptor	0.009	0.039	0.0627
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.009	0.039	0.0116
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.009	0.039	0.2685
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0289	0.2933	0.2731
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0173	0.1453	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.4997	0.4997
Echinococcus granulosus	cathepsin L	0.0095	0.0462	0.019
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.009	0.039	0.0116
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Brugia malayi	Papain family cysteine protease containing protein	0.0095	0.0462	0.0743
Onchocerca volvulus		0.0173	0.1453	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0173	0.1453	0.2491
Echinococcus multilocularis	cathepsin b	0.0451	0.4997	0.4854
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Leishmania major	cysteine peptidase A (CPA)	0.0173	0.1453	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Loa Loa (eye worm)	fibroinase	0.0173	0.1453	0.2311
Brugia malayi	Cathepsin L-like precursor	0.012	0.0777	0.1249
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0095	0.0462	0.019
Onchocerca volvulus	Cathepsin L homolog	0.0173	0.1453	1
Schistosoma mansoni	coup transcription factor	0.009	0.039	0.039
Trypanosoma cruzi	cysteine peptidase, putative	0.0173	0.1453	0.2491
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Onchocerca volvulus	Bile acid receptor homolog	0.009	0.039	0.2685
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.009	0.039	0.0116
Echinococcus granulosus	tumor protein p63	0.0413	0.4513	0.4356
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0173	0.1453	1
Echinococcus granulosus	ecdysone induced protein 78C	0.009	0.039	0.0116
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.009	0.039	0.0598
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0141	0.104	0.1672
Echinococcus granulosus	cysteine protease	0.0095	0.0462	0.019
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.009	0.039	0.039
Entamoeba histolytica	cysteine protease, putative	0.0095	0.0462	0.1572
Brugia malayi	nuclear hormone receptor	0.009	0.039	0.0627
Echinococcus multilocularis	cathepsin b	0.0451	0.4997	0.4854
Plasmodium vivax	vivapain-3	0.0095	0.0462	0.1572
Loa Loa (eye worm)	hypothetical protein	0.009	0.039	0.0598
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.0462	0.1572
Leishmania major	cathepsin L-like protease	0.0173	0.1453	1
Onchocerca volvulus		0.016	0.1287	0.8856
Echinococcus granulosus	cathepsin b	0.0451	0.4997	0.4854
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.009	0.039	0.0627
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0095	0.0462	0.0462
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0451	0.4997	0.4997
Loa Loa (eye worm)	hypothetical protein	0.012	0.0777	0.1222
Echinococcus granulosus	aryl hydrocarbon receptor	0.0161	0.1295	0.1047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0173	0.1453	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0244	0.2352	0.2133
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0173	0.1453	1
Entamoeba histolytica	cysteine proteinase, putative	0.012	0.0777	0.4254
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.009	0.039	0.0598
Brugia malayi	Cathepsin L-like precursor	0.0173	0.1453	0.2334
Loa Loa (eye worm)	steroid hormone receptor	0.009	0.039	0.0598

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 0.0000047 M	Binding affinity towards cyclophilin A by fluorescence	ChEMBL.	11472213
Kd (binding)	= 0.0000047 M	Binding affinity towards cyclophilin A by fluorescence	ChEMBL.	11472213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10051106

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 142548