Detailed information for compound 1426147

Basic information

Technical information
  • TDR Targets ID: 1426147
  • Name: 4-ethyl-N-[(1-morpholin-4-ylcyclohexyl)methyl ]benzenesulfonamide
  • MW: 366.518 | Formula: C19H30N2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)S(=O)(=O)NCC1(CCCCC1)N1CCOCC1
  • InChi: 1S/C19H30N2O3S/c1-2-17-6-8-18(9-7-17)25(22,23)20-16-19(10-4-3-5-11-19)21-12-14-24-15-13-21/h6-9,20H,2-5,10-16H2,1H3
  • InChiKey: BWZACQXXRDSVTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-ethyl-N-[(1-morpholinocyclohexyl)methyl]benzenesulfonamide
  • T5592292

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens corticotropin releasing hormone binding protein No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.078 0.1412
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0297 0.369
Mycobacterium leprae Probable lipase LipE 0.0043 0.078 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0097 0.0448
Echinococcus multilocularis General substrate transporter 0.0088 0.1832 0.3887
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0109 0.231 0.4074
Echinococcus multilocularis GPCR, family 2 0.0019 0.0206 0.0243
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0497 0.0497
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0055 0.01
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0482 0.0708
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0019 0.0194 0.0437
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.078 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0497 0.0899
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.0895
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0019 0.0194 0.0893
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0019 0.0194 0.0098
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0019 0.0194 0.0098
Loa Loa (eye worm) hypothetical protein 0.0043 0.078 0.1412
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0019 0.0194 0.0217
Schistosoma mansoni protein kinase 0.0031 0.0497 0.1806
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0097 0.109
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0097 0.109
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0097 0.0448
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0019 0.0194 0.0437
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0019 0.0194 0.0437
Trichomonas vaginalis esterase, putative 0.0043 0.078 0.3594
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.0895
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0167 0.1022
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2171 0.4647
Toxoplasma gondii DNA polymerase 0.0019 0.0194 0.0149
Mycobacterium ulcerans sugar transporter 0.0014 0.0097 0.109
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0506 0.5989
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0506 0.2332
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.078 0.3594
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0297 0.5182
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.078 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0506 0.2332
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0019 0.0194 0.1416
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0194 0.1416
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0297 0.0901
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0297 0.0447
Schistosoma mansoni glucose transport protein 0.0103 0.2171 0.9373
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0506 0.2332
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0497 0.0497
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0194 0.0893
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.078 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.078 0.1103
Onchocerca volvulus 0.0109 0.231 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0297 0.369
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0297 0.2918
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0497 0.0497
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0482 0.222
Plasmodium vivax DNA polymerase alpha, putative 0.0019 0.0194 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0097 0.0448
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0602 0.7388
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0602 0.0602
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0097 0.0097
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0019 0.0194 0.0217
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0297 0.0297
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0194 0.1416
Echinococcus granulosus General substrate transporter 0.0088 0.1832 0.3887
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0497 0.0617
Loa Loa (eye worm) hypothetical protein 0.0043 0.078 0.1412
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0019 0.0194 0.1416
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0497 0.2289
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0097 0.0176
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0194 0.1416
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0206 0.02
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0602 0.0779
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0097 0.0176
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0482 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.0895
Leishmania major glucose transporter, lmgt1 0.0032 0.0506 0.5989
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trypanosoma brucei glucose transporter 2A 0.0032 0.0506 0.5989
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Loa Loa (eye worm) hypothetical protein 0.0041 0.0726 0.1313
Schistosoma mansoni protein kinase 0.0031 0.0497 0.1806
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0497 0.0895
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0506 0.2332
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0019 0.0194 0.0217
Leishmania major protein kinase, putative 0.0031 0.0497 0.5851
Loa Loa (eye worm) hypothetical protein 0.0043 0.078 0.1412
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0602 0.7388
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0297 1
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0194 0.1416
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.078 0.3594
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0506 0.5989
Schistosoma mansoni hypothetical protein 0.0109 0.231 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.0895
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0019 0.0194 0.0437
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0019 0.0194 0.1416
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0497 0.0404
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0506 0.5989
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.078 0.1103
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.0895
Brugia malayi DNA polymerase alpha catalytic subunit 0.0019 0.0194 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0097 0.0448
Loa Loa (eye worm) hypothetical protein 0.0043 0.078 0.1412
Echinococcus multilocularis inhibitor of apoptosis protein 0.0109 0.231 0.4958
Mycobacterium tuberculosis Conserved protein 0.0043 0.078 0.1103
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.078 0.3594
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.456 1
Toxoplasma gondii protein kinase, putative 0.029 0.6576 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1174 0.1982
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Plasmodium vivax hypothetical protein, conserved 0.0043 0.078 0.069
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0019 0.0194 0.0178
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0019 0.0194 0.1416
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3657 0.3595
Echinococcus granulosus inhibitor of apoptosis protein 0.0109 0.231 0.4958
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.078 0.3087
Plasmodium falciparum hexose transporter 0.0103 0.2171 0.2171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Schistosoma mansoni glucose transport protein 0.0103 0.2171 0.9373
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0194 0.1416
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0297 0.0367
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Schistosoma mansoni hypothetical protein 0.0019 0.0206 0.0491
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2171 0.4647
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.0895
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Brugia malayi DNA polymerase family B containing protein 0.0019 0.0194 0.0178
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0297 0.0447
Schistosoma mansoni hypothetical protein 0.0019 0.0206 0.0491
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.078 0.3594
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0109 0.231 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0019 0.0194 0.0217
Mycobacterium ulcerans lipase LipD 0.0043 0.078 1
Onchocerca volvulus 0.0043 0.078 0.3087
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0109 0.231 0.4958
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.078 0.1103
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0497 0.0899
Loa Loa (eye worm) hypothetical protein 0.0025 0.0346 0.0626
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0019 0.0194 0.1416
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0019 0.0194 0.0217
Plasmodium vivax hexose transporter 0.0103 0.2171 0.2094
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0097 0.0448
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.078 0.153
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0602 0.7388
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2171 0.4647
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.078 0.3087
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0602 0.051
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0602 0.7388
Trichomonas vaginalis DNA polymerase II, putative 0.0019 0.0194 0.0893
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1174 0.2123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.456 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0602 0.7388
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Schistosoma mansoni hypothetical protein 0.0019 0.0206 0.0491
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0497 0.0497
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0451 0.0793
Loa Loa (eye worm) sugar transporter 0.0014 0.0097 0.0176
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0019 0.0194 0.2513
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0506 0.5989
Leishmania major glucose transporter, lmgt3 0.0032 0.0506 0.5989
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0506 0.5989
Mycobacterium leprae conserved hypothetical protein 0.0043 0.078 1
Schistosoma mansoni protein kinase 0.0031 0.0497 0.1806
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0109 0.231 0.4074
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0097 0.0448
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0109 0.231 0.4958
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0497 0.0736
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.078 0.1103
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.078 0.1103
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Brugia malayi beta-lactamase 0.0043 0.078 0.1258
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0019 0.0194 0.2513
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.078 0.3594
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0451 0.0793
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Schistosoma mansoni inhibitor of apoptosis protein 0.0109 0.231 1
Schistosoma mansoni hypothetical protein 0.0019 0.0206 0.0491
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0215 0.0191
Loa Loa (eye worm) hypothetical protein 0.0019 0.0194 0.0351
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0497 0.5851
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0497 0.1806
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.023 0.106
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0019 0.0194 0.0351
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.5528 1
Entamoeba histolytica protein kinase, putative 0.0031 0.0497 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3657 0.5495
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0206 0.0243
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0194 0.0893
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0019 0.0194 0.0437
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0019 0.0194 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0506 0.2332
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0506 0.2332
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0019 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0109 0.231 0.4179
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0019 0.0194 0.0437
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0019 0.0194 0.0149
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0206 0.0372
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2171 0.4647
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 1 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0482 0.0862
Mycobacterium ulcerans beta-lactamase 0.0043 0.078 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2171 0.4647
Echinococcus granulosus GPCR family 2 0.0019 0.0206 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.078 0.1103
Trypanosoma cruzi hexose transporter 0.0032 0.0506 0.5989
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.078 0.1258
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0497 0.0404
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0297 0.1437
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0215 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.078 0.153
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0497 0.0617
Loa Loa (eye worm) hypothetical protein 0.0043 0.078 0.1412
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0297 0.0201
Toxoplasma gondii ABC1 family protein 0.0043 0.078 0.1054
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0497 0.0895
Entamoeba histolytica hypothetical protein 0.0023 0.0297 0.3388
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0194 0.1416
Loa Loa (eye worm) hypothetical protein 0.0023 0.0297 0.0537
Trypanosoma brucei glucose transporter 1E 0.0032 0.0506 0.5989
Loa Loa (eye worm) hypothetical protein 0.0031 0.0482 0.0872
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.078 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0497 0.0617
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0297 0.2918
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0019 0.0194 0.0437
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Brugia malayi Sugar transporter family protein 0.0103 0.2171 0.3819
Toxoplasma gondii DNA polymerase family B protein 0.0019 0.0194 0.0149
Onchocerca volvulus 0.0043 0.078 0.3087
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0297 0.2918
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2171 0.3201
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0482 0.0862
Schistosoma mansoni hypothetical protein 0.0041 0.0726 0.284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0206 0.0372
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.078 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.078 0.1412
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0482 0.1738
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Leishmania major hypothetical protein, conserved 0.0043 0.078 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0482 0.1738
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0482 0.9506
Onchocerca volvulus DNA polymerase homolog 0.0019 0.0194 0.0437
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0297 0.0901
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2171 1
Plasmodium falciparum protein kinase 7 0.029 0.6576 0.6576
Mycobacterium ulcerans hypothetical protein 0.0043 0.078 1
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0297 0.0308
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0097 0.109
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.078 0.1103
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Loa Loa (eye worm) hypothetical protein 0.0245 0.5528 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2171 0.4647
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0726 0.1157
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3657 0.3657
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0297 0.1366
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0497 0.0404
Brugia malayi Cam kinase protein 1 0.0031 0.0497 0.0736
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Loa Loa (eye worm) sugar transporter 0.0103 0.2171 0.3928
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0506 0.5989
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0019 0.0194 0.0217
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0506 0.5989
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0497 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0019 0.0194 0.0217
Entamoeba histolytica protein kinase, putative 0.0031 0.0497 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0019 0.0194 0.0893
Onchocerca volvulus Deterin homolog 0.0109 0.231 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0497 0.0497
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0206 0.02
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0482 0.4718
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0097 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Schistosoma mansoni hypothetical protein 0.0103 0.2171 0.9373
Onchocerca volvulus 0.0043 0.078 0.3087
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Leishmania major glucose transporter, lmgt2 0.0032 0.0506 0.5989
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0506 0.2332
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0097 0.0448
Schistosoma mansoni glucose transport protein 0.0103 0.2171 0.9373
Trypanosoma brucei glucose transporter, putative 0.0032 0.0506 0.5989
Loa Loa (eye worm) beta-lactamase 0.0043 0.078 0.1412
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2171 0.4647
Loa Loa (eye worm) hypothetical protein 0.0031 0.0482 0.0872
Loa Loa (eye worm) hypothetical protein 0.0109 0.231 0.4179
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0097 0.0448
Brugia malayi DNA polymerase delta catalytic subunit 0.0019 0.0194 0.0178
Mycobacterium tuberculosis Conserved protein 0.0043 0.078 0.1103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0176
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0014 0.5
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0097 0.0448
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.078 0.1103
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0482 0.0708
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0497 0.0899
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0019 0.0194 0.0217
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0206 0.0243
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2171 0.4647
Brugia malayi beta-lactamase family protein 0.0043 0.078 0.1258
Brugia malayi beta-lactamase family protein 0.0043 0.078 0.1258
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.629 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 6.83 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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